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Papers by Scarlett Rodriguez
Neuro-Oncology
OBJECTIVE: We hypothesize that patients with neurocutaneous melanocytosis-associated melanoma and... more OBJECTIVE: We hypothesize that patients with neurocutaneous melanocytosis-associated melanoma and ventriculoperitoneal shunts are at risk of developing intraperitoneal spread of melanoma. BACKGROUND: Neurocutaneous melanocytosis, a rare condition characterized by excessive proliferation and deposition of melanocytes in the leptomeninges and brain parenchyma, typically occurs in children with large congenital melanocytic nevi and multiple smaller congenital nevi. These patients are at heightened risk for developing NRAS+ melanomas in the central nervous system, which in turn may lead to symptomatic hydrocephalus requiring cerebrospinal fluid diversion for symptom relief. METHODS: Retrospective single-institution study of patients with histologically or radiographically confirmed NCM evaluated at Memorial Sloan Kettering Cancer Center (MSKCC) from 2001-2022. RESULTS: Of the 47 patients with a diagnosis of NCM, 44 patients had symptomatic neurological complications. Eleven patients dev...
The dominant representations of Latinx immigrants in the U.S. media do a disservice to the humani... more The dominant representations of Latinx immigrants in the U.S. media do a disservice to the humanity of this group and overwhelmingly depict them in negative ways. This paper is an effort to counter these narratives and humanize the experiences of Latina immigrants. Specifically, it explores and analyzes four personal narratives from Latina women who migrated to the United States between 1950-1970s. The methodological approach in this report is qualitative and interpretive analysis, using open and axial coding. The author discusses how identities are constructed and shaped by the experiences of immigration, and connects it to extant research on power, coloniality, race, and intercultural communication
Journal of Clinical Oncology
11503 Background: Prexasertib (PRX) is an inhibitor of CHK1, prevents DNA repair leading to mitot... more 11503 Background: Prexasertib (PRX) is an inhibitor of CHK1, prevents DNA repair leading to mitotic catastrophe, and can enhance the activity of DNA-damaging chemotherapy. Translocation driven sarcomas exhibit high levels of replication stress and have demonstrated susceptibility to CHK1 inhibition in preclinical models. Desmoplastic small round cell tumor (DSRCT) and rhabdomyosarcoma (RMS) are aggressive sarcomas of children, adolescents and young adults for which novel therapies are urgently required. Methods: We conducted a phase I/II trial of PRX with irinotecan (irino) in patients ≥ 12 months of age with relapsed or refractory DSRCT or RMS. Eligible patients could have any number of prior therapies, including irino. Dose level 1 was PRX 80 mg/m2 on day 1 + irino 20 mg/m2 for 10 days. Dose levels 2 and 2A were PRX 105 or 150 mg/m2 (>21 years or ≤ 21 years) on day 1 and irino 20 mg/m2 for 10 (level 2) or 5 (level 2A) days. All cycles were 21 days. The primary objectives were t...
Neuro-Oncology
OBJECTIVE: We hypothesize that patients with neurocutaneous melanocytosis-associated melanoma and... more OBJECTIVE: We hypothesize that patients with neurocutaneous melanocytosis-associated melanoma and ventriculoperitoneal shunts are at risk of developing intraperitoneal spread of melanoma. BACKGROUND: Neurocutaneous melanocytosis, a rare condition characterized by excessive proliferation and deposition of melanocytes in the leptomeninges and brain parenchyma, typically occurs in children with large congenital melanocytic nevi and multiple smaller congenital nevi. These patients are at heightened risk for developing NRAS+ melanomas in the central nervous system, which in turn may lead to symptomatic hydrocephalus requiring cerebrospinal fluid diversion for symptom relief. METHODS: Retrospective single-institution study of patients with histologically or radiographically confirmed NCM evaluated at Memorial Sloan Kettering Cancer Center (MSKCC) from 2001-2022. RESULTS: Of the 47 patients with a diagnosis of NCM, 44 patients had symptomatic neurological complications. Eleven patients dev...
The dominant representations of Latinx immigrants in the U.S. media do a disservice to the humani... more The dominant representations of Latinx immigrants in the U.S. media do a disservice to the humanity of this group and overwhelmingly depict them in negative ways. This paper is an effort to counter these narratives and humanize the experiences of Latina immigrants. Specifically, it explores and analyzes four personal narratives from Latina women who migrated to the United States between 1950-1970s. The methodological approach in this report is qualitative and interpretive analysis, using open and axial coding. The author discusses how identities are constructed and shaped by the experiences of immigration, and connects it to extant research on power, coloniality, race, and intercultural communication
Journal of Clinical Oncology
11503 Background: Prexasertib (PRX) is an inhibitor of CHK1, prevents DNA repair leading to mitot... more 11503 Background: Prexasertib (PRX) is an inhibitor of CHK1, prevents DNA repair leading to mitotic catastrophe, and can enhance the activity of DNA-damaging chemotherapy. Translocation driven sarcomas exhibit high levels of replication stress and have demonstrated susceptibility to CHK1 inhibition in preclinical models. Desmoplastic small round cell tumor (DSRCT) and rhabdomyosarcoma (RMS) are aggressive sarcomas of children, adolescents and young adults for which novel therapies are urgently required. Methods: We conducted a phase I/II trial of PRX with irinotecan (irino) in patients ≥ 12 months of age with relapsed or refractory DSRCT or RMS. Eligible patients could have any number of prior therapies, including irino. Dose level 1 was PRX 80 mg/m2 on day 1 + irino 20 mg/m2 for 10 days. Dose levels 2 and 2A were PRX 105 or 150 mg/m2 (>21 years or ≤ 21 years) on day 1 and irino 20 mg/m2 for 10 (level 2) or 5 (level 2A) days. All cycles were 21 days. The primary objectives were t...