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Development of pyoderma occurs in 2 stages. Firstly the pathogen colonises areas of the body surf... more Development of pyoderma occurs in 2 stages. Firstly the pathogen colonises areas of the body surface. It may then become a surface pyoderma. The 2 most important of these surface pyodermas are skin fold pyodermas (intertrigo) and pyotraumatic dermatitis. The second phase occurs when the most superficial layer of the skin (the stratum corneum) is invaded to cause impetigo and/or invasion of the hair follicles causing folliculitis. The latter 2 are classified as superficial pyoderma. When the infected hair follicle ruptures, the infection spreads into the dermis (furunculosis) or spreads more deeply along tissue planes (cellulitis). The latter 2 are termed deep pyodermas. Resolution depends on the non-specific defenses (neutrophils and macrophages) and on the specific defenses (cell mediated immunity and antibodies). Resolution is accompanied by an inflammatory response, which is responsible for the clinical signs of pyoderma.
Journal of the South African Veterinary Association, Mar 30, 1991
Veterinary Dermatology, 1996
The efficacy of a topical antimicrobial-corticosteroid combination for the treatment of pyotrauma... more The efficacy of a topical antimicrobial-corticosteroid combination for the treatment of pyotraumatic dermatitis in dogs, was investigated. An open-ended, double-blind, randomized trial design was used. Forty dogs were divided into two vehicle-treated control groups and three treatment groups. The dogs in the respective treatment groups were treated with emulsions of either neomycin, prednisolone or a neomycin-prednisolone combination. Lesions were shaved and cleaned before treatment commenced, whereafter the allocated emulsion was applied twice daily for 7 days. Lesions were evaluated for surface area and degree of pruritus and inflammation. Skin biopsy specimens for bacterial culture and histopathological examination were taken. Staphylococcus aureus was the predominant organism isolated. The antimicrobialcorticosteroid combination emulsion resulted in the quickest recovery, followed by the antimicrobial drug alone. Prednisolone alone gave significantly poorer results. Dogs in all groups, including the control groups, recovered completely within 7 days.
Development of pyoderma occurs in 2 stages. Firstly the pathogen colonises areas of the body surf... more Development of pyoderma occurs in 2 stages. Firstly the pathogen colonises areas of the body surface. It may then become a surface pyoderma. The 2 most important of these surface pyodermas are skin fold pyodermas (intertrigo) and pyotraumatic dermatitis. The second phase occurs when the most superficial layer of the skin (the stratum corneum) is invaded to cause impetigo and/or invasion of the hair follicles causing folliculitis. The latter 2 are classified as superficial pyoderma. When the infected hair follicle ruptures, the infection spreads into the dermis (furunculosis) or spreads more deeply along tissue planes (cellulitis). The latter 2 are termed deep pyodermas. Resolution depends on the non-specific defenses (neutrophils and macrophages) and on the specific defenses (cell mediated immunity and antibodies). Resolution is accompanied by an inflammatory response, which is responsible for the clinical signs of pyoderma.
Journal of the South African Veterinary Association, Mar 30, 1991
Veterinary Dermatology, 1996
The efficacy of a topical antimicrobial-corticosteroid combination for the treatment of pyotrauma... more The efficacy of a topical antimicrobial-corticosteroid combination for the treatment of pyotraumatic dermatitis in dogs, was investigated. An open-ended, double-blind, randomized trial design was used. Forty dogs were divided into two vehicle-treated control groups and three treatment groups. The dogs in the respective treatment groups were treated with emulsions of either neomycin, prednisolone or a neomycin-prednisolone combination. Lesions were shaved and cleaned before treatment commenced, whereafter the allocated emulsion was applied twice daily for 7 days. Lesions were evaluated for surface area and degree of pruritus and inflammation. Skin biopsy specimens for bacterial culture and histopathological examination were taken. Staphylococcus aureus was the predominant organism isolated. The antimicrobialcorticosteroid combination emulsion resulted in the quickest recovery, followed by the antimicrobial drug alone. Prednisolone alone gave significantly poorer results. Dogs in all groups, including the control groups, recovered completely within 7 days.