Scott Whyte - Academia.edu (original) (raw)

Papers by Scott Whyte

White JH, Alston MK, Marquez JL, Sweetapple AL, Pollack MR, Attia J, Levi CR, Sturm J, Whyte S. C... more White JH, Alston MK, Marquez JL, Sweetapple AL, Pollack MR, Attia J, Levi CR, Sturm J, Whyte S. Community-dwelling stroke survivors: function is not the whole story with quality of life. Arch Phys Med Rehabil 2007; 88:1140-6.

Neurobiology of Aging, 1996

Modulation of the expression or processing of the amyloid precursor protein (APP) of Alzheimer's ... more Modulation of the expression or processing of the amyloid precursor protein (APP) of Alzheimer's disease (AD) by environmental factors may be relevant to the pathogenic accumulation of amyloid. We investigated the effect of short term oral zinc supplementation in both humans and rats, since earlier studies indicated extensive interactions between zinc and APP/bA4 amyloid.

The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 1999

Two hundred and thirty-eight volunteers (74 men) between the ages of 44 and 85 years, mean (SD) =... more Two hundred and thirty-eight volunteers (74 men) between the ages of 44 and 85 years, mean (SD) = 62.5 (8.6), participated in the study. shows the distribution of the participants' ages. We recruited participants from the general population via newspaper and radio advertisements. A neurologist, a neuropsychologist, and a psychiatric nurse, who rated the participants against strict exclusion criteria, assessed all participants. We excluded participants if they met the National Institute of P361 by guest on

Journal of Clinical Neuroscience, 2010

Aim: To compare the profile of behavioural features in patients with motor neurone disease (MND) ... more Aim: To compare the profile of behavioural features in patients with motor neurone disease (MND) vs. patients with behavioural variant Frontotemporal Dementia (bvFTD).

Journal of Clinical Neuroscience, 2007

Post-stroke homonymous visual field (PSHVF) loss has functional and driving implications for pati... more Post-stroke homonymous visual field (PSHVF) loss has functional and driving implications for patients. Automated, as opposed to confrontational, assessment of PSHVF loss has the potential to provide a more reliable indicator for field loss and thus ability to drive. Sixty-one consecutive stroke admissions were assessed at 9 months post-stroke. Driving status and the patient's awareness of any visual field loss was ascertained. Patients underwent formal perimetric visual field testing using a Humphrey Visual Field Analyser II. A separate, blinded, confrontational assessment of visual fields was made using the National Institutes of Health Stroke Scale (NIHSS) technique. Homonymous field defects were found in 10 (16%) patients, with 50% of these being hemianopia and 50% quadrantanopia. Right-sided field loss was more common (70%). No patients with PSHVF loss were aware of their loss, and only two were detected using NIHSS assessment. One patient was thought to have PSHVF loss on NIHSS assessment but this was not confirmed on perimetry. Of those with significant PSHVF loss at 9 months, 30% were driving. The prevalence of PSHVF loss is relatively high and is underestimated by confrontational testing. Stroke patients are often unaware of their field loss, with up to 5% driving with significantly affected visual fields at 9 months. Perimetric testing may be useful in decision-making regarding driving eligibility post-stroke.

Journal of Clinical Neuroscience, 2007

Background: Early identification of mood disorder post-stroke (MDPS) or its determinants could im... more Background: Early identification of mood disorder post-stroke (MDPS) or its determinants could improve stroke outcomes. However, the natural history, prevalence and determinants of MDPS within the first weeks post-stroke require further investigation. Methods: Consecutive hospitalised stroke survivors were assessed within 2-5 days of stroke, and at 1 and 3 months post-stroke. Baseline data included demographics, co-morbidities, stroke subtype, pre-stroke disability and cognition. At baseline, 1-and 3-month interviews physical impairment, disability, cognition and social support were assessed. MDPS was defined as a score of >8 on the depression subscale of the Hospital Anxiety Depression Scale. Factors independently associated with MDPS at each time-point were determined using regression analyses. Results: One hundred and twenty-five subjects were included. The prevalence of MDPS within 5 days and at 1 and 3 months post-stroke was 5%, 16% and 21% respectively. The independent determinants for MDPS at 1 month were disability, social support and change in impairment score between initial and 1-month assessments; and at 3 months were disability, social support and institutionalisation. Individuals moved in and out of the subset of depressed patients over time. MDPS was independently associated with mortality at 3 months post-stroke. Conclusion: Mood disorder post-stroke increases in prevalence over the initial weeks post-stroke despite an improvement in disability, and is associated with mortality. Patients with MDPS at 1 month were not necessarily affected at 3 months and vice versa, indicating the dynamic nature of MDPS in the early stages.

Journal of Clinical Neuroscience, 2008

The presence of glycogen granules in the cell cytoplasm as confrmed by periodic acid-Schiff stain... more The presence of glycogen granules in the cell cytoplasm as confrmed by periodic acid-Schiff stainning is used as a positive marker for Ewing's sarcoma. 5 Immunohistochemical analysis of Ewing's sarcoma reveals expression of vimentin and MIC-2 (CD 99) with characteristic perinuclear staining.

Cerebral abscess with pneumocephalus

Internal Medicine Journal, 2005

Stroke or encephalitis?

Emergency Medicine Australasia, 2005

Viral encephalitis is associated with significant morbidity and mortality, particularly when appr... more Viral encephalitis is associated with significant morbidity and mortality, particularly when appropriate management is omitted as a result of delayed diagnosis. A case of herpes simplex virus type 1 (HSV-1) encephalitis is presented, demonstrating that the presentation of confusion, speech difficulties and fever with non-specific early brain CT appearances can easily be misdiagnosed as pneumonia with stroke. This case highlights the need for increased awareness of HSV-1 encephalitis among emergency physicians and radiologists, given that the early spectrum of clinical and CT findings can mimic the more common diagnoses of sepsis and stroke.

Brain, 2008

Spatio-temporal clustering of sporadic Creutzfeldt-Jakob disease (sCJD) has been recognized and i... more Spatio-temporal clustering of sporadic Creutzfeldt-Jakob disease (sCJD) has been recognized and investigated previously in various global settings including Australia. Generally, despite often extensive investigation, explanations such as point source outbreaks and plausible case-to-case transmission links have not been identified to explain the apparently higher case rates than expected. In the context of national surveillance during the period 1993-2006, an increased number of cases of sCJD were recognized in a circumscribed coastal region of eastern Australia. To assess the significance of this apparent clustering, the Spatial Scan Statistic was used to examine for geographic excess of CJD mortality at spatial and temporal combined, spatial only and temporal only levels. A significant spatial cluster was confirmed, encompassing three contiguous statistical local areas within the state of New South Wales (NSW). Detailed epidemiological analysis did not reveal a plausible cross-over or point source transmission event. Further evaluation prompted the conclusion that vigilant and motivated managing clinicians in this geographically circumscribed area of NSW evinced a sustained higher level of clinical awareness for the broad phenotypic spectrum of CJD with reliable referral of suspect cases for further investigation. In addition, these physicians established and maintained a well-coordinated and active approach to suspect CJD autopsy. This combination of factors translated into a higher intensity of surveillance at approximately twice the rate per population observed in the entire state, culminating in twice the incidence of sCJD at around 2.28 cases/million population/year. The hypothesis that intensity of surveillance for rare disorders can be objectively measured and that this can positively correlate with disease incidence deserves further exploration. It may prove to be an important insight into the varying incidence rates over periods of time within individual nations and between different countries. Abbreviations: CJD = Creutzfeldt-Jakob disease; NSW = New South Wales; PRNP = prion protein gene; RR MH = Mantel-Haenszel rate ratio estimate; sCJD = sporadic CJD; SLA = statistical local area http://brain.oxfordjournals.org/ Downloaded from 494 | Brain 2009: 132; 493-501 G. M. Klug et al. by guest on October 23, 2016 http://brain.oxfordjournals.org/ Downloaded from Enhanced surveillance and CJD clustering Brain 2009: 132; 493-501 | 495 by guest on October 23, 2016 http://brain.oxfordjournals.org/ Downloaded from RPD = rapidly progressive dementia; NK = not known; ND = not done; MM = methionine homozygous; MV = methionine/valine heterozygous; VV = valine homozygous. a Indicates cases previously published. (Cohn et al., 2000).

Archives of Physical Medicine and Rehabilitation, 2007

Annals of Neurology, 1997

The amyloid precursor protein is contained in platelet alpha granules and released with degranula... more The amyloid precursor protein is contained in platelet alpha granules and released with degranulation. Methods are described to control for amyloid precursor protein release from platelets during blood collection and processing. In normal subjects (n = 97; age range, 44-84 years), the average plasma level of amyloid precursor protein was 6.5 +-1.8 nglml.

Annals of Neurology, 1992

PA4 amyloid deposition in the brain, which is characteristic of Alzheimer's disease (AD), may res... more PA4 amyloid deposition in the brain, which is characteristic of Alzheimer's disease (AD), may result from either overexpression of the amyloid protein precursor (APP) or failure of APP to be correctly processed. A blood marker reflecting this abnormal metabolism would be of diagnostic value and would provide a means of monitoring the efficacy of therapeutic interventions. We analyzed immunoblots of plasma APP enriched by heparin-Sepharose chromatography from patients with moderate to severe AD dementia (n = 34) and control subjects (n = 77) and found an approximately 50% increase in the proportion of 130-kd APP species in patients with AD (p < 0.001), no difference in the 110-kd form, a 15 to 30% decrease in the 65-kd form (p < 0.001), and a 20 to 35% decrease in the proportion of 42-kd APP (p < 0.001). These species of APP were soluble, lacked the carboxyl terminus, and the 110-and 42-kd species were shown to be consistent with degradation products derived from the 130-kd species. A comparison of levels of 130-kd plasma APP from moderately to severely demented patients with AD and control subjects distinguished the two groups with a specificity of 87.0% and a sensitivity of 79.4%.

Polymorphisms in Platelet Glycoprotein 1b and Factor VII and Risk of Ischemic Stroke: A Meta-Analysis

Stroke, 2008

Ann Neurol, 2000

We found that in vitro migration and interferon-␥ production by lymphocytes derived from primary ... more We found that in vitro migration and interferon-␥ production by lymphocytes derived from primary progressive multiple sclerosis patients preselected on the basis of a high T2-weighted lesion volume (>10 cm 3 ) on magnetic resonance imaging, were increased compared with that in primary progressive multiple sclerosis patients with a low T2-weighted lesion volume (<3 cm 3 ) and controls. Whether the heterogeneity of immune function within the primary progressive population will correlate with response to therapy remains to be established.

Background and Purpose-Platelets and components of the coagulation cascade are known to be instru... more Background and Purpose-Platelets and components of the coagulation cascade are known to be instrumental in the pathogenesis of arterial occlusive disorders. The aim of this meta-analysis is to test the hypothesis that genetic variation in the platelet glycoprotein 1b␣ and Factor VII genes influence the occurrence of ischemic stroke. All genetic association studies that examined the R353Q (rs6046) polymorphism of the Factor VII gene and 2 polymorphisms of the platelet glycoprotein (1b␣) gene (Thr/Met rs6065 and Kozak sequence Ϫ5 C/T rs2243093) in relation to ischemic stroke were examined. Methods-Electronic databases Embase, Medline, and HuGEnet were searched for all years up until June 2006 for all studies that evaluated any of these candidate genes and stroke.

37.: Lombard effect revisited: A different approach to hypophonia in Parkinson’s disease

Journal of Clinical Neuroscience, Nov 30, 2014

Background and Purpose—Platelets and components of the coagulation cascade are known to be instru... more Background and Purpose—Platelets and components of the coagulation cascade are known to be instrumental in the pathogenesis of arterial occlusive disorders. The aim of this meta-analysis is to test the hypothesis that genetic variation in the platelet glycoprotein 1b and Factor VII genes influence the occurrence of ischemic stroke. All genetic association studies that examined the R353Q (rs6046) polymorphism of

Neurobiology of Aging, 1996

The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 1999

Journal of Clinical Neuroscience, 2010

Journal of Clinical Neuroscience, 2007

Journal of Clinical Neuroscience, 2008

Cerebral abscess with pneumocephalus

Internal Medicine Journal, 2005

Stroke or encephalitis?

Emergency Medicine Australasia, 2005

Brain, 2008

Archives of Physical Medicine and Rehabilitation, 2007

Annals of Neurology, 1997

Annals of Neurology, 1992

Polymorphisms in Platelet Glycoprotein 1b and Factor VII and Risk of Ischemic Stroke: A Meta-Analysis

Stroke, 2008

Ann Neurol, 2000

37.: Lombard effect revisited: A different approach to hypophonia in Parkinson’s disease

Journal of Clinical Neuroscience, Nov 30, 2014