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Papers by Sean Lee
Physical Review D, 1992
We propose an improvement on existing coherent-state representations for (2+1)-dimensional lattic... more We propose an improvement on existing coherent-state representations for (2+1)-dimensional lattice fermions. Complex Langevin methods for such systems previously suffered under the weight of large numerical factors in the coherent-state action. The proposed generalization contains degrees of freedom which allow these factors to be favorably controlled. A numerical study of free ferrnions gives improved results over a previous effort and does so without the need to introduce a spatially inhomogeneous lattice.
Journal of Statistical Physics, 1993
We discuss conditions under which expectation values computed from a complex Langevin process Z w... more We discuss conditions under which expectation values computed from a complex Langevin process Z will converge to integral averages over a given complex valued weight function. The difficulties in proving a general result are pointed out. For complex valued polynomial actions, it is shown that for a process converging to a strongly stationary process one gets the correct answer for averages of polynomials if c τ (k) ≡ E(e ikZ(τ)) satisfies certain conditions. If these conditions are not satisfied, then the stochastic process is not necessarily described by a complex Fokker Planck equation. The result is illustrated with the exactly solvable complex frequency harmonic oscillator. * Supported by Fonds zur Förderung der Wissenschaftlichen Forschung inÖsterreich, project P7849.
Shock, 2002
Bioglass is a bioactive, resorbable ceramic particle that was developed to assure binding to livi... more Bioglass is a bioactive, resorbable ceramic particle that was developed to assure binding to living tissues. Bioglass is currently employed to fill osseus defects in oral surgery, and it possesses both unique anti-inflammatory and antimicrobial properties. In an effort to determine whether Bioglass may be useful as an adjunct anti-inflammatory device in local inflammatory processes, we examined whether exposure of the peritoneal cavity to Bioglass would induce a pro- or anti-inflammatory response, and then modulate a subsequent proinflammatory response to endotoxin. Three- to fifty-milligram doses of 5 pm Bioglass were administered intraperitoneally in C57BL/6 mice. Total leukocyte, myeloperoxidase, and cytokine levels in the peritoneal wash fluid were determined. In addition, the peritoneal cavity was preexposed to Bioglass, and was then subjected to a subsequent endotoxin administration. All doses of Bioglass were found to induce a significant peritoneal IL-6 response; however, Bioglass did not induce a TNF-alpha, IL-1alpha, IL-10, or a white cell recruitment into the peritoneal lavage fluid. Pretreatment of the peritoneal cavity with Bioglass produced a transient reduction in the proinflammatory response to endotoxin. We conclude that exposure to Bioglass produces an IL-6 response without concurrent expression of TNF-alpha or IL-1alpha. Bioglass appears to transiently suppress the inflammatory response to endotoxin, possibly through the early induction of IL-6. These findings suggest that Bioglass may offer a unique approach in modifying the inflammatory response in local tissue compartments.
Nuclear Physics B, 1994
We discuss conditions under which expectation values computed from a complex Langevin process Z w... more We discuss conditions under which expectation values computed from a complex Langevin process Z will converge to integral averages over a given complex valued weight function. The difficulties in proving a general result are pointed out. For complex valued polynomial actions, it is shown that for a process converging to a strongly stationary process one gets the correct answer for averages of polynomials if c τ (k) ≡ E(e ikZ(τ)) satisfies certain conditions. If these conditions are not satisfied, then the stochastic process is not necessarily described by a complex Fokker Planck equation. The result is illustrated with the exactly solvable complex frequency harmonic oscillator. * Supported by Fonds zur Förderung der Wissenschaftlichen Forschung inÖsterreich, project P7849.
Physical Review D, 1992
We propose an improvement on existing coherent-state representations for (2+1)-dimensional lattic... more We propose an improvement on existing coherent-state representations for (2+1)-dimensional lattice fermions. Complex Langevin methods for such systems previously suffered under the weight of large numerical factors in the coherent-state action. The proposed generalization contains degrees of freedom which allow these factors to be favorably controlled. A numerical study of free ferrnions gives improved results over a previous effort and does so without the need to introduce a spatially inhomogeneous lattice.
Journal of Statistical Physics, 1993
We discuss conditions under which expectation values computed from a complex Langevin process Z w... more We discuss conditions under which expectation values computed from a complex Langevin process Z will converge to integral averages over a given complex valued weight function. The difficulties in proving a general result are pointed out. For complex valued polynomial actions, it is shown that for a process converging to a strongly stationary process one gets the correct answer for averages of polynomials if c τ (k) ≡ E(e ikZ(τ)) satisfies certain conditions. If these conditions are not satisfied, then the stochastic process is not necessarily described by a complex Fokker Planck equation. The result is illustrated with the exactly solvable complex frequency harmonic oscillator. * Supported by Fonds zur Förderung der Wissenschaftlichen Forschung inÖsterreich, project P7849.
Shock, 2002
Bioglass is a bioactive, resorbable ceramic particle that was developed to assure binding to livi... more Bioglass is a bioactive, resorbable ceramic particle that was developed to assure binding to living tissues. Bioglass is currently employed to fill osseus defects in oral surgery, and it possesses both unique anti-inflammatory and antimicrobial properties. In an effort to determine whether Bioglass may be useful as an adjunct anti-inflammatory device in local inflammatory processes, we examined whether exposure of the peritoneal cavity to Bioglass would induce a pro- or anti-inflammatory response, and then modulate a subsequent proinflammatory response to endotoxin. Three- to fifty-milligram doses of 5 pm Bioglass were administered intraperitoneally in C57BL/6 mice. Total leukocyte, myeloperoxidase, and cytokine levels in the peritoneal wash fluid were determined. In addition, the peritoneal cavity was preexposed to Bioglass, and was then subjected to a subsequent endotoxin administration. All doses of Bioglass were found to induce a significant peritoneal IL-6 response; however, Bioglass did not induce a TNF-alpha, IL-1alpha, IL-10, or a white cell recruitment into the peritoneal lavage fluid. Pretreatment of the peritoneal cavity with Bioglass produced a transient reduction in the proinflammatory response to endotoxin. We conclude that exposure to Bioglass produces an IL-6 response without concurrent expression of TNF-alpha or IL-1alpha. Bioglass appears to transiently suppress the inflammatory response to endotoxin, possibly through the early induction of IL-6. These findings suggest that Bioglass may offer a unique approach in modifying the inflammatory response in local tissue compartments.
Nuclear Physics B, 1994
We discuss conditions under which expectation values computed from a complex Langevin process Z w... more We discuss conditions under which expectation values computed from a complex Langevin process Z will converge to integral averages over a given complex valued weight function. The difficulties in proving a general result are pointed out. For complex valued polynomial actions, it is shown that for a process converging to a strongly stationary process one gets the correct answer for averages of polynomials if c τ (k) ≡ E(e ikZ(τ)) satisfies certain conditions. If these conditions are not satisfied, then the stochastic process is not necessarily described by a complex Fokker Planck equation. The result is illustrated with the exactly solvable complex frequency harmonic oscillator. * Supported by Fonds zur Förderung der Wissenschaftlichen Forschung inÖsterreich, project P7849.