Sean Ward - Academia.edu (original) (raw)

Papers by Sean Ward

Wetland Trust and Christchurch City Council restore the wetland. Meet people interested in restor... more Wetland Trust and Christchurch City Council restore the wetland. Meet people interested in restoring the native biodiversity of our city, share ideas and do some light physical work. Tasks vary according to the seasons and range from planting, release weeding and invasive weed control. Morning tea provided. When: Third Saturday of every month 9am to 12.30pm. Where: Meet at the Beach Road car park. What: Bring gumboots or boots, gardening gloves and clothing suitable for the weather and season. Work day dates for 2014 are:

Dans un exemple, la presente invention concerne un kit pour l'implantation intravasculaire d&... more Dans un exemple, la presente invention concerne un kit pour l'implantation intravasculaire d'un dispositif medical implantable dans un patient comprenant une gaine externe allongee formant une lumiere interne avec une ouverture distale, la gaine externe etant dimensionnee pour traverser la vascularisation du patient, et une gaine interne allongee avec un bouchon. La gaine interne comprend en outre une attache configuree pour former une boucle sur un cote distal du bouchon, la boucle etant configuree pour engager un element boucle du dispositif medical implantable de maniere a coupler le dispositif medical implantable a la gaine interne. Le bouchon peut coulisser par rapport a la gaine externe. L'attache est configuree pour liberer l'element boucle du dispositif medical implantable de la gaine interne par ouverture de la boucle d'attache lorsqu'une partie du bouchon est situee en position distale par rapport a l'ouverture distale de la gaine externe.

Media International Australia, 2020

The postmodern medical paradigm is becoming increasingly relevant to vaccine communication. Gover... more The postmodern medical paradigm is becoming increasingly relevant to vaccine communication. Government and health authorities pushing a pro-vaccine position often fall short in this climate due to a reliance unemotional and fact-based communication. The news media, however, often deviate from this norm by incorporating emotionality to legitimise vaccination. This article analyses how such emotionality manifests in pro-vaccination communication. Van Leeuwen’s typology of discursive legitimation strategies and Van Dijk’s ideological square were used to analyse The Daily Telegraph’ s No Jab No Pay(Play) campaign. The findings demonstrate a primary intention to polarise, as this may justify financial sanctions against vaccine-hesitant parents. However, several identified strategies could be effective at reducing hesitancy in a postmodern medical discourse if adapted under such an intention. Notably, in generating concern through parental and motherhood figures rather than expert authori...

Essays in the History of Canadian Law, 2008

American journal of physiology. Gastrointestinal and liver physiology, Jan 15, 2016

Inhibitory motor neurons regulate several gastric motility patterns including receptive relaxatio... more Inhibitory motor neurons regulate several gastric motility patterns including receptive relaxation, gastric peristaltic motor patterns and pyloric sphincter opening. Nitric oxide (NO) and purines have been identified as likely candidates that mediate inhibitory neural responses. However, the contribution from each neurotransmitter has received little attention in the distal stomach. The aims of this study were to identify the roles played by NO and purines in inhibitory motor responses in the antrums of mice and monkeys. By using wildtype mice and mutants with genetically deleted neural nitric oxide synthase (Nos1(-/-)) and P2Y1 receptors (P2ry1(-/-)) we examined the roles of NO and purines in post-junctional inhibitory responses in the distal stomach and compared these responses to those in primate stomach. Activation of inhibitory motor nerves using electrical field stimulation (EFS) produced frequency-dependent inhibitory junction potentials (IJPs) that produced muscle relaxation...

Advances in Experimental Medicine and Biology, 2019

Japanese Journal of Pharmacology

International Journal of Molecular Sciences

Gangliosides are sialic acid-containing glycosphingolipids, which are the most abundant family of... more Gangliosides are sialic acid-containing glycosphingolipids, which are the most abundant family of glycolipids in eukaryotes. Gangliosides have been suggested to be important lipid molecules required for the control of cellular procedures, such as cell differentiation, proliferation, and signaling. GD1a is expressed in interstitial cells during ovarian maturation in mice and exogenous GD1a is important to oocyte maturation, monospermic fertilization, and embryonic development. In this context, GM1 is known to influence signaling pathways in cells and is important in sperm–oocyte interactions and sperm maturation processes, such as capacitation. GM3 is expressed in the vertebrate oocyte cytoplasm, and exogenously added GM3 induces apoptosis and DNA injury during in vitro oocyte maturation and embryogenesis. As a consequence of this, ganglioside GT1b and GM1 decrease DNA fragmentation and act as H2O2 inhibitors on germ cells and preimplantation embryos. This review describes the functi...

Journal of Heredity

... Seed was removed from the dried panicles by hand and planted in a greenhouse at Colorado Stat... more ... Seed was removed from the dried panicles by hand and planted in a greenhouse at Colorado State University, Fort Collins, in January ... We cannot determine whether the male sterility gene we have identified in Ama-chuma is one previously reported in South American material ...

Journal of Food Composition and Analysis

The Journal of Physiology

eLife

Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity... more Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA mediating LTCC potentiation during diabetic hyperglycemia. Experiments in apyrase-treated cells suggested involvement of a P2Y receptor underlying the glucose effects on LTTCs. Using human tissue, expression for P2Y11, the only Gs-coupled P2Y receptor, was detected in nanometer proximity to CaV1.2 and PKA. FRET-based experiments revealed that the selective P2Y11 agonist NF546 and elevated glucose stimulate cAMP production resulting in enhanced PKA-dependent LTCC activity. These changes were blocked by the selective P2Y11 inhibitor NF340. Comparable results were observed in mouse tissue, suggesting that a P2Y11-like receptor is mediating the glucose response in these cells. These findings established a key role for P2Y11 in regulating PKA-de...

American Journal of Physiology-Gastrointestinal and Liver Physiology

Interstitial cells of Cajal (ICC) are the pacemaker cells in gastrointestinal (GI) muscles. They ... more Interstitial cells of Cajal (ICC) are the pacemaker cells in gastrointestinal (GI) muscles. They also mediate or transduce inputs from enteric motor nerves to the smooth muscle syncytium. What is known about functional roles of ICC comes from developmental studies based on the discovery that ICC express c- kit. Functional development of ICC networks depends on signaling via the Kit receptor pathway. Immunohistochemical studies using Kit antibodies have expanded our knowledge about the ICC phenotype, the structure of ICC networks, the interactions of ICC with other cells within the tunica muscularis, and the loss of ICC in some motility disorders. Manipulating Kit signaling with reagents to block the receptor or downstream signaling pathways or by using mutant mice in which Kit or its ligand, stem cell factor, are defective has allowed novel studies of the development of these cells within the tunica muscularisand also allowed the study of specific functions of different classes of I...