Seana Adams - Academia.edu (original) (raw)
Papers by Seana Adams
Temporomandibular joint disease (TMD) is a musculoskeletal pain disorder occurring at the temporo... more Temporomandibular joint disease (TMD) is a musculoskeletal pain disorder occurring at the temporomandibular joint (TMJ), the interface of the skull’s temporal bone and the mandible 1 . This literature review examines the anatomy, epidemiology, biochemistry and cellular biology of TMD in order to frame underlying biochemical and cellular events within the human context of the disease. This review identifies several key elements pertaining to TMD pathogenesis, including mechanical stress-induced hypoxia-reperfusion, disruption of mitochondrial function, arachidonic acid catabolism (through prostaglandins and leukotrienes), cartilage degradation, bone resorption, and breakdown of joint lubrication. Based on a thorough analysis of established correlations and causations we propose an overarching mechanism that provides a holistic representation of TMD, something noticeably absent in the literature to-date. This mechanism clearly highlights the central role of reactive oxygen species (RO...
Canadian Journal of Science, Mathematics and Technology Education, 2021
The existence of systemic racism in Canadian healthcare, among other determinants including acces... more The existence of systemic racism in Canadian healthcare, among other determinants including accessible education, available occupation, and affordable housing, contributes to the racial divide in treatment and poor health outcomes for Black communities. Recent promising work has demonstrated patient-physician racial concordance in populations of colour as a potential area of focus for addressing health inequities for diverse communities. The impact of shared cultural experiences and cultural competency leads to mutual respect, trust, and improved communication between patients and physicians guiding their care. This approach is dependent on the availability of physicians of colour and similarly other healthcare providers. The Temerty Faculty of Medicine at the University of Toronto has attempted to address the deficit in its own community through a two-pronged approach: mentorship through the Community of Support (COS) and the Summer Mentorship Program (SMP), and the implementation of the Black Student Application Program (BSAP). These initiatives have significantly increased Black medical student representation and continue to have considerable impact on Black communities in the surrounding area. Through partnerships with community organizations that support the ethos of these programs, the vision of a more culturally diverse physician workforce in Canada has been reinforced. The adoption of similar programs across Canadian medical schools can lead to better representation within medicine and help contribute to a necessary culture shift within the ranks of medical institutions. These are critical steps in laying the foundation for a medical education grounded in equity, excellence, and strength in diversity, and a healthcare system that truly provides patient-centred care.
The Canadian journal of cardiology, 2018
Surgical timing in infective endocarditis (IE) with preoperative neurological events remains cont... more Surgical timing in infective endocarditis (IE) with preoperative neurological events remains controversial. The relevant society guidelines are each on the basis of a small number of observational studies. This meta-analysis was designed to search the available literature broadly and assess the weight of available evidence as comprehensively as possible. We searched MEDLINE and EMBASE to April 2018 for studies that compared mortality or neurological exacerbation in early vs late surgery for IE complicated by neurological events. Random effects meta-analysis was performed. Twenty-seven observational studies (25 unadjusted, n = 879; 2 adjusted, n = 451) met inclusion criteria. Using early and late thresholds defined in each study (7 or 14 days), early surgery in ischemic or hemorrhagic stroke was associated with elevated perioperative mortality vs late surgery (pooled relative risk [RR], 1.74; 95% confidence interval, 1.34-2.25; P < 0.0001; I = 0%) and greater neurological exacerba...
Advances in Physiology Education, 2017
Three undergraduate students and their teacher discuss two crucial issues that form the implicit ... more Three undergraduate students and their teacher discuss two crucial issues that form the implicit basis of active learning: effort and trust. They use a single course in a Health Sciences Program to anchor their comments.
Temporomandibular joint disease (TMD) is a musculoskeletal pain disorder occurring at the temporo... more Temporomandibular joint disease (TMD) is a musculoskeletal pain disorder occurring at the temporomandibular joint (TMJ), the interface of the skull’s temporal bone and the mandible 1 . This literature review examines the anatomy, epidemiology, biochemistry and cellular biology of TMD in order to frame underlying biochemical and cellular events within the human context of the disease. This review identifies several key elements pertaining to TMD pathogenesis, including mechanical stress-induced hypoxia-reperfusion, disruption of mitochondrial function, arachidonic acid catabolism (through prostaglandins and leukotrienes), cartilage degradation, bone resorption, and breakdown of joint lubrication. Based on a thorough analysis of established correlations and causations we propose an overarching mechanism that provides a holistic representation of TMD, something noticeably absent in the literature to-date. This mechanism clearly highlights the central role of reactive oxygen species (RO...
Canadian Journal of Science, Mathematics and Technology Education, 2021
The existence of systemic racism in Canadian healthcare, among other determinants including acces... more The existence of systemic racism in Canadian healthcare, among other determinants including accessible education, available occupation, and affordable housing, contributes to the racial divide in treatment and poor health outcomes for Black communities. Recent promising work has demonstrated patient-physician racial concordance in populations of colour as a potential area of focus for addressing health inequities for diverse communities. The impact of shared cultural experiences and cultural competency leads to mutual respect, trust, and improved communication between patients and physicians guiding their care. This approach is dependent on the availability of physicians of colour and similarly other healthcare providers. The Temerty Faculty of Medicine at the University of Toronto has attempted to address the deficit in its own community through a two-pronged approach: mentorship through the Community of Support (COS) and the Summer Mentorship Program (SMP), and the implementation of the Black Student Application Program (BSAP). These initiatives have significantly increased Black medical student representation and continue to have considerable impact on Black communities in the surrounding area. Through partnerships with community organizations that support the ethos of these programs, the vision of a more culturally diverse physician workforce in Canada has been reinforced. The adoption of similar programs across Canadian medical schools can lead to better representation within medicine and help contribute to a necessary culture shift within the ranks of medical institutions. These are critical steps in laying the foundation for a medical education grounded in equity, excellence, and strength in diversity, and a healthcare system that truly provides patient-centred care.
The Canadian journal of cardiology, 2018
Surgical timing in infective endocarditis (IE) with preoperative neurological events remains cont... more Surgical timing in infective endocarditis (IE) with preoperative neurological events remains controversial. The relevant society guidelines are each on the basis of a small number of observational studies. This meta-analysis was designed to search the available literature broadly and assess the weight of available evidence as comprehensively as possible. We searched MEDLINE and EMBASE to April 2018 for studies that compared mortality or neurological exacerbation in early vs late surgery for IE complicated by neurological events. Random effects meta-analysis was performed. Twenty-seven observational studies (25 unadjusted, n = 879; 2 adjusted, n = 451) met inclusion criteria. Using early and late thresholds defined in each study (7 or 14 days), early surgery in ischemic or hemorrhagic stroke was associated with elevated perioperative mortality vs late surgery (pooled relative risk [RR], 1.74; 95% confidence interval, 1.34-2.25; P < 0.0001; I = 0%) and greater neurological exacerba...
Advances in Physiology Education, 2017
Three undergraduate students and their teacher discuss two crucial issues that form the implicit ... more Three undergraduate students and their teacher discuss two crucial issues that form the implicit basis of active learning: effort and trust. They use a single course in a Health Sciences Program to anchor their comments.