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Papers by Piero Sebastiani

Research paper thumbnail of Faster imaging for MEG-MRI

Angelo Galante, Allegra Conti, Cinzia De Luca, Vittorio Pizzella, Gian Luca Romani, Raffaele Sini... more Angelo Galante, Allegra Conti, Cinzia De Luca, Vittorio Pizzella, Gian Luca Romani, Raffaele Sinibaldi, Marcello Alecci, Piero Sebastiani, Antonello Sotgiu, and Stefania Della Penna MESVA, Department of Life, Health & Environmental Sciences, L'Aquila University, L'Aquila, AQ, Italy, Department of Neuroscience and Imaging, University of Chieti, CH, Italy, Institute of Advanced Biomedical Technologies, University of Chieti, CH, Italy, MESVA, Department of Life, Health & Environmental Sciences, L'Aquila University, AQ, Italy, ITA S.r.l., AQ, Italy

Research paper thumbnail of Very Low Field MRI: A fast system compatible with Magnetoencephalography

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings, 2015

In recent years, Ultra Low Field (ULF) Magnetic Resonance Imaging (MRI) is being given more and m... more In recent years, Ultra Low Field (ULF) Magnetic Resonance Imaging (MRI) is being given more and more attention, thanks to the possibility of integrating ULF-MRI with MagnetoEncephaloGraphy (MEG) in the same set-up. A MEG-compatible Very Low Field (VLF) MRI device working in the hundreds of kHz, without sample prepolarization and with room temperature receiving channel, is presented. Considering the same imaging conditions and SNR value, the system has better performances in terms of scan time if compared with existing ULF devices while preserving many of the ULF-MRI advantages.

Research paper thumbnail of Fast Room Temperature Very Low Field-Magnetic Resonance Imaging System Compatible with MagnetoEncephaloGraphy Environment

PLOS ONE, 2015

In recent years, ultra-low field (ULF)-MRI is being given more and more attention, due to the pos... more In recent years, ultra-low field (ULF)-MRI is being given more and more attention, due to the possibility of integrating ULF-MRI and Magnetoencephalography (MEG) in the same device. Despite the signal-to-noise ratio (SNR) reduction, there are several advantages to operating at ULF, including increased tissue contrast, reduced cost and weight of the scanners, the potential to image patients that are not compatible with clinical scanners, and the opportunity to integrate different imaging modalities. The majority of ULF-MRI systems are based, until now, on magnetic field pulsed techniques for increasing SNR, using SQUID based detectors with Larmor frequencies in the kHz range. Although promising results were recently obtained with such systems, it is an open question whether similar SNR and reduced acquisition time can be achieved with simpler devices. In this work a room-temperature, MEG-compatible very-low field (VLF)-MRI device working in the range of several hundred kHz without sample pre-polarization is presented. This preserves many advantages of ULF-MRI, but for equivalent imaging conditions and SNR we achieve reduced imaging time based on preliminary results using phantoms and ex-vivo rabbits heads.

Research paper thumbnail of Mobile NMR for surface analysis

2011 IEEE International Symposium on Medical Measurements and Applications, 2011

It is described the realization of a single sided scanner suitable for Nuclear Magnetic Resonance... more It is described the realization of a single sided scanner suitable for Nuclear Magnetic Resonance (NMR). A new design of a hand-size elliptical magnet, coil system and electronics is presented. First results demonstrate the possibility to measure relaxation times and diffusion coefficient in a small volume and open the possibility to use the prototype for in vivo skin studies. Possibility to extend the scanner functionality to 1D/2D Magnetic Resonance Imaging (MRI) is discussed.

Research paper thumbnail of NMR Detection at 8.9 MT with a GMR Based Sensor Coupled to a Superconducting NB Flux Transformer

Progress In Electromagnetics Research, 2013

This study presents NMR signal detection by means of a superconducting channel consisting of a Nb... more This study presents NMR signal detection by means of a superconducting channel consisting of a Nb surface detection coil inductively coupled to a YBCO mixed sensor. The NMR system operates at a low-field (8.9 mT) in a magnetically shielded room suitable for magnetoencephalographic (MEG) recordings. The main field is generated by a compact solenoid and the geometry of the pick-up coil has been optimized to provide high spatial sensitivity * Corresponding author: Raffaele Sinibaldi (r.sinibaldi@unich.it).

Research paper thumbnail of NMR Detection at 8.9 MT with a GMR Based Sensor Coupled to a Superconducting NB Flux Transformer

Progress In Electromagnetics Research, 2013

This study presents NMR signal detection by means of a superconducting channel consisting of a Nb... more This study presents NMR signal detection by means of a superconducting channel consisting of a Nb surface detection coil inductively coupled to a YBCO mixed sensor. The NMR system operates at a low-field (8.9 mT) in a magnetically shielded room suitable for magnetoencephalographic (MEG) recordings. The main field is generated by a compact solenoid and the geometry of the pick-up coil has been optimized to provide high spatial sensitivity * Corresponding author: Raffaele Sinibaldi (r.sinibaldi@unich.it).

Research paper thumbnail of Faster imaging for MEG-MRI

Angelo Galante, Allegra Conti, Cinzia De Luca, Vittorio Pizzella, Gian Luca Romani, Raffaele Sini... more Angelo Galante, Allegra Conti, Cinzia De Luca, Vittorio Pizzella, Gian Luca Romani, Raffaele Sinibaldi, Marcello Alecci, Piero Sebastiani, Antonello Sotgiu, and Stefania Della Penna MESVA, Department of Life, Health & Environmental Sciences, L'Aquila University, L'Aquila, AQ, Italy, Department of Neuroscience and Imaging, University of Chieti, CH, Italy, Institute of Advanced Biomedical Technologies, University of Chieti, CH, Italy, MESVA, Department of Life, Health & Environmental Sciences, L'Aquila University, AQ, Italy, ITA S.r.l., AQ, Italy

Research paper thumbnail of Very Low Field MRI: A fast system compatible with Magnetoencephalography

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings, 2015

In recent years, Ultra Low Field (ULF) Magnetic Resonance Imaging (MRI) is being given more and m... more In recent years, Ultra Low Field (ULF) Magnetic Resonance Imaging (MRI) is being given more and more attention, thanks to the possibility of integrating ULF-MRI with MagnetoEncephaloGraphy (MEG) in the same set-up. A MEG-compatible Very Low Field (VLF) MRI device working in the hundreds of kHz, without sample prepolarization and with room temperature receiving channel, is presented. Considering the same imaging conditions and SNR value, the system has better performances in terms of scan time if compared with existing ULF devices while preserving many of the ULF-MRI advantages.

Research paper thumbnail of Fast Room Temperature Very Low Field-Magnetic Resonance Imaging System Compatible with MagnetoEncephaloGraphy Environment

PLOS ONE, 2015

In recent years, ultra-low field (ULF)-MRI is being given more and more attention, due to the pos... more In recent years, ultra-low field (ULF)-MRI is being given more and more attention, due to the possibility of integrating ULF-MRI and Magnetoencephalography (MEG) in the same device. Despite the signal-to-noise ratio (SNR) reduction, there are several advantages to operating at ULF, including increased tissue contrast, reduced cost and weight of the scanners, the potential to image patients that are not compatible with clinical scanners, and the opportunity to integrate different imaging modalities. The majority of ULF-MRI systems are based, until now, on magnetic field pulsed techniques for increasing SNR, using SQUID based detectors with Larmor frequencies in the kHz range. Although promising results were recently obtained with such systems, it is an open question whether similar SNR and reduced acquisition time can be achieved with simpler devices. In this work a room-temperature, MEG-compatible very-low field (VLF)-MRI device working in the range of several hundred kHz without sample pre-polarization is presented. This preserves many advantages of ULF-MRI, but for equivalent imaging conditions and SNR we achieve reduced imaging time based on preliminary results using phantoms and ex-vivo rabbits heads.

Research paper thumbnail of Mobile NMR for surface analysis

2011 IEEE International Symposium on Medical Measurements and Applications, 2011

It is described the realization of a single sided scanner suitable for Nuclear Magnetic Resonance... more It is described the realization of a single sided scanner suitable for Nuclear Magnetic Resonance (NMR). A new design of a hand-size elliptical magnet, coil system and electronics is presented. First results demonstrate the possibility to measure relaxation times and diffusion coefficient in a small volume and open the possibility to use the prototype for in vivo skin studies. Possibility to extend the scanner functionality to 1D/2D Magnetic Resonance Imaging (MRI) is discussed.

Research paper thumbnail of NMR Detection at 8.9 MT with a GMR Based Sensor Coupled to a Superconducting NB Flux Transformer

Progress In Electromagnetics Research, 2013

This study presents NMR signal detection by means of a superconducting channel consisting of a Nb... more This study presents NMR signal detection by means of a superconducting channel consisting of a Nb surface detection coil inductively coupled to a YBCO mixed sensor. The NMR system operates at a low-field (8.9 mT) in a magnetically shielded room suitable for magnetoencephalographic (MEG) recordings. The main field is generated by a compact solenoid and the geometry of the pick-up coil has been optimized to provide high spatial sensitivity * Corresponding author: Raffaele Sinibaldi (r.sinibaldi@unich.it).

Research paper thumbnail of NMR Detection at 8.9 MT with a GMR Based Sensor Coupled to a Superconducting NB Flux Transformer

Progress In Electromagnetics Research, 2013

This study presents NMR signal detection by means of a superconducting channel consisting of a Nb... more This study presents NMR signal detection by means of a superconducting channel consisting of a Nb surface detection coil inductively coupled to a YBCO mixed sensor. The NMR system operates at a low-field (8.9 mT) in a magnetically shielded room suitable for magnetoencephalographic (MEG) recordings. The main field is generated by a compact solenoid and the geometry of the pick-up coil has been optimized to provide high spatial sensitivity * Corresponding author: Raffaele Sinibaldi (r.sinibaldi@unich.it).