Seema Joshi - Academia.edu (original) (raw)

Papers by Seema Joshi

Combinatorial Chemistry & High Throughput Screening, 2020

The article has been withdrawn at the request of the authors of the journal "Combinatorial C... more The article has been withdrawn at the request of the authors of the journal "Combinatorial Chemistry & High Throughput Screening". Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the...

Journal of Alloys and Compounds, 2016

The nickel containing ferrites are found to exhibit a dramatic flipping of the conductivity type ... more The nickel containing ferrites are found to exhibit a dramatic flipping of the conductivity type for CO gas and increase in response with increasing nickel content.

Materials Chemistry and Physics, 2009

The polymeric film electrodes of chitosan are deposited by electrochemical deposition method on t... more The polymeric film electrodes of chitosan are deposited by electrochemical deposition method on the stainless steel substrates. The prepared film electrodes are characterized by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, contact angle techniques and evaluated for the supercapacitor application by studying electrochemical properties through cyclic voltammetry. The XRD study depicts nanocrystalline nature of deposited chitosan with 36 nm crystallite size. The uniform, compact and spongy chitosan thin film covers the utmost substrate surface and has hydrophilic nature with mean water contact angle 57.9°. The chitosan electrode exhibits 13 kW kg −1 power density from the galvanostatic charge discharge study. The chitosan electrode shows the maximum electrochemical capacitance of 36 F g −1 in non-aqueous KCl electrolyte, which presents a new anodic material for supercapacitor application.

Journal of chemical biology, 2017

2-Butanone thiosemicarbazone ligand was prepared by condensation reaction between thiosemicarbazi... more 2-Butanone thiosemicarbazone ligand was prepared by condensation reaction between thiosemicarbazide and butanone. The ligand was characterized by (1)H NMR, (13)C NMR, FT-IR, mass spectrometry and UV spectroscopic studies. Docking studies were performed to study inhibitory action against topoisomerase II (Topo II) and ribonucleoside diphosphate reductase (RR) enzymes. Inhibition constants (Ki ) of the ligand were 437.87 and 327.4 μM for the two enzymes, respectively. The ligand was tested for its potential anticancer activity against two cancer cell lines MDA-MB-231 and A549 using MTT assay and was found to exhibit good activity at higher doses with an IC50 = 80 μM against human breast cancer cell line MDA-MB-231. On the other hand, no significant activity was obtained against the lung carcinoma cell line A549. Antibacterial activity of the ligand was tested against Staphylococcus aureus and E. coli using the disc diffusion method. Ligand did not exhibit any significant antibacterial...

Electroanalysis, 2004

Cyclic voltammetry, using graphite paste electrode (GPE) and chemically modified GPE with Ni(II) ... more Cyclic voltammetry, using graphite paste electrode (GPE) and chemically modified GPE with Ni(II) mixed ligand complex (MGPE), is described for sensing and detoxification of phenol. A novel mixed ligand complex of nickel with 1,4,8,11-tetraaza cyclotetradecane (cyclam) and thiocyanate in the molar ratio of 1 : 2 : 5 is synthesized and characterized by spectroscopic and electrochemical studies. The Ni(II)-cyclam-thiocyanate complex behaves as a fast electron-transfer mediator, as nickel ions exist in higher oxidation state of Ni(III) on applying a potential of 1.25 V (vs. Ag/AgCl), which catalyses the oxidation of the target species. The mixed ligand complex, when incorporated in the graphite paste electrode, is sensitive to detect phenol as low as 10 mg/L in solution. The catalytic effect of the Ni(II)-cyclam-thiocyanate complex enhanced many folds the oxidation of phenol compared to GPE. The technique has potential for sensing/monitoring and detoxification of phenol released in the ecosystem from polluting industries.

EXCLI journal, 2018

Mixed-ligand metal (II) (M=Cu, Fe, Co and Zn) complexes containing 2-butanone thiosemicarbazone a... more Mixed-ligand metal (II) (M=Cu, Fe, Co and Zn) complexes containing 2-butanone thiosemicarbazone and 1, 10-phenanthroline have been synthesized and characterized by melting point, FT-IR, H-NMR, UV-spectrophotometry and molar conductance measurements. All the complexes were soluble in DMSO and DMF. They were thermally stable with high melting points. The computational studies of the complexes were also performed to assess toxicity potential, bioactivity score prediction and drug likeliness assessment based on various drug filters. All the complexes showed no Veber's violations whereas only Cu complex showed one Lipinski's violation. Almost all synthesized compounds were predicted to have no toxic effects. Some of them showed positive bioactivity as enzyme inhibitors. Molecular docking of the complexes was also performed against ribonucleotide diphosphate reductase (RR) and topoisomerase II (Topo II) for minimum binding energy (kcal/mol) calculations. Cu complex was found to ha...

Human & Experimental Toxicology, 2005

L-histidine, L-cysteine, reduced glutathione (GSH) and other bioligands, which are ubiquitously p... more L-histidine, L-cysteine, reduced glutathione (GSH) and other bioligands, which are ubiquitously present in biological systems, are recognized as antioxidants. Studies have shown that nickel (II) complexed with these ligands catalyzes the disproportionation of H2O2, leading to the generation of hydroxyl radicals (OH•). However, none of the studies could provide information regarding effective concentrations at which these ligands act either as pro-oxidant or antioxidant. Therefore, the observed paradoxical behaviour of biological antioxidants in nickel-induced oxidative response was evaluated. Benzoic acid (BA) is hydroxylated by OH• radical to form highly fluorescent dihydroxy benzoate (OH-BA). We used this model to study the effect of nickel complexes of L-histidine, GSH or L-cysteine on the hydroxylation of BA. The concentration-dependent effect of L-histidine, GSH and L-cysteine, or nickel on the hydroxylation of BA was studied. The hydroxylation of BA was significantly enhanced up to 1:0.5 molar ratio (Ni:hist or GSH). However, beyond 1:0.5 molar ratios, histidine/GSH inhibited the hydroxylation and complete inhibition was observed at 1:1 molar ratios. Sorbitol and caffeic acid, considered as scavengers of hydroxyl radicals, inhibited nickel-induced hydroxylation of BA. The present study demonstrates paradoxical behaviour of these bioligands. They act as pro-oxidant at lower ligand ratios and as antioxidant at higher ligand ratios. The redox properties of nickel complexes with histidine, GSH or cysteine reported here may be crucial for the toxicity of nlckel.

Combinatorial Chemistry & High Throughput Screening, 2020

The article has been withdrawn at the request of the authors of the journal "Combinatorial C... more The article has been withdrawn at the request of the authors of the journal "Combinatorial Chemistry & High Throughput Screening". Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the...

Journal of Alloys and Compounds, 2016

The nickel containing ferrites are found to exhibit a dramatic flipping of the conductivity type ... more The nickel containing ferrites are found to exhibit a dramatic flipping of the conductivity type for CO gas and increase in response with increasing nickel content.

Materials Chemistry and Physics, 2009

The polymeric film electrodes of chitosan are deposited by electrochemical deposition method on t... more The polymeric film electrodes of chitosan are deposited by electrochemical deposition method on the stainless steel substrates. The prepared film electrodes are characterized by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, contact angle techniques and evaluated for the supercapacitor application by studying electrochemical properties through cyclic voltammetry. The XRD study depicts nanocrystalline nature of deposited chitosan with 36 nm crystallite size. The uniform, compact and spongy chitosan thin film covers the utmost substrate surface and has hydrophilic nature with mean water contact angle 57.9°. The chitosan electrode exhibits 13 kW kg −1 power density from the galvanostatic charge discharge study. The chitosan electrode shows the maximum electrochemical capacitance of 36 F g −1 in non-aqueous KCl electrolyte, which presents a new anodic material for supercapacitor application.

Journal of chemical biology, 2017

2-Butanone thiosemicarbazone ligand was prepared by condensation reaction between thiosemicarbazi... more 2-Butanone thiosemicarbazone ligand was prepared by condensation reaction between thiosemicarbazide and butanone. The ligand was characterized by (1)H NMR, (13)C NMR, FT-IR, mass spectrometry and UV spectroscopic studies. Docking studies were performed to study inhibitory action against topoisomerase II (Topo II) and ribonucleoside diphosphate reductase (RR) enzymes. Inhibition constants (Ki ) of the ligand were 437.87 and 327.4 μM for the two enzymes, respectively. The ligand was tested for its potential anticancer activity against two cancer cell lines MDA-MB-231 and A549 using MTT assay and was found to exhibit good activity at higher doses with an IC50 = 80 μM against human breast cancer cell line MDA-MB-231. On the other hand, no significant activity was obtained against the lung carcinoma cell line A549. Antibacterial activity of the ligand was tested against Staphylococcus aureus and E. coli using the disc diffusion method. Ligand did not exhibit any significant antibacterial...

Electroanalysis, 2004

Cyclic voltammetry, using graphite paste electrode (GPE) and chemically modified GPE with Ni(II) ... more Cyclic voltammetry, using graphite paste electrode (GPE) and chemically modified GPE with Ni(II) mixed ligand complex (MGPE), is described for sensing and detoxification of phenol. A novel mixed ligand complex of nickel with 1,4,8,11-tetraaza cyclotetradecane (cyclam) and thiocyanate in the molar ratio of 1 : 2 : 5 is synthesized and characterized by spectroscopic and electrochemical studies. The Ni(II)-cyclam-thiocyanate complex behaves as a fast electron-transfer mediator, as nickel ions exist in higher oxidation state of Ni(III) on applying a potential of 1.25 V (vs. Ag/AgCl), which catalyses the oxidation of the target species. The mixed ligand complex, when incorporated in the graphite paste electrode, is sensitive to detect phenol as low as 10 mg/L in solution. The catalytic effect of the Ni(II)-cyclam-thiocyanate complex enhanced many folds the oxidation of phenol compared to GPE. The technique has potential for sensing/monitoring and detoxification of phenol released in the ecosystem from polluting industries.

EXCLI journal, 2018

Mixed-ligand metal (II) (M=Cu, Fe, Co and Zn) complexes containing 2-butanone thiosemicarbazone a... more Mixed-ligand metal (II) (M=Cu, Fe, Co and Zn) complexes containing 2-butanone thiosemicarbazone and 1, 10-phenanthroline have been synthesized and characterized by melting point, FT-IR, H-NMR, UV-spectrophotometry and molar conductance measurements. All the complexes were soluble in DMSO and DMF. They were thermally stable with high melting points. The computational studies of the complexes were also performed to assess toxicity potential, bioactivity score prediction and drug likeliness assessment based on various drug filters. All the complexes showed no Veber's violations whereas only Cu complex showed one Lipinski's violation. Almost all synthesized compounds were predicted to have no toxic effects. Some of them showed positive bioactivity as enzyme inhibitors. Molecular docking of the complexes was also performed against ribonucleotide diphosphate reductase (RR) and topoisomerase II (Topo II) for minimum binding energy (kcal/mol) calculations. Cu complex was found to ha...

Human & Experimental Toxicology, 2005

L-histidine, L-cysteine, reduced glutathione (GSH) and other bioligands, which are ubiquitously p... more L-histidine, L-cysteine, reduced glutathione (GSH) and other bioligands, which are ubiquitously present in biological systems, are recognized as antioxidants. Studies have shown that nickel (II) complexed with these ligands catalyzes the disproportionation of H2O2, leading to the generation of hydroxyl radicals (OH•). However, none of the studies could provide information regarding effective concentrations at which these ligands act either as pro-oxidant or antioxidant. Therefore, the observed paradoxical behaviour of biological antioxidants in nickel-induced oxidative response was evaluated. Benzoic acid (BA) is hydroxylated by OH• radical to form highly fluorescent dihydroxy benzoate (OH-BA). We used this model to study the effect of nickel complexes of L-histidine, GSH or L-cysteine on the hydroxylation of BA. The concentration-dependent effect of L-histidine, GSH and L-cysteine, or nickel on the hydroxylation of BA was studied. The hydroxylation of BA was significantly enhanced up to 1:0.5 molar ratio (Ni:hist or GSH). However, beyond 1:0.5 molar ratios, histidine/GSH inhibited the hydroxylation and complete inhibition was observed at 1:1 molar ratios. Sorbitol and caffeic acid, considered as scavengers of hydroxyl radicals, inhibited nickel-induced hydroxylation of BA. The present study demonstrates paradoxical behaviour of these bioligands. They act as pro-oxidant at lower ligand ratios and as antioxidant at higher ligand ratios. The redox properties of nickel complexes with histidine, GSH or cysteine reported here may be crucial for the toxicity of nlckel.