Segan Murugan - Academia.edu (original) (raw)

Papers by Segan Murugan

ChemistrySelect, 2017

A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensi... more A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensitive and selective colorimetric detection of Al 3 + / Cu 2 + in partial aqueous DMSO mixture (1:1) as a solvent medium. It showed a rapid fluorescence response (~10 Sec) with Al 3 + as greenish yellow from weak orange fluorescence while, Cu 2 + ions affords yellow colour from fade orange colour and it can be sensed even by naked eyes. Besides showing great selectivity, the probe gives a lower sensitivity of 20 nM for Al 3 + and 0.27 mM for Cu 2 + in the fluorescence and UV-vis. spectral studies respectively. The solid state colorimetric and fluorescence changes of the probe were examined in silica supported TLC plates. The sensing mechanism of the proposed probe in the presence of Al 3 + and Cu 2 + was determined with the support of a job's plot, 1 H-NMR, ESI-Mass and theoretical (DFT) analysis. Based on the observed results from the absorbance and fluorescence spectroscopic studies, a logic circuit was designed with the combination of OR, NOT and AND logic gates. Moreover, the probe DSA has been employed for live cell imaging to detect Al 3 + ions in C6 glioma cells and it showed a good cell permeability and efficiency in the detection of Al 3 + ions.

Inorganica Chimica Acta, 2016

A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was desi... more A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was designed to detect Cu 2+ / Fions in aqueous and DMSO solutions at physiological pH conditions with the detection limit of 0.25 µM and 3 µM for Cu 2+ / Fions respectively. The probe was found to be highly selective to sense Fion rather than CH 3 COOand H 2 PO 4 ions. Interestingly, the probe behaved as a promising receptor by detecting Fions even in ordinary tap water through distinct colour change. Moreover, the chemosensor showed lower cytotoxicity against AGS cancer cells and thus found to be biologically friendly. The reversibility of probe-Fbinding was investigated using HCl in UV-vis experiment. The binding mechanism of chemosensor to Cu 2+ / Fions was elucidated based on the UV-vis spectroscopy, NMR, ESI-Mass spectroscopy and cyclic voltammogram techniques. Furthermore, theoretical investigation was carried out using Gaussian 09 program.

Journal of Materials Chemistry B, 2017

A quinoline based chemosensor for dual detection of Ni2+/Zn2+ ions and its bio-analytical applica... more A quinoline based chemosensor for dual detection of Ni2+/Zn2+ ions and its bio-analytical applications.

An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environm... more An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environmentally as well as biologically important Zn 2+ /Ni 2+ ions in a highly selective manner using different analytical techniques. The fluorescence profile was enhanced to 663 nm (red region) due to the formation of its 1 : 1 complex with Zn 2+ at room temperature even in the presence of other interfering ions such as Cd 2+ and Hg 2+. Moreover, it exhibits excellent chromo-isomerism with Ni 2+ ions. Meanwhile, this assay could be successfully oriented with molecular logic functions of AND, OR, NOR and NOT logic gates. The obtained large Stokes shift (B274 nm) value and red emission promoted this receptor as a potential tool for biological studies (e.g. live cell imaging in cancer cell line and zebrafish models).

A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensi... more A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensitive and selective colorimetric detection of Al 3 + / Cu 2 + in partial aqueous DMSO mixture (1:1) as a solvent medium. It showed a rapid fluorescence response (~ 10 Sec) with Al 3 + as greenish yellow from weak orange fluorescence while, Cu 2 + ions affords yellow colour from fade orange colour and it can be sensed even by naked eyes. Besides showing great selectivity, the probe gives a lower sensitivity of 20 nM for Al 3 + and 0.27 mM for Cu 2 + in the fluorescence and UV-vis. spectral studies respectively. The solid state colorimetric and fluorescence changes of the probe were examined in silica supported TLC plates. The sensing mechanism of the proposed probe in the presence of Al 3 + and Cu 2 + was determined with the support of a job's plot, 1 H-NMR, ESI-Mass and theoretical (DFT) analysis. Based on the observed results from the absorbance and fluorescence spectroscopic studies, a logic circuit was designed with the combination of OR, NOT and AND logic gates. Moreover, the probe DSA has been employed for live cell imaging to detect Al 3 + ions in C6 glioma cells and it showed a good cell permeability and efficiency in the detection of Al 3 + ions.

An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environm... more An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environmentally as well as
biologically important Zn2+/Ni2+ ions in a highly selective manner using different analytical techniques. The fluorescence
profile was enhanced at 663 nm (Red region) due to formation of its 1:1 complex with Zn2+ at room temperature even in
the presence of other interfering ions such as Cd2+ and Hg2+. Moreover, it exhibits excellent chromo-isomerism with Ni2+
ions. Meanwhile, this assay could successfully oriented with molecular logic functions of AND, OR, NOR and NOT logic
gates. The obtained large Stoke shift (~274 nm) value and red emission were promoted this receptor as a potential tool for
the biological studies (e.g. live cell imaging in cancer cell line and zebrafish models).

A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was desi... more A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was designed to detect Cu 2+ /F À ions in aqueous and DMSO solutions at physiological pH conditions with the detection limit of 0.25 lM and 3 lM for Cu 2+ /F À ions respectively. The probe was found to be highly selective to sense F À ion rather than CH 3 COO À and H 2 PO 4 À ions. Interestingly, the probe behaved as a promising receptor by detecting F À ions even in ordinary tap water through distinct colour change. Moreover, the chemosensor showed lower cytotoxicity against AGS cancer cells and thus found to be biologically friendly. The reversibility of probe-F À binding was investigated using HCl in UV–vis experiment. The binding mechanism of chemosensor to Cu 2+ /F À ions was elucidated based on the UV–vis spec-troscopy, NMR, ESI-Mass spectroscopy and cyclic voltammogram techniques. Furthermore, theoretical investigation was carried out using Gaussian 09 program.

ChemistrySelect, 2017

A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensi... more A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensitive and selective colorimetric detection of Al 3 + / Cu 2 + in partial aqueous DMSO mixture (1:1) as a solvent medium. It showed a rapid fluorescence response (~10 Sec) with Al 3 + as greenish yellow from weak orange fluorescence while, Cu 2 + ions affords yellow colour from fade orange colour and it can be sensed even by naked eyes. Besides showing great selectivity, the probe gives a lower sensitivity of 20 nM for Al 3 + and 0.27 mM for Cu 2 + in the fluorescence and UV-vis. spectral studies respectively. The solid state colorimetric and fluorescence changes of the probe were examined in silica supported TLC plates. The sensing mechanism of the proposed probe in the presence of Al 3 + and Cu 2 + was determined with the support of a job's plot, 1 H-NMR, ESI-Mass and theoretical (DFT) analysis. Based on the observed results from the absorbance and fluorescence spectroscopic studies, a logic circuit was designed with the combination of OR, NOT and AND logic gates. Moreover, the probe DSA has been employed for live cell imaging to detect Al 3 + ions in C6 glioma cells and it showed a good cell permeability and efficiency in the detection of Al 3 + ions.

Inorganica Chimica Acta, 2016

A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was desi... more A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was designed to detect Cu 2+ / Fions in aqueous and DMSO solutions at physiological pH conditions with the detection limit of 0.25 µM and 3 µM for Cu 2+ / Fions respectively. The probe was found to be highly selective to sense Fion rather than CH 3 COOand H 2 PO 4 ions. Interestingly, the probe behaved as a promising receptor by detecting Fions even in ordinary tap water through distinct colour change. Moreover, the chemosensor showed lower cytotoxicity against AGS cancer cells and thus found to be biologically friendly. The reversibility of probe-Fbinding was investigated using HCl in UV-vis experiment. The binding mechanism of chemosensor to Cu 2+ / Fions was elucidated based on the UV-vis spectroscopy, NMR, ESI-Mass spectroscopy and cyclic voltammogram techniques. Furthermore, theoretical investigation was carried out using Gaussian 09 program.

Journal of Materials Chemistry B, 2017

A quinoline based chemosensor for dual detection of Ni2+/Zn2+ ions and its bio-analytical applica... more A quinoline based chemosensor for dual detection of Ni2+/Zn2+ ions and its bio-analytical applications.

An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environm... more An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environmentally as well as biologically important Zn 2+ /Ni 2+ ions in a highly selective manner using different analytical techniques. The fluorescence profile was enhanced to 663 nm (red region) due to the formation of its 1 : 1 complex with Zn 2+ at room temperature even in the presence of other interfering ions such as Cd 2+ and Hg 2+. Moreover, it exhibits excellent chromo-isomerism with Ni 2+ ions. Meanwhile, this assay could be successfully oriented with molecular logic functions of AND, OR, NOR and NOT logic gates. The obtained large Stokes shift (B274 nm) value and red emission promoted this receptor as a potential tool for biological studies (e.g. live cell imaging in cancer cell line and zebrafish models).

A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensi... more A simple and smart chemosensor (DSA) has been developed using Schiff base ligand for highly sensitive and selective colorimetric detection of Al 3 + / Cu 2 + in partial aqueous DMSO mixture (1:1) as a solvent medium. It showed a rapid fluorescence response (~ 10 Sec) with Al 3 + as greenish yellow from weak orange fluorescence while, Cu 2 + ions affords yellow colour from fade orange colour and it can be sensed even by naked eyes. Besides showing great selectivity, the probe gives a lower sensitivity of 20 nM for Al 3 + and 0.27 mM for Cu 2 + in the fluorescence and UV-vis. spectral studies respectively. The solid state colorimetric and fluorescence changes of the probe were examined in silica supported TLC plates. The sensing mechanism of the proposed probe in the presence of Al 3 + and Cu 2 + was determined with the support of a job's plot, 1 H-NMR, ESI-Mass and theoretical (DFT) analysis. Based on the observed results from the absorbance and fluorescence spectroscopic studies, a logic circuit was designed with the combination of OR, NOT and AND logic gates. Moreover, the probe DSA has been employed for live cell imaging to detect Al 3 + ions in C6 glioma cells and it showed a good cell permeability and efficiency in the detection of Al 3 + ions.

An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environm... more An interesting dual chemoreceptor (QAMP) was synthesized to quantify the presence of two environmentally as well as
biologically important Zn2+/Ni2+ ions in a highly selective manner using different analytical techniques. The fluorescence
profile was enhanced at 663 nm (Red region) due to formation of its 1:1 complex with Zn2+ at room temperature even in
the presence of other interfering ions such as Cd2+ and Hg2+. Moreover, it exhibits excellent chromo-isomerism with Ni2+
ions. Meanwhile, this assay could successfully oriented with molecular logic functions of AND, OR, NOR and NOT logic
gates. The obtained large Stoke shift (~274 nm) value and red emission were promoted this receptor as a potential tool for
the biological studies (e.g. live cell imaging in cancer cell line and zebrafish models).

A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was desi... more A novel colorimetric chemosensor based on terephthalic acid and pyridine aldehyde moiety was designed to detect Cu 2+ /F À ions in aqueous and DMSO solutions at physiological pH conditions with the detection limit of 0.25 lM and 3 lM for Cu 2+ /F À ions respectively. The probe was found to be highly selective to sense F À ion rather than CH 3 COO À and H 2 PO 4 À ions. Interestingly, the probe behaved as a promising receptor by detecting F À ions even in ordinary tap water through distinct colour change. Moreover, the chemosensor showed lower cytotoxicity against AGS cancer cells and thus found to be biologically friendly. The reversibility of probe-F À binding was investigated using HCl in UV–vis experiment. The binding mechanism of chemosensor to Cu 2+ /F À ions was elucidated based on the UV–vis spec-troscopy, NMR, ESI-Mass spectroscopy and cyclic voltammogram techniques. Furthermore, theoretical investigation was carried out using Gaussian 09 program.