Selim Dereci - Academia.edu (original) (raw)

Papers by Selim Dereci

Journal of Pediatric Gastroenterology & Nutrition

International Journal of Clinical Practice

Annals of Medical Research

Journal of Contemporary Medicine

Pompe hastalığı, otozomal resesif geçiş gösteren, lizozomal asit α-glikosidaz enzim eksikliği son... more Pompe hastalığı, otozomal resesif geçiş gösteren, lizozomal asit α-glikosidaz enzim eksikliği sonucunda iskelet kasları, kalp, karaciğer ve sinir sisteminde glikojen birikimiyle seyreden metabolik bir hastalıktır. Hastalığın belirti ve bulguları bazen gözden kaçmakta ve tanı geç konulabilmektedir. En sık kalp dokusu ve solunum sistemi etkilenmekte olup, yaşam süresi bu organlardaki fonksiyon kayıplarına göre değişmektedir. İnfantil tip en ağır form olup genellikle süt çocukluğu döneminde ölümle sonuçlanmaktadır. Enzim yerine koyma tedavisi ile geç ve erişkin formlarında başarı sağlanırken infantil tipte tedavinin yaşam süresine katkısı fazla değildir. Bu makalede erken dönemde tanı konulup, 6. ayda enzim tedavisi başladığımız 3 yaş 10 aylıkken kaybedilen bir olgumuzun sunulması amaçlanmıştır. Anahtar Sözcükler: Çocuk; enzim yerine koyma tedavisi; komplikasyonlar; Pompe hastalığı. Pompe disease is a metabolic disease, showing an autosomal recessive trait which is seen with glycogen accumulation in the skeletal muscles, the heart, the liver and the nervous system as a result of lysomal acid α-glycosidase enzyme deficiency. The symptoms and findings of the disease are sometimes overlooked and diagnosis may be delayed. As the cardiac tissue and respiratory system are most affected, survival varies depending on the loss of function in these organs. The infantile type is the most severe form, generally resulting in death in infancy. While late and adult forms can be treated successfully with enzyme replacement therapy, treatment in the infatile form does not greatly contribute to survival. We aimed to present this case as an exitus at the age of 3 years and 10 months when we were diagnosed at an early stage and we started enzyme replacement therapy at 6 months.

European Journal of Pediatrics

Pediatric Allergy and Immunology, 2016

Indian pediatrics, 2016

Enterochromaffin-like cell hyperplasia and neuroendocrine tumors are relatively rare in childhood... more Enterochromaffin-like cell hyperplasia and neuroendocrine tumors are relatively rare in childhood. A 15-year-old girl who presented with epigastric pain and a 6-year-old boy who was admitted with hematochezia. Endoscopy revealed nodules in the stomach in Case 1, and polyploidy lesion in the rectum in Case 2. Enterochromaffin-like cell hyperplasia in Case 1 and neuroendocrine tumor in Case 2. A low index of suspicion for neuroendocrine tumors in children can result in delay in the detection of these rare but potentially malignant diseases.

Indian pediatrics, Jan 8, 2016

To study the characteristics of peptic ulcer and erosion in pediatric patients. Over a period of ... more To study the characteristics of peptic ulcer and erosion in pediatric patients. Over a period of seven years, 1,026 children underwent upper gastrointestinal endoscopy in our pediatric gastroenterology unit. Peptic ulcers and erosions were found in 59 (7.2%) patients [ulcers in 42 (5.1%)and erosions in 17 (2.1%)]. Thirty (50.9%) children presented with acute upper gastrointestinal bleeding. Helicobacter pylori positivity was found in 27 patients (45.8%), and ulcerogenic medication use was found in 13 (22%) patients. The main risk factors for childhood peptic ulcer and erosions were H. pylori infection and non-steroidal anti-inflammatory drug use.

European Journal of Gastroenterology & Hepatology, 2016

The aim of this study was to determine demographic and clinical features in children diagnosed wi... more The aim of this study was to determine demographic and clinical features in children diagnosed with gallstones, risk factors for gallstone formation, the effectiveness of ursodeoxycholic acid therapy, and the course of the disease. Patients aged 0-18 years were followed up for at least 6 months after the diagnosis of gallstones with ultrasonography and were evaluated retrospectively. Patients were evaluated with respect to age, sex, presenting symptoms, BMI, facilitating factors, accompanying diseases, family history of gallstones, history of ceftriaxone use, laboratory tests, ultrasonography findings and follow-up, and therapeutic approaches and results. The study was completed with 70 patients. Thirty-nine (55.7%) patients were females. The mean age of the patients was 9.3±5.29 (0.3-18) years. The mean age among females was statistically significantly higher than that among males (P=0.007).No risk factor for stone formation was encountered in 50% of cases, whereas a family history of gallstones was present in 17.1%. Use of ceftriaxone was present in 8.6% of cases, total parenteral nutrition in 10%, obesity in 5.7%, hereditary spherocytosis in 4.3%, and Down&amp;amp;amp;#39;s syndrome in 4.3%. The probability of dissolution of stones was 3.6 times higher in patients with stone sizes up to 5 mm [odds ratio (OR): 3.65, P=0.020], 3.9 times higher in those aged younger than 2 years (OR: 3.92, P=0.021), and 13.9 times higher in those with a single stone (OR: 13.97, P=0.003). Our findings show that unknown causes are still prevalent in stone formation and that ursodeoxycholic acid exerts no effect on stone dissolution; however, diagnosis at younger than 2 years of age, a single stone, and small size of stone are factors affecting dissolution.

The Journal of Pediatric Research, 2016

Turkish Journal of Parasitology, 2016

Çocuk polikliniklerimizde 5 yıllık sürede takip edilen kistik ekinokokkozis tanılı hastaların kli... more Çocuk polikliniklerimizde 5 yıllık sürede takip edilen kistik ekinokokkozis tanılı hastaların klinik ve takip bulgularının değerlendirilmesi. Yöntemler: 2009-2014 yılları arasında kistik ekinokokkozis tespit edilen 34 hastanın demografik, klinik, laboratuar ve takip bulguları geriye dönük olarak incelendi. Çeşitli nedenlerle düzgün takip edilmeyen veya dosya kayıtlarına ulaşılamayan 10 hasta çalışma dışı bırakıldı. Bulgular: Çalışmaya dâhil edilen 24 hastanın 12'si (%50) kız, 12'si (%50) erkek olup, yaş ortalaması 11,17±3,71 (5-17) yıl olarak saptandı. En sık başvuru yakınmaları; karın ağrısı (%41,7), öksürük (%16,7) ve halsizlikti (%12,5). Hastaların %54,2'sinde sadece karaciğer tutulumu, %33,3'ünde sadece akciğer tutulumu, %4,2'sinde intraabdominal tutulum ve %8,3'ünde çoklu organ tutulumu mevcuttu. Hastaların ilk başvuru anında yapılan ekinokok indirekt hemaglütinasyon testi 13 (%54,2) hastada pozitif idi. Hastaların tümü albendazol tedavisi aldı. Yedi hastaya ponksiyon-aspirasyon-injeksiyon-reaspirasyon (PAIR) (%29,2), altı hastaya açık cerrahi (%24,2), bir hastaya da hem PAIR işlemi hem de açık cerrahi uygulandı. Sonuç: Kistik ekinokokkozis, gelişmekte olan ülkeler için ciddi bir sağlık sorunudur. Endemik bölgelerde şüpheli radyolojik ve klinik bulgular varlığında mutlaka akla getirilmelidir.

European Journal of Ophthalmology, Oct 26, 2012

Pediatric Allergy, Immunology, and Pulmonology, 2016

Türk Pediatri Arşivi, 2016

Bosnian Journal of Basic Medical Sciences, 2016

The transaminase levels of the outpatients and patients were recorded from the hospital records s... more The transaminase levels of the outpatients and patients were recorded from the hospital records system (MEDULA). Local Clinical Research Ethics Committee approved the study

Türk Pediatri Arşivi, 2015

Dicle Medical Journal / Dicle Tip Dergisi, 2015

Objective: The purpose of this study was to assess the patients who presented with intoxication c... more Objective: The purpose of this study was to assess the patients who presented with intoxication case to our Children Emergency Department of Süleyman Demirel University Medical Faculty Hospital, retrospectively. Methods: The patients, who were admitted to our children emergency service between the dates July 2013 and July 2014 were searched retrospectively. The age, sex, the admission time, the admission duration, the way of intoxication, symptoms, the items caused intoxication, the aim of taking the item and the hospital stay of the cases were evaluated. Results: For the study, the files of 82 patients aged from 1 to 18 years (mean 8,9±6,3 years) were scanned; 50 (60.9%) cases were female, 32 (39.1%) were male. Intoxication cases constituted 3.6% of all cases admitted to the children's emergency unit over one year period. A high proportion (51%) of intoxication cases were between 1 and 5 years of age. Thirty of the thirty (100%) patients that were intoxicated because of a suicide attempt were girls and all of them were over 12 years of age. The most common substance for intoxication was drugs (76%), followed by insecticides and herbal (6.5%). Amon the medication, cold relief drugs (14%), antidepressant (13%) and paracetamol (12%) drugs were most common. Conclusion: Poisoning shows a peak in two periods of childhood and adolescence in this study. We think that accidental ingestion in childhood can be prevented by parents' education and simple precautions in general. In addition, we recommend that families should demonstrate appropriate approaches, especially with regards to the psychology of adolescent girls, and, if necessary, get help from a specialist.