Selim Unlu - Academia.edu (original) (raw)

Papers by Selim Unlu

Research paper thumbnail of New Instrumentation for Nanoscale Subsurface Spectroscopy and Tomography

Research paper thumbnail of Integrated Nanoantenna Labels for Rapid Security Testing of Semiconductor Circuits

Frontiers in Optics 2015, 2015

We demonstrate a multi-spectral imaging technique that utilizes integrated nanoantenna labels to ... more We demonstrate a multi-spectral imaging technique that utilizes integrated nanoantenna labels to enable rapid mapping of the type and location of every logical gate in an integrated circuit, and thereby detect hardware tampering.

Research paper thumbnail of Detecting hardware trojans using backside optical imaging of embedded watermarks

Proceedings of the 52nd Annual Design Automation Conference, 2015

Research paper thumbnail of Interferometric Mapping of Charge Carrier Modulation in CMOS ICs

Frontiers in Optics 2012/Laser Science XXVIII, 2012

ABSTRACT We demonstrate spatial mapping of time-dependent electrical activity of ICs through dual... more ABSTRACT We demonstrate spatial mapping of time-dependent electrical activity of ICs through dual-phase interferometric back-side imaging with an aplanatic solid-immersion-lens. Inverter chains in a 180nm technology-node chip are investigated at the clock frequency of the circuit.

Research paper thumbnail of System and method for neural stimulation via optically activated floating microdevices

Research paper thumbnail of Applications of Optical Resonance to Biological Sensing and Imaging

Frontiers in Optics, 2006

ABSTRACT

Research paper thumbnail of Multiplexed, rapid, point of care device to quantify allergen-specific IgE

16th International Conference on Optical MEMS and Nanophotonics, 2011

ABSTRACT In this paper, we have integrated our in-house Interferometric Reflectance Imaging Senso... more ABSTRACT In this paper, we have integrated our in-house Interferometric Reflectance Imaging Sensor (IRIS), a simple, sensitive, and cost-effective technology for label-free detection of proteins in multiplexed format, with enhanced fluorescence technology into a calibrated, compact, inexpensive, and multiplexed point-of-care protein microarray sensor called the Calibrated Fluorescence Enhancement (CaFE) platform. This platform utilizes both label-free and fluorescence modalities in order to correlate surface probe density to captured labeled secondary antibody. The platform includes a chip fabricated with two areas of oxide layers with different thicknesses: one area with a 500 nm SiO2 layer optimized for interferometric label-free detection and quantification of proteins and one area with a 100 nm SiO2 layer optimized for enhanced fluorescence over a broad range of fluorophores that are commonly used in bioassays. Probes spotted on the thick region are measured to quantify the capturing immobilized probe density on the platform. However, given a specific fluorophore, we can design a chip of a single thickness that operates well at both label-free and enhanced fluorescence measurements for single spot analysis. We have identified three major technological advantages of our Calibrated Enhancement (CaFE) platform: a ten-fold gain in fluorescence signal due to optimized substrate; a calibrated, quantitative method that uses the combined fluorescent and label-free modalities to accurately measure the density of probe and bound target for a variety of systems; and a compact measurement platform offering reliable and rapid results at the doctor's office for any test that uses a known antibody-antigen pair.

Research paper thumbnail of Integrating microfluidic sample concentrator with Interferometric Reflectance Imaging Sensor for point-of-care viral identification

16th International Conference on Optical MEMS and Nanophotonics, 2011

ABSTRACT We integrated a portable, disposable, simple to fabricate, and highly effective polymeri... more ABSTRACT We integrated a portable, disposable, simple to fabricate, and highly effective polymeric microfluidic viral sample concentration device to the Interferometric Reflectance Imaging Sensor (IRIS) to increase infectious disease diagnostic speed and sensitivity at the point-of-care.

Research paper thumbnail of Widefield subsurface microscopy of integrated circuits

Research paper thumbnail of Screening of Excitons in Single, Suspended Carbon Nanotubes

Research paper thumbnail of An Interferometric Reflectance Imaging Sensor for Point of Care Viral Diagnostics

IEEE Transactions on Biomedical Engineering, 2013

Research paper thumbnail of Hyperspectral Fourier transform spectrometer for reflection spectroscopy and spectral self-interference fluorescence microscopy

Research paper thumbnail of Inelastic Light Scattering and Light Emission of Individual and Suspended Carbon Nanotubes

Research paper thumbnail of Time Resolved Micro-Pl Spectroscopy of Individual Quantum Dots

Experimental and theorectical investigations of the physics of self-assembled quantum dots (SADs)... more Experimental and theorectical investigations of the physics of self-assembled quantum dots (SADs) have focused largely on the nature of the individual dots, independent of their surroundings. However, the coupling of dots to each other, an external microcavity or nearby localized states is an important area of investigation, critical to issues of coherence and quantum information processing. For example, it has

Research paper thumbnail of Signal Enhancement in Resonant Raman Spectra from Suspended Carbon Nanotubes

Research paper thumbnail of Probing DNA-Protein Interactions on Surfaces Using Spectral Self-interference Fluorescence Microscopy

Research paper thumbnail of Probing the Phonon-Assisted Relaxation Process in DNA-wrapped Carbon Nanotubes Using Polarization Dependent Optical Spectroscopy

Bulletin of the American Physical Society, Mar 23, 2005

In this study, polarization-dependent spectroscopy is carried out on DNA-wrapped single walled na... more In this study, polarization-dependent spectroscopy is carried out on DNA-wrapped single walled nanotube hybrids, deposited onto a Sapphire substrate. By using a nanotube sample highly enriched in one specific (n,m) species and an intense light source, the various phonon-assisted excitonic relaxation processes, in addition to the commonly observed electronic interband transitions, can be separately identified and studied in detail. The phonon-assisted relaxation processes involving different phonon branches is emphasized in this study. The MIT ...

Research paper thumbnail of Allergen microarrays on high-sensitivity silicon slides

Analytical and Bioanalytical Chemistry, 2010

Research paper thumbnail of Record Extinction of a Laser Beam by a Single Quantum Dot

Research paper thumbnail of New Instrumentation for Nanoscale Subsurface Spectroscopy and Tomography

Research paper thumbnail of Integrated Nanoantenna Labels for Rapid Security Testing of Semiconductor Circuits

Frontiers in Optics 2015, 2015

We demonstrate a multi-spectral imaging technique that utilizes integrated nanoantenna labels to ... more We demonstrate a multi-spectral imaging technique that utilizes integrated nanoantenna labels to enable rapid mapping of the type and location of every logical gate in an integrated circuit, and thereby detect hardware tampering.

Research paper thumbnail of Detecting hardware trojans using backside optical imaging of embedded watermarks

Proceedings of the 52nd Annual Design Automation Conference, 2015

Research paper thumbnail of Interferometric Mapping of Charge Carrier Modulation in CMOS ICs

Frontiers in Optics 2012/Laser Science XXVIII, 2012

ABSTRACT We demonstrate spatial mapping of time-dependent electrical activity of ICs through dual... more ABSTRACT We demonstrate spatial mapping of time-dependent electrical activity of ICs through dual-phase interferometric back-side imaging with an aplanatic solid-immersion-lens. Inverter chains in a 180nm technology-node chip are investigated at the clock frequency of the circuit.

Research paper thumbnail of System and method for neural stimulation via optically activated floating microdevices

Research paper thumbnail of Applications of Optical Resonance to Biological Sensing and Imaging

Frontiers in Optics, 2006

ABSTRACT

Research paper thumbnail of Multiplexed, rapid, point of care device to quantify allergen-specific IgE

16th International Conference on Optical MEMS and Nanophotonics, 2011

ABSTRACT In this paper, we have integrated our in-house Interferometric Reflectance Imaging Senso... more ABSTRACT In this paper, we have integrated our in-house Interferometric Reflectance Imaging Sensor (IRIS), a simple, sensitive, and cost-effective technology for label-free detection of proteins in multiplexed format, with enhanced fluorescence technology into a calibrated, compact, inexpensive, and multiplexed point-of-care protein microarray sensor called the Calibrated Fluorescence Enhancement (CaFE) platform. This platform utilizes both label-free and fluorescence modalities in order to correlate surface probe density to captured labeled secondary antibody. The platform includes a chip fabricated with two areas of oxide layers with different thicknesses: one area with a 500 nm SiO2 layer optimized for interferometric label-free detection and quantification of proteins and one area with a 100 nm SiO2 layer optimized for enhanced fluorescence over a broad range of fluorophores that are commonly used in bioassays. Probes spotted on the thick region are measured to quantify the capturing immobilized probe density on the platform. However, given a specific fluorophore, we can design a chip of a single thickness that operates well at both label-free and enhanced fluorescence measurements for single spot analysis. We have identified three major technological advantages of our Calibrated Enhancement (CaFE) platform: a ten-fold gain in fluorescence signal due to optimized substrate; a calibrated, quantitative method that uses the combined fluorescent and label-free modalities to accurately measure the density of probe and bound target for a variety of systems; and a compact measurement platform offering reliable and rapid results at the doctor's office for any test that uses a known antibody-antigen pair.

Research paper thumbnail of Integrating microfluidic sample concentrator with Interferometric Reflectance Imaging Sensor for point-of-care viral identification

16th International Conference on Optical MEMS and Nanophotonics, 2011

ABSTRACT We integrated a portable, disposable, simple to fabricate, and highly effective polymeri... more ABSTRACT We integrated a portable, disposable, simple to fabricate, and highly effective polymeric microfluidic viral sample concentration device to the Interferometric Reflectance Imaging Sensor (IRIS) to increase infectious disease diagnostic speed and sensitivity at the point-of-care.

Research paper thumbnail of Widefield subsurface microscopy of integrated circuits

Research paper thumbnail of Screening of Excitons in Single, Suspended Carbon Nanotubes

Research paper thumbnail of An Interferometric Reflectance Imaging Sensor for Point of Care Viral Diagnostics

IEEE Transactions on Biomedical Engineering, 2013

Research paper thumbnail of Hyperspectral Fourier transform spectrometer for reflection spectroscopy and spectral self-interference fluorescence microscopy

Research paper thumbnail of Inelastic Light Scattering and Light Emission of Individual and Suspended Carbon Nanotubes

Research paper thumbnail of Time Resolved Micro-Pl Spectroscopy of Individual Quantum Dots

Experimental and theorectical investigations of the physics of self-assembled quantum dots (SADs)... more Experimental and theorectical investigations of the physics of self-assembled quantum dots (SADs) have focused largely on the nature of the individual dots, independent of their surroundings. However, the coupling of dots to each other, an external microcavity or nearby localized states is an important area of investigation, critical to issues of coherence and quantum information processing. For example, it has

Research paper thumbnail of Signal Enhancement in Resonant Raman Spectra from Suspended Carbon Nanotubes

Research paper thumbnail of Probing DNA-Protein Interactions on Surfaces Using Spectral Self-interference Fluorescence Microscopy

Research paper thumbnail of Probing the Phonon-Assisted Relaxation Process in DNA-wrapped Carbon Nanotubes Using Polarization Dependent Optical Spectroscopy

Bulletin of the American Physical Society, Mar 23, 2005

In this study, polarization-dependent spectroscopy is carried out on DNA-wrapped single walled na... more In this study, polarization-dependent spectroscopy is carried out on DNA-wrapped single walled nanotube hybrids, deposited onto a Sapphire substrate. By using a nanotube sample highly enriched in one specific (n,m) species and an intense light source, the various phonon-assisted excitonic relaxation processes, in addition to the commonly observed electronic interband transitions, can be separately identified and studied in detail. The phonon-assisted relaxation processes involving different phonon branches is emphasized in this study. The MIT ...

Research paper thumbnail of Allergen microarrays on high-sensitivity silicon slides

Analytical and Bioanalytical Chemistry, 2010

Research paper thumbnail of Record Extinction of a Laser Beam by a Single Quantum Dot