Septimiu Voidazan - Academia.edu (original) (raw)

Papers by Septimiu Voidazan

Acta Medica Marisiensis, 2014

Background: Rectal cancer management has as its main component the surgical treatment. The purpos... more Background: Rectal cancer management has as its main component the surgical treatment. The purpose of the paper is to point out the advantages and disadvantages of sphincter saving techniques, respecting the oncological principles. Material and method: A cross-sectional, retrospective study was performed on a group of 69 patients admitted and surgically treated for rectal cancers in the Surgical Clinic I of the County Emergency Clinical Hospital of Tîrgu Mureș, for a period of one year (April 2012 - April 2013) and to whom rectal resections were performed. We followed the immediate postoperative evolutions in these patients, making a comparative analysis between those with the sphincter saving surgery and those in which other operations were performed. Results: From the total of 69 patients diagnosed with rectal cancer, sphincter saving procedures with restoration of digestive continuity by coloanal anastomosis were performed in 12 patients (17.39%) using the peranal or transanal ap...

Diagnostics, 2021

Objectives: To investigate the relationship between neurophysiological sensory and motor nerve fu... more Objectives: To investigate the relationship between neurophysiological sensory and motor nerve function parameters, assessed by nerve conduction studies (NCS) with parasympathetic autonomic function and by heart rate variability (HRV) tests in patients with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 161 T2DM patients underwent NCS. Cardiac autonomic response was assessed by HRV tests to deep breathing (HRV DB), to Valsalva manoeuvre, and during postural change from lying to standing. Results: The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV DB (p = 0.0001). The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV Valsalva (p = 0.0001). The correlation between the amplitude of response in all sensory nerves (sural, median, and ulnar) and HRV DB was statistically significant (p = 0.0001). Conclusion: The results indicate that there is...

Critical Care Medicine, 2019

Additional file 1: Supplemental Table S1. Overall demographic, detailed clinical and outcome char... more Additional file 1: Supplemental Table S1. Overall demographic, detailed clinical and outcome characteristics of septic patients. Supplemental Table S2. Age, sex and BMI distributions in the study group according to TNF-α SNP genotypes. Supplemental Table S3. Genotype and allele frequencies of TNF-α -308G/C, -238G/A, -376G/A gene polymorphisms in control and septic patient group and subgroups.

Revista Romana de Medicina de Laborator, 2022

Introduction: Acute abdominal pain persists in defying modern diagnostic procedures. Inflammatory... more Introduction: Acute abdominal pain persists in defying modern diagnostic procedures. Inflammatory response variables in urine and blood tests can help rule out other disorders and support a clinical diagnosis of acute appendicitis (AA), but there is no specific blood test that can diagnose AA. In order to address this, our study sought to establish the value of (NLR) as a prognostic and severity predictor in patients with AA. Material and method: We conducted an observational retrospective study of 356 patients who had undergone surgery for AA, assessing NLR as an outcome metric. The NLR was estimated using the differential WBC (white blood count) reported on admission; the data obtained were then recorded in a database and statistically analyzed. Results: The NLR medians correlated (p<0.001) in uncomplicated AA, AA with localized peritonitis, and AA with generalized peritonitis (Kruskal-Wallis test). The ROC curve identified 81.4 % sensitivity, 62.5 % specificity, and a 73 % AUC...

Revista Romana de Medicina de Laborator, 2020

Introduction: Our study investigated the importance of inflammation markers – ratio of platelets ... more Introduction: Our study investigated the importance of inflammation markers – ratio of platelets and lymphocytes (PLR), ratio of neutrophils and lymphocytes (NLR) and ratio of lymphocytes and monocytes (LMR) – as predictive markers in the occurrence of fistula or stenosis in patients diagnosed with gastric adenocarcinoma who underwent gastric resections. Materials and Methods: We conducted a retrospective study of 178 patients diagnosed with gastric adenocarcinoma. The included patients were divided into 3 groups: group 1 (77 patients, who underwent lower gastrectomy), group 2 (27 patients, who had upper polar gastrectomy otherwise known as proximal gastrectomy), group 3 (74 patients, who underwent total gastrectomy). Ratios of PLR, NLR, respectively LMR were calculated for all patients. Results: Out of 178 patients 52 (29.2%) developed postoperative stenosis and 16 patients (9.0%) had postoperative fistulae. The occurrence of anastomotic stenosis was associated with significantly h...

International Journal of Clinical and Experimental Medicine, Jun 15, 2015

Multifocality is not listed among prognostic factors in international breast cancer guidelines. T... more Multifocality is not listed among prognostic factors in international breast cancer guidelines. This study aims to analyze survival in multiple breast carcinomas (MFMC cc) compared to unifocal ones (UF cc), in order to assess the prognostic impact of multifocality. The study included 460 breast carcinomas (2002-2006) with a median follow-up time of 104 months (74-134 months). We assessed mortality rates, overall survival at 5 years and 10 years in general, overall survival at 5 and 10 years in MFMC cc compared to UF cc, as well as median survival and survival rate according to age, T status and axillary lymph node status in MFMC cc compared to UF cc. We carried out a multivariate analysis in order to identify independent predictor factors for survival. 69/460 (15%) of cases were MFMC cc. Mortality rates were 56.5% in MFMC cc versus 45.1% (UF cc) (P = 0.08). 5-year overall survival was 55.9% in MFMC cc vs. 64.7% UF cc, and the 10-year overall survival was 34.9% MFMC cc vs. 52.7% UF c...

Journal of Interdisciplinary Medicine, 2020

Background: Heart transplantation is still the treatment of choice in patients with end-stage hea... more Background: Heart transplantation is still the treatment of choice in patients with end-stage heart failure, refractory to medical treatment, in NYHA class III and IV, with dilated cardiomyopathy of various etiologies, including post-myocardial infarction. Objective: The aim of the study was to provide a descriptive analysis of the clinical, laboratory, and imaging parameters of patients undergoing heart transplantation during the pre- and postoperative period, as well as postoperative complications (including infections) and death rates. Material and methods: The variables collected from 53 patients who underwent a heart transplant were: age at heart transplant, gender, diagnosis at hospitalization, comorbidities, pre- and postoperative virology, pre- and postoperative laboratory analyses, pre- and postoperative echocardiography, post-transplant infections, complications, and treatment before and after the surgery. Results: Mean age at the time of transplant was 40.72 ± 14.07 years...

The aim of the present study was to establish the importance as a predictive factor of the NLR (n... more The aim of the present study was to establish the importance as a predictive factor of the NLR (neutrophil to lymphocyte ratio) for the occurrence of intestinal necrosis in patients with incisional hernias. Material and methods: We conducted a retrospective study including 141 patients over a 3-year period in which we analyzed the values of NLR. Results: Thus, we noticed that there is a direct, statistically significant correlation between the NLR and the indication of small bowel resection in patients with incisional hernias. Depending on the binary variable resection yes or no, we set a cutoff threshold of 2.553 with predictive value, threshold for which we have the best values of sensitivity and specificity as performance parameters. Over this threshold the sensitivity increases, so the patients or the risk of resection is highly appreciated, AUC=0.853 (CI 95%=0.784 to 0.907), p<0.001. Conclusions: Increased NLR values may play a particularly important role in predicting the e...

Journal of Critical Care, 2017

Journal of Interdisciplinary Medicine, 2020

Background: Although the clinical evolution of a patient with heart failure is initially improved... more Background: Although the clinical evolution of a patient with heart failure is initially improved by transplantation, a number of potential complications may occur in the post-transplant period, which may be directly related to the effects of chronic immunosuppression. The purpose of this study was to analyze the occurrence and frequency of post-transplant complications related to immunosuppressive treatment in the Institute of Cardiovascular Diseases and Transplantation of Târgu Mureș, Romania. Material and methods: This is a descriptive study including 53 patients out of a total of 71 patients who underwent cardiac transplantation between 2000 and 2017 in the Institute of Cardiovascular Disease and Cardiac Transplantation in Târgu Mureș, Romania. Data were collected from the patient files and included demographic, clinical and laboratory data, as well as information about post-transplant complications related to immunosuppressive treatment. Results: The mean age of patients underg...

Journal of Hypertension, 2015

Objective: Heart failure (HF) is a common feature in hypertensive patients, increasing the risk o... more Objective: Heart failure (HF) is a common feature in hypertensive patients, increasing the risk of mortality. Chronic kidney disease (CKD) is also known to be involved in the etiology of HF. However, among hypertensive patients the associations of different stages of CKD and changes in cardiac structure, respectively in left ventricular systolic function are not well described. A cross-sectional study was performed to evaluate the impact of different stages of CKD concerning left heart failure. Design and method: 79 hypertensive patients, mean age 64.09+/-10.05 years were evaluated. Left ventricle dimensions and ejection fraction (EF) were assessed by 2D echocardiography and CKD by determining estimated Glomerular Filtration Rate (eGFR) using MDRD formula. Subjects were divided in two subgroups (49 pts. – 62.03% with CKD hemodialysis naive and 30 pts. – 37.97% without CKD). Other variables: presence of diabetes mellitus, total cholesterol, triglycerides were also considered. Results...

Critical Care Medicine, 2018

Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives... more Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Sepsis represents the main cause of death in the noncardiac Intensive Care Unit (ICU). Early identification of sepsis in patients with Systemic Inflammatory Response Syndrome (SIRS) is the determining factor in reducing the mortality. The objective of this study is to compare the diagnostic value of soluble urokinase plasminogen receptor (suPAR) to that of CReactive Protein (CRP) and procalcitonin (PCT) in septic patients. Methods: We designed a prospective study on 67 patients presenting SIRS criteria, divided into 2 groups: patients with SIRS infectious (Group A, n = 49) and with SIRS noninfectious (Group B, n = 18). On the first day of admission into the ICU, the serum levels of suPAR, PCT and CRP were determined. Student’s t test was used for continuous variables. Receiver operating characteristics (ROC) curve analysis was performed for biomarkers and combinations. We calculated th...

Pervenuto in Redazione Aprile 2019. Accettato per la pubblicazione Giugno 2019 Correspondence to:... more Pervenuto in Redazione Aprile 2019. Accettato per la pubblicazione Giugno 2019 Correspondence to: Daniela Tatiana Sala, Second Department of General Surgery, University of Medicine, Pharmacy, Science and Technology of Targu Mureș, 38th Gh. Marinescu str. Tirgu Mures, Romania, (e-mail: salatatiana@yahoo.com) Radu Mircea Neagoe*, Daniela Tatiana Sala*, Septimiu Voidazan**, Torok Arpad*, Gliga Maximilian Cosma***, Simona Mureșan°, Bogdan Suciu°°, Marina Isabela Melano°°°, Mircea Mureșan *

Persons exposed to "natural" or "engineered" nanoparticles – either in produc... more Persons exposed to "natural" or "engineered" nanoparticles – either in production processes or during the transport of these materials, and especially when using nanoparticles/nanomaterials – are susceptible to their toxic action by inhalation, ingestion or skin contact. The study aimed to analyse the legislation and concerns of international nanoscience agencies as compared to the provisions of the relevant legislation in Romania, in order to describe the current status quo of health policies in the field of occupational exposures to nanoparticles. European institutions are turning to modern and varied solutions to raise awareness of the risk that nanoparticle represent for public health, and to stimulate scientific research in the field; they also encourage Member States to pursue a similar policy. Romanian legislation has not yet taken on the European Union's recommendations regarding health protection for occupational exposure to nanoparticles. Keywords: ...

The Journal of Critical Care Medicine, 2021

Following the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, design, development, ... more Following the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, design, development, validation, verification and implementation of diagnostic tests were actively addressed by a large number of diagnostic test manufacturers. This paper deals with the biases and sources of variation which influence the accuracy of diagnostic tests, including calculating and interpreting test characteristics, defining what is meant by test accuracy, understanding the basic study design for evaluating test accuracy, understanding the meaning of Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value, and evaluating them numerically, and the ROC curve (or Receiver Operating Characteristic ) and the Area under the Curve (AUC).

Journal of Men’s Health, 2021

Background and objectives: The aim of this study was to evaluate the impact of the COVID-19 pande... more Background and objectives: The aim of this study was to evaluate the impact of the COVID-19 pandemic on the detection of prostate cancer in men considered at high risk. This was done by comparing data from the Mures County Clinical Hospital, Clinic of Urology one year before (non-pandemic, NP) and during (pandemic, P) the global COVID-19 pandemic.Methods: A retrospective study was performed based on the Mures County Clinical Hospital database. The inclusion criteria were clinical suspicion (digital rectal examination) and elevated prostate-specific antigen (PSA) level (threshold 3.2 ng/mL). Statistical analysis was performed with STATA 11 Program. Mann-Whitney, Student and chi-square tests were used to compare median PSA, prostate volume, number of TRUSbx performed, number of core biopsies, Gleason Score values, and perineural invasion between the NP and P groups.Results: A total of 440 patients were studied, comprising 271 in the NP group and 169 in the P group. The average number of TRUSbx procedures was 22.58 per month in 2019 (NP group) and 14.08 per month in 2020 (P group), representing a decrease of 37.65%. Analysis of data for the P and NP groups showed a median PSA of 10.48 vs 10.58, mean prostatic volume of 43.69 vs 43.26, number of core biopsies 11.39 vs 11.70, and Gleason score of 7.31 vs 7.15, respectively. Mann-Whitney U test revealed no statistically significant differences between the two groups, with only the Gleason Score showing a trend for significance (p = 0.065).Conclusions: The COVID-19 pandemic led to a major decrease in the number of surgeries performed, with TRUSbx declining by almost 40%. No differences between P and NP periods were observed for median PSA, prostate volume, number of core biopsies, and perineural invasion. The Gleason Score showed a slightly higher incidence of advanced prostate cancer in the P group, but this did not reach statistical significance.

Future Science OA, 2021

Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer pati... more Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer patients compared with patients without neoplasia. Material & methods: Clinical data and blood specimens from patients with and without prostate cancer were obtained. A quantitative sandwich ELISA method was used to determine serological values of FSCN1. Results: Although serum values of FSCN1 were dissimilar in the two cohorts of patients (6.90 vs 7.33 ng/ml), the difference was not statistically significant (p = 0.20). Serum values of FSCN1 stratified for Gleason score groups were not significantly distinguishable (p = 0.65). A negative correlation (rho = -0.331; p = 0.009) was reported between FSCN1 and age. Conclusion: Further studies are required to evaluate a possible diagnostic role of FSCN1 in prostate cancer.

Journal of Gastrointestinal and Liver Diseases, 2020

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of col... more Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent var...

Acta Medica Marisiensis, 2014

Background: Rectal cancer management has as its main component the surgical treatment. The purpos... more Background: Rectal cancer management has as its main component the surgical treatment. The purpose of the paper is to point out the advantages and disadvantages of sphincter saving techniques, respecting the oncological principles. Material and method: A cross-sectional, retrospective study was performed on a group of 69 patients admitted and surgically treated for rectal cancers in the Surgical Clinic I of the County Emergency Clinical Hospital of Tîrgu Mureș, for a period of one year (April 2012 - April 2013) and to whom rectal resections were performed. We followed the immediate postoperative evolutions in these patients, making a comparative analysis between those with the sphincter saving surgery and those in which other operations were performed. Results: From the total of 69 patients diagnosed with rectal cancer, sphincter saving procedures with restoration of digestive continuity by coloanal anastomosis were performed in 12 patients (17.39%) using the peranal or transanal ap...

Diagnostics, 2021

Objectives: To investigate the relationship between neurophysiological sensory and motor nerve fu... more Objectives: To investigate the relationship between neurophysiological sensory and motor nerve function parameters, assessed by nerve conduction studies (NCS) with parasympathetic autonomic function and by heart rate variability (HRV) tests in patients with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 161 T2DM patients underwent NCS. Cardiac autonomic response was assessed by HRV tests to deep breathing (HRV DB), to Valsalva manoeuvre, and during postural change from lying to standing. Results: The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV DB (p = 0.0001). The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV Valsalva (p = 0.0001). The correlation between the amplitude of response in all sensory nerves (sural, median, and ulnar) and HRV DB was statistically significant (p = 0.0001). Conclusion: The results indicate that there is...

Critical Care Medicine, 2019

Additional file 1: Supplemental Table S1. Overall demographic, detailed clinical and outcome char... more Additional file 1: Supplemental Table S1. Overall demographic, detailed clinical and outcome characteristics of septic patients. Supplemental Table S2. Age, sex and BMI distributions in the study group according to TNF-α SNP genotypes. Supplemental Table S3. Genotype and allele frequencies of TNF-α -308G/C, -238G/A, -376G/A gene polymorphisms in control and septic patient group and subgroups.

Revista Romana de Medicina de Laborator, 2022

Introduction: Acute abdominal pain persists in defying modern diagnostic procedures. Inflammatory... more Introduction: Acute abdominal pain persists in defying modern diagnostic procedures. Inflammatory response variables in urine and blood tests can help rule out other disorders and support a clinical diagnosis of acute appendicitis (AA), but there is no specific blood test that can diagnose AA. In order to address this, our study sought to establish the value of (NLR) as a prognostic and severity predictor in patients with AA. Material and method: We conducted an observational retrospective study of 356 patients who had undergone surgery for AA, assessing NLR as an outcome metric. The NLR was estimated using the differential WBC (white blood count) reported on admission; the data obtained were then recorded in a database and statistically analyzed. Results: The NLR medians correlated (p<0.001) in uncomplicated AA, AA with localized peritonitis, and AA with generalized peritonitis (Kruskal-Wallis test). The ROC curve identified 81.4 % sensitivity, 62.5 % specificity, and a 73 % AUC...

Revista Romana de Medicina de Laborator, 2020

Introduction: Our study investigated the importance of inflammation markers – ratio of platelets ... more Introduction: Our study investigated the importance of inflammation markers – ratio of platelets and lymphocytes (PLR), ratio of neutrophils and lymphocytes (NLR) and ratio of lymphocytes and monocytes (LMR) – as predictive markers in the occurrence of fistula or stenosis in patients diagnosed with gastric adenocarcinoma who underwent gastric resections. Materials and Methods: We conducted a retrospective study of 178 patients diagnosed with gastric adenocarcinoma. The included patients were divided into 3 groups: group 1 (77 patients, who underwent lower gastrectomy), group 2 (27 patients, who had upper polar gastrectomy otherwise known as proximal gastrectomy), group 3 (74 patients, who underwent total gastrectomy). Ratios of PLR, NLR, respectively LMR were calculated for all patients. Results: Out of 178 patients 52 (29.2%) developed postoperative stenosis and 16 patients (9.0%) had postoperative fistulae. The occurrence of anastomotic stenosis was associated with significantly h...

International Journal of Clinical and Experimental Medicine, Jun 15, 2015

Multifocality is not listed among prognostic factors in international breast cancer guidelines. T... more Multifocality is not listed among prognostic factors in international breast cancer guidelines. This study aims to analyze survival in multiple breast carcinomas (MFMC cc) compared to unifocal ones (UF cc), in order to assess the prognostic impact of multifocality. The study included 460 breast carcinomas (2002-2006) with a median follow-up time of 104 months (74-134 months). We assessed mortality rates, overall survival at 5 years and 10 years in general, overall survival at 5 and 10 years in MFMC cc compared to UF cc, as well as median survival and survival rate according to age, T status and axillary lymph node status in MFMC cc compared to UF cc. We carried out a multivariate analysis in order to identify independent predictor factors for survival. 69/460 (15%) of cases were MFMC cc. Mortality rates were 56.5% in MFMC cc versus 45.1% (UF cc) (P = 0.08). 5-year overall survival was 55.9% in MFMC cc vs. 64.7% UF cc, and the 10-year overall survival was 34.9% MFMC cc vs. 52.7% UF c...

Journal of Interdisciplinary Medicine, 2020

Background: Heart transplantation is still the treatment of choice in patients with end-stage hea... more Background: Heart transplantation is still the treatment of choice in patients with end-stage heart failure, refractory to medical treatment, in NYHA class III and IV, with dilated cardiomyopathy of various etiologies, including post-myocardial infarction. Objective: The aim of the study was to provide a descriptive analysis of the clinical, laboratory, and imaging parameters of patients undergoing heart transplantation during the pre- and postoperative period, as well as postoperative complications (including infections) and death rates. Material and methods: The variables collected from 53 patients who underwent a heart transplant were: age at heart transplant, gender, diagnosis at hospitalization, comorbidities, pre- and postoperative virology, pre- and postoperative laboratory analyses, pre- and postoperative echocardiography, post-transplant infections, complications, and treatment before and after the surgery. Results: Mean age at the time of transplant was 40.72 ± 14.07 years...

The aim of the present study was to establish the importance as a predictive factor of the NLR (n... more The aim of the present study was to establish the importance as a predictive factor of the NLR (neutrophil to lymphocyte ratio) for the occurrence of intestinal necrosis in patients with incisional hernias. Material and methods: We conducted a retrospective study including 141 patients over a 3-year period in which we analyzed the values of NLR. Results: Thus, we noticed that there is a direct, statistically significant correlation between the NLR and the indication of small bowel resection in patients with incisional hernias. Depending on the binary variable resection yes or no, we set a cutoff threshold of 2.553 with predictive value, threshold for which we have the best values of sensitivity and specificity as performance parameters. Over this threshold the sensitivity increases, so the patients or the risk of resection is highly appreciated, AUC=0.853 (CI 95%=0.784 to 0.907), p<0.001. Conclusions: Increased NLR values may play a particularly important role in predicting the e...

Journal of Critical Care, 2017

Journal of Interdisciplinary Medicine, 2020

Background: Although the clinical evolution of a patient with heart failure is initially improved... more Background: Although the clinical evolution of a patient with heart failure is initially improved by transplantation, a number of potential complications may occur in the post-transplant period, which may be directly related to the effects of chronic immunosuppression. The purpose of this study was to analyze the occurrence and frequency of post-transplant complications related to immunosuppressive treatment in the Institute of Cardiovascular Diseases and Transplantation of Târgu Mureș, Romania. Material and methods: This is a descriptive study including 53 patients out of a total of 71 patients who underwent cardiac transplantation between 2000 and 2017 in the Institute of Cardiovascular Disease and Cardiac Transplantation in Târgu Mureș, Romania. Data were collected from the patient files and included demographic, clinical and laboratory data, as well as information about post-transplant complications related to immunosuppressive treatment. Results: The mean age of patients underg...

Journal of Hypertension, 2015

Objective: Heart failure (HF) is a common feature in hypertensive patients, increasing the risk o... more Objective: Heart failure (HF) is a common feature in hypertensive patients, increasing the risk of mortality. Chronic kidney disease (CKD) is also known to be involved in the etiology of HF. However, among hypertensive patients the associations of different stages of CKD and changes in cardiac structure, respectively in left ventricular systolic function are not well described. A cross-sectional study was performed to evaluate the impact of different stages of CKD concerning left heart failure. Design and method: 79 hypertensive patients, mean age 64.09+/-10.05 years were evaluated. Left ventricle dimensions and ejection fraction (EF) were assessed by 2D echocardiography and CKD by determining estimated Glomerular Filtration Rate (eGFR) using MDRD formula. Subjects were divided in two subgroups (49 pts. – 62.03% with CKD hemodialysis naive and 30 pts. – 37.97% without CKD). Other variables: presence of diabetes mellitus, total cholesterol, triglycerides were also considered. Results...

Critical Care Medicine, 2018

Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives... more Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Sepsis represents the main cause of death in the noncardiac Intensive Care Unit (ICU). Early identification of sepsis in patients with Systemic Inflammatory Response Syndrome (SIRS) is the determining factor in reducing the mortality. The objective of this study is to compare the diagnostic value of soluble urokinase plasminogen receptor (suPAR) to that of CReactive Protein (CRP) and procalcitonin (PCT) in septic patients. Methods: We designed a prospective study on 67 patients presenting SIRS criteria, divided into 2 groups: patients with SIRS infectious (Group A, n = 49) and with SIRS noninfectious (Group B, n = 18). On the first day of admission into the ICU, the serum levels of suPAR, PCT and CRP were determined. Student’s t test was used for continuous variables. Receiver operating characteristics (ROC) curve analysis was performed for biomarkers and combinations. We calculated th...

Pervenuto in Redazione Aprile 2019. Accettato per la pubblicazione Giugno 2019 Correspondence to:... more Pervenuto in Redazione Aprile 2019. Accettato per la pubblicazione Giugno 2019 Correspondence to: Daniela Tatiana Sala, Second Department of General Surgery, University of Medicine, Pharmacy, Science and Technology of Targu Mureș, 38th Gh. Marinescu str. Tirgu Mures, Romania, (e-mail: salatatiana@yahoo.com) Radu Mircea Neagoe*, Daniela Tatiana Sala*, Septimiu Voidazan**, Torok Arpad*, Gliga Maximilian Cosma***, Simona Mureșan°, Bogdan Suciu°°, Marina Isabela Melano°°°, Mircea Mureșan *

Persons exposed to "natural" or "engineered" nanoparticles – either in produc... more Persons exposed to "natural" or "engineered" nanoparticles – either in production processes or during the transport of these materials, and especially when using nanoparticles/nanomaterials – are susceptible to their toxic action by inhalation, ingestion or skin contact. The study aimed to analyse the legislation and concerns of international nanoscience agencies as compared to the provisions of the relevant legislation in Romania, in order to describe the current status quo of health policies in the field of occupational exposures to nanoparticles. European institutions are turning to modern and varied solutions to raise awareness of the risk that nanoparticle represent for public health, and to stimulate scientific research in the field; they also encourage Member States to pursue a similar policy. Romanian legislation has not yet taken on the European Union's recommendations regarding health protection for occupational exposure to nanoparticles. Keywords: ...

The Journal of Critical Care Medicine, 2021

Following the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, design, development, ... more Following the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, design, development, validation, verification and implementation of diagnostic tests were actively addressed by a large number of diagnostic test manufacturers. This paper deals with the biases and sources of variation which influence the accuracy of diagnostic tests, including calculating and interpreting test characteristics, defining what is meant by test accuracy, understanding the basic study design for evaluating test accuracy, understanding the meaning of Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value, and evaluating them numerically, and the ROC curve (or Receiver Operating Characteristic ) and the Area under the Curve (AUC).

Journal of Men’s Health, 2021

Background and objectives: The aim of this study was to evaluate the impact of the COVID-19 pande... more Background and objectives: The aim of this study was to evaluate the impact of the COVID-19 pandemic on the detection of prostate cancer in men considered at high risk. This was done by comparing data from the Mures County Clinical Hospital, Clinic of Urology one year before (non-pandemic, NP) and during (pandemic, P) the global COVID-19 pandemic.Methods: A retrospective study was performed based on the Mures County Clinical Hospital database. The inclusion criteria were clinical suspicion (digital rectal examination) and elevated prostate-specific antigen (PSA) level (threshold 3.2 ng/mL). Statistical analysis was performed with STATA 11 Program. Mann-Whitney, Student and chi-square tests were used to compare median PSA, prostate volume, number of TRUSbx performed, number of core biopsies, Gleason Score values, and perineural invasion between the NP and P groups.Results: A total of 440 patients were studied, comprising 271 in the NP group and 169 in the P group. The average number of TRUSbx procedures was 22.58 per month in 2019 (NP group) and 14.08 per month in 2020 (P group), representing a decrease of 37.65%. Analysis of data for the P and NP groups showed a median PSA of 10.48 vs 10.58, mean prostatic volume of 43.69 vs 43.26, number of core biopsies 11.39 vs 11.70, and Gleason score of 7.31 vs 7.15, respectively. Mann-Whitney U test revealed no statistically significant differences between the two groups, with only the Gleason Score showing a trend for significance (p = 0.065).Conclusions: The COVID-19 pandemic led to a major decrease in the number of surgeries performed, with TRUSbx declining by almost 40%. No differences between P and NP periods were observed for median PSA, prostate volume, number of core biopsies, and perineural invasion. The Gleason Score showed a slightly higher incidence of advanced prostate cancer in the P group, but this did not reach statistical significance.

Future Science OA, 2021

Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer pati... more Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer patients compared with patients without neoplasia. Material & methods: Clinical data and blood specimens from patients with and without prostate cancer were obtained. A quantitative sandwich ELISA method was used to determine serological values of FSCN1. Results: Although serum values of FSCN1 were dissimilar in the two cohorts of patients (6.90 vs 7.33 ng/ml), the difference was not statistically significant (p = 0.20). Serum values of FSCN1 stratified for Gleason score groups were not significantly distinguishable (p = 0.65). A negative correlation (rho = -0.331; p = 0.009) was reported between FSCN1 and age. Conclusion: Further studies are required to evaluate a possible diagnostic role of FSCN1 in prostate cancer.

Journal of Gastrointestinal and Liver Diseases, 2020

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of col... more Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent var...