Sergio Israel Trejo Ponce - Academia.edu (original) (raw)

Papers by Sergio Israel Trejo Ponce

Protein IDs and output tables after STRING analysis. Protein IDs induced under similar experiment... more Protein IDs and output tables after STRING analysis. Protein IDs induced under similar experimental conditions of heat stress in (1) WT tomato plants (where HsfA2 is present), (2) tomato protoplasts (where HsfA2 was inhibited using RNAi) and (3) WT Arabidopsis plants, were used as input for STRING analysis. Overlapping nodes corresponding to HSP70, HSP90, HSP100 and sHSPs families, are indicated in bold in the output tables. (XLSX 123 kb)

Fil: Spetale, Flavio Ezequiel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro... more Fil: Spetale, Flavio Ezequiel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Rosario. Centro Internacional Franco Argentino de Ciencias de la Informacion y de Sistemas. Universidad Nacional de Rosario. Centro Internacional Franco Argentino de Ciencias de la Informacion y de Sistemas; Argentina

Revista Mexicana de Ciencias Pecuarias, 2018

El objetivo fue evaluar algunas características morfológicas de gallinas de traspatio (n= 255) pr... more El objetivo fue evaluar algunas características morfológicas de gallinas de traspatio (n= 255) provenientes de 65 unidades rurales de producción, localizadas en 52 municipios de 18 estados de la República Mexicana. El modelo estadístico incluyó los efectos de sexo, estado y municipio anidado en estado. El efecto de sexo fue importante para todas las variables analizadas (P<0.0001), excepto para robustez (P=0.33). El efecto de estado fue importante (P<0.0001) para todas las variables analizadas, mientras que municipio solo influyó significativamente a envergadura (P<0.0001), peso corporal (P=0.0271) y solidez (P=0.0267). Los machos tuvieron mayor (P<0.0001) longitud corporal (4.85 cm), envergadura (5.66 cm), circunferencia de la pechuga (2.94 cm), longitud del tarso (1.73 cm), peso corporal (0.65 kg) y solidez (0.99 puntos porcentuales). El peso corporal aumentó 126 g (P<0.01) en machos y 61 g en hembras (P<0.01) por cada centímetro que aumentó la circunferencia de ...

IFMBE Proceedings, 2007

During the past years, the complexity of biomedical technology and the hospital’s facilities have... more During the past years, the complexity of biomedical technology and the hospital’s facilities have been increased in a great way, becoming in a possible health risk. Biomedical equipment security must be considered an important issue to protect patients and users. Testing laboratories have to assure devices working in optimal performance following local an international normative.

Revista Brasileira de Zootecnia, 2018

IFMBE Proceedings, 2019

This paper presents a modular system of wireless monitoring of physiological and ambient conditio... more This paper presents a modular system of wireless monitoring of physiological and ambient conditions based on Internet of Things (IoT). It is specially designed for elderly people and people with chronic diseases to promote their independent living. The system consists of a network of physiological and home ambient sensors developed under standard IoT protocols. These sensors are designed and manufactured at the laboratory with low-cost components. In addition, commercial sensors can be added according to the requirements of the patient. The system also provides a web based user interface for medical and family caregivers. It displays real time data and it includes an alarm system to report unsafe events via email. The caregiver can also see historical data with the possibility to compare all the parameters of a certain day and time. Furthermore, a home automation system was proposed to control home devices to improve home safety. The evaluation of the system was performed under a controlled environment at the laboratory in pilot tests before being tested in patients.

VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016, 2017

Gene Ontology is a hierarchical controlled vocabulary for protein annotation. Its synergy with au... more Gene Ontology is a hierarchical controlled vocabulary for protein annotation. Its synergy with automatic classification methods, ensemble, has been widely used for the prediction of protein functions. Current classification methods use only the relation is_a and a few little part_of to generate prediction model. In this work we formalize the GO part_of, regulates; negatively_regulates and positively_regulates relationships through predicate logic. This formalization is incorporated within an ensemble method based on graph factor called Factor Graph GO Annotation. The proposed model is validated against four model organisms for GO Biological Process prediction.

IFMBE Proceedings, 2019

Monitoring electrical failures in biomedical devices makes it possible to ensure patient’s safety... more Monitoring electrical failures in biomedical devices makes it possible to ensure patient’s safety. While assessing risk in medical equipment, we observed that electrical failures are one of the adverse events detected. Biomedical laboratories include procedures and design devices for testing electrical safety. In this work, we develop procedures to perform electrical safety test based on national and international standards. One of them is the Protective Earth Resistance test. Currently, the main standard applied to medical equipment tests is IEC 62353: 2014 “Medical electrical Equipment - recurrent test and test after repair of medical electrical equipment”. Specifically, this standard is a guideline that describes the requirements to ensure the electrical safety through comparable and reproducible tests.

Due to the lately increase of medical technology in the hospital practice; it is necessary to be ... more Due to the lately increase of medical technology in the hospital practice; it is necessary to be aware of the crucial importance of the performance verification of this technology. On the contrary, an increase of failures or accidents may occur, which in some cases, can be dangerous or fatal for the patients. In order to offer more security to the patients, some performance procedures on the infusion pumps were developed. The measures and verifications were done under laboratories procedures, based on IEC 60601-2-24: 2012 standards, “Particular requirements for the basic safety and essential performance of infusion pumps and controllers”. With the use of specialize equipment, some measures were obtained to graphic the established flow and trumpet curves. Eight infusion pumps of the same brand and model were analyzed in the laboratory. The obtained curves and the typical curves from the manufacturer were compared, using digital programs and statistical studies. As a result, some diff...

Revista Mexicana de Ciencias Pecuarias, 2013

Con el objetivo de evaluar los efectos de cruzamiento en tres subpoblaciones de ganado bovino cru... more Con el objetivo de evaluar los efectos de cruzamiento en tres subpoblaciones de ganado bovino cruzados de doble proposito en el tropico humedo se utilizaron 5,040 lactancias y pesajes corporales al nacimiento [4,429] y pesos ajustados a 205 [3.878], 365 [3,017] y 540 [2,276] dias (PN, P205, P365 y P540, respectivamente) de Cebu (CE) y sus cruzas con Holstein (HS), Suizo Pardo (SP) y Simmental (SM). Los efectos aditivos directos de raza (PG), heterocigocidad (HT) y perdidas por recombinacion (RC) se estimaron mediante un analisis de regresion a traves de modelos mixtos. Los efectos fijos fueron el hato y ano de parto, epoca, numero de lactancia y sexo de la cria para produccion total de leche (PL), asi como el hato, y ano de nacimiento y epoca para crecimiento corporal. Los efectos aleatorios para PL fueron el efecto genetico directo (animal) y el ambiente permanente. Para crecimiento corporal fueron los efectos geneticos directos y maternos, asi como los efectos ambientales permanen...

IFMBE Proceedings, 2019

Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single ... more Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.

In Buenos Aires province, first and second levels are provided by City government, whereas third ... more In Buenos Aires province, first and second levels are provided by City government, whereas third and fourth levels are provided by 77 provincial Hospitals. The Public System is free of charge for all citizens. In these hospitals technical support of medical devices, preventive and corrective maintenance, has been and is carried out by the vendors´ technical services (manufacturers and distributors), or by companies that are dedicated to the technical service of medical equipment. These services do not include the permanent presence of technicians or engineers in the hospital. There is an exception to the procedure mentioned in 18 hospitals, which, by means of an agreement between the MoH and the National Technological University, have implemented clinical engineering departments. The department activities are carried out by graduates and undergraduate students, who perform tasks within the Hospital every weekday in an office assigned for that purpose, and with the support of the Uni...

Resumen en: In this paper a description of an acquisition system and a wavelet-based software to ... more Resumen en: In this paper a description of an acquisition system and a wavelet-based software to be used in the analysis of ECG signals is presented. The development...

IFMBE Proceedings, 2018

Technology is an important instrument for a new concept of home care and continuous monitoring. N... more Technology is an important instrument for a new concept of home care and continuous monitoring. New and smaller devices and communication advances have constructed a more humanitarian model of assisted alternative to hospital. For this purpose an integral scheme must to consider physiological, emotional, social and environmental conditions that promote the multidisciplinary support for the patients. In this work we present an Integral Assistive Home Care System, specially designed for elderly or chronic illness people. The approach proposed comprises a user wearable device, a domotic system’s core installed in a personal computer (PC) and an ichnographic software (SICAA) that allows the interaction of the patient with the environment and peripheral devices. Wearable sensors system have a master module that deals with data acquisition, synchronization and wireless transmission, connected to sensors or slaves which acquire biological signals and process them to minimize the amount of ...

Caregiving and Home Care, 2018

In this chapter, we propose a system especially created for elderly or chronically ill people tha... more In this chapter, we propose a system especially created for elderly or chronically ill people that are with special needs and poor familiarity with technology. The system combines home monitoring of physiological and emotional states through a set of wearable sensors, user-controlled (automated) home devices, and a central control for integration of the data, in order to provide a safe and friendly environment according to the limited capabilities of the users. The main objective is to create the easy, low-cost automation of a room or house to provide a friendly environment that enhances the psychological condition of immobilized users. In addition, the complete interaction of the components provides an overview of the physical and emotional state of the user, building a behavior pattern that can be supervised by the care giving staff. This approach allows the integration of physiological signals with the patient's environmental and social context to obtain a complete framework of the emotional states.

IFMBE Proceedings, 2018

Parkinson’s disease in an advanced stage presents the symptom of freezing of gait, approximately ... more Parkinson’s disease in an advanced stage presents the symptom of freezing of gait, approximately 80% of patients may have a freeze after 17 years of illness, provoking falls and injuries in the 60% of them, the medication is obsolete before this symptom. In search of new methodologies and instruments to help improve the lifestyle of these patients, a non-invasive wireless system is proposed to detect freezing and restart walking by means of superficial electrical stimulation during an episode. A sensor based on a triaxial accelerometer placed on the posterior secondary nerve was used to acquire and store the data of the right lower extremity during the presence of a freezing episode. The data was processed on a smartphone with Android operative system using the tool of discrete wavelet transform developed in Java. The transcutaneous electrical stimulation is applied near the posterior tibial nerve of the lower extremities to continue the walk, which presents better results compared to the vibratory stimulation presented in an earlier version from the authors. The results show feasible diagnostic tests for the validation of the system, such as precision, sensitivity and specificity.

Protein IDs and output tables after STRING analysis. Protein IDs induced under similar experiment... more Protein IDs and output tables after STRING analysis. Protein IDs induced under similar experimental conditions of heat stress in (1) WT tomato plants (where HsfA2 is present), (2) tomato protoplasts (where HsfA2 was inhibited using RNAi) and (3) WT Arabidopsis plants, were used as input for STRING analysis. Overlapping nodes corresponding to HSP70, HSP90, HSP100 and sHSPs families, are indicated in bold in the output tables. (XLSX 123 kb)

Fil: Spetale, Flavio Ezequiel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro... more Fil: Spetale, Flavio Ezequiel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Rosario. Centro Internacional Franco Argentino de Ciencias de la Informacion y de Sistemas. Universidad Nacional de Rosario. Centro Internacional Franco Argentino de Ciencias de la Informacion y de Sistemas; Argentina

Revista Mexicana de Ciencias Pecuarias, 2018

El objetivo fue evaluar algunas características morfológicas de gallinas de traspatio (n= 255) pr... more El objetivo fue evaluar algunas características morfológicas de gallinas de traspatio (n= 255) provenientes de 65 unidades rurales de producción, localizadas en 52 municipios de 18 estados de la República Mexicana. El modelo estadístico incluyó los efectos de sexo, estado y municipio anidado en estado. El efecto de sexo fue importante para todas las variables analizadas (P<0.0001), excepto para robustez (P=0.33). El efecto de estado fue importante (P<0.0001) para todas las variables analizadas, mientras que municipio solo influyó significativamente a envergadura (P<0.0001), peso corporal (P=0.0271) y solidez (P=0.0267). Los machos tuvieron mayor (P<0.0001) longitud corporal (4.85 cm), envergadura (5.66 cm), circunferencia de la pechuga (2.94 cm), longitud del tarso (1.73 cm), peso corporal (0.65 kg) y solidez (0.99 puntos porcentuales). El peso corporal aumentó 126 g (P<0.01) en machos y 61 g en hembras (P<0.01) por cada centímetro que aumentó la circunferencia de ...

IFMBE Proceedings, 2007

During the past years, the complexity of biomedical technology and the hospital’s facilities have... more During the past years, the complexity of biomedical technology and the hospital’s facilities have been increased in a great way, becoming in a possible health risk. Biomedical equipment security must be considered an important issue to protect patients and users. Testing laboratories have to assure devices working in optimal performance following local an international normative.

Revista Brasileira de Zootecnia, 2018

IFMBE Proceedings, 2019

This paper presents a modular system of wireless monitoring of physiological and ambient conditio... more This paper presents a modular system of wireless monitoring of physiological and ambient conditions based on Internet of Things (IoT). It is specially designed for elderly people and people with chronic diseases to promote their independent living. The system consists of a network of physiological and home ambient sensors developed under standard IoT protocols. These sensors are designed and manufactured at the laboratory with low-cost components. In addition, commercial sensors can be added according to the requirements of the patient. The system also provides a web based user interface for medical and family caregivers. It displays real time data and it includes an alarm system to report unsafe events via email. The caregiver can also see historical data with the possibility to compare all the parameters of a certain day and time. Furthermore, a home automation system was proposed to control home devices to improve home safety. The evaluation of the system was performed under a controlled environment at the laboratory in pilot tests before being tested in patients.

VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016, 2017

Gene Ontology is a hierarchical controlled vocabulary for protein annotation. Its synergy with au... more Gene Ontology is a hierarchical controlled vocabulary for protein annotation. Its synergy with automatic classification methods, ensemble, has been widely used for the prediction of protein functions. Current classification methods use only the relation is_a and a few little part_of to generate prediction model. In this work we formalize the GO part_of, regulates; negatively_regulates and positively_regulates relationships through predicate logic. This formalization is incorporated within an ensemble method based on graph factor called Factor Graph GO Annotation. The proposed model is validated against four model organisms for GO Biological Process prediction.

IFMBE Proceedings, 2019

Monitoring electrical failures in biomedical devices makes it possible to ensure patient’s safety... more Monitoring electrical failures in biomedical devices makes it possible to ensure patient’s safety. While assessing risk in medical equipment, we observed that electrical failures are one of the adverse events detected. Biomedical laboratories include procedures and design devices for testing electrical safety. In this work, we develop procedures to perform electrical safety test based on national and international standards. One of them is the Protective Earth Resistance test. Currently, the main standard applied to medical equipment tests is IEC 62353: 2014 “Medical electrical Equipment - recurrent test and test after repair of medical electrical equipment”. Specifically, this standard is a guideline that describes the requirements to ensure the electrical safety through comparable and reproducible tests.

Due to the lately increase of medical technology in the hospital practice; it is necessary to be ... more Due to the lately increase of medical technology in the hospital practice; it is necessary to be aware of the crucial importance of the performance verification of this technology. On the contrary, an increase of failures or accidents may occur, which in some cases, can be dangerous or fatal for the patients. In order to offer more security to the patients, some performance procedures on the infusion pumps were developed. The measures and verifications were done under laboratories procedures, based on IEC 60601-2-24: 2012 standards, “Particular requirements for the basic safety and essential performance of infusion pumps and controllers”. With the use of specialize equipment, some measures were obtained to graphic the established flow and trumpet curves. Eight infusion pumps of the same brand and model were analyzed in the laboratory. The obtained curves and the typical curves from the manufacturer were compared, using digital programs and statistical studies. As a result, some diff...

Revista Mexicana de Ciencias Pecuarias, 2013

Con el objetivo de evaluar los efectos de cruzamiento en tres subpoblaciones de ganado bovino cru... more Con el objetivo de evaluar los efectos de cruzamiento en tres subpoblaciones de ganado bovino cruzados de doble proposito en el tropico humedo se utilizaron 5,040 lactancias y pesajes corporales al nacimiento [4,429] y pesos ajustados a 205 [3.878], 365 [3,017] y 540 [2,276] dias (PN, P205, P365 y P540, respectivamente) de Cebu (CE) y sus cruzas con Holstein (HS), Suizo Pardo (SP) y Simmental (SM). Los efectos aditivos directos de raza (PG), heterocigocidad (HT) y perdidas por recombinacion (RC) se estimaron mediante un analisis de regresion a traves de modelos mixtos. Los efectos fijos fueron el hato y ano de parto, epoca, numero de lactancia y sexo de la cria para produccion total de leche (PL), asi como el hato, y ano de nacimiento y epoca para crecimiento corporal. Los efectos aleatorios para PL fueron el efecto genetico directo (animal) y el ambiente permanente. Para crecimiento corporal fueron los efectos geneticos directos y maternos, asi como los efectos ambientales permanen...

IFMBE Proceedings, 2019

Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single ... more Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.

In Buenos Aires province, first and second levels are provided by City government, whereas third ... more In Buenos Aires province, first and second levels are provided by City government, whereas third and fourth levels are provided by 77 provincial Hospitals. The Public System is free of charge for all citizens. In these hospitals technical support of medical devices, preventive and corrective maintenance, has been and is carried out by the vendors´ technical services (manufacturers and distributors), or by companies that are dedicated to the technical service of medical equipment. These services do not include the permanent presence of technicians or engineers in the hospital. There is an exception to the procedure mentioned in 18 hospitals, which, by means of an agreement between the MoH and the National Technological University, have implemented clinical engineering departments. The department activities are carried out by graduates and undergraduate students, who perform tasks within the Hospital every weekday in an office assigned for that purpose, and with the support of the Uni...

Resumen en: In this paper a description of an acquisition system and a wavelet-based software to ... more Resumen en: In this paper a description of an acquisition system and a wavelet-based software to be used in the analysis of ECG signals is presented. The development...

IFMBE Proceedings, 2018

Technology is an important instrument for a new concept of home care and continuous monitoring. N... more Technology is an important instrument for a new concept of home care and continuous monitoring. New and smaller devices and communication advances have constructed a more humanitarian model of assisted alternative to hospital. For this purpose an integral scheme must to consider physiological, emotional, social and environmental conditions that promote the multidisciplinary support for the patients. In this work we present an Integral Assistive Home Care System, specially designed for elderly or chronic illness people. The approach proposed comprises a user wearable device, a domotic system’s core installed in a personal computer (PC) and an ichnographic software (SICAA) that allows the interaction of the patient with the environment and peripheral devices. Wearable sensors system have a master module that deals with data acquisition, synchronization and wireless transmission, connected to sensors or slaves which acquire biological signals and process them to minimize the amount of ...

Caregiving and Home Care, 2018

In this chapter, we propose a system especially created for elderly or chronically ill people tha... more In this chapter, we propose a system especially created for elderly or chronically ill people that are with special needs and poor familiarity with technology. The system combines home monitoring of physiological and emotional states through a set of wearable sensors, user-controlled (automated) home devices, and a central control for integration of the data, in order to provide a safe and friendly environment according to the limited capabilities of the users. The main objective is to create the easy, low-cost automation of a room or house to provide a friendly environment that enhances the psychological condition of immobilized users. In addition, the complete interaction of the components provides an overview of the physical and emotional state of the user, building a behavior pattern that can be supervised by the care giving staff. This approach allows the integration of physiological signals with the patient's environmental and social context to obtain a complete framework of the emotional states.

IFMBE Proceedings, 2018

Parkinson’s disease in an advanced stage presents the symptom of freezing of gait, approximately ... more Parkinson’s disease in an advanced stage presents the symptom of freezing of gait, approximately 80% of patients may have a freeze after 17 years of illness, provoking falls and injuries in the 60% of them, the medication is obsolete before this symptom. In search of new methodologies and instruments to help improve the lifestyle of these patients, a non-invasive wireless system is proposed to detect freezing and restart walking by means of superficial electrical stimulation during an episode. A sensor based on a triaxial accelerometer placed on the posterior secondary nerve was used to acquire and store the data of the right lower extremity during the presence of a freezing episode. The data was processed on a smartphone with Android operative system using the tool of discrete wavelet transform developed in Java. The transcutaneous electrical stimulation is applied near the posterior tibial nerve of the lower extremities to continue the walk, which presents better results compared to the vibratory stimulation presented in an earlier version from the authors. The results show feasible diagnostic tests for the validation of the system, such as precision, sensitivity and specificity.