Frendy Setyawan - Academia.edu (original) (raw)
Papers by Frendy Setyawan
Journal of Pharmaceutical and Health Research, Feb 16, 2023
Nypa fruticans) merupakan jenis sawit yang banyak digunakan oleh masyarakat. Masyarakat Jambi men... more Nypa fruticans) merupakan jenis sawit yang banyak digunakan oleh masyarakat. Masyarakat Jambi menggunakan daun Nipah sebagai membran nipah untuk selaput rokok. Namun, kami menemukan laporan kasus penggunaan rokok yang berimplikasi pada tingkat keparahan penyakit pneumotoraks spontan. Seorang pria berusia 57 tahun datang ke ruang gawat darurat menderita sesak napas, ketidaknyamanan dada sisi kanan, batuk dahak hijau kekuningan, sakit perut, mual, kelemahan, nafsu makan menurun, dan ketidakmampuan untuk tidur. Selama dua tahun, pria ini mengonsumsi sepuluh batang membran Nipah yang dibuatnya secara mandiri setiap hari, sehingga mengakibatkan penyakit paru-paru. Paru-paru ditemukan asimetris dengan fremitus batang paru-paru kanan yang melemah; perkusi mengungkapkan resonansi hiper di paru-paru kanan dan resonansi di paru-paru kiri; Auskultasi mengungkapkan adanya penurunan suara pernapasan vesikular di paru-paru kanan, dan suara pernapasan lainnya berderak di kedua paru-paru. Asidosis pernapasan kompensasi parsial berat pasien menunjukkan tingkat pH, pO2, pCO2, HCO3, total CO2, dan BE. Sinus takikardia, normoaxis dan hipertrofi atrium yang cocok ditemukan. Daerah luscen terlihat, dan garis putih pleura di hemithorax kanan menunjukkan pneumotoraks paru-paru kanan. Kasus ini relatif jarang terjadi, dan kelebihan mengkonsumsi rokok selaput daun Nipah sebagai pengganti rokok meningkatkan keparahan penyakit pneumotoraks spontan penyebab PPOK.
Journal of research in pharmacy, 2024
Terna plants are used by Indonesians as raw materials for herbal and traditional medicine, includ... more Terna plants are used by Indonesians as raw materials for herbal and traditional medicine, including Phyllantus niruri L. and Phyllantus urinaria L. Therefore, this study aimed to explore, analyze and compile the activities and potential of Phyllantus niruri L. and Phyllantus urinaria L. as agents of hepatitis B virus (HBV) inhibitors using a narrative review approach. It was conducted based on the Scale for the Assessment of Narrative Review Articles (SANRA) by establishing inclusion and exclusion criteria. The study selected and reviewed 15 out of 38 articles. The Phyllantus genus is a group of seasonal herbs containing bioactive compounds and activity as HBV Inhibitors. In this study, 23 compounds were identified in the two species,
Deleted Journal, Feb 13, 2024
Refillable drinking water has become an option to meet the hydration needs of the community, espe... more Refillable drinking water has become an option to meet the hydration needs of the community, especially in Jembrana District, Bali. However, comprehensive monitoring of hygiene and sanitation has yet to be reported. This study aims to identify, evaluate, and describe the quality of hygiene and sanitation at the refillable drinking water depot in Jembrana District. The mixed-methods research design was used to monitor the hygiene and sanitation of 46 DAMIU in Jembrana District. Environmental inspections are conducted in the field, and water samples are taken for bacteriological analysis. All results are presented descriptively. The results showed that 82.60% had met the requirements to be free from coliform contamination, and 86.96% had met the requirements to be free of E. coli in the resulting refill water. A total of 17.40% coliformswere contaminated, and 13.04% E. coli were contaminated. Overall, improved monitoring of the hygienic characteristics of handlers, sanitary characteri...
Incense (bakhour) is used by the community through ceremonies, traditional health practices, and ... more Incense (bakhour) is used by the community through ceremonies, traditional health practices, and aromatherapy. Nevertheless, evidence from experiments and studies of populations suggests that a habit of burning incense makes the lungs work less well. The study investigated the relationship between exposure to incense smoke and impaired lung function and respiratory diseases. Data tracing was carried out systematically by following PRISMA guidelines and establishing inclusion and exclusion criteria for filtering, selecting, and including articles registered in the PROSPERO database. This study describes respiratory symptoms/ diseases, home use of incense, and lung function measurement. Six articles were included; 6 articles (100%) reported using incense indoors, and five (83%) reported using incense outside the home. Respiratory symptoms and diseases caused by exposure to incense sticks are 5 (83%) shortness of breath, 6 (100%) wheezing, asthma, and inflammation of the lungs, 2 (33%)...
Research Journal of Pharmacy and Technology, 2019
PubMed, Sep 30, 2023
Background: The use of bedaquiline has been reported to minimize the number of lost to follow-up ... more Background: The use of bedaquiline has been reported to minimize the number of lost to follow-up and fewer rejections from the patients. This study is the first to depict the use of bedaquiline. It aims to provide information related to the profile of the MDR-TB drug regimen in the last 7 years with the treatment outcomes of pulmonary MDR-TB patients at a tertiary referral hospital in East Java. Methods: This study was a retrospective, descriptive, and data analysis on 1053 pulmonary MDR-TB patients in tertiary referral hospital Dr Soetomo, East Java, Indonesia, with the SPSS software version 25 and Microsoft Excel 2021. Results: The study analyzed the MDR-TB treatment regimen following the latest guidelines from WHO (2020) at a tertiary referral hospital in East Java. This study shows that a bedaquiline-containing regimen started in January 2015 to July 2022 with the percentage of distribution (1, 3, 11, 4, 18, 13, 29, 21)% consecutively in the regimen. The treatment outcome profile of MDR-TB patients shows the average percentage of cured (15%), died (12%), lost-to-follow-up cases (27%), moved to an individualized regimen or a different health facility (42%), and currently in the evaluation stage (4%). Overall from January 2017 to July 2022, the number of LTFU cases decreased (42, 46, 29, 19, 8, 4)%. However, the cured case fluctuated between 2017-2022 (16, 28, 26, 32)% respectively after Bdq started to be included in the regimen regularly for treating RR/MDR-TB. Conclusion: After seven years of study, we revealed an association between adding bedaquiline to the regimen and the treatment success and decreasing lost-to-follow-up cases.
Introduction: Diabetes mellitus (DM) is a chronic disease with diverse and complex metabolic diso... more Introduction: Diabetes mellitus (DM) is a chronic disease with diverse and complex metabolic disorders. DM can be identified with hyperglycemic conditions. In 2017, Indonesia ranked sixth in the world for the highest number of diabetic patients after China, India, United States, Brazil, and Mexico. Objective: This study aims to determine the combined effect of alginate extract from Sargassum duplicatum and Sargassum ilicifolium with okra (Abelmoschus esculentus) and mangosteen (Garcinia mangostana) pericarp extracts to ameliorate the wound width process, the number of neutrophil cells, macrophages, fibroblasts, fibrocytes, and collagen density in streptozotocin-induced diabetic mice. Methods: This study used male mice (strain BALB/C, weighting 30±5 g each) which were grouped into four groups; normal control with water only; diabetic control group; combination treatment group with S. duplicatum extract, A. esculentus extract, and G. mangostana extract; and combination treatment group...
Annals of Biology, 2020
This study aimed at determining the effect of various fractions of okra pods extract (VOPE) on fa... more This study aimed at determining the effect of various fractions of okra pods extract (VOPE) on fasting blood glucose, the diameter of the islets of Langerhans, number of β-cells of the islets of Langerhans and homeostatic model assessment for insulin resistance (HOMA-IR) in diabetic mice. This study used 35 male Balb/c strain mice. The samples were divided into seven groups, KN (normal control), KD (diabetic control), KA (acarbose control; 100 mg/kg body weight), EK (crude extract; 100 mg/kg body weight), NP (non-polar; 20.04 mg/kg body weight), SP (semi-polar; 27.39 mg/kg body weight) and EP (polar; 54.11 mg/kg body weight). VOPE and acarbose administered orally for 14 days in streptozotocin-induced diabetic mice. The diabetes was induced by intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. On day 15 th , mice were sacrified. Interestingly, administration of VOPE decreased fasting blood glucose level, increasing th...
Research Journal of Pharmacy and Technology
This study aims to evaluate the effects of alginate extract from Sargassum ilicifolium and okra (... more This study aims to evaluate the effects of alginate extract from Sargassum ilicifolium and okra (Abelmoschus esculentus) pods extract on the re-epithelialization rate of the wound area and the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density in streptozotocin-induced diabetic mice. This study was done in vivo using male mice (strain BALB/C, 3 to 4 months old, 30 to 40g). The normal control group (KN) and the diabetic groups (induced by streptozotocin). The diabetic group was divided into 9 groups: three diabetic control groups (KD), three alginate treatment groups (KAI), and three treatment groups of alginate-okra (Abelmoschus esculentus) pods extract (KAIO). The treatment dose was 50 mg/kg body weight. Measurement of fasting blood sugar levels was done before and after streptozotocin injection. The treatment was carried out in three different time periods: 3 days, 7 days, and 14 days. Then, mice skin was cut and proceed for histopathological analysis. Interestingly, we indicated that the administration of okra (Abelmoschus esculentus) pods extract combined with alginate from Sargassum ilicifolium could increase the rate of re-epithelialization of the wound area, increase the number of neutrophils, macrophages, fibroblasts, fibrocytes, as well as increase synthesized collagen. The combined extract was able to improve the healing process of open wounds in diabetic mice. Therefore, it can be concluded that the administration of alginate from Sargassum ilicifolium and okra (Abelmoschus esculentus) pods extract was able to improve open wounds healing in diabetic mice due to the role of antioxidant from polysaccharides and quercetin which acted as anti-hyperglycemic to anti-inflammatory properties.
Journal of Pharmaceutical and Health Research, Feb 16, 2023
Nypa fruticans) merupakan jenis sawit yang banyak digunakan oleh masyarakat. Masyarakat Jambi men... more Nypa fruticans) merupakan jenis sawit yang banyak digunakan oleh masyarakat. Masyarakat Jambi menggunakan daun Nipah sebagai membran nipah untuk selaput rokok. Namun, kami menemukan laporan kasus penggunaan rokok yang berimplikasi pada tingkat keparahan penyakit pneumotoraks spontan. Seorang pria berusia 57 tahun datang ke ruang gawat darurat menderita sesak napas, ketidaknyamanan dada sisi kanan, batuk dahak hijau kekuningan, sakit perut, mual, kelemahan, nafsu makan menurun, dan ketidakmampuan untuk tidur. Selama dua tahun, pria ini mengonsumsi sepuluh batang membran Nipah yang dibuatnya secara mandiri setiap hari, sehingga mengakibatkan penyakit paru-paru. Paru-paru ditemukan asimetris dengan fremitus batang paru-paru kanan yang melemah; perkusi mengungkapkan resonansi hiper di paru-paru kanan dan resonansi di paru-paru kiri; Auskultasi mengungkapkan adanya penurunan suara pernapasan vesikular di paru-paru kanan, dan suara pernapasan lainnya berderak di kedua paru-paru. Asidosis pernapasan kompensasi parsial berat pasien menunjukkan tingkat pH, pO2, pCO2, HCO3, total CO2, dan BE. Sinus takikardia, normoaxis dan hipertrofi atrium yang cocok ditemukan. Daerah luscen terlihat, dan garis putih pleura di hemithorax kanan menunjukkan pneumotoraks paru-paru kanan. Kasus ini relatif jarang terjadi, dan kelebihan mengkonsumsi rokok selaput daun Nipah sebagai pengganti rokok meningkatkan keparahan penyakit pneumotoraks spontan penyebab PPOK.
Journal of research in pharmacy, 2024
Terna plants are used by Indonesians as raw materials for herbal and traditional medicine, includ... more Terna plants are used by Indonesians as raw materials for herbal and traditional medicine, including Phyllantus niruri L. and Phyllantus urinaria L. Therefore, this study aimed to explore, analyze and compile the activities and potential of Phyllantus niruri L. and Phyllantus urinaria L. as agents of hepatitis B virus (HBV) inhibitors using a narrative review approach. It was conducted based on the Scale for the Assessment of Narrative Review Articles (SANRA) by establishing inclusion and exclusion criteria. The study selected and reviewed 15 out of 38 articles. The Phyllantus genus is a group of seasonal herbs containing bioactive compounds and activity as HBV Inhibitors. In this study, 23 compounds were identified in the two species,
Deleted Journal, Feb 13, 2024
Refillable drinking water has become an option to meet the hydration needs of the community, espe... more Refillable drinking water has become an option to meet the hydration needs of the community, especially in Jembrana District, Bali. However, comprehensive monitoring of hygiene and sanitation has yet to be reported. This study aims to identify, evaluate, and describe the quality of hygiene and sanitation at the refillable drinking water depot in Jembrana District. The mixed-methods research design was used to monitor the hygiene and sanitation of 46 DAMIU in Jembrana District. Environmental inspections are conducted in the field, and water samples are taken for bacteriological analysis. All results are presented descriptively. The results showed that 82.60% had met the requirements to be free from coliform contamination, and 86.96% had met the requirements to be free of E. coli in the resulting refill water. A total of 17.40% coliformswere contaminated, and 13.04% E. coli were contaminated. Overall, improved monitoring of the hygienic characteristics of handlers, sanitary characteri...
Incense (bakhour) is used by the community through ceremonies, traditional health practices, and ... more Incense (bakhour) is used by the community through ceremonies, traditional health practices, and aromatherapy. Nevertheless, evidence from experiments and studies of populations suggests that a habit of burning incense makes the lungs work less well. The study investigated the relationship between exposure to incense smoke and impaired lung function and respiratory diseases. Data tracing was carried out systematically by following PRISMA guidelines and establishing inclusion and exclusion criteria for filtering, selecting, and including articles registered in the PROSPERO database. This study describes respiratory symptoms/ diseases, home use of incense, and lung function measurement. Six articles were included; 6 articles (100%) reported using incense indoors, and five (83%) reported using incense outside the home. Respiratory symptoms and diseases caused by exposure to incense sticks are 5 (83%) shortness of breath, 6 (100%) wheezing, asthma, and inflammation of the lungs, 2 (33%)...
Research Journal of Pharmacy and Technology, 2019
PubMed, Sep 30, 2023
Background: The use of bedaquiline has been reported to minimize the number of lost to follow-up ... more Background: The use of bedaquiline has been reported to minimize the number of lost to follow-up and fewer rejections from the patients. This study is the first to depict the use of bedaquiline. It aims to provide information related to the profile of the MDR-TB drug regimen in the last 7 years with the treatment outcomes of pulmonary MDR-TB patients at a tertiary referral hospital in East Java. Methods: This study was a retrospective, descriptive, and data analysis on 1053 pulmonary MDR-TB patients in tertiary referral hospital Dr Soetomo, East Java, Indonesia, with the SPSS software version 25 and Microsoft Excel 2021. Results: The study analyzed the MDR-TB treatment regimen following the latest guidelines from WHO (2020) at a tertiary referral hospital in East Java. This study shows that a bedaquiline-containing regimen started in January 2015 to July 2022 with the percentage of distribution (1, 3, 11, 4, 18, 13, 29, 21)% consecutively in the regimen. The treatment outcome profile of MDR-TB patients shows the average percentage of cured (15%), died (12%), lost-to-follow-up cases (27%), moved to an individualized regimen or a different health facility (42%), and currently in the evaluation stage (4%). Overall from January 2017 to July 2022, the number of LTFU cases decreased (42, 46, 29, 19, 8, 4)%. However, the cured case fluctuated between 2017-2022 (16, 28, 26, 32)% respectively after Bdq started to be included in the regimen regularly for treating RR/MDR-TB. Conclusion: After seven years of study, we revealed an association between adding bedaquiline to the regimen and the treatment success and decreasing lost-to-follow-up cases.
Introduction: Diabetes mellitus (DM) is a chronic disease with diverse and complex metabolic diso... more Introduction: Diabetes mellitus (DM) is a chronic disease with diverse and complex metabolic disorders. DM can be identified with hyperglycemic conditions. In 2017, Indonesia ranked sixth in the world for the highest number of diabetic patients after China, India, United States, Brazil, and Mexico. Objective: This study aims to determine the combined effect of alginate extract from Sargassum duplicatum and Sargassum ilicifolium with okra (Abelmoschus esculentus) and mangosteen (Garcinia mangostana) pericarp extracts to ameliorate the wound width process, the number of neutrophil cells, macrophages, fibroblasts, fibrocytes, and collagen density in streptozotocin-induced diabetic mice. Methods: This study used male mice (strain BALB/C, weighting 30±5 g each) which were grouped into four groups; normal control with water only; diabetic control group; combination treatment group with S. duplicatum extract, A. esculentus extract, and G. mangostana extract; and combination treatment group...
Annals of Biology, 2020
This study aimed at determining the effect of various fractions of okra pods extract (VOPE) on fa... more This study aimed at determining the effect of various fractions of okra pods extract (VOPE) on fasting blood glucose, the diameter of the islets of Langerhans, number of β-cells of the islets of Langerhans and homeostatic model assessment for insulin resistance (HOMA-IR) in diabetic mice. This study used 35 male Balb/c strain mice. The samples were divided into seven groups, KN (normal control), KD (diabetic control), KA (acarbose control; 100 mg/kg body weight), EK (crude extract; 100 mg/kg body weight), NP (non-polar; 20.04 mg/kg body weight), SP (semi-polar; 27.39 mg/kg body weight) and EP (polar; 54.11 mg/kg body weight). VOPE and acarbose administered orally for 14 days in streptozotocin-induced diabetic mice. The diabetes was induced by intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. On day 15 th , mice were sacrified. Interestingly, administration of VOPE decreased fasting blood glucose level, increasing th...
Research Journal of Pharmacy and Technology
This study aims to evaluate the effects of alginate extract from Sargassum ilicifolium and okra (... more This study aims to evaluate the effects of alginate extract from Sargassum ilicifolium and okra (Abelmoschus esculentus) pods extract on the re-epithelialization rate of the wound area and the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density in streptozotocin-induced diabetic mice. This study was done in vivo using male mice (strain BALB/C, 3 to 4 months old, 30 to 40g). The normal control group (KN) and the diabetic groups (induced by streptozotocin). The diabetic group was divided into 9 groups: three diabetic control groups (KD), three alginate treatment groups (KAI), and three treatment groups of alginate-okra (Abelmoschus esculentus) pods extract (KAIO). The treatment dose was 50 mg/kg body weight. Measurement of fasting blood sugar levels was done before and after streptozotocin injection. The treatment was carried out in three different time periods: 3 days, 7 days, and 14 days. Then, mice skin was cut and proceed for histopathological analysis. Interestingly, we indicated that the administration of okra (Abelmoschus esculentus) pods extract combined with alginate from Sargassum ilicifolium could increase the rate of re-epithelialization of the wound area, increase the number of neutrophils, macrophages, fibroblasts, fibrocytes, as well as increase synthesized collagen. The combined extract was able to improve the healing process of open wounds in diabetic mice. Therefore, it can be concluded that the administration of alginate from Sargassum ilicifolium and okra (Abelmoschus esculentus) pods extract was able to improve open wounds healing in diabetic mice due to the role of antioxidant from polysaccharides and quercetin which acted as anti-hyperglycemic to anti-inflammatory properties.