Sevgen Tanır Basaranoglu - Academia.edu (original) (raw)

Papers by Sevgen Tanır Basaranoglu

Klinik Tıp Pediatri Dergisi, Jul 8, 2016

Öz Ekinokokkoz insanlarda Echinococcus cinsinin sestodlarının larva formlarının sebep olduğu enfe... more Öz Ekinokokkoz insanlarda Echinococcus cinsinin sestodlarının larva formlarının sebep olduğu enfeksiyon nedeniyle gelişmektedir. Tanısal çalışmalar ve tedavi yaklaşımı açısından çok yol katedilmiş olmasına rağmen, birçok çalışma halen dünya çapında ekinokokkozun ciddi bir halk sağlığı problemi teşkil ettiğini göstermektedir.

Italian Journal of Pediatrics, Sep 12, 2017

Background: Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. p... more Background: Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. Methods: A retrospective review of patients younger than 18 years-old with blood stream infection caused by K. pneumoniae was performed. Patients with ESBL-producing K. pneumoniae isolates were compared with ESBL-nonproducing isolates in terms of risk factors, outcome and mortality. Results: Among 111 K. pneumoniae isolates 62% (n = 69) were ESBL-producing K. pneumoniae. The median total length of hospitalization and median length of stay in hospital before infection was significantly higher in patients with ESBL-producing isolates than ESBL-non-producing. Use of combined antimicrobial treatment was significantly different between ESBL-producing and ESBL-non-producing groups, 75.4% and 24.6%, respectively (p = 0.001). Previous aminoglycoside use was higher in cases with ESBL-producing isolates (p = 0.001). Logistic regression analysis showed a significant correlation between mortality and use of combined antibiotics (OR 4.22; p = 0.01). Conclusion: ESBL production in K. pneumoniae isolates has a significant impact on clinical course of BSIs. Total length of hospitalization, length of hospital stay before infection, prior combined antibiotic use and use of aminoglycosides were significant risk factors for development of ESBL-producing K. pneumoniae related BSI.

Journal of Medical Virology, Feb 9, 2021

Severity of disease caused by influenza virus and the influencing factors that may be different. ... more Severity of disease caused by influenza virus and the influencing factors that may be different. Moreover, the disease course actually may not be determined specifically in children because of lower seroprotection rates of children. Herein, the results clinic and outcome data of children with influenza from Turkey were reported. We present here the results from 2013 to 2017. Nasopharyngeal swab samples of the children with influenza were investigated via multiplex polymerase chain reaction. A total of 348 children were diagnosed with influenza; 143 (41.1%) were influenza A, 85 (24.4%) were influenza B, and 120 (34.5%) were mixt infection with other respiratory viruses. Fifty‐four percent of children admitted to intensive care unit (ICU) were under 2 years of age (p = .001). Having an underlying disease was detected as the main predictor for both hospitalization and ICU stay according to multiple logistic regression analysis (odds ratio [OR], 11.784: 95% confidence interval [CI], 5.212–26.643; p = .001 and OR, 4.972: 95% CI, 2.331–10.605; p = .001, respectively). Neurological symptoms most frequently seen in cases who died (44.4%; p = .02). Lymphopenia was relatively higher (55.6%) and thrombocytopenia was most frequently seen in cases who died (77.8%) with a significant ratio (p = .001). Underlying diseases was found a risk factor for influenza being hospitalized and being admitted to ICU. Children under 2 years of age and with underlying diseases should be vaccinated particularly in countries where the influenza vaccination is still not routinely implemented in the immunization schedule.Highlights Underlying diseases is a risk factor for influenza to be hospitalized and admitted to ICU. Influenza vaccination is of great importance to prevent life‐threatening complications of influenza, particularly in children require ICU admission. The possibility to reduce the outpatient visit number by vaccination has a great impact on disease burden in addition to the underestimated crucial social benefits, as well.

Journal of Pediatric Hematology Oncology, Nov 1, 2017

With improvements in molecular diagnostic methods, report of Human bocavirus (HBoV) as an etiolog... more With improvements in molecular diagnostic methods, report of Human bocavirus (HBoV) as an etiologic agent in many studies on viral respiratory and gastrointestinal infections has been increasing. Two pediatric patients who presented with secondary hemophagocytic lymphohistiocytosis were examined for etiologic causes, including viruses. Whole bacterial and fungal cultures and viral serological studies were negative. Viral polymerase chain reaction of nasopharyngeal secretions showed HBoV. One was successfully treated with intravenous immunoglobulins, whereas the other died with multiorgan failure. Here we report 2 pediatric patients with secondary hemophagocytic lymphohistiocytosis and detection of HBoV as the sole agent, predicting an association.

BMC Pediatrics, Mar 18, 2023

Background Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobi... more Background Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region. Methods The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre. Results A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect. Conclusion This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.

Turkiye Klinikleri Pediatric Dentistry - Special Topics, 2016

Journal of Infection and Public Health, Sep 1, 2018

Background: Myocarditis is an inflammatory condition located mainly in the myocardium. It is caus... more Background: Myocarditis is an inflammatory condition located mainly in the myocardium. It is caused by a variety of bacterial and viral infections. Influenza is one of the most common relevant viruses that cause myocarditis. Objectives: We attempted to share our experiences about clinical and laboratory findings, cardiac evaluation, and treatment of children with influenza myocarditis. Methods: This retrospective study was performed by the Department of Pediatric Infectious Diseases at the Faculty of Medicine, Hacettepe University in Turkey. The medical records of patients diagnosed with myocarditis associated with an influenza infection between January 2014 and January 2017 were systematically reviewed. Results: Vaccination seems likely to be an important protection strategy for both influenza infections and complications.

The Clinical Respiratory Journal, 2021

Discrimination of the cases with severe and mild pneumonia is crucial due to the requirement of h... more Discrimination of the cases with severe and mild pneumonia is crucial due to the requirement of hospitalization, additional management, and treatment protocols. We aimed to analyze the role of IL6 (Interleukin), IL8, IL10, VCAM‐1 (soluble Vascular Cell Adhesion Molecule), and sSELE (soluble E‐selectin) in the diagnosis and prognostic evaluation of community‐acquired pneumonia (CAP).

Neuropediatrics, 2021

Encephalitis is a serious neurological syndrome caused by inflammation of the brain. The diagnosi... more Encephalitis is a serious neurological syndrome caused by inflammation of the brain. The diagnosis can be challenging and etiology remains unidentified in about half of the pediatric cases. We aimed to investigate demographic, clinical, laboratory, electroencephalographic and neuroimaging findings, and outcome of acute encephalitis of nonbacterial etiology. This prospective study included children hospitalized with the diagnosis of acute encephalitis between 2017 and 2019. Microbiological investigations of the cerebrospinal fluid (CSF) were recorded. All CSF specimens were tested for anti-N methyl D-aspartate receptor (NMDAR) antibodies. In total, 31 children aged 10 months to 17 years (median = 6 years) were included. Pathogens were confirmed in CSF in three patients (9.7%): varicella zoster virus, herpes simplex virus type 1 (HSV-1), and both HSV-1 and NMDAR antibodies. Presenting features included encephalopathy (100%), fever (80.6%), seizure (45.2%), focal neurological signs (29...

Flora the Journal of Infectious Diseases and Clinical Microbiology, 2018

Giriş: Respiratuvar sinsityal virüs (RSV), dünya genelinde çocuk hastalarda da erişkinlerde de ci... more Giriş: Respiratuvar sinsityal virüs (RSV), dünya genelinde çocuk hastalarda da erişkinlerde de ciddi mortalite ve morbiditeye sebep olan ana patojenlerdendir. Ülkemizde RSV seyrini ortaya koymak amacıyla bu çalışma dizayn edildi.

Turkish Journal of Pediatric Disease, 2017

İdrar yolu enfeksiyonları (İYE) çocukluk yaş grubunda en sık karşılaşılan enfeksiyonlar arasındad... more İdrar yolu enfeksiyonları (İYE) çocukluk yaş grubunda en sık karşılaşılan enfeksiyonlar arasındadır. Bu çalışma ile üçüncü basamak bir hastanede idrar yolu enfeksiyonlarında etiyolojik ajanların değerlendirilmesi, antimikrobiyal direnç paternlerinin belirlenmesi, ampirik tedavi önerilerinin gözden geçirilmesi amaçlandı. Gereç ve Yöntemler: Hacettepe Üniversitesi İhsan Doğramacı Çocuk Hastanesi yataklı servis ve polikliniklerinden 01.01.2012-31.12.2015 tarihleri arasında hastanemiz mikrobiyoloji laboratuvarına gönderilen ve Gram negatif (-) üreme saptanan 4421 idrar örneğinin kültür ve antibiyogram sonuçları retrospektif olarak değerlendirildi. Bulgular: Gram negatif üreme saptanan 4421 örnekten %64.1'inde Escherichia coli, %17.1'inde Klebsiella spp, %7.4'ünde Proteus spp üremesi saptandı. Tüm gram negatif mikroorganizmalar birlikte değerlendirildiğinde; en yüksek direnç ampisilin (%75.1), sefazolin (%59), ampisilin-sulbaktam (%49.7), trimetoprim-sulfametoksazol (TMP-SMX) (%45.2), sefiksim (%33.1) ve seftriaksona (%31.4) karşı saptandı. En düşük direnç meropenem (%3.2), ertapenem (%3.4), kolistin (%7.2), amikasin (%16.2), siprofloksasin (%21.1), piperasilin tazobaktama karşı (%23.2)'di. Sonuç: Çalışmamızda çocukluk çağı idrar yolu enfeksiyonlarında ilk seçenek olarak kullanılan birinci kuşak sefalosporinlere, ampisilin, ampisilin-sulbaktam ve TMP-SMX'e karşı yüksek direnç saptanmıştır. Tedavide başarılı olabilmek, morbidite ve uzun dönem sekellerini en aza indirebilmek için İYE nedeni olan patojenlerin sıklığı, yerel veya bölgesel antibiyotik dirençlerinin bilinmesi ve bu doğrultuda ampirik tedavinin düzenlenmesi gereklidir.

The Turkish Journal of Pediatrics, 2018

and seasonal distribution of viral etiology of respiratory tract infections in inpatients and out... more and seasonal distribution of viral etiology of respiratory tract infections in inpatients and outpatients of the pediatric population: 10 year follow-up.

Journal of Pediatric Infection, 2019

Tırnağı çevreleyen epidermisin enfeksiyonu olan paronişi, elin en sık görülen enfeksiyonudur. Çal... more Tırnağı çevreleyen epidermisin enfeksiyonu olan paronişi, elin en sık görülen enfeksiyonudur. Çalışmamızda hastanemizde paronişi tanısı alan hastaların klinik özelliklerini ve tedavilerini tartışmayı planladık.

Türk Pediatri Arşivi, 2018

Bu çalışmada çocuk hekimlerinin bilimsel araştırmaların raporlama kılavuzları ile ilgili düşünce ... more Bu çalışmada çocuk hekimlerinin bilimsel araştırmaların raporlama kılavuzları ile ilgili düşünce ve farkındalıklarının ve rutin pratikte bu kılavuzların kullanımının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu kesitsel anket çalışması, Ankara'da bulunan en büyük iki çocuk hastanesinde çalışan çocuk hekimleri ile yapılmıştır. Çocuk hekimlerinden raporlama kılavuzları ve Sağlık Araştırmalarında Kalite ve Şeffaflığın sağlanması [Enhancing the Quality and Transparency of Health Research] internet ağı ile ilgili olarak hazırlanan Türkçe 13 soruya yanıt vermeleri istenmiş ve bu kılavuzlar ile ilgili bilgi, farkındalık ve kullanım durumu araştırılmıştır. Bulgular: Her iki merkezden 224 klinisyen çalışmaya katılmayı kabul etti (hedef topluluğun %56,4). Katılımcıların ortalama yaşları 34±9,24 iken, ortanca yaşı 31 idi (en küçük-en büyük: 24-63 yaş) ve katılımcıların %71,4'ü kadındı. Katılımcılar meslek yaşamlarının ortanca 6 yılında (en küçük-en büyük: 1-39 yıl) idi ve %63,8'i bir bilimsel çalışmada araştırıcı olarak yer almıştı. Katılımcıların 45'i (%20) daha önceden raporlama kılavuzlarını biliyordu ve büyük kısmı bu kılavuzları dergilerden, kongrelerden ve seminerlerden duymuştu. Bunların 20'si (%26,6) kılavuzları kullanmıştı. Altmış beş (%29) katılımcı bir bilimsel araştırma değerlendirmişti, ancak bunların sadece üçü (%4,6) bu kılavuzları hakemlik yaparken kullanmıştı. Katılımcıların %83,5'i bu kılavuzlarla ilgili bilgi almak istediğini bildirdi. Her iki merkezde de bu kılavuzlarla ilgili bilgi düzeyi ve kullanım durumu benzerdi. Çıkarımlar: Çocuk hekimlerinin bilimsel araştırmanın raporlama kılavuzları ile ilgili farkındalıkları ve kullanımları yetersizdir.

Journal of global antimicrobial resistance, Jan 10, 2017

The increasing incidence of infections caused by drug-resistant Gram-negative organisms has led t... more The increasing incidence of infections caused by drug-resistant Gram-negative organisms has led to a reemergence in worldwide. This study attempted to investigate the changes in resistance of Gram-negative bacteria to different classes of antibiotics and treatment options in invasive infections. We performed this study retrospectively between January 2012 and January 2017 in our tertiary care university hospital. A total of 302 patients with Gram-negative bacterial bacteremia and meningitis were defined. Demographic, clinical and microbiological features of patients were evaluated. A total of 302 patients with Gram-negative bacterial infection, which were diagnosed as bacteremia (n=274, 90.7%) and meningitis (n=28, 9.3%) were investigated. Klebsiella spp. was the most frequent agent with rate of 119 (%39.4), followed by Escherichia coli 67 (%22.2), Pseudomonas spp. 41 (13.6%), Acinetobacter spp. 42 (13.9%), and Enterobacter spp. 33 (10.9%). Totally, 115 (38.1%) multidrug-resistance ...

Journal of Pediatric Hematology/Oncology, 2017

Current Medical Research and Opinion, 2017

Global Influenza Hospital Surveillance Network is a worldwide initiative that aims to document th... more Global Influenza Hospital Surveillance Network is a worldwide initiative that aims to document the burden of influenza infections among acute admissions and vaccine effectiveness in particular countries. As a partner of this platform, we aimed to determine the frequency of influenza infections among acute admissions with influenza-like illness and the outcomes of enrolled patients during the 2015-2016 influenza season in selected hospitals in Turkey. The investigators screened the hospital admission registries, chart review or available records, and screened all patients hospitalized in the previous 24-48 hours or overnight in the predefined wards or emergency room. A total of 1351 patients were screened for enrollment in five tertiary care referral hospitals in Ankara and 774 patients (57.3% of the initial screened population) were eligible for swabbing. All of the eligible patients who consented were swabbed and tested for influenza with real-time polymerase chain reaction (PCR) based methods. Overall, influenza positivity was detected in 142 patients (18.4%). The predominant influenza strain was A H1N1pdm09. Outcomes were worse among elderly patients, regardless of the presence of the influenza virus. Half of the patients over 65 years of age were admitted to the intensive care unit, while one third required any mode of mechanical ventilation and one fourth died in the hospital in that particular episode. These findings can guide hospitals to plan and prepare for the influenza season. Effective influenza vaccination strategies, particularly aimed at the elderly and adults with chronic diseases, can provide an opportunity for prevention of deaths due to influenza-like illness.

European Journal of Inflammation

Common variable immunodeficiency (CVID) is a heterogenous group of immunologic disorders of unkno... more Common variable immunodeficiency (CVID) is a heterogenous group of immunologic disorders of unknown etiology. Alterations of the normal cellular balance due to an increase in reactive oxygen species and/or decrease in antioxidant defense may lead to increased oxidative stress. We aimed to evaluate the levels of oxidative stress biomarkers in patients with CVID who had different presentations. We investigated the serum catalase (CAT), erythrocyte superoxide dismutase (SOD), erythrocyte reduced glutathione as antioxidants and serum malondialdehyde levels as lipid peroxidation marker in patients with CVID in Uludag University Hospital Department of Pediatric Allergy and Immunology’s outpatient clinics. In the analysis, there were 21 patients and 27 matched healthy controls. The median levels of CAT in patients with CVID was significantly lower than in healthy controls ( p = 0.04). Among the patients with CVID, 19% had autoimmune disease, one had Sjögren’s syndrome, one had autoimmune a...

Minerva Pediatrics, 2020

BACKGROUND There is a crucial balance between oxidant and antioxidant defense mechanisms. We aime... more BACKGROUND There is a crucial balance between oxidant and antioxidant defense mechanisms. We aimed to evaluate the role of the balance of these systems in children with bloodstream infection. METHODS We analyzed prospectively oxidant and antioxidant stress parameters from serum samples of children with BSI besides demographic and clinical data of children. Serum levels of the total antioxidant status (TAS), total oxidant status (TOS), albumin, plasma thiol, disulphide, catalase (CAT), myeloperoxidase (MPO), ischemia-modified albumin (IMA) levels, ferroxidase and arylesterase (ARES) activity were evaluated in both patients and healthy controls. RESULTS A total of 113 children were evaluated, 50 of them had bacteremia and the remaining 63 were healthy subjects. The median TOS values were 18.5 μmol H2O2/L and 13.1 μmol H2O2/L in patient and control groups, respectively with a statistically significant difference between groups. The mean serum IMA levels were 0.8 ± 0.1 absorbance unit (ABSU) in patients and 0.5 ± 0.09 ABSU in control, the difference between groups was statistically significant. The native thiol, total thiol levels and the disulphide levels were significantly lower in the patient group as compared with the control group. The myeloperoxidase level was 136 U/L in patients and 107 in controls with a statistically significant difference between groups. CONCLUSIONS TOS, IMA, MPO, and particularly plasma thiols seem good candidates for accurate diagnosis of bacteremia in children.

Amac: Idrar yolu enfeksiyonlari (IYE) cocukluk yas grubunda en sik karsilasilan enfeksiyonlar ara... more Amac: Idrar yolu enfeksiyonlari (IYE) cocukluk yas grubunda en sik karsilasilan enfeksiyonlar arasindadir. Bu calisma ile ucuncu basamak bir hastanede idrar yolu enfeksiyonlarinda etiyolojik ajanlarin degerlendirilmesi, antimikrobiyal direnc paternlerinin belirlenmesi, ampirik tedavi onerilerinin gozden gecirilmesi amaclandi.Gerec ve Yontemler: Hacettepe Universitesi Ihsan Dogramaci Cocuk Hastanesi yatakli servis ve polikliniklerinden 01.01.2012-31.12.2015 tarihleri arasinda hastanemiz mikrobiyoloji laboratuvarina gonderilen ve Gram negatif (-) ureme saptanan 4421 idrar orneginin kultur ve antibiyogram sonuclari retrospektif olarak degerlendirildi.Bulgular: Gram negatif ureme saptanan 4421 ornekten %64.1’inde Escherichia coli, %17.1’inde Klebsiella spp, %7.4’unde Proteus spp uremesi saptandi. Tum gram negatif mikroorganizmalar birlikte degerlendirildiginde; en yuksek direnc ampisilin (%75.1), sefazolin (%59), ampisilin-sulbaktam (%49.7), trimetoprim-sulfametoksazol (TMP-SMX) (%45.2)...