Seyfettin Köklü - Academia.edu (original) (raw)

Papers by Seyfettin Köklü

Research paper thumbnail of Endoscopic retrograde cholangiopancreatography in the elderly: a prospective and comparative study

Research paper thumbnail of Atypical presentation of hepatocellular carcinoma: a mass on the left thoracic wall

BMC cancer, 2004

Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been ... more Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been defined as the most common etiologic factor. The most frequent metastatic sites are the lung, bone, lymphatics, and brain, respectively. Metastases to the chest wall have been reported only rarely. We report a patient with hepatocellular carcinoma who presented with an isolated metastatic mass on the left anterolateral chest wall in the axillary region. Metastasis of HCC should be included in the differential diagnosis of rapidly growing lesions in unusual localizations, particularly in patients with chronic liver disease even if a primary tumor can not be radiologically identified.

Research paper thumbnail of Viral and host causes of fatty liver in chronic hepatitis B

World journal of gastroenterology : WJG, Jan 28, 2005

To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the r... more To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage. A total of 164 patients (113 males and 51 females, average age 35+/-11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and t...

Research paper thumbnail of Onerous Concomitant Complications of Ulcerative Colitis: A Case Report

Zeitschrift Fur Gastroenterologie, 2007

Ulcerative colitis is a chronic inflammatory disease of the colon characterized by intermittent e... more Ulcerative colitis is a chronic inflammatory disease of the colon characterized by intermittent exacerbations and remissions. It may be complicated with colon cancer or autoimmune-related extracolonic problems. Herein, we present a woman with ulcerative colitis who developed sarcoidosis, colon cancer, primary sclerosing cholangitis, and cholangiocarcinoma. To our knowledge, such associations in a patient have not been reported before.

Research paper thumbnail of Diffuse Gastroduodenal Metastasis of Conjunctival Malignant Melanoma

The American Journal of Gastroenterology, 2008

ABSTRACT

Research paper thumbnail of Should We Perform Polypectomy for All Colorectal Polyps, or Follow-Up?

Chirurgische Gastroenterologie, 2008

SummaryBackground: There is controversy as to whether all colorectal polyps detected on colonosco... more SummaryBackground: There is controversy as to whether all colorectal polyps detected on colonoscopy should be removed. This study evaluated the histopathological characteristics of colorectal polyps in Turkish patients, and further determined their relationship to age, gender, size, and location. We aimed to determine the risk of neoplasms in patients with small polyps (≤5 mm), and emphasize the importance of polyp

Research paper thumbnail of Cholestasis preceding ileal perforation in a patient with typhoid fever

Internal and Emergency Medicine, 2009

Typhoid fever is a severe febrile systemic infection caused by gram-negative bacillus, Salmonella... more Typhoid fever is a severe febrile systemic infection caused by gram-negative bacillus, Salmonella typhi [1]. Hepatitis may occur during the course of typhoid fever. To our knowledge, typhoid fever associated pure cholestasis has been reported only once before [2].A 43-year-old man was admitted to our hospital with the chief complaint of abdominal pain. He had been well until 2 weeks earlier, when abdominal discomfort, fever, and jaundice developed. His past medical history was unremarkable. The temperature was 39°C. He had been admitted to a physician with those complaints. Oral ciprofloxacin (500 mg bid) was prescribed, and he used it for 5 days. Despite antibiotic therapy, the symptoms did not improve. The degree of abdominal pain increased progressively, and was accompanied by constipation. The patient was admitted to the emergency department (ED) of our hospital. On admission, he appeared ill and malnourished. The abdomen was distended and diffusely tender. The laboratory findings

Research paper thumbnail of Bismuth, moxifloxacin, tetracycline, lansoprazole quadruple first line therapy for eradication of H. pylori: A prospective study

Clinics and Research in Hepatology and Gastroenterology, 2013

Research paper thumbnail of Inlet patch: Associations with endoscopic findings in the upper gastrointestinal system

Scandinavian Journal of Gastroenterology, 2008

Ectopic gastric tissue in the esophagus (inlet patch) mostly presents in the upper part of the es... more Ectopic gastric tissue in the esophagus (inlet patch) mostly presents in the upper part of the esophagus and is usually under-diagnosed because of its localization. Little is known about its pathogenesis and significance. The aim of this study was to investigate whether there is an association between ectopic gastric tissue development and endoscopic features of the upper gastrointestinal tract, especially in the esophagus. A total of 9437 endoscopic examinations were analyzed prospectively. Endoscopic features and histological examinations of inlet patch and stomach specimens were documented. Endoscopic findings in patients with inlet patch were compared with those in patients without inlet patch. Inlet patch was present in 171 (1.8%) of all patients. Forty-three (25.1%) patients with inlet patch and 519 (5.6%) patients without inlet patch had esophagitis (p = 0.000). Histologically proven Barrett&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s esophagus was more frequent among patients with inlet patch than among patients without inlet patch (3.5% versus 0.5%, p = 0.000). Prevalences of hiatal hernia in the two groups were similar. Open cardia was diagnosed more frequently in the inlet patch group than in the other group (24.5% versus 10.0%, p = 0.000). Helicobacter pylori colonization was detected in only 11% of inlet patch specimens, whereas 58% of stomach specimens from the same patients contained H. pylori colonies. Patients with inlet patch seem to have predisposing factors for gastroesophageal reflux, and Barrett&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s esophagus is found more frequently in those patients. H. pylori colonization is involved in ectopic gastric tissue less frequently than in gastric tissue.

Research paper thumbnail of An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume

Platelets, 2009

Many non-invasive tests have been studied for diagnosis and determining the activation degree of ... more Many non-invasive tests have been studied for diagnosis and determining the activation degree of inflammatory bowel disease (IBD). Nevertheless, an ideal test has not been found yet. Mean platelet volume (MPV) is influenced by the inflammation. In a few study, decreased platelet volume have been reported in IBD. The aim of this study is to determine whether platelet volume would be useful in ulcerative colitis (UC) activity. Additionally we have analyzed overall accuracy of MPV in disease activity and compared with other inflammatory markers. A total of 61 UC patients (male/female : 41/20), and 27 healthy subjects (male/female : 18/9) were enrolled into the study. For all subjects following tests were performed; ESR, CRP, white blood cell count and mean platelet volume. A statistically significant decrease in MPV was noted in patients with UC (8.29 +/- 1.02 fL) compared with healthy controls (8.65 +/- 0.79 fL). MPV of active UC (8.06 +/- 1.19 fL) patients were significantly lower than that of inactive UC (8.45 +/- 0.87 fL). Overall accuracy of MPV in determination of active UC was 71% (with sensitivity 67%, specificity 73%). A negative correlation was found between MPV and endoscopic activity index (r : -0.358 p : 0.005). In UC, MPV did not correlate with ESR, CRP and white blood cell. Our study showed that MPV reduced in UC, particularly in patients with active UC. Decreased MPV may be an indicator for increased disease activity in patients with UC.

Research paper thumbnail of Fatal Colonic Perforation in a Pregnant with Behçet's Disease

Journal of Crohn's and Colitis, 2011

Research paper thumbnail of Serum adenosine deaminase activity as a predictor of disease severity in ulcerative colitis

Journal of Crohn's and Colitis, 2012

Background and aim: Ulcerative colitis (UC) is a chronic inflammatory disease characterized by re... more Background and aim: Ulcerative colitis (UC) is a chronic inflammatory disease characterized by recurrent inflammation and ulcerations of colonic mucosa and an inappropriate and delayed healing. Adenosine deaminase (ADA) is a cytoplasmic enzyme involved in the catabolism of purine bases, capable of catalyzing the deamination of adenosine, forming inosine in the result process. Although ADA has been shown to increase in several inflammatory conditions, there are no literature data indicating an alteration in UC. Methods: This study evaluated the activity of total ADA in serum of 43 patients with UC and 18 healthy controls. Patients' age, disease duration, drug intake, and other medical history were all noted for each subject. Complete blood count, erythrocyte sedimentation rate (ESR), and Creactive protein (CRP) were determined for both patients and controls. Correlation analysis was also performed between ADA and other inflammation markers of UC. Results: Serum mean ADA levels were 11.12 ± 2.03 and 7.99 ± 2.04 U/l for patients with UC in active state and in remission and 8.55 ± 2.26 U/l in the healthy control group. Mean serum ADA levels were significantly elevated in active UC patients compared with patients with UC in remission and control groups. Overall accuracy of ADA in determination of active UC was 83.7 with sensitivity 83.3%, specificity 84.2%. Conclusions: Serum ADA levels were found to be elevated in UC patients in active state suggesting a partial role of activated T-cell response in the disease pathophysiology. Further randomized controlled studies are warranted to demonstrate the role of ADA in UC patients, with

Research paper thumbnail of Henoch Schonlein purpura mimicking Crohn's ileitis

Journal of Crohn's and Colitis, 2011

Journal of Crohn&amp;amp;amp;amp;amp;amp;#x27;s and Colitis, Volume 5, Issue 3, Pages 271-272... more Journal of Crohn&amp;amp;amp;amp;amp;amp;#x27;s and Colitis, Volume 5, Issue 3, Pages 271-272, June 2011, Authors:Alper Yavuz; Mustafa Yıldız; Altan Aydın; Ali Cihat Yıldırım; Hakan Buluş; Seyfettin Köklü. Advertisement. Journal Home. Access this journal ...

Research paper thumbnail of Cancer antigen 125 levels in inflammatory bowel diseases

Journal of Clinical Laboratory Analysis, 2009

Cancer antigen 125 (CA-125) is a tumor marker used for the diagnosis and monitoring of ovarian ca... more Cancer antigen 125 (CA-125) is a tumor marker used for the diagnosis and monitoring of ovarian carcinoma. It can also be elevated in endometriosis, inflammations, and in nongynecological malignancies. Up to date, serum CA-125 levels in inflammatory bowel diseases (IBD) have not been studied before. To assess the levels of CA-125 in patients with ulcerative colitis (UC) and Crohn&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (CD). Serum levels of CA-125 were investigated in 68 cases with UC (male/female: 47/21), 32 CD (male/female: 21/11), and 31 healthy controls (male/female: 16/15). Levels of CA-125 were also compared among UC patients according to lesion location, severity, and activity of CD. Serum CA-125 levels were 17.29+/-24.50 U/ml, 15.56+/-20.74 U/ml, and 8.85+/-2.62 U/ml in patients with UC, CD, and healthy controls, respectively. Serum CA-125 levels were significantly higher in UC compared to control group (P=0.001). Serum CA-125 levels were higher in CD patients compared to control group but there was no significance (P=0.087). Serum CA-125 levels were higher in pancolitis compared to distal type and left-sided UC. Our data suggest that serum CA-125 levels may be increased in patients with IBDs.

Research paper thumbnail of Nitric oxide, lipid peroxidation and total thiol levels in acute appendicitis

Journal of Clinical Laboratory Analysis, 2010

The mechanisms involved in the pathology of acute appendicitis (AA) and the factors affecting the... more The mechanisms involved in the pathology of acute appendicitis (AA) and the factors affecting the progression have still been investigated. Oxidative stress is one of the factors of interest. Nitric oxide (NO) and its role in AA has not been studied previously. Thirty-four patients who underwent operation with a perioperative diagnosis of AA and 16 age and sex-matched controls were included in the study. Serum thiobarbituric acid reactive substances (TBARS), thiol groups (SH), NO metabolites (NO(x)), and conventional inflammation markers were determined. NO(x), TBARS, C-reactive protein (CRP) levels, white blood cell (WBC) count, and erythrocyte sedimentation rate (ESR) were significantly higher, and total SH was significantly lower in AA than in control group. NO(x), TBARS, and SH levels were comparable in acute phlegmonous appendicitis and advanced appendicitis. There was a significant positive correlation between NO(x) and TBARS, CRP, ESR, WBC and a significant negative correlation between NO(x) and SH. Serum NO(x) levels and oxidative stress elevate in AA independent from the extent of the lesion. Increased NO may play a role in the increased oxidative stress in AA.

Research paper thumbnail of Diagnostic and prognostic role of serum glypican 3 in patients with hepatocellular carcinoma

Journal of Clinical Laboratory Analysis, 2011

α-Feto protein (AFP) is the widely used tumor marker in the diagnosis of hepatocellular carcinoma... more α-Feto protein (AFP) is the widely used tumor marker in the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to assess the diagnostic and prognostic validity of a novel marker, serum Glypican-3 (GPC3) and to compare AFP in patients with HCC. One hundred and twenty-eight patients (75 patients with HCC, 55 patients with cirrhosis, and 28 healthy controls) were included in this study. Cut-off value of GPC3 was 3.9 pg/ml. AFP was divided into four subgroups, according to cut-off values with 13, 20, 100, and 200 ng/ml. Sensitivity, specificity, and positive and negative predictive values of GPC3 and AFP13, AFP20, AFP100, AFP200 subgroups and also GPC3+AFP13, GPC3+AFP20 , GPC3+AFP100 , GPC3+AFP200 combinations were compared. Serum GPC3 levels were significantly higher in patients with HCC and cirrhosis compared with control subjects (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). The median serum GPC3 levels were 3.9 pg/ml in controls, 5.51 pg/ml in patients with cirrhosis, and 5.13 pg/ml in those with HCC. The median serum AFP levels were 1.37 ng/ml in controls, 2.32 ng/ml in cirrhotics, and 50.65 ng/ml in HCC patients. The sensitivity, specificity, and positive and negative predictive values of GPC3 was 61.33, 41.82, 58.97, and 44.43%, respectively. The values for AFP were 68.57, 94.55, 94.12, and 70.27%, respectively. There was no correlation between GPC3 levels and prognostic parameters. GPC3 is not a useful diagnostic and prognostic marker for HCC.

Research paper thumbnail of Unusual Cause of Severe Nausea and Vomiting in an Elderly Man: Heterotopic Pancreas

International Journal of Gerontology, 2011

Research paper thumbnail of Development of glomerulonephritis early in the course of Crohnʼs disease

Inflammatory Bowel Diseases, 2010

Research paper thumbnail of Multiple intestinal perforation in a patient with Wegener's granulomatosis: A case report and review of the literature

Gastroentérologie Clinique et Biologique, 2010

Wegener's granulomatosis is a necrotizing vasculitis of unknown etiology characterized mainly by ... more Wegener's granulomatosis is a necrotizing vasculitis of unknown etiology characterized mainly by inflammation of the small-and medium-sized arteries and veins that affect any viscera. It may rarely involve the gastrointestinal tract. Only a few cases of multiple focus ileal perforation due to ulcers associated with Wegener's granulomatosis have been reported. Herein we report a case of a 32-year-old man with extensive intestinal small bowel ischaemic perforation due to Wegener's granulomatosis.

Research paper thumbnail of Serum adenosine deaminase activities during acute attacks and attack-free periods of familial Mediterranean fever

European Journal of Internal Medicine, 2009

Background: Familial Mediterranean Fever (FMF) is a systemic relapsing autoinflammatory disorder.... more Background: Familial Mediterranean Fever (FMF) is a systemic relapsing autoinflammatory disorder. Adenosine deaminase (ADA) is an enzyme widely distribute in tissues and body fluids. Circulating levels of ADA have been shown to increase in several inflammatory conditions. This study was designed to evaluate the serum ADA in patients with FMF during acute attacks and attack-free periods. Methods: The study groups comprised 23 FMF patients in attack-free period (male/female: 11/12), 30 FMF patients in attack period (male/female: 11/19) and 20 healthy control (male/female:10/10). The groups were similar for age, gender and disease duration. Results: The mean age of FMF patients in attack-free period, patient with acute attack were 34.3 ± 11.7 and 29.4 ± 11.1 respectively. The disease durations were 13.1 ± 10.2 and 8.2 ± 7.6 years for patients in attack-free periods and patients with acute FMF attack, respectively. Patients with acute attack had significantly higher ADA levels than both patients with attack-free periods and healthy controls (for each, p b 0.001).

Research paper thumbnail of Endoscopic retrograde cholangiopancreatography in the elderly: a prospective and comparative study

Research paper thumbnail of Atypical presentation of hepatocellular carcinoma: a mass on the left thoracic wall

BMC cancer, 2004

Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been ... more Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been defined as the most common etiologic factor. The most frequent metastatic sites are the lung, bone, lymphatics, and brain, respectively. Metastases to the chest wall have been reported only rarely. We report a patient with hepatocellular carcinoma who presented with an isolated metastatic mass on the left anterolateral chest wall in the axillary region. Metastasis of HCC should be included in the differential diagnosis of rapidly growing lesions in unusual localizations, particularly in patients with chronic liver disease even if a primary tumor can not be radiologically identified.

Research paper thumbnail of Viral and host causes of fatty liver in chronic hepatitis B

World journal of gastroenterology : WJG, Jan 28, 2005

To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the r... more To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage. A total of 164 patients (113 males and 51 females, average age 35+/-11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and t...

Research paper thumbnail of Onerous Concomitant Complications of Ulcerative Colitis: A Case Report

Zeitschrift Fur Gastroenterologie, 2007

Ulcerative colitis is a chronic inflammatory disease of the colon characterized by intermittent e... more Ulcerative colitis is a chronic inflammatory disease of the colon characterized by intermittent exacerbations and remissions. It may be complicated with colon cancer or autoimmune-related extracolonic problems. Herein, we present a woman with ulcerative colitis who developed sarcoidosis, colon cancer, primary sclerosing cholangitis, and cholangiocarcinoma. To our knowledge, such associations in a patient have not been reported before.

Research paper thumbnail of Diffuse Gastroduodenal Metastasis of Conjunctival Malignant Melanoma

The American Journal of Gastroenterology, 2008

ABSTRACT

Research paper thumbnail of Should We Perform Polypectomy for All Colorectal Polyps, or Follow-Up?

Chirurgische Gastroenterologie, 2008

SummaryBackground: There is controversy as to whether all colorectal polyps detected on colonosco... more SummaryBackground: There is controversy as to whether all colorectal polyps detected on colonoscopy should be removed. This study evaluated the histopathological characteristics of colorectal polyps in Turkish patients, and further determined their relationship to age, gender, size, and location. We aimed to determine the risk of neoplasms in patients with small polyps (≤5 mm), and emphasize the importance of polyp

Research paper thumbnail of Cholestasis preceding ileal perforation in a patient with typhoid fever

Internal and Emergency Medicine, 2009

Typhoid fever is a severe febrile systemic infection caused by gram-negative bacillus, Salmonella... more Typhoid fever is a severe febrile systemic infection caused by gram-negative bacillus, Salmonella typhi [1]. Hepatitis may occur during the course of typhoid fever. To our knowledge, typhoid fever associated pure cholestasis has been reported only once before [2].A 43-year-old man was admitted to our hospital with the chief complaint of abdominal pain. He had been well until 2 weeks earlier, when abdominal discomfort, fever, and jaundice developed. His past medical history was unremarkable. The temperature was 39°C. He had been admitted to a physician with those complaints. Oral ciprofloxacin (500 mg bid) was prescribed, and he used it for 5 days. Despite antibiotic therapy, the symptoms did not improve. The degree of abdominal pain increased progressively, and was accompanied by constipation. The patient was admitted to the emergency department (ED) of our hospital. On admission, he appeared ill and malnourished. The abdomen was distended and diffusely tender. The laboratory findings

Research paper thumbnail of Bismuth, moxifloxacin, tetracycline, lansoprazole quadruple first line therapy for eradication of H. pylori: A prospective study

Clinics and Research in Hepatology and Gastroenterology, 2013

Research paper thumbnail of Inlet patch: Associations with endoscopic findings in the upper gastrointestinal system

Scandinavian Journal of Gastroenterology, 2008

Ectopic gastric tissue in the esophagus (inlet patch) mostly presents in the upper part of the es... more Ectopic gastric tissue in the esophagus (inlet patch) mostly presents in the upper part of the esophagus and is usually under-diagnosed because of its localization. Little is known about its pathogenesis and significance. The aim of this study was to investigate whether there is an association between ectopic gastric tissue development and endoscopic features of the upper gastrointestinal tract, especially in the esophagus. A total of 9437 endoscopic examinations were analyzed prospectively. Endoscopic features and histological examinations of inlet patch and stomach specimens were documented. Endoscopic findings in patients with inlet patch were compared with those in patients without inlet patch. Inlet patch was present in 171 (1.8%) of all patients. Forty-three (25.1%) patients with inlet patch and 519 (5.6%) patients without inlet patch had esophagitis (p = 0.000). Histologically proven Barrett&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s esophagus was more frequent among patients with inlet patch than among patients without inlet patch (3.5% versus 0.5%, p = 0.000). Prevalences of hiatal hernia in the two groups were similar. Open cardia was diagnosed more frequently in the inlet patch group than in the other group (24.5% versus 10.0%, p = 0.000). Helicobacter pylori colonization was detected in only 11% of inlet patch specimens, whereas 58% of stomach specimens from the same patients contained H. pylori colonies. Patients with inlet patch seem to have predisposing factors for gastroesophageal reflux, and Barrett&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s esophagus is found more frequently in those patients. H. pylori colonization is involved in ectopic gastric tissue less frequently than in gastric tissue.

Research paper thumbnail of An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume

Platelets, 2009

Many non-invasive tests have been studied for diagnosis and determining the activation degree of ... more Many non-invasive tests have been studied for diagnosis and determining the activation degree of inflammatory bowel disease (IBD). Nevertheless, an ideal test has not been found yet. Mean platelet volume (MPV) is influenced by the inflammation. In a few study, decreased platelet volume have been reported in IBD. The aim of this study is to determine whether platelet volume would be useful in ulcerative colitis (UC) activity. Additionally we have analyzed overall accuracy of MPV in disease activity and compared with other inflammatory markers. A total of 61 UC patients (male/female : 41/20), and 27 healthy subjects (male/female : 18/9) were enrolled into the study. For all subjects following tests were performed; ESR, CRP, white blood cell count and mean platelet volume. A statistically significant decrease in MPV was noted in patients with UC (8.29 +/- 1.02 fL) compared with healthy controls (8.65 +/- 0.79 fL). MPV of active UC (8.06 +/- 1.19 fL) patients were significantly lower than that of inactive UC (8.45 +/- 0.87 fL). Overall accuracy of MPV in determination of active UC was 71% (with sensitivity 67%, specificity 73%). A negative correlation was found between MPV and endoscopic activity index (r : -0.358 p : 0.005). In UC, MPV did not correlate with ESR, CRP and white blood cell. Our study showed that MPV reduced in UC, particularly in patients with active UC. Decreased MPV may be an indicator for increased disease activity in patients with UC.

Research paper thumbnail of Fatal Colonic Perforation in a Pregnant with Behçet's Disease

Journal of Crohn's and Colitis, 2011

Research paper thumbnail of Serum adenosine deaminase activity as a predictor of disease severity in ulcerative colitis

Journal of Crohn's and Colitis, 2012

Background and aim: Ulcerative colitis (UC) is a chronic inflammatory disease characterized by re... more Background and aim: Ulcerative colitis (UC) is a chronic inflammatory disease characterized by recurrent inflammation and ulcerations of colonic mucosa and an inappropriate and delayed healing. Adenosine deaminase (ADA) is a cytoplasmic enzyme involved in the catabolism of purine bases, capable of catalyzing the deamination of adenosine, forming inosine in the result process. Although ADA has been shown to increase in several inflammatory conditions, there are no literature data indicating an alteration in UC. Methods: This study evaluated the activity of total ADA in serum of 43 patients with UC and 18 healthy controls. Patients' age, disease duration, drug intake, and other medical history were all noted for each subject. Complete blood count, erythrocyte sedimentation rate (ESR), and Creactive protein (CRP) were determined for both patients and controls. Correlation analysis was also performed between ADA and other inflammation markers of UC. Results: Serum mean ADA levels were 11.12 ± 2.03 and 7.99 ± 2.04 U/l for patients with UC in active state and in remission and 8.55 ± 2.26 U/l in the healthy control group. Mean serum ADA levels were significantly elevated in active UC patients compared with patients with UC in remission and control groups. Overall accuracy of ADA in determination of active UC was 83.7 with sensitivity 83.3%, specificity 84.2%. Conclusions: Serum ADA levels were found to be elevated in UC patients in active state suggesting a partial role of activated T-cell response in the disease pathophysiology. Further randomized controlled studies are warranted to demonstrate the role of ADA in UC patients, with

Research paper thumbnail of Henoch Schonlein purpura mimicking Crohn's ileitis

Journal of Crohn's and Colitis, 2011

Journal of Crohn&amp;amp;amp;amp;amp;amp;#x27;s and Colitis, Volume 5, Issue 3, Pages 271-272... more Journal of Crohn&amp;amp;amp;amp;amp;amp;#x27;s and Colitis, Volume 5, Issue 3, Pages 271-272, June 2011, Authors:Alper Yavuz; Mustafa Yıldız; Altan Aydın; Ali Cihat Yıldırım; Hakan Buluş; Seyfettin Köklü. Advertisement. Journal Home. Access this journal ...

Research paper thumbnail of Cancer antigen 125 levels in inflammatory bowel diseases

Journal of Clinical Laboratory Analysis, 2009

Cancer antigen 125 (CA-125) is a tumor marker used for the diagnosis and monitoring of ovarian ca... more Cancer antigen 125 (CA-125) is a tumor marker used for the diagnosis and monitoring of ovarian carcinoma. It can also be elevated in endometriosis, inflammations, and in nongynecological malignancies. Up to date, serum CA-125 levels in inflammatory bowel diseases (IBD) have not been studied before. To assess the levels of CA-125 in patients with ulcerative colitis (UC) and Crohn&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (CD). Serum levels of CA-125 were investigated in 68 cases with UC (male/female: 47/21), 32 CD (male/female: 21/11), and 31 healthy controls (male/female: 16/15). Levels of CA-125 were also compared among UC patients according to lesion location, severity, and activity of CD. Serum CA-125 levels were 17.29+/-24.50 U/ml, 15.56+/-20.74 U/ml, and 8.85+/-2.62 U/ml in patients with UC, CD, and healthy controls, respectively. Serum CA-125 levels were significantly higher in UC compared to control group (P=0.001). Serum CA-125 levels were higher in CD patients compared to control group but there was no significance (P=0.087). Serum CA-125 levels were higher in pancolitis compared to distal type and left-sided UC. Our data suggest that serum CA-125 levels may be increased in patients with IBDs.

Research paper thumbnail of Nitric oxide, lipid peroxidation and total thiol levels in acute appendicitis

Journal of Clinical Laboratory Analysis, 2010

The mechanisms involved in the pathology of acute appendicitis (AA) and the factors affecting the... more The mechanisms involved in the pathology of acute appendicitis (AA) and the factors affecting the progression have still been investigated. Oxidative stress is one of the factors of interest. Nitric oxide (NO) and its role in AA has not been studied previously. Thirty-four patients who underwent operation with a perioperative diagnosis of AA and 16 age and sex-matched controls were included in the study. Serum thiobarbituric acid reactive substances (TBARS), thiol groups (SH), NO metabolites (NO(x)), and conventional inflammation markers were determined. NO(x), TBARS, C-reactive protein (CRP) levels, white blood cell (WBC) count, and erythrocyte sedimentation rate (ESR) were significantly higher, and total SH was significantly lower in AA than in control group. NO(x), TBARS, and SH levels were comparable in acute phlegmonous appendicitis and advanced appendicitis. There was a significant positive correlation between NO(x) and TBARS, CRP, ESR, WBC and a significant negative correlation between NO(x) and SH. Serum NO(x) levels and oxidative stress elevate in AA independent from the extent of the lesion. Increased NO may play a role in the increased oxidative stress in AA.

Research paper thumbnail of Diagnostic and prognostic role of serum glypican 3 in patients with hepatocellular carcinoma

Journal of Clinical Laboratory Analysis, 2011

α-Feto protein (AFP) is the widely used tumor marker in the diagnosis of hepatocellular carcinoma... more α-Feto protein (AFP) is the widely used tumor marker in the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to assess the diagnostic and prognostic validity of a novel marker, serum Glypican-3 (GPC3) and to compare AFP in patients with HCC. One hundred and twenty-eight patients (75 patients with HCC, 55 patients with cirrhosis, and 28 healthy controls) were included in this study. Cut-off value of GPC3 was 3.9 pg/ml. AFP was divided into four subgroups, according to cut-off values with 13, 20, 100, and 200 ng/ml. Sensitivity, specificity, and positive and negative predictive values of GPC3 and AFP13, AFP20, AFP100, AFP200 subgroups and also GPC3+AFP13, GPC3+AFP20 , GPC3+AFP100 , GPC3+AFP200 combinations were compared. Serum GPC3 levels were significantly higher in patients with HCC and cirrhosis compared with control subjects (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). The median serum GPC3 levels were 3.9 pg/ml in controls, 5.51 pg/ml in patients with cirrhosis, and 5.13 pg/ml in those with HCC. The median serum AFP levels were 1.37 ng/ml in controls, 2.32 ng/ml in cirrhotics, and 50.65 ng/ml in HCC patients. The sensitivity, specificity, and positive and negative predictive values of GPC3 was 61.33, 41.82, 58.97, and 44.43%, respectively. The values for AFP were 68.57, 94.55, 94.12, and 70.27%, respectively. There was no correlation between GPC3 levels and prognostic parameters. GPC3 is not a useful diagnostic and prognostic marker for HCC.

Research paper thumbnail of Unusual Cause of Severe Nausea and Vomiting in an Elderly Man: Heterotopic Pancreas

International Journal of Gerontology, 2011

Research paper thumbnail of Development of glomerulonephritis early in the course of Crohnʼs disease

Inflammatory Bowel Diseases, 2010

Research paper thumbnail of Multiple intestinal perforation in a patient with Wegener's granulomatosis: A case report and review of the literature

Gastroentérologie Clinique et Biologique, 2010

Wegener's granulomatosis is a necrotizing vasculitis of unknown etiology characterized mainly by ... more Wegener's granulomatosis is a necrotizing vasculitis of unknown etiology characterized mainly by inflammation of the small-and medium-sized arteries and veins that affect any viscera. It may rarely involve the gastrointestinal tract. Only a few cases of multiple focus ileal perforation due to ulcers associated with Wegener's granulomatosis have been reported. Herein we report a case of a 32-year-old man with extensive intestinal small bowel ischaemic perforation due to Wegener's granulomatosis.

Research paper thumbnail of Serum adenosine deaminase activities during acute attacks and attack-free periods of familial Mediterranean fever

European Journal of Internal Medicine, 2009

Background: Familial Mediterranean Fever (FMF) is a systemic relapsing autoinflammatory disorder.... more Background: Familial Mediterranean Fever (FMF) is a systemic relapsing autoinflammatory disorder. Adenosine deaminase (ADA) is an enzyme widely distribute in tissues and body fluids. Circulating levels of ADA have been shown to increase in several inflammatory conditions. This study was designed to evaluate the serum ADA in patients with FMF during acute attacks and attack-free periods. Methods: The study groups comprised 23 FMF patients in attack-free period (male/female: 11/12), 30 FMF patients in attack period (male/female: 11/19) and 20 healthy control (male/female:10/10). The groups were similar for age, gender and disease duration. Results: The mean age of FMF patients in attack-free period, patient with acute attack were 34.3 ± 11.7 and 29.4 ± 11.1 respectively. The disease durations were 13.1 ± 10.2 and 8.2 ± 7.6 years for patients in attack-free periods and patients with acute FMF attack, respectively. Patients with acute attack had significantly higher ADA levels than both patients with attack-free periods and healthy controls (for each, p b 0.001).