Seyyed Ali A Mard - Academia.edu (original) (raw)

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Papers by Seyyed Ali A Mard

Reports of Biochemistry and Molecular Biology

Background: The effect of total suspended particulate matter (TSP) was investigated on the expres... more Background: The effect of total suspended particulate matter (TSP) was investigated on the expression of inflammatory and apoptotic factors in diabetic rats, and the effect of crocin and insulin was examined on these factors. Methods: Fifty-four adult male wistar rats were divided into nine experimental groups: control group, crocin group (received crocin, 50 mg/kg), diabetic group (received a single dose of alloxan at 120 mg/kg, IP), TSP group (5 mg/kg TSP instilled intratracheally), diabetic-crocin group (received crocin at 50 mg/kg after the induction of diabetes by alloxan (120 mg/kg)), diabetic-insulin group (received regular insulin (5 U/kg), crocin-TSP group (received crocin at 50 mg/kg, IP, and then 5 mg/kg TSP was instilled intratracheally), diabetic-TSP-insulin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose (5 U/kg) of regular insulin), and diabetic-TSP-crocin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose of crocin (50 mg/kg, IP)). Quantitative real-time PCR was performed to measure the expression of the mRNAs of apoptotic (Bax and Bcl2) and inflammatory mediators (TNFα, COX2, iNOS/eNOS) in Wistar rats. Results: In diabetic and TSP groups the inflammatory factors and BAX/Bcl2 ratio significantly increased compared to the control group. In diabetic-TSP-insulin and diabetic-TSP-crocin, a significant decrease was observed in the rate of inflammatory factors and BAX/Bcl2 ratio. Conclusions: The results suggested that diabetes and exposure to TSP increase the rate of apoptosis and inflammation, and also demonstrated the anti-apoptotic and anti-inflammation role of insulin and crocin.

Environmental Science and Pollution Research

Neurogastroenterology & Motility

Biomedicine & Pharmacotherapy

Biomedicine & Pharmacotherapy

British Journal of Nutrition

Vitamin-D deficiency is now recognized problem affecting multiple physiological functions. The ai... more Vitamin-D deficiency is now recognized problem affecting multiple physiological functions. The aim of this study was to evaluate the effect of a single dose of vitamin D3injection on the inflammatory, muscular damage, metabolic and cardiovascular responses to an acute bout of resistance exercise (RE)in vitamin D-deficient resistance-trained males.Blood samples from 14 vitamin D-deficient resistance-trained males were obtained during two separate trials: lower vitamin-D (LVD) and higher vitamin-D (HVD, after vitamin D3injection). Metabolic, inflammatory, muscle damage and cardiovascular markers were evaluated at baseline, immediately and 1-hour after RE. There were significant trial-by-time interactions for insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) which significantly (P ˂ 0.05) declined for 1-hour after RE in the HVD compared to LVD trial. Homeostasis Model Assessment of β-Cell Function (HOMA-ß) decline at 1-hour post-RE in the HVD trial. There was als...

Neurology, Psychiatry and Brain Research

Biomedicine & Pharmacotherapy

BMC Gastroenterology

Background: General overnutrition is one of the key factors involved in the development of nonalc... more Background: General overnutrition is one of the key factors involved in the development of nonalcoholic fatty liver disease (NAFLD) as the most common liver disease occur by two steps of liver injury ranges from steatosis to nonalcoholic steatohepatitis (NASH). Here the effect of fructose, fat-rich and western diet (WD) feeding was studied along with aggravative effect of cigarette smoking on liver status in mice. Methods: Sixty-four male NMRI mice were included in this study and assigned into 4 groups that fed standard, fructose-rich, high fat-, and western-diet for 8 weeks and then each group divided in two smoker and nonsmoker subgroups according to smoke exposing in the last 4 weeks of feeding time (n = 8). Histopathological studies, serum biochemical analyses and hepatic TNF-α level were evaluated in mice to compare alone or combination effects of dietary regimen and cigarette smoking. Results: Serum liver enzymes and lipid profile levels in WD fed mice were significantly higher than in other studied diets. Exposing to cigarette smoke led to more elevation of serum biochemical parameters that was also accompanied by a significant increase in hepatic damage shown as more severe fat accumulation, hepatocyte ballooning and inflammation infiltrate. Elevated TNF-α level confirmed incidence of liver injury. Conclusion: The finding of this study demonstrated that a combination of cigarette smoke exposure and WD (rich in fat, fructose, and cholesterol) could induce a more reliable mouse model of NASH.

Biological Trace Element Research

Environmental Science and Pollution Research

Reports of Biochemistry and Molecular Biology

Background: The effect of total suspended particulate matter (TSP) was investigated on the expres... more Background: The effect of total suspended particulate matter (TSP) was investigated on the expression of inflammatory and apoptotic factors in diabetic rats, and the effect of crocin and insulin was examined on these factors. Methods: Fifty-four adult male wistar rats were divided into nine experimental groups: control group, crocin group (received crocin, 50 mg/kg), diabetic group (received a single dose of alloxan at 120 mg/kg, IP), TSP group (5 mg/kg TSP instilled intratracheally), diabetic-crocin group (received crocin at 50 mg/kg after the induction of diabetes by alloxan (120 mg/kg)), diabetic-insulin group (received regular insulin (5 U/kg), crocin-TSP group (received crocin at 50 mg/kg, IP, and then 5 mg/kg TSP was instilled intratracheally), diabetic-TSP-insulin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose (5 U/kg) of regular insulin), and diabetic-TSP-crocin group (after receiving alloxan (120 mg/kg) and instilling TSP (5 mg/kg, intratracheally), a single dose of crocin (50 mg/kg, IP)). Quantitative real-time PCR was performed to measure the expression of the mRNAs of apoptotic (Bax and Bcl2) and inflammatory mediators (TNFα, COX2, iNOS/eNOS) in Wistar rats. Results: In diabetic and TSP groups the inflammatory factors and BAX/Bcl2 ratio significantly increased compared to the control group. In diabetic-TSP-insulin and diabetic-TSP-crocin, a significant decrease was observed in the rate of inflammatory factors and BAX/Bcl2 ratio. Conclusions: The results suggested that diabetes and exposure to TSP increase the rate of apoptosis and inflammation, and also demonstrated the anti-apoptotic and anti-inflammation role of insulin and crocin.

Environmental Science and Pollution Research

Neurogastroenterology & Motility

Biomedicine & Pharmacotherapy

Biomedicine & Pharmacotherapy

British Journal of Nutrition

Vitamin-D deficiency is now recognized problem affecting multiple physiological functions. The ai... more Vitamin-D deficiency is now recognized problem affecting multiple physiological functions. The aim of this study was to evaluate the effect of a single dose of vitamin D3injection on the inflammatory, muscular damage, metabolic and cardiovascular responses to an acute bout of resistance exercise (RE)in vitamin D-deficient resistance-trained males.Blood samples from 14 vitamin D-deficient resistance-trained males were obtained during two separate trials: lower vitamin-D (LVD) and higher vitamin-D (HVD, after vitamin D3injection). Metabolic, inflammatory, muscle damage and cardiovascular markers were evaluated at baseline, immediately and 1-hour after RE. There were significant trial-by-time interactions for insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) which significantly (P ˂ 0.05) declined for 1-hour after RE in the HVD compared to LVD trial. Homeostasis Model Assessment of β-Cell Function (HOMA-ß) decline at 1-hour post-RE in the HVD trial. There was als...

Neurology, Psychiatry and Brain Research

Biomedicine & Pharmacotherapy

BMC Gastroenterology

Background: General overnutrition is one of the key factors involved in the development of nonalc... more Background: General overnutrition is one of the key factors involved in the development of nonalcoholic fatty liver disease (NAFLD) as the most common liver disease occur by two steps of liver injury ranges from steatosis to nonalcoholic steatohepatitis (NASH). Here the effect of fructose, fat-rich and western diet (WD) feeding was studied along with aggravative effect of cigarette smoking on liver status in mice. Methods: Sixty-four male NMRI mice were included in this study and assigned into 4 groups that fed standard, fructose-rich, high fat-, and western-diet for 8 weeks and then each group divided in two smoker and nonsmoker subgroups according to smoke exposing in the last 4 weeks of feeding time (n = 8). Histopathological studies, serum biochemical analyses and hepatic TNF-α level were evaluated in mice to compare alone or combination effects of dietary regimen and cigarette smoking. Results: Serum liver enzymes and lipid profile levels in WD fed mice were significantly higher than in other studied diets. Exposing to cigarette smoke led to more elevation of serum biochemical parameters that was also accompanied by a significant increase in hepatic damage shown as more severe fat accumulation, hepatocyte ballooning and inflammation infiltrate. Elevated TNF-α level confirmed incidence of liver injury. Conclusion: The finding of this study demonstrated that a combination of cigarette smoke exposure and WD (rich in fat, fructose, and cholesterol) could induce a more reliable mouse model of NASH.

Biological Trace Element Research

Environmental Science and Pollution Research