Shady Farah-Abo George - Academia.edu (original) (raw)

Shady Farah-Abo George

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Papers by Shady Farah-Abo George

Research paper thumbnail of Synthesis, molecular modeling of novel 1, 2, 4-triazole derivatives with potential antimicrobial and antiviral activities

actapharmasciencia.org

A new series of 3,5-disubstituted triazoles were synthesized and evaluated for in vitro antifunga... more A new series of 3,5-disubstituted triazoles were synthesized and evaluated for in vitro antifungal and antibacterial activity. All compounds tested showed significant antifungal activity against micromycetes, compared to the commercial fungicide, clotrimazol. The binding modes of the docked compounds at the active site of 1EA1 enzyme were examined and the recognition modes of these new analogs with the catalytic triad amino acids were explored. Compound 8b performed highest antifungal activity against C. albicans and antibacterial activity against S. aureus.

Research paper thumbnail of Synthesis, molecular modeling of novel 1, 2, 4-triazole derivatives with potential antimicrobial and antiviral activities

actapharmasciencia.org

A new series of 3,5-disubstituted triazoles were synthesized and evaluated for in vitro antifunga... more A new series of 3,5-disubstituted triazoles were synthesized and evaluated for in vitro antifungal and antibacterial activity. All compounds tested showed significant antifungal activity against micromycetes, compared to the commercial fungicide, clotrimazol. The binding modes of the docked compounds at the active site of 1EA1 enzyme were examined and the recognition modes of these new analogs with the catalytic triad amino acids were explored. Compound 8b performed highest antifungal activity against C. albicans and antibacterial activity against S. aureus.

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