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Papers by Shahzad Ahmed
Tetrahedron Letters, 2013
The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboron... more The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphane ligands.
Journal of Electromagnetic Waves and Applications, 2012
In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossl... more In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossless uniaxial chiral medium is derived using dyadic transmission coefficient. Derived geometrical optics field is valid everywhere except at focal point where it gives infinite value.Singularity of the field at focal point is addressed using Maslov's method. The effects of different constitutive parameters on the refracted field are also discussed.
ACS Medicinal Chemistry Letters, 2010
Ureases are important in both agriculture and human health. Bacterial ureases are directly involv... more Ureases are important in both agriculture and human health. Bacterial ureases are directly involved in many farm-field problems and pathological conditions. Here, we report a structure-based virtual screening of an in-house compound bank of about 6000 molecular entities by computational docking and binding free energy calculations followed by in vitro screening. Applied protocol leads to the identification of novel urease inhibitors, which can serve as starting points for structural optimization.
Tetrahedron Letters, 2013
The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboron... more The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphane ligands.
Journal of Electromagnetic Waves and Applications, 2012
In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossl... more In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossless uniaxial chiral medium is derived using dyadic transmission coefficient. Derived geometrical optics field is valid everywhere except at focal point where it gives infinite value.Singularity of the field at focal point is addressed using Maslov's method. The effects of different constitutive parameters on the refracted field are also discussed.
ACS Medicinal Chemistry Letters, 2010
Ureases are important in both agriculture and human health. Bacterial ureases are directly involv... more Ureases are important in both agriculture and human health. Bacterial ureases are directly involved in many farm-field problems and pathological conditions. Here, we report a structure-based virtual screening of an in-house compound bank of about 6000 molecular entities by computational docking and binding free energy calculations followed by in vitro screening. Applied protocol leads to the identification of novel urease inhibitors, which can serve as starting points for structural optimization.
Tetrahedron Letters, 2013
The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboron... more The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphane ligands.
Journal of Electromagnetic Waves and Applications, 2012
In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossl... more In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossless uniaxial chiral medium is derived using dyadic transmission coefficient. Derived geometrical optics field is valid everywhere except at focal point where it gives infinite value.Singularity of the field at focal point is addressed using Maslov's method. The effects of different constitutive parameters on the refracted field are also discussed.
ACS Medicinal Chemistry Letters, 2010
Ureases are important in both agriculture and human health. Bacterial ureases are directly involv... more Ureases are important in both agriculture and human health. Bacterial ureases are directly involved in many farm-field problems and pathological conditions. Here, we report a structure-based virtual screening of an in-house compound bank of about 6000 molecular entities by computational docking and binding free energy calculations followed by in vitro screening. Applied protocol leads to the identification of novel urease inhibitors, which can serve as starting points for structural optimization.
Tetrahedron Letters, 2013
The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboron... more The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphane ligands.
Journal of Electromagnetic Waves and Applications, 2012
In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossl... more In this paper, the transmission of the electromagnetic waves through a plano convex lens of lossless uniaxial chiral medium is derived using dyadic transmission coefficient. Derived geometrical optics field is valid everywhere except at focal point where it gives infinite value.Singularity of the field at focal point is addressed using Maslov's method. The effects of different constitutive parameters on the refracted field are also discussed.
ACS Medicinal Chemistry Letters, 2010
Ureases are important in both agriculture and human health. Bacterial ureases are directly involv... more Ureases are important in both agriculture and human health. Bacterial ureases are directly involved in many farm-field problems and pathological conditions. Here, we report a structure-based virtual screening of an in-house compound bank of about 6000 molecular entities by computational docking and binding free energy calculations followed by in vitro screening. Applied protocol leads to the identification of novel urease inhibitors, which can serve as starting points for structural optimization.