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The human gut microbiome includes beneficial, commensal and pathogenic bacteria that possess anti... more The human gut microbiome includes beneficial, commensal and pathogenic bacteria that possess antimicrobial resistance (AMR) genes and exchange these predominantly through conjugative plasmids. Escherichia coli is a significant component of the gastrointestinal microbiome and is typically non-pathogenic in this niche. In contrast, extra-intestinal pathogenic E. coli (ExPEC) including ST131 may occupy other environments like the urinary tract or bloodstream where they express genes enabling AMR and host adhesion like type 1 fimbriae. The extent to which non-pathogenic gut E. coli and infectious ST131 share AMR genes and key associated plasmids remains understudied at a genomic level. Here, we examined AMR gene sharing between gut E. coli and ST131 to discover an extensive shared preterm infant resistome. In addition, individual ST131 show extensive AMR gene diversity highlighting that analyses restricted to the core genome may be limiting and could miss AMR gene transfer patterns. We ...
Trends in Anaesthesia and Critical Care, 2020
International Journal of Psychology, 1993
The relationship between the Type A Behaviour Pattern and heart‐rate reactivity to the onset of a... more The relationship between the Type A Behaviour Pattern and heart‐rate reactivity to the onset of a typical stressor was investigated with a sample of Australian boys and girls from three age‐grade levels: preschool, middle‐elementary, and upper‐elementary. Behaviour Pattern was measured with the Matthews Youth Test for Health (Matthews & Angulo, 1980), and data were collected on children's second‐by‐second heart rate during rest and the stressor tasks. Reactivity to the onset of the stressor task (a puzzle game or mental arithmetic), was assessed. Results indicated that there were expected age differences in resting and stressor task heart rates, but that there was no significant difference in heart‐rate reactivity between children classified as Type A or B Behaviour Pattern, either for the entire sample, for two extreme subsamples, or within each of the three age groups.
The human gut microbiome includes beneficial, commensal and pathogenic bacteria that possess anti... more The human gut microbiome includes beneficial, commensal and pathogenic bacteria that possess antimicrobial resistance (AMR) genes and exchange these predominantly through conjugative plasmids. Escherichia coli is a significant component of the gastrointestinal microbiome and is typically non-pathogenic in this niche. In contrast, extra-intestinal pathogenic E. coli (ExPEC) including ST131 may occupy other environments like the urinary tract or bloodstream where they express genes enabling AMR and host adhesion like type 1 fimbriae. The extent to which non-pathogenic gut E. coli and infectious ST131 share AMR genes and key associated plasmids remains understudied at a genomic level. Here, we examined AMR gene sharing between gut E. coli and ST131 to discover an extensive shared preterm infant resistome. In addition, individual ST131 show extensive AMR gene diversity highlighting that analyses restricted to the core genome may be limiting and could miss AMR gene transfer patterns. We ...
Trends in Anaesthesia and Critical Care, 2020
International Journal of Psychology, 1993
The relationship between the Type A Behaviour Pattern and heart‐rate reactivity to the onset of a... more The relationship between the Type A Behaviour Pattern and heart‐rate reactivity to the onset of a typical stressor was investigated with a sample of Australian boys and girls from three age‐grade levels: preschool, middle‐elementary, and upper‐elementary. Behaviour Pattern was measured with the Matthews Youth Test for Health (Matthews & Angulo, 1980), and data were collected on children's second‐by‐second heart rate during rest and the stressor tasks. Reactivity to the onset of the stressor task (a puzzle game or mental arithmetic), was assessed. Results indicated that there were expected age differences in resting and stressor task heart rates, but that there was no significant difference in heart‐rate reactivity between children classified as Type A or B Behaviour Pattern, either for the entire sample, for two extreme subsamples, or within each of the three age groups.