Shaukath Khanum - Academia.edu (original) (raw)

Papers by Shaukath Khanum

Medicinal Plants - International Journal of Phytomedicines and Related Industries, 2022

Asian Journal of Chemistry, Jun 28, 2019

Germacrene D an important sesquiterpenoid has been extracted from leaves of Zanthoxylum ovalifoil... more Germacrene D an important sesquiterpenoid has been extracted from leaves of Zanthoxylum ovalifoilum and high performance thin-layer chromatographic method has been developed for its simultaneous identification and determination. The compound was extracted by cold extraction and separated and identified on a AgNO3 impregnated silica gel 60 F254 HPTLC plates with dichloromethane:acetone (9.8:0.2 v/v) as mobile phase. The quantification of geremcare D was carried out by densitometry scanning performed at λ = 254 nm by reflectance scanning. This facilitated a well-resolved band for the compound with a Rf value of 0.46 ± 0.01. Linear regression concentration analysis data for mean calibration plots showed good linear relationship in the range of 1000-10000 ng/mL, with a correlation coefficient, slope and intercept of 0.9985 ± 0.0004, 21.62 ± 0.435 and 3308.87 ± 10.24, respectively. The minimum amount of germacrene D that could be authentically detected (LOD) and quantified (LOQ) were determined and found to be 212.07 and 521.23 ng/spot, respectively. The method was validated by considering the parameters linearity, precision, accuracy, specificity and robustness wherein, it is evident from the results that the proposed method was simple, safe and reliable.

Journal of Applied Chemical Science International

Iron is one among the oldest metals known to man and is quite rich in our country. 95% of the tot... more Iron is one among the oldest metals known to man and is quite rich in our country. 95% of the total iron reserves of India were accounted from few states such as Jharkhand, Orissa, Madhya Pradesh, Chhattisgarh, Karnataka and Goa. Kudremukha and Donimalai is known for producing high grades of iron in Karnataka state. The present study aims to analyze the spectral signatures and volumetric determinations of iron ore deposits which were well developed and was being mined in Kemmanagundi of Bababudan hills in Chikmagalur district. Field random samples were collected for laboratory work and analysis in determining the spectral signature curves and volumetric content. The spectral signatures of any mineral will discriminated based on their characteristics features of absorption and reflectance curves. Volumetric analysis is generally one of the quantitative methods that deal with determination of amount of particular elements in tested sample. As demand of iron in India is expected to inc...

The title compound, (2-oxo-2H-pyridin-1-yl)-acetic acid hydrazide was synthesized in good yield b... more The title compound, (2-oxo-2H-pyridin-1-yl)-acetic acid hydrazide was synthesized in good yield by refluxing 2- hydroxypyridine with ethyl chloroacetate in the presence of K2CO3 in anhydrous acetone. The product obtained was characterized by spectroscopic techniques and finally the structure was confirmed by X-ray diffraction studies. The compound crystallizes in the monoclinic crystal system with the space group P21/c with unit cell parameters a = 8.6789(4) A, b = 10.4374(5) A, c = 8.3596(4) A, β = 92.873(3)o and Z=4. The crystal structure features two strong N--H…O hydrogen bonds with different packing motifs. Hirshfeld surface analysis for visually analyzing intermolecular interactions in crystal structures employing molecular surface contours and 2D fingerprint plots have been used to examine molecular shapes.

The chiral N-D-ribosylnitrones 5-10 have been synthesized in four steps respectively, in the four... more The chiral N-D-ribosylnitrones 5-10 have been synthesized in four steps respectively, in the fourth step, D-ribosyloxime (4) condensed with substituted benzaldehyde in cool condition. The heterocyclization of Z-nitrone 6 with substituted Narylmaleimide by 1,3-dipolar cycloaddition were afforded new heterocyclic system of isoxazolidine derivatives 11-16 and 11'-16' as a mixture of diastereoisomers, the new isoxazolidines 11-16 have been separated purely and characterized by 1 H NMR, mass spectra and elemental analysis.

Indian Journal of Pharmaceutical Sciences, May 1, 2004

Indo American Journal of Pharmaceutical Research, 2013

Acta Crystallographica Section E-structure Reports Online, 2009

Free Radicals and Antioxidants, 2011

DNA. This imbalance provides a logical pathobiochemical mechanism for the initiation and developm... more DNA. This imbalance provides a logical pathobiochemical mechanism for the initiation and development of several disease states. It is believed that several diseases, for instance cancer, diabetes, ageing, hypertension, obesity and cardiac dysfunction and other degenerative diseases in humans which involve oxidative processes are mediated by free radicals. [1-4] Various phytochemicals including lignans and their related natural antioxidants from tea, spices and herbs, have intensively been studied and reported for their most important part in suppression of reactive oxygen species. [5] Lignans are widely distributed polyphenol compounds isolated from diverse plants, trees or seeds. Being an essential class of natural products and second class of phytoestrogens, they have attracted considerable interest due to their fascinating biological activities.

Bioorganic Chemistry, Aug 1, 2004

A series of substituted benzophenone analogues has been synthesized and evaluated as orally activ... more A series of substituted benzophenone analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indomethacin, and phenylbutazone. In carrageenan-induced foot pad edema assay, benzophenone analogues showed an interesting anti-inflammatory activity. In the air-pouch test, some of the analogues reduced the total number of leukocytes of the exudate, which indicates inhibition of prostaglandin production. Side effects of the compounds were examined on gastric mucosa, in the liver and stomach. None of the compounds showed significant side effects compared with nonsteroidal anti-inflammatory drugs such as indomethacin and naproxen.

Journal of Molecular Structure, Oct 1, 2023

Crystals, Jul 9, 2022

Structure and Molecular Modeling Studies of 1-(4-(Methoxy(phenyl)methyl)-2methylphenoxy)butan-2-o... more Structure and Molecular Modeling Studies of 1-(4-(Methoxy(phenyl)methyl)-2methylphenoxy)butan-2-one Derivative as a Novel α-Glucosidase Inhibitor. Crystals 2022, 12, 960.

European journal of medicinal chemistry, Nov 1, 2014

A series of 2-(4-benzoyl-phenoxy)-N-(4-phenyl-thiazol-2-yl)-acetamides (10a-n) were synthesized b... more A series of 2-(4-benzoyl-phenoxy)-N-(4-phenyl-thiazol-2-yl)-acetamides (10a-n) were synthesized by multistep reaction sequence and all the compounds were well characterized for structural elucidation. The in vitro cytotoxicity of compounds 10a-n was evaluated against EAC and DLA cell lines using trypan blue dye exclusion method. Further MTT assay and LDH release assay, followed by in vivo studies on murine model were also evaluated. The compound 10h with a methyl and fluoro groups at benzophenone moiety and methoxy group at phenyl ring was in a leading position to exhibit the promising antiproliferative effect through translational VEGF-A inhibition.

European journal of medicinal chemistry, May 1, 2013

A series of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles 9aej were obtained via multistep syn... more A series of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles 9aej were obtained via multistep synthesis from hydroxybenzophenones 4aee. The cytotoxicity of compounds 9aej was evaluated against human leukemia cell lines (K562 and CEM). The compounds exhibited moderate to good anti-cancer activity with compounds 9b and 9i having a chloro group exhibiting the best activity (IC 50 ¼ 10 mM). Compound 9i exhibited activity against both the cell lines and 9b only exhibited activity against CEM. Further, a lactate dehydrogenase (LDH) assay and DNA fragmentation studies of the compounds 9aej were also performed.

Bioorganic & Medicinal Chemistry Letters, Apr 1, 2009

Der Pharmacia Lettre, 2016

Green Tea is one of the most ancient and popular therapeutic beverages consumed around the world.... more Green Tea is one of the most ancient and popular therapeutic beverages consumed around the world. This product is made from the leaf of the plant called "Camellia sinensis". It can be prepared as a drink, which can have many systemic health effects or an "extract" can be made from the leaves to use as medicine. This beneficial effect has been attributed to the presence of high amounts of polyphenols, which are potent antioxidants. In particular, green tea may lower blood pressure and thus reduce the risk of stroke and coronary heart disease. The aim of recent study was achieved to compare the antioxidant properties and phenolic contents. In this view the antioxidant efficacy of green tea extract and the effectiveness compared to the standard antioxidant, ascorbic acid based on many methods have been demonstrated.

Der Pharma Chemica, 2016

The title compound, 2,6-difluoro phenoxy acetic acid was synthesized by refluxing 2,6-difluorophe... more The title compound, 2,6-difluoro phenoxy acetic acid was synthesized by refluxing 2,6-difluorophenol with ethyl chloroacetate to achieve 2,6-difluoro phenoxy ethyl acetate, followed by the hydrolysis with sodium hydroxide in presence of ethanol. The product obtained was characterized by spectroscopic techniques and finally the structure was confirmed by X-ray diffraction studies. The compound crystallizes in the monoclinic crystal system with the space group P21/n with unit cell parameters a = 4.2443(3) A, b = 20.0337(14) A, c = 9.2243(8) A, β = 96.258(5)o and Z=4. The structure exhibits both inter and intra-molecular hydrogen bonds of the type C—H...O, O—H...O and C—H...F respectively. In the crystal, adjacent molecules form inversion-related dimers through strong O-H...O hydrogen bonds, generating R2 2(8) ring motif. Hirshfeld analysis was carried out in order to understand the packing pattern and intermolecular interactions.