Charles Sherman - Academia.edu (original) (raw)
Papers by Charles Sherman
BMC research notes, Jan 6, 2017
Uncontrolled asthma negatively impacts patients, families, and the community. The level of sympto... more Uncontrolled asthma negatively impacts patients, families, and the community. The level of symptom control among asthmatics in Ethiopia has not been well studied. We investigated the level of asthma control and risk factors for poor asthma control in clinic patients seen in the largest public hospital in Ethiopia. In this cross-sectional study, we studied all 182 consecutive subjects with a physician diagnosis of asthma who were seen in chest clinic at Tikur Anbessa Specialized Hospital between July and December 2015. Of the 182 subjects, 68.1% were female. The mean age was 52 ± 12 years and the median duration of asthma was 20 ± 12.7 years. One hundred and seventeen subjects (64.3%) had nighttime awakening due to asthma. Fifty-eight (31%) were not using controller medications and 62 (34.6%) had improper inhaler technique. Only 44 (24.2%) subjects had well-controlled asthma. On multivariate analysis, variables associated with uncontrolled asthma included: use of biomass fuel for coo...
Annals of the American Thoracic Society, Jan 18, 2016
Despite an extensive burden of lung disease in East Africa, there are remarkably few pulmonary ph... more Despite an extensive burden of lung disease in East Africa, there are remarkably few pulmonary physicians in the region and no pulmonary subspecialty training programs. We developed a unique training program for pulmonary medicine in Ethiopia. The East African Training Initiative (EATI) is a two-year fellowship program at Tikur Anbessa (Black Lion) Specialized Teaching Hospital, the largest public hospital in Ethiopia and the teaching hospital for the Addis Ababa University (AAU) School of Medicine. The first year is devoted to clinical care and procedural skills. Lectures, conferences, daily inpatient and outpatient rounds and procedure supervision by visiting faculty provide the clinical knowledge foundation. In the second year, training in clinical research is added to ongoing clinical training. Before graduation, fellows must pass rigorous written and oral examinations and achieve high marks on faculty evaluations. Funding for the program is from several sources. Ethiopian train...
Environmental Research, 2015
Household air pollution from the burning of biomass fuels is recognized as the third greatest con... more Household air pollution from the burning of biomass fuels is recognized as the third greatest contributor to the global burden of disease. Incomplete combustion of biomass fuels releases a complex mixture of carbon monoxide (CO), particulate matter (PM) and other toxins into the household environment. Some investigators have used indoor CO concentrations as a reliable surrogate of indoor PM concentrations; however, the assumption that indoor CO concentration is a reasonable proxy of indoor PM concentration has been a subject of controversy. We sought to describe the relationship between indoor PM2.5 and CO concentrations in 128 households across three resource-poor settings in Peru, Nepal, and Kenya. We simultaneously collected minute-to-minute PM2.5 and CO concentrations within a meter of the open-fire stove for approximately 24h using the EasyLog-USB-CO data logger (Lascar Electronics, Erie, PA) and the personal DataRAM-1000AN (Thermo Fisher Scientific Inc., Waltham, MA), respectively. We also collected information regarding household construction characteristics, and cooking practices of the primary cook. Average 24h indoor PM2.5 and CO concentrations ranged between 615 and 1440μg/m(3), and between 9.1 and 35.1ppm, respectively. Minute-to-minute indoor PM2.5 concentrations were in a safe range (<25μg/m(3)) between 17% and 65% of the time, and exceeded 1000μg/m(3) between 8% and 21% of the time, whereas indoor CO concentrations were in a safe range (<7ppm) between 46% and 79% of the time and exceeded 50ppm between 4%, and 20% of the time. Overall correlations between indoor PM2.5 and CO concentrations were low to moderate (Spearman ρ between 0.59 and 0.83). There was also poor agreement and evidence of proportional bias between observed indoor PM2.5 concentrations vs. those estimated based on indoor CO concentrations, with greater discordance at lower concentrations. Our analysis does not support the notion that indoor CO concentration is a surrogate marker for indoor PM2.5 concentration across all settings. Both are important markers of household air pollution with different health and environmental implications and should therefore be independently measured.
Annals of the American Thoracic Society, 2015
Rhode Island medical journal (2013), Jan 2, 2014
Young healthy women without a genetic predisposition are considered to be at low risk for deep ve... more Young healthy women without a genetic predisposition are considered to be at low risk for deep vein thrombosis and pulmonary emboli. We present an unusual case of pulmonary embolism in a 21-year-old female competitive rower likely caused by oral contraception and trauma of the axillary-subclavian vein by extrinsic compression due to repetitive arm movements.
Journal of the American Geriatrics Society, 1996
... Titre du document / Document title. ACUTE EPIGLOTTITIS IN A NONAGENARIAN Auteur(s) / Author(s... more ... Titre du document / Document title. ACUTE EPIGLOTTITIS IN A NONAGENARIAN Auteur(s) / Author(s). RASHED NIZAM ; LERAKIS S. ; SHERMAN CB ; SCHIFFMAN FJ ; KAYE W. ; Revue / Journal Title. Journal of the American Geriatrics Society ISSN 0002-8614 Source / Source ...
The Western journal of medicine, 1983
This discussion was selected from the weekly Grand Rounds in the Department of Medicine, Universi... more This discussion was selected from the weekly Grand Rounds in the Department of Medicine, University of New Mexico School of Medicine and Veterans Administration Medical Center, Albuquerque. Taken from a transcription, it has been edited by Drs Charles Sherman, Resident in Medicine, and Maire T. Buckman, Associate Professor of Medicine and Chief, Endocrinology Section, Veterans Administration Medical Center, Alburquerque.
The American review of respiratory disease, 1989
The acute effects of the products of combustion and pyrolysis on airway responsiveness among fire... more The acute effects of the products of combustion and pyrolysis on airway responsiveness among firefighters are poorly documented. To study this relationship, spirometry and methacholine challenge testing (MCT) were performed on 18 active Seattle firefighters before and 5 to 24 h after firefighting. Body plethysmography was used to measure changes in specific airway conductance (SGaw), and results of MCT were analyzed using PD35-SGaw, the cumulative dose causing a 35% decrease in SGaw. Subjects who did not react by the end of the protocol were assigned a value of 640 inhalational units, the largest cumulative dose. Fire exposure was defined as the total time (hours) spent without a self-contained breathing apparatus at the firesite and was categorized as mild (less than 1 h, n = 7), moderate (1 to 2 h, n = 5), or severe (greater than 2 h, n = 6). Mean age of the 18 firefighters was 36.7 +/- 6.7 yr (range, 25 to 51), with a mean of 9.1 +/- 7.9 active years in the trade (range, zero to ...
American journal of epidemiology, 1990
To investigate potential risk factors for the development of childhood asthma, the authors undert... more To investigate potential risk factors for the development of childhood asthma, the authors undertook a longitudinal study using a cohort of 770 children aged 5-9 years from East Boston, Massachusetts, that has been under study since 1975. The disease outcome considered was age at first onset of asthma, as determined by parental or self-reporting of a physician's diagnosis. Potential risk factors were evaluated specifically in relation to their presence antecedent to a diagnosis of asthma. Standardized questionnaires were used to obtain childhood illness histories, environmental exposures, and the asthmatic and atopic statuses of first-degree relatives. Ninety-one cases of asthma were identified from 1975 to 1988 (57 males and 34 females). Significant sex-adjusted relative risk estimates were seen for antecedent pneumonia, bronchitis, hay fever, sinusitis, parental asthma, and parental atopy. Neither bronchiolitis, eczema, croup, personal cigarette smoking, maternal smoking, pate...
Rhode Island medical journal (2013), Jan 6, 2013
Global Heart, 2014
Background-Small observational studies have found that isolated right heart failure (IRHF) is pre... more Background-Small observational studies have found that isolated right heart failure (IRHF) is prevalent among women of sub-Saharan Africa. Further, several risk factors for the development of IRHF have been identified. However, no similar studies have been conducted in Kenya. Objective-We hypothesized that specific environmental exposures and comorbidities were associated with IRHF in women of western Kenya. Methods-We conducted a case-control study at a referral hospital in western Kenya. Cases were defined as women at least 35 years old with IRHF. Control subjects were similarly aged volunteers without IRHF. Exclusion criteria in both groups included history of tobacco use, tuberculosis, or thromboembolic disease. Participants underwent echocardiography, spirometry, 6min walk test, rest/exercise oximetry, respiratory health interviews, and human immunodeficiency virus (HIV) testing. Home visits were performed to evaluate kitchen ventilation, fuel use, and cook smoke exposure time, all surrogate measures of indoor air pollution (IAP). A total of 31 cases and 65 control subjects were enrolled. Surrogate measures of indoor air pollution were not associated with IRHF. However, lower forced expiratory volume at 1 s percent predicted (adjusted odds ratio [AOR]: 2.02, 95% confidence interval [CI]: 1.27 to 3.20; p = 0.004), HIV positivity
Rhode Island medical journal (2013), Jan 6, 2013
Rhode Island medical journal (2013), 2013
B53. ASTHMA EPIDEMIOLOGY: TRENDS AND RISK FACTORS, 2012
Parkinsonism & Related Disorders, 2011
JAMA: The Journal of the American Medical Association, 1983
Page 1. presenting sickle cell trait (about 8% of the population, or 2 1/2million per-sons in the... more Page 1. presenting sickle cell trait (about 8% of the population, or 2 1/2million per-sons in the United States). Such knowledge is obtainable through ade-quate mass screening, to which many blacks are opposed for reasons that are not valid. ...
Diabetes Care, 1982
This 34 year old man presented with a 3 week history of fever, dry cough and exertional dyspnoea.... more This 34 year old man presented with a 3 week history of fever, dry cough and exertional dyspnoea. He had returned from holiday in Madeira only 2 days previously. He was a non-smoker and drank alcohol moderately. In the past he had been treated for syphilis in 1974. At that time he also had genital herpes. He remained well until 1980 when he presented with acute hepatitis A and was also found to be hepatitis B immune, with positive anti-core and antisurface antibodies. In September 1988 he presented with cutaneous lesions of Kaposi's sarcoma and was found to be HIV-1 antibody positive. He commenced zidovudine shortly afterwards. He was looked after at another hospital and remained well for approximately 1 year when he developed oesophageal candida, increasingly widespread lesions of Kaposi's sarcoma and was commenced on a-interferon therapy. Despite this his Kaposi's sarcoma skin lesions continued to enlarge and become more widespread. At this point his CD4 count was 30 and he was p24 antigen positive. Therapy was then changed and epirubicin was given on a weekly basis but he became anaemic very quickly on this and so it was temporarily discontinued. Shortly afterwards he was admitted to this hospital. At the time of admission he was taking zidovudine 250 mg tds, acyclovir 400 mg tds, and Fansidar (pyrimethamine 25 mg and sulfadoxine 500 mg) 1 tablet per week (as primary prophylaxis against Pneumocystis carinii pneumonia as he was thought to be allergic to co-trimoxazole) and epirubicin 20 mg once a week. On examination at the time ofadmission he was febrile at 37 8°C, he had widespread lesions of cutaneous and also oral
CHEST Journal, 1994
Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft... more Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft tissue sarcomas. J
BMC research notes, Jan 6, 2017
Uncontrolled asthma negatively impacts patients, families, and the community. The level of sympto... more Uncontrolled asthma negatively impacts patients, families, and the community. The level of symptom control among asthmatics in Ethiopia has not been well studied. We investigated the level of asthma control and risk factors for poor asthma control in clinic patients seen in the largest public hospital in Ethiopia. In this cross-sectional study, we studied all 182 consecutive subjects with a physician diagnosis of asthma who were seen in chest clinic at Tikur Anbessa Specialized Hospital between July and December 2015. Of the 182 subjects, 68.1% were female. The mean age was 52 ± 12 years and the median duration of asthma was 20 ± 12.7 years. One hundred and seventeen subjects (64.3%) had nighttime awakening due to asthma. Fifty-eight (31%) were not using controller medications and 62 (34.6%) had improper inhaler technique. Only 44 (24.2%) subjects had well-controlled asthma. On multivariate analysis, variables associated with uncontrolled asthma included: use of biomass fuel for coo...
Annals of the American Thoracic Society, Jan 18, 2016
Despite an extensive burden of lung disease in East Africa, there are remarkably few pulmonary ph... more Despite an extensive burden of lung disease in East Africa, there are remarkably few pulmonary physicians in the region and no pulmonary subspecialty training programs. We developed a unique training program for pulmonary medicine in Ethiopia. The East African Training Initiative (EATI) is a two-year fellowship program at Tikur Anbessa (Black Lion) Specialized Teaching Hospital, the largest public hospital in Ethiopia and the teaching hospital for the Addis Ababa University (AAU) School of Medicine. The first year is devoted to clinical care and procedural skills. Lectures, conferences, daily inpatient and outpatient rounds and procedure supervision by visiting faculty provide the clinical knowledge foundation. In the second year, training in clinical research is added to ongoing clinical training. Before graduation, fellows must pass rigorous written and oral examinations and achieve high marks on faculty evaluations. Funding for the program is from several sources. Ethiopian train...
Environmental Research, 2015
Household air pollution from the burning of biomass fuels is recognized as the third greatest con... more Household air pollution from the burning of biomass fuels is recognized as the third greatest contributor to the global burden of disease. Incomplete combustion of biomass fuels releases a complex mixture of carbon monoxide (CO), particulate matter (PM) and other toxins into the household environment. Some investigators have used indoor CO concentrations as a reliable surrogate of indoor PM concentrations; however, the assumption that indoor CO concentration is a reasonable proxy of indoor PM concentration has been a subject of controversy. We sought to describe the relationship between indoor PM2.5 and CO concentrations in 128 households across three resource-poor settings in Peru, Nepal, and Kenya. We simultaneously collected minute-to-minute PM2.5 and CO concentrations within a meter of the open-fire stove for approximately 24h using the EasyLog-USB-CO data logger (Lascar Electronics, Erie, PA) and the personal DataRAM-1000AN (Thermo Fisher Scientific Inc., Waltham, MA), respectively. We also collected information regarding household construction characteristics, and cooking practices of the primary cook. Average 24h indoor PM2.5 and CO concentrations ranged between 615 and 1440μg/m(3), and between 9.1 and 35.1ppm, respectively. Minute-to-minute indoor PM2.5 concentrations were in a safe range (<25μg/m(3)) between 17% and 65% of the time, and exceeded 1000μg/m(3) between 8% and 21% of the time, whereas indoor CO concentrations were in a safe range (<7ppm) between 46% and 79% of the time and exceeded 50ppm between 4%, and 20% of the time. Overall correlations between indoor PM2.5 and CO concentrations were low to moderate (Spearman ρ between 0.59 and 0.83). There was also poor agreement and evidence of proportional bias between observed indoor PM2.5 concentrations vs. those estimated based on indoor CO concentrations, with greater discordance at lower concentrations. Our analysis does not support the notion that indoor CO concentration is a surrogate marker for indoor PM2.5 concentration across all settings. Both are important markers of household air pollution with different health and environmental implications and should therefore be independently measured.
Annals of the American Thoracic Society, 2015
Rhode Island medical journal (2013), Jan 2, 2014
Young healthy women without a genetic predisposition are considered to be at low risk for deep ve... more Young healthy women without a genetic predisposition are considered to be at low risk for deep vein thrombosis and pulmonary emboli. We present an unusual case of pulmonary embolism in a 21-year-old female competitive rower likely caused by oral contraception and trauma of the axillary-subclavian vein by extrinsic compression due to repetitive arm movements.
Journal of the American Geriatrics Society, 1996
... Titre du document / Document title. ACUTE EPIGLOTTITIS IN A NONAGENARIAN Auteur(s) / Author(s... more ... Titre du document / Document title. ACUTE EPIGLOTTITIS IN A NONAGENARIAN Auteur(s) / Author(s). RASHED NIZAM ; LERAKIS S. ; SHERMAN CB ; SCHIFFMAN FJ ; KAYE W. ; Revue / Journal Title. Journal of the American Geriatrics Society ISSN 0002-8614 Source / Source ...
The Western journal of medicine, 1983
This discussion was selected from the weekly Grand Rounds in the Department of Medicine, Universi... more This discussion was selected from the weekly Grand Rounds in the Department of Medicine, University of New Mexico School of Medicine and Veterans Administration Medical Center, Albuquerque. Taken from a transcription, it has been edited by Drs Charles Sherman, Resident in Medicine, and Maire T. Buckman, Associate Professor of Medicine and Chief, Endocrinology Section, Veterans Administration Medical Center, Alburquerque.
The American review of respiratory disease, 1989
The acute effects of the products of combustion and pyrolysis on airway responsiveness among fire... more The acute effects of the products of combustion and pyrolysis on airway responsiveness among firefighters are poorly documented. To study this relationship, spirometry and methacholine challenge testing (MCT) were performed on 18 active Seattle firefighters before and 5 to 24 h after firefighting. Body plethysmography was used to measure changes in specific airway conductance (SGaw), and results of MCT were analyzed using PD35-SGaw, the cumulative dose causing a 35% decrease in SGaw. Subjects who did not react by the end of the protocol were assigned a value of 640 inhalational units, the largest cumulative dose. Fire exposure was defined as the total time (hours) spent without a self-contained breathing apparatus at the firesite and was categorized as mild (less than 1 h, n = 7), moderate (1 to 2 h, n = 5), or severe (greater than 2 h, n = 6). Mean age of the 18 firefighters was 36.7 +/- 6.7 yr (range, 25 to 51), with a mean of 9.1 +/- 7.9 active years in the trade (range, zero to ...
American journal of epidemiology, 1990
To investigate potential risk factors for the development of childhood asthma, the authors undert... more To investigate potential risk factors for the development of childhood asthma, the authors undertook a longitudinal study using a cohort of 770 children aged 5-9 years from East Boston, Massachusetts, that has been under study since 1975. The disease outcome considered was age at first onset of asthma, as determined by parental or self-reporting of a physician's diagnosis. Potential risk factors were evaluated specifically in relation to their presence antecedent to a diagnosis of asthma. Standardized questionnaires were used to obtain childhood illness histories, environmental exposures, and the asthmatic and atopic statuses of first-degree relatives. Ninety-one cases of asthma were identified from 1975 to 1988 (57 males and 34 females). Significant sex-adjusted relative risk estimates were seen for antecedent pneumonia, bronchitis, hay fever, sinusitis, parental asthma, and parental atopy. Neither bronchiolitis, eczema, croup, personal cigarette smoking, maternal smoking, pate...
Rhode Island medical journal (2013), Jan 6, 2013
Global Heart, 2014
Background-Small observational studies have found that isolated right heart failure (IRHF) is pre... more Background-Small observational studies have found that isolated right heart failure (IRHF) is prevalent among women of sub-Saharan Africa. Further, several risk factors for the development of IRHF have been identified. However, no similar studies have been conducted in Kenya. Objective-We hypothesized that specific environmental exposures and comorbidities were associated with IRHF in women of western Kenya. Methods-We conducted a case-control study at a referral hospital in western Kenya. Cases were defined as women at least 35 years old with IRHF. Control subjects were similarly aged volunteers without IRHF. Exclusion criteria in both groups included history of tobacco use, tuberculosis, or thromboembolic disease. Participants underwent echocardiography, spirometry, 6min walk test, rest/exercise oximetry, respiratory health interviews, and human immunodeficiency virus (HIV) testing. Home visits were performed to evaluate kitchen ventilation, fuel use, and cook smoke exposure time, all surrogate measures of indoor air pollution (IAP). A total of 31 cases and 65 control subjects were enrolled. Surrogate measures of indoor air pollution were not associated with IRHF. However, lower forced expiratory volume at 1 s percent predicted (adjusted odds ratio [AOR]: 2.02, 95% confidence interval [CI]: 1.27 to 3.20; p = 0.004), HIV positivity
Rhode Island medical journal (2013), Jan 6, 2013
Rhode Island medical journal (2013), 2013
B53. ASTHMA EPIDEMIOLOGY: TRENDS AND RISK FACTORS, 2012
Parkinsonism & Related Disorders, 2011
JAMA: The Journal of the American Medical Association, 1983
Page 1. presenting sickle cell trait (about 8% of the population, or 2 1/2million per-sons in the... more Page 1. presenting sickle cell trait (about 8% of the population, or 2 1/2million per-sons in the United States). Such knowledge is obtainable through ade-quate mass screening, to which many blacks are opposed for reasons that are not valid. ...
Diabetes Care, 1982
This 34 year old man presented with a 3 week history of fever, dry cough and exertional dyspnoea.... more This 34 year old man presented with a 3 week history of fever, dry cough and exertional dyspnoea. He had returned from holiday in Madeira only 2 days previously. He was a non-smoker and drank alcohol moderately. In the past he had been treated for syphilis in 1974. At that time he also had genital herpes. He remained well until 1980 when he presented with acute hepatitis A and was also found to be hepatitis B immune, with positive anti-core and antisurface antibodies. In September 1988 he presented with cutaneous lesions of Kaposi's sarcoma and was found to be HIV-1 antibody positive. He commenced zidovudine shortly afterwards. He was looked after at another hospital and remained well for approximately 1 year when he developed oesophageal candida, increasingly widespread lesions of Kaposi's sarcoma and was commenced on a-interferon therapy. Despite this his Kaposi's sarcoma skin lesions continued to enlarge and become more widespread. At this point his CD4 count was 30 and he was p24 antigen positive. Therapy was then changed and epirubicin was given on a weekly basis but he became anaemic very quickly on this and so it was temporarily discontinued. Shortly afterwards he was admitted to this hospital. At the time of admission he was taking zidovudine 250 mg tds, acyclovir 400 mg tds, and Fansidar (pyrimethamine 25 mg and sulfadoxine 500 mg) 1 tablet per week (as primary prophylaxis against Pneumocystis carinii pneumonia as he was thought to be allergic to co-trimoxazole) and epirubicin 20 mg once a week. On examination at the time ofadmission he was febrile at 37 8°C, he had widespread lesions of cutaneous and also oral
CHEST Journal, 1994
Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft... more Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft tissue sarcomas. J