Sherry Selevan - Academia.edu (original) (raw)
Papers by Sherry Selevan
Several authors have considered the importance of exposure timing and how this affects the outcom... more Several authors have considered the importance of exposure timing and how this affects the outcomes observed, but no one has systematically compiled preconceptional, prenatal, and postnatal developmental exposures and subsequent outcomes. Efforts were undertaken to examine the information available and to evaluate implications for risk assessment for several areas: a) respiratory and immune systems, b) reproductive system, c) nervous system, d) cardiovascular system, endocrine system, and general growth, and e) cancer. Major conclusions from a workshop on "Critical Windows of Exposure for Children's Health " included a) broad windows of sensitivity can be identified for many systems but detailed information is limited; b) cross-species comparisons of dose to target tissue and better data on the exposure-dose-outcome continuum are needed; c) increased interaction among scientific disciplines can further understanding by using laboratory animal results in designing epid...
Birth Defects Research Part B Developmental and Reproductive Toxicology, Jun 1, 2008
... Teresa M. Schnorr 9 ,; Sherry G. Selevan 10 ,; John G. Vandenbergh 11 ,; Susan R. Woskie 12,*... more ... Teresa M. Schnorr 9 ,; Sherry G. Selevan 10 ,; John G. Vandenbergh 11 ,; Susan R. Woskie 12,*. Article first published online: 20 JUN 2008. DOI: 10.1002/bdrb.20147. © 2008 Wiley-Liss, Inc. Issue. Birth Defects Research Part B: Developmental and Reproductive Toxicology. ...
A walk-through survey was conducted at Courtaulds North America, Inc., Mobile, Alabama on July 21... more A walk-through survey was conducted at Courtaulds North America, Inc., Mobile, Alabama on July 21-22, 1977. The purpose of the survey was to evaluate the factory for possible inclusion in a NIOSH study on the medical and reproductive effects of carbon disulfide (CSâ) exposure. The viscose rayon work force consisted of 750 production workers, and all but one were males. The average age was 42, and 80 to 85% were married. The factory was surveyed periodically for CSâ vapors, and samples were analyzed by spectrophotometry. Concentrations of CSâ ranged from 0 to 75 parts per million (ppm) in operating areas; average concentrations ranged from 4 to 20 ppm. Personal breathing-zone samples ranged from 1 to 57 ppm, with averages from 4 to 15 ppm. Employees received annual blood profiles, pulmonary function tests, audiometric tests, and vision tests. In 1 year, there were 28 lost work-day injuries. The operations reported to have the greatest CSâ exposure during the industrial process were spinning and cutting. The churning and mixing operations were also expected to produce CSâ vapors. However, those operations were never monitored. NIOSH concludes that potential health hazards at the factory include exposure to carbon disulfide, hydrogen sulfide, noise, sodium-hydroxide, and sulfuric acid.
Fert Steril, 1998
Objective: To determine whether moderate cigarette smoking and alcohol consumption in teenage men... more Objective: To determine whether moderate cigarette smoking and alcohol consumption in teenage men is associated with increases in disomic sperm and detectable changes in semen quality.
Fertility and Sterility, Mar 1, 1996
To examine the fertility and pregnancy wastage rates in a group of presumably fertile couples. Pr... more To examine the fertility and pregnancy wastage rates in a group of presumably fertile couples. Prospective observational study of 200 couples desiring to achieve pregnancy over 12 menstrual cycles coupled with pregnancy outcome follow-up. A university-based obstetrics and gynecological center. Personal interviews and questionnaires were used to screen couples for entry into the study. Couples were counseled to have intercourse centered on predicted day of ovulation. Phase 1 included the first three cycles in which women collected daily morning urine samples, underwent midcycle postcoital tests, and, if late for their menses, presented for serum hCG testing. Phase 2 encompassed the next nine cycles in which women were contacted monthly by phone and underwent serum hCG testing if menses was delayed. Urine samples from cycles in which clinical (serum hCG) pregnancy did not occur underwent sensitive hCG testing to detect occult pregnancies. Pregnancies were followed until delivery to ascertain outcome. Eighty-two percent of the 200 couples followed for the entire study period conceived. The maximal fertility rate was approximately 30% per cycle in the first two cycles. This rate quickly tapered over the remainder of the study. Pregnancy wastage during phase 1 accounted for 31% of the pregnancies detected. Forty-one percent (15/36) of these losses were seen only by urine hCG testing and were categorized as occult. Eleven of these same patients later achieved clinically recognized conceptions during the study. These results support the concept that the efficiency of human reproduction is maximum at approximately 30% per cycle. A very significant number of these pregnancies end in spontaneous abortion. In addition, pregnancy loss before missed menses occurs in a significant proportion of women.
Reference Module in Earth Systems and Environmental Sciences, 2013
Http Dx Doi Org 10 1080 00039896 1992 9938381, Aug 3, 2010
Information about human exposures to environmental agents is a crucial component of informed deci... more Information about human exposures to environmental agents is a crucial component of informed decisions about protection of public health. Results from an inventory of exposure-related databases are used to examine the value of exposure information for risk assessment, risk management, surveillance of status and trends, and epidemiologic studies. Findings indicate that current and future exposure-related databases should include (1) standardized procedures for the collection, storage, analysis, and reporting of data; (2) an enhanced ability to compare data over time, i.e., conduct comparison studies of "old" and "new" methods; (3) mechanisms for coordination and cooperation among public and private-sector organizations with respect to the design, maintenance, exchange, and review of information systems; (4) measurements of actual exposures and dose for relevant human populations; and (5) data collection, storage, and retrieval methods that permit easy manipulation of information for both model building and testing.
Scandinavian Journal of Work, Environment & Health
SELEVAN SG. Design cOl1JSiderations in pregnancy outcome studies of occupational populations. Sca... more SELEVAN SG. Design cOl1JSiderations in pregnancy outcome studies of occupational populations. Scand j work environ health 7 (1981): suppl 4, 76-82. Increased attention has been focused on lJhe relati'onshiJp between adverse pregnancy outcomes and occupational exposures to parents of both sexes. However, the c'haracteri'stics and dynamics of warMng populations impose liJrnitationson potential study populatiJons. These limitations result 'from the ,combined eJiiects :of wor'lclovoe si2Je, exposure, age dis'tribuUon, and mari'tal status, w'hidh limit the number of pregnancies ,ava:Ha!ble ror study. The smaller .popul1ations available typically r,esult in r,etrospectiv,e studJiescover~ng extended time periods. Pobential data sources f()JI" these studies include inteI"View data, medical records, vital statistics data, and~nsuran(le records. An sour-c,es may have 1)jased ascertainment of certain pregnancy ou'tcomes such as .early f.etal ,!Joss due to errors in recall in interview data, legal requirements for recording vital statistics data, and differences in medJical care patterns.
Journal of environmental pathology and toxicology
American Journal of Epidemiology
ABSTRACT
In response to numerous requests for information related to odor thresholds, this document was pr... more In response to numerous requests for information related to odor thresholds, this document was prepared by the Air Risk Information Support Center in its role in providing technical assistance to State and Local government agencies on risk assessment of air pollutants. A discussion of basic concepts related to olfactory function and the measurement of odor thresholds is presented. A detailed discussion of criteria which are used to evaluate the quality of published odor threshold values is provided. The use of odor threshold information in risk assessment is discussed. The results of a literature search and review of odor threshold information for the chemicals listed as hazardous air pollutants in the Clean Air Act amendments of 1990 is presented. The published odor threshold values are critically evaluated based on the criteria discussed and the values of acceptable quality are used to determine a geometric mean or best estimate.
Mutation research, 2007
Previous studies have provided evidence for an association between exposure to high levels of air... more Previous studies have provided evidence for an association between exposure to high levels of air pollution and increased DNA damage in human sperm. In these studies DNA damage was measured using the sperm chromatin structure assay (SCSA) wherein the percentage of sperm with abnormal chromatin/fragmented DNA is determined and expressed as % DNA fragmentation index (%DFI). Here we extend these observations to address the following hypothesis: men who are homozygous null for glutathione-S-transferase M1 (GSTM1-) are less able to detoxify reactive metabolites of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) found in air pollution. Consequently they are more susceptible to the effects of air pollution on sperm chromatin. Using a longitudinal study design in which men provided semen samples during periods of both low (baseline) and episodically high air pollution, this study revealed a statistically significant association between GSTM1 null genotype and increased SCSA-defined %...
Casopís lékar̆ů c̆eských, Jan 29, 2000
Recently, an association between adverse pregnancy outcome and air pollution was hypothesized in ... more Recently, an association between adverse pregnancy outcome and air pollution was hypothesized in several papers. The aim of the present study is to evaluate the impact of particles with aerodynamic diameter < or = 10 microns (PM10) on the intrauterine growth retardation (IUGR) in two regions with the different levels of air pollution. The study group includes all singleton full term births of European origin over a two-year period in the district of Teplice (n = 1,943) and Prachatice (n = 883). Information on reproductive and health history and lifestyle was obtained from maternal questionnaires and medical records. IUGR was chosen as the indicator of reproductive effects. The mean concentration of PM10 for each women in particular gestational month was calculated. Three concentration intervals were constructed (low < 40 micrograms/m3; medium 40-50 micrograms/m3; high > or = 50 micrograms/m3). Relative risk of IUGR was estimated for particular month and pollutant level. Inf...
Casopís lékar̆ů c̆eských, Jan 30, 2001
A study of morbidity of children aged 0 to 3 years was organized in two districts in the Czech Re... more A study of morbidity of children aged 0 to 3 years was organized in two districts in the Czech Republic. Comparisons were drawn between children living in district Teplice, known for its high air pollution, and those living in Practice, the district with consistently lower particulate and SO2 exposures. 452 children of the follow up study were born between May 1994 and December 1996. Childhood morbidity during the first three years of life was obtained from their pediatric records. Diagnoses were coded using the International Classification of Diseases--the 10th edition, and categorized into broad groups. Children born in Teplice experienced a significantly higher rate of otitis media (and otalgia), gastrointestinal infections, upper respiratory infections, and pneumonia, but they did not differ in the risk of bronchitis or that of viral infections such as varicella. These findings remained valid after the multiple linear regression models were calculated and adjusted for education,...
Journal of andrology
Large, population-based studies of semen quality are encumbered by the logistics and expense of o... more Large, population-based studies of semen quality are encumbered by the logistics and expense of obtaining semen samples from men who live in a variety of locations. A prototype semen collection and transportation kit, the TRANSEM100, can be distributed to study participants and then directly shipped to a central laboratory for analysis. This study was designed to evaluate the ability of male volunteers to correctly use the kit. Thirty volunteers aged 20 to 44 years with no history of diabetes, recent chemotherapy, fertility problems, or vasectomy were recruited through a newspaper advertisement, interviewed to obtain demographic information, and instructed on the use of the kit. Twenty-six of the initial subjects provided at least 1 semen specimen using the kit and returned the specimens by overnight delivery to the laboratory for analysis, 25 completed a follow-up interview on the use of the collection kit, and 20 submitted a second semen sample using the same method. The average v...
Journal of andrology
Measures of semen quality are used as surrogate measures of male fertility in clinical andrology,... more Measures of semen quality are used as surrogate measures of male fertility in clinical andrology, reproductive toxicology, epidemiology, and risk assessment. However, only limited data are available to relate those measures to fertility. This prospective study with 210 reproductive-age couples was conducted to provide information on the value of semen quality measures for predicting human male fertility potential and for development of models to estimate the effects of changes in semen quality on fertility in a given population for risk assessment. Couples without known risk factors for infertility and who had discontinued contraception to have a child were accepted. The study followed each couple for up to 12 menstrual cycles while they attempted to conceive and evaluated semen quality measures from multiple ejaculates per man with known abstinence intervals. For each cycle, the day of ovulation was predicted, and the couple was advised to have intercourse multiple times on that da...
Several authors have considered the importance of exposure timing and how this affects the outcom... more Several authors have considered the importance of exposure timing and how this affects the outcomes observed, but no one has systematically compiled preconceptional, prenatal, and postnatal developmental exposures and subsequent outcomes. Efforts were undertaken to examine the information available and to evaluate implications for risk assessment for several areas: a) respiratory and immune systems, b) reproductive system, c) nervous system, d) cardiovascular system, endocrine system, and general growth, and e) cancer. Major conclusions from a workshop on "Critical Windows of Exposure for Children's Health " included a) broad windows of sensitivity can be identified for many systems but detailed information is limited; b) cross-species comparisons of dose to target tissue and better data on the exposure-dose-outcome continuum are needed; c) increased interaction among scientific disciplines can further understanding by using laboratory animal results in designing epid...
Birth Defects Research Part B Developmental and Reproductive Toxicology, Jun 1, 2008
... Teresa M. Schnorr 9 ,; Sherry G. Selevan 10 ,; John G. Vandenbergh 11 ,; Susan R. Woskie 12,*... more ... Teresa M. Schnorr 9 ,; Sherry G. Selevan 10 ,; John G. Vandenbergh 11 ,; Susan R. Woskie 12,*. Article first published online: 20 JUN 2008. DOI: 10.1002/bdrb.20147. © 2008 Wiley-Liss, Inc. Issue. Birth Defects Research Part B: Developmental and Reproductive Toxicology. ...
A walk-through survey was conducted at Courtaulds North America, Inc., Mobile, Alabama on July 21... more A walk-through survey was conducted at Courtaulds North America, Inc., Mobile, Alabama on July 21-22, 1977. The purpose of the survey was to evaluate the factory for possible inclusion in a NIOSH study on the medical and reproductive effects of carbon disulfide (CSâ) exposure. The viscose rayon work force consisted of 750 production workers, and all but one were males. The average age was 42, and 80 to 85% were married. The factory was surveyed periodically for CSâ vapors, and samples were analyzed by spectrophotometry. Concentrations of CSâ ranged from 0 to 75 parts per million (ppm) in operating areas; average concentrations ranged from 4 to 20 ppm. Personal breathing-zone samples ranged from 1 to 57 ppm, with averages from 4 to 15 ppm. Employees received annual blood profiles, pulmonary function tests, audiometric tests, and vision tests. In 1 year, there were 28 lost work-day injuries. The operations reported to have the greatest CSâ exposure during the industrial process were spinning and cutting. The churning and mixing operations were also expected to produce CSâ vapors. However, those operations were never monitored. NIOSH concludes that potential health hazards at the factory include exposure to carbon disulfide, hydrogen sulfide, noise, sodium-hydroxide, and sulfuric acid.
Fert Steril, 1998
Objective: To determine whether moderate cigarette smoking and alcohol consumption in teenage men... more Objective: To determine whether moderate cigarette smoking and alcohol consumption in teenage men is associated with increases in disomic sperm and detectable changes in semen quality.
Fertility and Sterility, Mar 1, 1996
To examine the fertility and pregnancy wastage rates in a group of presumably fertile couples. Pr... more To examine the fertility and pregnancy wastage rates in a group of presumably fertile couples. Prospective observational study of 200 couples desiring to achieve pregnancy over 12 menstrual cycles coupled with pregnancy outcome follow-up. A university-based obstetrics and gynecological center. Personal interviews and questionnaires were used to screen couples for entry into the study. Couples were counseled to have intercourse centered on predicted day of ovulation. Phase 1 included the first three cycles in which women collected daily morning urine samples, underwent midcycle postcoital tests, and, if late for their menses, presented for serum hCG testing. Phase 2 encompassed the next nine cycles in which women were contacted monthly by phone and underwent serum hCG testing if menses was delayed. Urine samples from cycles in which clinical (serum hCG) pregnancy did not occur underwent sensitive hCG testing to detect occult pregnancies. Pregnancies were followed until delivery to ascertain outcome. Eighty-two percent of the 200 couples followed for the entire study period conceived. The maximal fertility rate was approximately 30% per cycle in the first two cycles. This rate quickly tapered over the remainder of the study. Pregnancy wastage during phase 1 accounted for 31% of the pregnancies detected. Forty-one percent (15/36) of these losses were seen only by urine hCG testing and were categorized as occult. Eleven of these same patients later achieved clinically recognized conceptions during the study. These results support the concept that the efficiency of human reproduction is maximum at approximately 30% per cycle. A very significant number of these pregnancies end in spontaneous abortion. In addition, pregnancy loss before missed menses occurs in a significant proportion of women.
Reference Module in Earth Systems and Environmental Sciences, 2013
Http Dx Doi Org 10 1080 00039896 1992 9938381, Aug 3, 2010
Information about human exposures to environmental agents is a crucial component of informed deci... more Information about human exposures to environmental agents is a crucial component of informed decisions about protection of public health. Results from an inventory of exposure-related databases are used to examine the value of exposure information for risk assessment, risk management, surveillance of status and trends, and epidemiologic studies. Findings indicate that current and future exposure-related databases should include (1) standardized procedures for the collection, storage, analysis, and reporting of data; (2) an enhanced ability to compare data over time, i.e., conduct comparison studies of "old" and "new" methods; (3) mechanisms for coordination and cooperation among public and private-sector organizations with respect to the design, maintenance, exchange, and review of information systems; (4) measurements of actual exposures and dose for relevant human populations; and (5) data collection, storage, and retrieval methods that permit easy manipulation of information for both model building and testing.
Scandinavian Journal of Work, Environment & Health
SELEVAN SG. Design cOl1JSiderations in pregnancy outcome studies of occupational populations. Sca... more SELEVAN SG. Design cOl1JSiderations in pregnancy outcome studies of occupational populations. Scand j work environ health 7 (1981): suppl 4, 76-82. Increased attention has been focused on lJhe relati'onshiJp between adverse pregnancy outcomes and occupational exposures to parents of both sexes. However, the c'haracteri'stics and dynamics of warMng populations impose liJrnitationson potential study populatiJons. These limitations result 'from the ,combined eJiiects :of wor'lclovoe si2Je, exposure, age dis'tribuUon, and mari'tal status, w'hidh limit the number of pregnancies ,ava:Ha!ble ror study. The smaller .popul1ations available typically r,esult in r,etrospectiv,e studJiescover~ng extended time periods. Pobential data sources f()JI" these studies include inteI"View data, medical records, vital statistics data, and~nsuran(le records. An sour-c,es may have 1)jased ascertainment of certain pregnancy ou'tcomes such as .early f.etal ,!Joss due to errors in recall in interview data, legal requirements for recording vital statistics data, and differences in medJical care patterns.
Journal of environmental pathology and toxicology
American Journal of Epidemiology
ABSTRACT
In response to numerous requests for information related to odor thresholds, this document was pr... more In response to numerous requests for information related to odor thresholds, this document was prepared by the Air Risk Information Support Center in its role in providing technical assistance to State and Local government agencies on risk assessment of air pollutants. A discussion of basic concepts related to olfactory function and the measurement of odor thresholds is presented. A detailed discussion of criteria which are used to evaluate the quality of published odor threshold values is provided. The use of odor threshold information in risk assessment is discussed. The results of a literature search and review of odor threshold information for the chemicals listed as hazardous air pollutants in the Clean Air Act amendments of 1990 is presented. The published odor threshold values are critically evaluated based on the criteria discussed and the values of acceptable quality are used to determine a geometric mean or best estimate.
Mutation research, 2007
Previous studies have provided evidence for an association between exposure to high levels of air... more Previous studies have provided evidence for an association between exposure to high levels of air pollution and increased DNA damage in human sperm. In these studies DNA damage was measured using the sperm chromatin structure assay (SCSA) wherein the percentage of sperm with abnormal chromatin/fragmented DNA is determined and expressed as % DNA fragmentation index (%DFI). Here we extend these observations to address the following hypothesis: men who are homozygous null for glutathione-S-transferase M1 (GSTM1-) are less able to detoxify reactive metabolites of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) found in air pollution. Consequently they are more susceptible to the effects of air pollution on sperm chromatin. Using a longitudinal study design in which men provided semen samples during periods of both low (baseline) and episodically high air pollution, this study revealed a statistically significant association between GSTM1 null genotype and increased SCSA-defined %...
Casopís lékar̆ů c̆eských, Jan 29, 2000
Recently, an association between adverse pregnancy outcome and air pollution was hypothesized in ... more Recently, an association between adverse pregnancy outcome and air pollution was hypothesized in several papers. The aim of the present study is to evaluate the impact of particles with aerodynamic diameter < or = 10 microns (PM10) on the intrauterine growth retardation (IUGR) in two regions with the different levels of air pollution. The study group includes all singleton full term births of European origin over a two-year period in the district of Teplice (n = 1,943) and Prachatice (n = 883). Information on reproductive and health history and lifestyle was obtained from maternal questionnaires and medical records. IUGR was chosen as the indicator of reproductive effects. The mean concentration of PM10 for each women in particular gestational month was calculated. Three concentration intervals were constructed (low < 40 micrograms/m3; medium 40-50 micrograms/m3; high > or = 50 micrograms/m3). Relative risk of IUGR was estimated for particular month and pollutant level. Inf...
Casopís lékar̆ů c̆eských, Jan 30, 2001
A study of morbidity of children aged 0 to 3 years was organized in two districts in the Czech Re... more A study of morbidity of children aged 0 to 3 years was organized in two districts in the Czech Republic. Comparisons were drawn between children living in district Teplice, known for its high air pollution, and those living in Practice, the district with consistently lower particulate and SO2 exposures. 452 children of the follow up study were born between May 1994 and December 1996. Childhood morbidity during the first three years of life was obtained from their pediatric records. Diagnoses were coded using the International Classification of Diseases--the 10th edition, and categorized into broad groups. Children born in Teplice experienced a significantly higher rate of otitis media (and otalgia), gastrointestinal infections, upper respiratory infections, and pneumonia, but they did not differ in the risk of bronchitis or that of viral infections such as varicella. These findings remained valid after the multiple linear regression models were calculated and adjusted for education,...
Journal of andrology
Large, population-based studies of semen quality are encumbered by the logistics and expense of o... more Large, population-based studies of semen quality are encumbered by the logistics and expense of obtaining semen samples from men who live in a variety of locations. A prototype semen collection and transportation kit, the TRANSEM100, can be distributed to study participants and then directly shipped to a central laboratory for analysis. This study was designed to evaluate the ability of male volunteers to correctly use the kit. Thirty volunteers aged 20 to 44 years with no history of diabetes, recent chemotherapy, fertility problems, or vasectomy were recruited through a newspaper advertisement, interviewed to obtain demographic information, and instructed on the use of the kit. Twenty-six of the initial subjects provided at least 1 semen specimen using the kit and returned the specimens by overnight delivery to the laboratory for analysis, 25 completed a follow-up interview on the use of the collection kit, and 20 submitted a second semen sample using the same method. The average v...
Journal of andrology
Measures of semen quality are used as surrogate measures of male fertility in clinical andrology,... more Measures of semen quality are used as surrogate measures of male fertility in clinical andrology, reproductive toxicology, epidemiology, and risk assessment. However, only limited data are available to relate those measures to fertility. This prospective study with 210 reproductive-age couples was conducted to provide information on the value of semen quality measures for predicting human male fertility potential and for development of models to estimate the effects of changes in semen quality on fertility in a given population for risk assessment. Couples without known risk factors for infertility and who had discontinued contraception to have a child were accepted. The study followed each couple for up to 12 menstrual cycles while they attempted to conceive and evaluated semen quality measures from multiple ejaculates per man with known abstinence intervals. For each cycle, the day of ovulation was predicted, and the couple was advised to have intercourse multiple times on that da...