Shiu Kum Lam - Academia.edu (original) (raw)
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Papers by Shiu Kum Lam
Best Practice & Research Clinical Gastroenterology, 2000
Alimentary Pharmacology and Therapeutics, 2003
Zhonghua Yi Xue Za Zhi, Feb 1, 2003
To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, ... more To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, and to determine the effect of chronic H.pylori infection on apoptosis of gastric epithelial cells. Human non-tumor gastric epithelial cells GES-1 were cocultured with an H.pylori strain SS1 for 16 weeks, in order to obtain GES-1 "model" cells. Biological characteristics of the model cells including growth, adherence and clone formation were determined. Apoptosis of the "model" cells in response to apoptosis inducers such as H.pylori and other enterobacteria and agents commonly used in the chemotherapy of gastric cancer were measured by flow cytometry. A cell model of human gastric epithelial cells with chronic H.pylori infection (GES-1 model cells) was successfully established. Apoptosis was dramatically decreased in the "model" cells with and without stimulation by H.pylori and other enterobacteria and some chemotherapeutic agents. Chronic H.pylori infection induces apoptosis resistance in gastric epithelial cells, which may increase the risk of the development of gastric cancer.
Cancer Research, Nov 15, 2003
The Quarterly journal of medicine
ABSTRACT
Clinics in gastroenterology
ABSTRACT
The Yale journal of biology and medicine
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
A total of 108 patients with duodenal ulcers were divided into 4 groups in a double-blind study c... more A total of 108 patients with duodenal ulcers were divided into 4 groups in a double-blind study controlled by endoscopic examinations. Patients in each group were given either an antacid mixture or sulpiride alone, antacid mixture plus sulpiride, or a placebo. The highest complete recovery rate (84 per cent) was noted in the antacid mixture plus sulpiride group, while partial healing (more than 50 per cent reduction in ulcer size) was highest in the sulpiride group (84,6 per cent). As sulpiride has both healing effects on the ulcer and an analgesic effect against pain it can be prescribed in association with antacid mixtures for the treatment of duodenal ulcers.
Best Practice & Research Clinical Gastroenterology, 2000
Alimentary Pharmacology and Therapeutics, 2003
Zhonghua Yi Xue Za Zhi, Feb 1, 2003
To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, ... more To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, and to determine the effect of chronic H.pylori infection on apoptosis of gastric epithelial cells. Human non-tumor gastric epithelial cells GES-1 were cocultured with an H.pylori strain SS1 for 16 weeks, in order to obtain GES-1 "model" cells. Biological characteristics of the model cells including growth, adherence and clone formation were determined. Apoptosis of the "model" cells in response to apoptosis inducers such as H.pylori and other enterobacteria and agents commonly used in the chemotherapy of gastric cancer were measured by flow cytometry. A cell model of human gastric epithelial cells with chronic H.pylori infection (GES-1 model cells) was successfully established. Apoptosis was dramatically decreased in the "model" cells with and without stimulation by H.pylori and other enterobacteria and some chemotherapeutic agents. Chronic H.pylori infection induces apoptosis resistance in gastric epithelial cells, which may increase the risk of the development of gastric cancer.
Cancer Research, Nov 15, 2003
The Quarterly journal of medicine
ABSTRACT
Clinics in gastroenterology
ABSTRACT
The Yale journal of biology and medicine
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
A total of 108 patients with duodenal ulcers were divided into 4 groups in a double-blind study c... more A total of 108 patients with duodenal ulcers were divided into 4 groups in a double-blind study controlled by endoscopic examinations. Patients in each group were given either an antacid mixture or sulpiride alone, antacid mixture plus sulpiride, or a placebo. The highest complete recovery rate (84 per cent) was noted in the antacid mixture plus sulpiride group, while partial healing (more than 50 per cent reduction in ulcer size) was highest in the sulpiride group (84,6 per cent). As sulpiride has both healing effects on the ulcer and an analgesic effect against pain it can be prescribed in association with antacid mixtures for the treatment of duodenal ulcers.