Shiva Prasad - Academia.edu (original) (raw)
Papers by Shiva Prasad
Asian Journal of Pharmaceutical and Clinical Research, 2021
Smoking ambiguity contributes to a certain revelation regarding the process by which cancer is in... more Smoking ambiguity contributes to a certain revelation regarding the process by which cancer is induced. In the laboratory, carcinogens induce clear lung tumor to lung cancer induction. For instance, carcinogenic chemicals, namely, 4(methyl nitrosomine)-1-(3-pyridyl)-1-butanol, and nitrosonornicotine (NNN) cause tumor malignancy. It is evident from the mechanistic studies that the carcinogens have a stronger tendency to mutate the genes like suppresser gene, a gene that encodes the receptor of the cell surface to the nucleus, thus, giving way to the proliferation of mutation leading to neoplastic cells. In this analysis article, we have discussed molecular mechanics that can cause cancer by nitrosamines such as nicotine-derived nitrosamine ketone and NNN regarding a variety of significant cigarette combustion carcinogens and the effort to introduce a different dimensional approach to the prevention of cancer, by understanding the perspective of various treatments.
arXiv: Materials Science, 2018
We report the synthesis and theoretical investigations of three novel pseudo-peptide molecules de... more We report the synthesis and theoretical investigations of three novel pseudo-peptide molecules derived from 2-amino-2-(1H-indole-2-yl) acetamides. The compounds were subjected to spectroscopic characterization ($^1$H, 13^{13}13C-NMR and MS) and their chemical, electronic, and optical properties have been investigated. To ascertain their potential pharmacological applicability, the prospective reactive centers and molecular sites prone to interaction with water were identified along with possible sensitivity to autoxidation. Further, we have studied the optical response in the presence of different solvents and compared the electronic and optical properties of the pristine molecules. We highlight the subtle dependence of the properties on the structure and composition of these pseudo-peptides. Our results indicate that these molecules have high pharmaceutical potential and could serve as lead components in new drug formulations.
Chemical Science, 2011
The new mononuclear neutral metal complexes of the type [M(L)2(H2O)nXn] (where n= 0,1,2…; X= Cl; ... more The new mononuclear neutral metal complexes of the type [M(L)2(H2O)nXn] (where n= 0,1,2…; X= Cl; ½ SO4; CH3COO; Br) by using the metal(II/III) salts {M = Cu(II), Co(II), Ni(II), Pd(II) and Ru(III)} with the Clomiphene citrate (L) were synthesized. The ligand and its complexes were characterized by elemental analysis, infrared, ESR, 1H-NMR, electronic spectral studies and magnetic susceptibility measurement, which reveals that L acts as a monodentate ligand. They simultaneously give Thermogravimetric and Differential Thermal Analysis patterns of the complexes recorded at heating rate of 10 °C min-1. The antimicrobial activity of ligand and its metal complexes were evaluated against Gram positive and Gram negative bacteria.
Environmental Challenges, 2021
The outbreak of novel coronavirus strain (Covid-19) with a high pandemic threat has predict grave... more The outbreak of novel coronavirus strain (Covid-19) with a high pandemic threat has predict grave public health and economic concerns. This virus, originating from the Wuhan region in China has spread worldwide affecting millions with no registered persuasive targeted therapy. In this paper, we analyze the three important proteins encoded by the virus, envelope protein 5 × 29, RNA binding nucleocapsid protein 1SSK, and spike glycoprotein 6ACD, for an effective virion accumulation, and remdesivir was the first drug approved by the FDA and EMA for the treatment of COVID-19 cases that require hospitalization, there is still much controversy about its efficacy and also an alternative for novel phytochemicals, deoxynojirimycin, trigoneoside IB, and octanoic acid. The insilico evaluations were conducted using the PyRx virtual screening tools which lead to the target based on high binding affinity. Trigoneoside IB, derived from Trigonella foenum-graecum (Fenugreek), showed the highest binding affinity and stable interaction with the amino acid residues present in active sites of Covid-19 proteins. Meanwhile, the other two compounds derived from Morus alba (Mulberry) and Morinda citrifolia (Noni), as well as the anti-HIV remdesivir drug exhibited good binding affinity and favorable ADME properties. Thereby offering scope for validation of the new therapeutic components for their in vitro and in vivo efficacy against the Covid-19 proteins.
Current Issues in Molecular Biology, 2021
Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of b... more Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations into mechanisms of the anti-cancer activity have revealed many pathways including induction of cell proliferation, suppression of tyrosine kinases, regulation of Hedgehog-Gli1 signaling, modulation of epigenetic activities, seizing of cell cycle and Akt and MEK signaling pathways, among others via which the cancer cell proliferation can be controlled. Notwithstanding, the observed activities have been time- and dose-dependent. In addition, genistein has also shown varying results in women depending on the physiological parameters, such as the early or post-menopausal states.
Saudi Journal of Biological Sciences, 2021
The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12... more The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12 million people have been infected so far according to the reports from World Health Organization (WHO). Preventive measures are being taken globally to avoid the rapid spread of virus. In the current study, an in silico approach is carried out as a means of inhibiting the spike protein of the novel coronavirus by flavonoids from natural sources that possess both antiviral and anti-inflammatory properties. The methodology is focused on molecular docking of 10 flavonoid compounds that are docked with the spike protein of SARS-CoV-2, to determine the highest binding affinity at the binding site. Molecular dynamics simulation was carried out with the flavonoid-protein complex showing the highest binding affinity and highest interactions. The flavonoid naringin showed the least binding energy of À9.8 Kcal/mol with the spike protein which was compared with the standard drug, dexamethasone which is being repurposed to treat critically ill patients. MD simulation was carried out on naringin-spike protein complex for their conformational stability in the active site of the novel coronavirus spike protein. The RMSD of the complex appeared to be more stable when compared to that of the protein from 0.2 nm to 0.4 nm. With the aid of this in silico approach further in vitro studies can be carried out on these flavonoids against the novel coronavirus as a means of viral protein inhibitors.
Saudi Journal of Biological Sciences, 2021
Organic pollutants present in waste water have undesirable effect on the environment. Industry ac... more Organic pollutants present in waste water have undesirable effect on the environment. Industry activities are the key sources of organic pollutants. Prime pollutants released from various sources react instantly with the environment and become derived (secondary) pollutants, which stay for an elongated time. The present research work has been carried out using biosorbent prepared from various Zea mays wastes for elimination of oxybenzene. Different parameters viz contact time, initial concentration; adsorbent dose, temperature and pH were optimized for the biosorption of oxybenzene on to the biosorbent samples. BCS (Baby corn silk) showed higher percentage of biosorption at optimum contact time of 3 h, pH between 5 and 6 and temperature at 25°C. Analysis of equilibrium biosorption data in terms of several isotherm models revealed that Langmuir isotherm and Freundlich isotherm indicates better agreement with the experimental data. The kinetics of oxybenzene biosorption on to the biosorbents was described with the pseudo-first-order model. Thermodynamic parameters indicated that biosorption onto biosorbent was feasible in nature, spontaneous, and endothermic for some biosorbents, but on contrary not feasible, exothermic and non spontaneous for other biosorbents. The result of this study showed that the biosorbent derived from Zea mays can be used as a prospective biosorbent for oxybenzene in wastewater and also can be an alternative for the commercially activated carbon.
Biomolecules, 2020
In this work, we aimed to synthesize zinc oxide nanoparticles (ZnONPs) using an aqueous extract o... more In this work, we aimed to synthesize zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Cassia auriculata leaves (CAE) at room temperature without the provision of additional surfactants or capping agents. The formation of as-obtained ZnONPs was analyzed by UV–visible (ultraviolet) absorption and emission spectroscopy, X-ray photoemission spectroscopy (XPS), X-ray diffraction analysis (XRD), energy dispersive X-ray diffraction (EDX), thermogravimetric analysis/differential thermal analysis (TGA-DTA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and selected area electron diffraction (SAED). The XRD results reflect the wurtzite structure of as-prepared ZnONPs, which produced diffraction patterns showing hexagonal phases. The SEM images indicate that the morphology of as-prepared ZnONPs is composed of hexagonal nanostructures with an average diameter of 20 nm. The HR-TEM result shows th...
RSC Advances, 2018
A novel chemosensor for Cu2+ ion detection with LOD 1.6 μM.
Sensors (Basel, Switzerland), Jan 16, 2018
In the present study, we describe the facile synthesis of silver nanoparticles (AgNPs) and their ... more In the present study, we describe the facile synthesis of silver nanoparticles (AgNPs) and their nanostructures functionalized with 2-aminopyrimidine-4,6-diol (APD-AgNPs) for Hg ion detection. The promising colorimetric response of APD-AgNPs to detect Hg ions was visible with naked eyes and spectroscopic changes were examined by using a UV-Visible spectrophotometer. The aggregation of APD-AgNPs upon addition of Hg ions was due to the chelation effect of the functionalized nanostructures and results in a color change from pale brown to deep yellow color. The probing sensitivity was observed within five minutes with a detection limit of about 0.35 µM/L. The TEM images of APD-AgNPs showed polydispersed morphologies with hexagonal, heptagonal and spherical nanostructures with an average size between 10 to 40 nm. Furthermore, the sensing behavior of APD-AgNPs towards Hg ions detection was investigated using docking and interaction studies.
Journal of Nanotechnology, 2017
The present study is mainly aimed at the synthesis of copper oxide nanoparticles of varied size b... more The present study is mainly aimed at the synthesis of copper oxide nanoparticles of varied size by green synthetic approach. The structural and morphological behavior of as-synthesized CuO nanoparticles were investigated using ultraviolet-visible spectral studies (UV-Vis), Fourier transform-Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HRTEM). The reduction of copper ions using aqueous extract of S. indica leaves produces nanoparticles of varied size and morphology. The images from SEM investigation revealed that the particles are spherical in shape with average diameter of 40–70 nm. TEM and HRTEM images clearly indicate the crystallinity and spherical nature of as-synthesized CuO nanoparticles with interplanar distance between two neighboring lattice fringes of ...
Green Processing and Synthesis, 2017
The present work describes a facile, convenient, and green pathway for MnO
Journal of Porphyrins and Phthalocyanines, 2011
The water-soluble tin(IV) tetrakis(2-N-hydroxyethyl-4-pyridinium)porphyrin 1 photocatalyst was sy... more The water-soluble tin(IV) tetrakis(2-N-hydroxyethyl-4-pyridinium)porphyrin 1 photocatalyst was synthesized in good yield and its structure determined by single crystal X-ray crystallography. Electrochemical measurements on tin(IV) porphyrin 1 reveal a range of complex redox processes that are highly dependent on the pH and electrode used. The cathodic processes at ca. -0.6 to -0.8 V were assigned to electrochemical processes on the pyridyl moiety following differential pulse voltammetry and spectroelectrochemical investigation into the electrochemical properties of tin(IV) porphyrin. Photocatalytic experiment on tin(IV) porphyrin 1 under anaerobic conditions using triethanolamine (TEAO) as a sacrifical donor reveal a phlorin species as the main product which rapidly disappears upon exposure to oxygen. These results suggest that tin(IV) porphyrin π-radical anion is perhaps not the species responsible for the apparent ability tin(IV) porphyrins to photocatalytically reduce various sub...
Bioinorganic Chemistry and Applications, 2010
Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-... more Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes1and3with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes1and3with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex1can act as effective DNA cleaving agent when compared to complex3resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.
![Research paper thumbnail of Preparation, Spectroscopic Characterization and X-Ray Structure of [Dicyclohexylphosphinyl-N-methyl(thioformamide)]gold(I) Chloride: Au[Cy 2 P(O)C(S)N(H)Me]Cl](https://attachments.academia-assets.com/87170440/thumbnails/1.jpg)
](Australian Journal of Chemistry, 1995
The reaction of [AuCl4]- with Cy2P(O)C(S)N(H)Me in the presence of thiodiglycol affords the air-s... more The reaction of [AuCl4]- with Cy2P(O)C(S)N(H)Me in the presence of thiodiglycol affords the air-stable adduct Au[Cy2P(O)C(S)N(H)Me] Cl which features a linear gold atom geometry defined by a chloride atom and a sulfur atom derived from a monodentate thioformamide ligand. The pale-green crystals are monoclinic, space group P21, with unit cell dimensions a 18.507(4), b 12.204(2), c 18.513(6) Ǻ, β 117.69(2)°, Z 8; the structure was refined to final R 0.042, 4106 reflections being used.
Chinese Journal of Polymer Science, 2010
The synthesis, characterization, thermal degradation and stability of polyaniline (PANI), poly(m-... more The synthesis, characterization, thermal degradation and stability of polyaniline (PANI), poly(m-nitroaniline), poly(m-chloroaniline) and poly(o-methylaniline) were reported. Different properties were measured and compared with PANI to find out the effect of electron donating groups (−CH3) and electron withdrawing groups (−Cl, t—NO2). It was found that the presence of any type of substitution in the benzene ring of aniline increased the solubility but reduced the yield, thermal stability and electrical conductivity. Two probe methods were used to measure the electrical conductivity of these polymers. The structural properties of these polymers were characterized by using FTIR and UV-Vis spectroscopic methods. Thermal degradation and stability of these polymers were explained by using thermogravimetric analysis (TGA) and conductivity measurements.
… Journal of Chemistry, Jan 1, 2011
Chemical Sciences …, Jan 1, 2011
The new mononuclear neutral metal complexes of the type [M(L) 2 (H 2 O) n X n ] (where n= 0,1,2…;... more The new mononuclear neutral metal complexes of the type [M(L) 2 (H 2 O) n X n ] (where n= 0,1,2…; X= Cl; ½ SO 4 ; CH 3 COO; Br) by using the metal(II/III) salts {M = Cu(II), Co(II), Ni(II), Pd(II) and Ru(III)} with the Clomiphene citrate (L) were synthesized. The ligand and its complexes were characterized by elemental analysis, infrared, ESR, 1 H-NMR, electronic spectral studies and magnetic susceptibility measurement, which reveals that L acts as a monodentate ligand. They simultaneously give Thermogravimetric and Differential Thermal Analysis patterns of the complexes recorded at heating rate of 10 °C min -1 . The antimicrobial activity of ligand and its metal complexes were evaluated against Gram positive and Gram negative bacteria.
Analele …, Jan 1, 2011
A novel copper(II) complex of quinolin-4(3H)-one derived Schiff base ligand was synthesized and c... more A novel copper(II) complex of quinolin-4(3H)-one derived Schiff base ligand was synthesized and characterized by elemental analyses, IR, 1H-NMR, MS, UV-Vis, magnetic moments, conductance measurements and thermal studies. The DNA binding and nuclease activities of copper(II) complex was performed.
Chemical Sciences …, Jan 1, 2011
Novel oxovanadium(IV) complexes (1-4) with 2-methyl-3-(pyridine-2-ylmethyleneamino)quinazolin-4(3... more Novel oxovanadium(IV) complexes (1-4) with 2-methyl-3-(pyridine-2-ylmethyleneamino)quinazolin-4(3H)-one (L 1 ) or3-(2-hydroxy-3methoxybenzylideneamino)-2-methylquinolin-4(3H)-one (L 2 ) were synthesized and characterized by elemental analysis, IR, 1 H-NMR, electronic spectra, molar conductance and thermal studies. Based on the above spectral studies, the complexes have the general formula [VO(L 1 ) 2 ] (1), [VO(L 1 )phen] (2), [VO(L 2 ) 2 ] (3) and [VO(L 2 )phen] ( . The synthesized compounds were tested for antimicrobial activity by disc diffusion method.
Asian Journal of Pharmaceutical and Clinical Research, 2021
Smoking ambiguity contributes to a certain revelation regarding the process by which cancer is in... more Smoking ambiguity contributes to a certain revelation regarding the process by which cancer is induced. In the laboratory, carcinogens induce clear lung tumor to lung cancer induction. For instance, carcinogenic chemicals, namely, 4(methyl nitrosomine)-1-(3-pyridyl)-1-butanol, and nitrosonornicotine (NNN) cause tumor malignancy. It is evident from the mechanistic studies that the carcinogens have a stronger tendency to mutate the genes like suppresser gene, a gene that encodes the receptor of the cell surface to the nucleus, thus, giving way to the proliferation of mutation leading to neoplastic cells. In this analysis article, we have discussed molecular mechanics that can cause cancer by nitrosamines such as nicotine-derived nitrosamine ketone and NNN regarding a variety of significant cigarette combustion carcinogens and the effort to introduce a different dimensional approach to the prevention of cancer, by understanding the perspective of various treatments.
arXiv: Materials Science, 2018
We report the synthesis and theoretical investigations of three novel pseudo-peptide molecules de... more We report the synthesis and theoretical investigations of three novel pseudo-peptide molecules derived from 2-amino-2-(1H-indole-2-yl) acetamides. The compounds were subjected to spectroscopic characterization ($^1$H, 13^{13}13C-NMR and MS) and their chemical, electronic, and optical properties have been investigated. To ascertain their potential pharmacological applicability, the prospective reactive centers and molecular sites prone to interaction with water were identified along with possible sensitivity to autoxidation. Further, we have studied the optical response in the presence of different solvents and compared the electronic and optical properties of the pristine molecules. We highlight the subtle dependence of the properties on the structure and composition of these pseudo-peptides. Our results indicate that these molecules have high pharmaceutical potential and could serve as lead components in new drug formulations.
Chemical Science, 2011
The new mononuclear neutral metal complexes of the type [M(L)2(H2O)nXn] (where n= 0,1,2…; X= Cl; ... more The new mononuclear neutral metal complexes of the type [M(L)2(H2O)nXn] (where n= 0,1,2…; X= Cl; ½ SO4; CH3COO; Br) by using the metal(II/III) salts {M = Cu(II), Co(II), Ni(II), Pd(II) and Ru(III)} with the Clomiphene citrate (L) were synthesized. The ligand and its complexes were characterized by elemental analysis, infrared, ESR, 1H-NMR, electronic spectral studies and magnetic susceptibility measurement, which reveals that L acts as a monodentate ligand. They simultaneously give Thermogravimetric and Differential Thermal Analysis patterns of the complexes recorded at heating rate of 10 °C min-1. The antimicrobial activity of ligand and its metal complexes were evaluated against Gram positive and Gram negative bacteria.
Environmental Challenges, 2021
The outbreak of novel coronavirus strain (Covid-19) with a high pandemic threat has predict grave... more The outbreak of novel coronavirus strain (Covid-19) with a high pandemic threat has predict grave public health and economic concerns. This virus, originating from the Wuhan region in China has spread worldwide affecting millions with no registered persuasive targeted therapy. In this paper, we analyze the three important proteins encoded by the virus, envelope protein 5 × 29, RNA binding nucleocapsid protein 1SSK, and spike glycoprotein 6ACD, for an effective virion accumulation, and remdesivir was the first drug approved by the FDA and EMA for the treatment of COVID-19 cases that require hospitalization, there is still much controversy about its efficacy and also an alternative for novel phytochemicals, deoxynojirimycin, trigoneoside IB, and octanoic acid. The insilico evaluations were conducted using the PyRx virtual screening tools which lead to the target based on high binding affinity. Trigoneoside IB, derived from Trigonella foenum-graecum (Fenugreek), showed the highest binding affinity and stable interaction with the amino acid residues present in active sites of Covid-19 proteins. Meanwhile, the other two compounds derived from Morus alba (Mulberry) and Morinda citrifolia (Noni), as well as the anti-HIV remdesivir drug exhibited good binding affinity and favorable ADME properties. Thereby offering scope for validation of the new therapeutic components for their in vitro and in vivo efficacy against the Covid-19 proteins.
Current Issues in Molecular Biology, 2021
Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of b... more Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations into mechanisms of the anti-cancer activity have revealed many pathways including induction of cell proliferation, suppression of tyrosine kinases, regulation of Hedgehog-Gli1 signaling, modulation of epigenetic activities, seizing of cell cycle and Akt and MEK signaling pathways, among others via which the cancer cell proliferation can be controlled. Notwithstanding, the observed activities have been time- and dose-dependent. In addition, genistein has also shown varying results in women depending on the physiological parameters, such as the early or post-menopausal states.
Saudi Journal of Biological Sciences, 2021
The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12... more The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12 million people have been infected so far according to the reports from World Health Organization (WHO). Preventive measures are being taken globally to avoid the rapid spread of virus. In the current study, an in silico approach is carried out as a means of inhibiting the spike protein of the novel coronavirus by flavonoids from natural sources that possess both antiviral and anti-inflammatory properties. The methodology is focused on molecular docking of 10 flavonoid compounds that are docked with the spike protein of SARS-CoV-2, to determine the highest binding affinity at the binding site. Molecular dynamics simulation was carried out with the flavonoid-protein complex showing the highest binding affinity and highest interactions. The flavonoid naringin showed the least binding energy of À9.8 Kcal/mol with the spike protein which was compared with the standard drug, dexamethasone which is being repurposed to treat critically ill patients. MD simulation was carried out on naringin-spike protein complex for their conformational stability in the active site of the novel coronavirus spike protein. The RMSD of the complex appeared to be more stable when compared to that of the protein from 0.2 nm to 0.4 nm. With the aid of this in silico approach further in vitro studies can be carried out on these flavonoids against the novel coronavirus as a means of viral protein inhibitors.
Saudi Journal of Biological Sciences, 2021
Organic pollutants present in waste water have undesirable effect on the environment. Industry ac... more Organic pollutants present in waste water have undesirable effect on the environment. Industry activities are the key sources of organic pollutants. Prime pollutants released from various sources react instantly with the environment and become derived (secondary) pollutants, which stay for an elongated time. The present research work has been carried out using biosorbent prepared from various Zea mays wastes for elimination of oxybenzene. Different parameters viz contact time, initial concentration; adsorbent dose, temperature and pH were optimized for the biosorption of oxybenzene on to the biosorbent samples. BCS (Baby corn silk) showed higher percentage of biosorption at optimum contact time of 3 h, pH between 5 and 6 and temperature at 25°C. Analysis of equilibrium biosorption data in terms of several isotherm models revealed that Langmuir isotherm and Freundlich isotherm indicates better agreement with the experimental data. The kinetics of oxybenzene biosorption on to the biosorbents was described with the pseudo-first-order model. Thermodynamic parameters indicated that biosorption onto biosorbent was feasible in nature, spontaneous, and endothermic for some biosorbents, but on contrary not feasible, exothermic and non spontaneous for other biosorbents. The result of this study showed that the biosorbent derived from Zea mays can be used as a prospective biosorbent for oxybenzene in wastewater and also can be an alternative for the commercially activated carbon.
Biomolecules, 2020
In this work, we aimed to synthesize zinc oxide nanoparticles (ZnONPs) using an aqueous extract o... more In this work, we aimed to synthesize zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Cassia auriculata leaves (CAE) at room temperature without the provision of additional surfactants or capping agents. The formation of as-obtained ZnONPs was analyzed by UV–visible (ultraviolet) absorption and emission spectroscopy, X-ray photoemission spectroscopy (XPS), X-ray diffraction analysis (XRD), energy dispersive X-ray diffraction (EDX), thermogravimetric analysis/differential thermal analysis (TGA-DTA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and selected area electron diffraction (SAED). The XRD results reflect the wurtzite structure of as-prepared ZnONPs, which produced diffraction patterns showing hexagonal phases. The SEM images indicate that the morphology of as-prepared ZnONPs is composed of hexagonal nanostructures with an average diameter of 20 nm. The HR-TEM result shows th...
RSC Advances, 2018
A novel chemosensor for Cu2+ ion detection with LOD 1.6 μM.
Sensors (Basel, Switzerland), Jan 16, 2018
In the present study, we describe the facile synthesis of silver nanoparticles (AgNPs) and their ... more In the present study, we describe the facile synthesis of silver nanoparticles (AgNPs) and their nanostructures functionalized with 2-aminopyrimidine-4,6-diol (APD-AgNPs) for Hg ion detection. The promising colorimetric response of APD-AgNPs to detect Hg ions was visible with naked eyes and spectroscopic changes were examined by using a UV-Visible spectrophotometer. The aggregation of APD-AgNPs upon addition of Hg ions was due to the chelation effect of the functionalized nanostructures and results in a color change from pale brown to deep yellow color. The probing sensitivity was observed within five minutes with a detection limit of about 0.35 µM/L. The TEM images of APD-AgNPs showed polydispersed morphologies with hexagonal, heptagonal and spherical nanostructures with an average size between 10 to 40 nm. Furthermore, the sensing behavior of APD-AgNPs towards Hg ions detection was investigated using docking and interaction studies.
Journal of Nanotechnology, 2017
The present study is mainly aimed at the synthesis of copper oxide nanoparticles of varied size b... more The present study is mainly aimed at the synthesis of copper oxide nanoparticles of varied size by green synthetic approach. The structural and morphological behavior of as-synthesized CuO nanoparticles were investigated using ultraviolet-visible spectral studies (UV-Vis), Fourier transform-Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HRTEM). The reduction of copper ions using aqueous extract of S. indica leaves produces nanoparticles of varied size and morphology. The images from SEM investigation revealed that the particles are spherical in shape with average diameter of 40–70 nm. TEM and HRTEM images clearly indicate the crystallinity and spherical nature of as-synthesized CuO nanoparticles with interplanar distance between two neighboring lattice fringes of ...
Green Processing and Synthesis, 2017
The present work describes a facile, convenient, and green pathway for MnO
Journal of Porphyrins and Phthalocyanines, 2011
The water-soluble tin(IV) tetrakis(2-N-hydroxyethyl-4-pyridinium)porphyrin 1 photocatalyst was sy... more The water-soluble tin(IV) tetrakis(2-N-hydroxyethyl-4-pyridinium)porphyrin 1 photocatalyst was synthesized in good yield and its structure determined by single crystal X-ray crystallography. Electrochemical measurements on tin(IV) porphyrin 1 reveal a range of complex redox processes that are highly dependent on the pH and electrode used. The cathodic processes at ca. -0.6 to -0.8 V were assigned to electrochemical processes on the pyridyl moiety following differential pulse voltammetry and spectroelectrochemical investigation into the electrochemical properties of tin(IV) porphyrin. Photocatalytic experiment on tin(IV) porphyrin 1 under anaerobic conditions using triethanolamine (TEAO) as a sacrifical donor reveal a phlorin species as the main product which rapidly disappears upon exposure to oxygen. These results suggest that tin(IV) porphyrin π-radical anion is perhaps not the species responsible for the apparent ability tin(IV) porphyrins to photocatalytically reduce various sub...
Bioinorganic Chemistry and Applications, 2010
Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-... more Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes1and3with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes1and3with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex1can act as effective DNA cleaving agent when compared to complex3resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.
Australian Journal of Chemistry, 1995
The reaction of [AuCl4]- with Cy2P(O)C(S)N(H)Me in the presence of thiodiglycol affords the air-s... more The reaction of [AuCl4]- with Cy2P(O)C(S)N(H)Me in the presence of thiodiglycol affords the air-stable adduct Au[Cy2P(O)C(S)N(H)Me] Cl which features a linear gold atom geometry defined by a chloride atom and a sulfur atom derived from a monodentate thioformamide ligand. The pale-green crystals are monoclinic, space group P21, with unit cell dimensions a 18.507(4), b 12.204(2), c 18.513(6) Ǻ, β 117.69(2)°, Z 8; the structure was refined to final R 0.042, 4106 reflections being used.
Chinese Journal of Polymer Science, 2010
The synthesis, characterization, thermal degradation and stability of polyaniline (PANI), poly(m-... more The synthesis, characterization, thermal degradation and stability of polyaniline (PANI), poly(m-nitroaniline), poly(m-chloroaniline) and poly(o-methylaniline) were reported. Different properties were measured and compared with PANI to find out the effect of electron donating groups (−CH3) and electron withdrawing groups (−Cl, t—NO2). It was found that the presence of any type of substitution in the benzene ring of aniline increased the solubility but reduced the yield, thermal stability and electrical conductivity. Two probe methods were used to measure the electrical conductivity of these polymers. The structural properties of these polymers were characterized by using FTIR and UV-Vis spectroscopic methods. Thermal degradation and stability of these polymers were explained by using thermogravimetric analysis (TGA) and conductivity measurements.
… Journal of Chemistry, Jan 1, 2011
Chemical Sciences …, Jan 1, 2011
The new mononuclear neutral metal complexes of the type [M(L) 2 (H 2 O) n X n ] (where n= 0,1,2…;... more The new mononuclear neutral metal complexes of the type [M(L) 2 (H 2 O) n X n ] (where n= 0,1,2…; X= Cl; ½ SO 4 ; CH 3 COO; Br) by using the metal(II/III) salts {M = Cu(II), Co(II), Ni(II), Pd(II) and Ru(III)} with the Clomiphene citrate (L) were synthesized. The ligand and its complexes were characterized by elemental analysis, infrared, ESR, 1 H-NMR, electronic spectral studies and magnetic susceptibility measurement, which reveals that L acts as a monodentate ligand. They simultaneously give Thermogravimetric and Differential Thermal Analysis patterns of the complexes recorded at heating rate of 10 °C min -1 . The antimicrobial activity of ligand and its metal complexes were evaluated against Gram positive and Gram negative bacteria.
Analele …, Jan 1, 2011
A novel copper(II) complex of quinolin-4(3H)-one derived Schiff base ligand was synthesized and c... more A novel copper(II) complex of quinolin-4(3H)-one derived Schiff base ligand was synthesized and characterized by elemental analyses, IR, 1H-NMR, MS, UV-Vis, magnetic moments, conductance measurements and thermal studies. The DNA binding and nuclease activities of copper(II) complex was performed.
Chemical Sciences …, Jan 1, 2011
Novel oxovanadium(IV) complexes (1-4) with 2-methyl-3-(pyridine-2-ylmethyleneamino)quinazolin-4(3... more Novel oxovanadium(IV) complexes (1-4) with 2-methyl-3-(pyridine-2-ylmethyleneamino)quinazolin-4(3H)-one (L 1 ) or3-(2-hydroxy-3methoxybenzylideneamino)-2-methylquinolin-4(3H)-one (L 2 ) were synthesized and characterized by elemental analysis, IR, 1 H-NMR, electronic spectra, molar conductance and thermal studies. Based on the above spectral studies, the complexes have the general formula [VO(L 1 ) 2 ] (1), [VO(L 1 )phen] (2), [VO(L 2 ) 2 ] (3) and [VO(L 2 )phen] ( . The synthesized compounds were tested for antimicrobial activity by disc diffusion method.