Shota Janjgava - Academia.edu (original) (raw)

Papers by Shota Janjgava

Macedonian Journal of Medical Sciences, Dec 15, 2014

European Journal of Medical Research, Oct 23, 2014

Endocrine, metabolic & immune disorders, Feb 20, 2023

DAVID AGHMASHENEBELI UNIVERSITY OF GEORGIA SCIENTIFIC JOURNAL „SPECTRI“

Georgian medical news, 2018

The aim of our investigation was to determine the impact of the degree of obesity on metabolic ch... more The aim of our investigation was to determine the impact of the degree of obesity on metabolic characteristics in children and adolescents with metabolic syndrome. We studied 117 children and adolescents 8-15 years of age with BMI exceeded the 85th percentile for their age and sex and the complaints associated with obesity. Investigated patients were divided according BMI percentiles for age and sex established by the U.S. Centers for Disease Control and Prevention (CDC) as follows: Group 1. Overweight (OW; 85-94.99th percentiles, n=10); Group 2. Obesity of I degree (Ob1; 95-96.99th percentile, n=12); Group 3. Obesity of II degree (Ob2; 97-98.99th percentile, n=51); Group 4. Obesity of III degree (Ob3; >98.99th percentile, n=39). Plasma glucose levels (fasting plasma glucose - FPG, postprandial plasma glucose - PPG) were determined by glucose oxidase method and Serum lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, Triglycerides) levels have been meas...

Georgian medical news, 2017

Growth hormone deficiency (GHD) is one of the reasons of significant metabolic morbidities inchil... more Growth hormone deficiency (GHD) is one of the reasons of significant metabolic morbidities inchildren and adults. The aim of our study was to evaluate the impact of growth hormone (GH) replacement therapy on lipid profile and adipose tissue distribution in adults with GHD. Twenty hypopituitary adults, aged 40.75±2.2 years (mean ± SE, range 20.5-60), with adult onset GHD (aGHD) were enrolled in a randomized, double blind, placebo-controlled study. 10 patients received recombinant growth hormone injection once weekly for 12 months, and the rest 10 patients (as control group) received placebo. The patients were selected from the basis of National Institute of Endocrinology. After 12 months of treatment mean values of low density lipoprotein cholesterol (LDL-CH), total cholesterol (CH) and triglycerides (TG) were increased in GH treated patients, compared to the control group (median increase in LDL-CH, CH and TG were 0.1 mmol/l, 0.1 mmol/l and 0.3mmol/l, respectively). In contrast, the...

International Congress Series, 2007

ABSTRACT Evidence is accumulating in favour of a link between erectile dysfunction (ED) and coron... more ABSTRACT Evidence is accumulating in favour of a link between erectile dysfunction (ED) and coronary artery disease (CAD). Prevalence of common risk factors for atherosclerosis is similar. ED is frequently found in patients with CAD and shares a similar pathogenic involvement of nitric oxide-pathway leading to impairment of endothelium-dependent vasodilatation (early phase) and structural vascular abnormalities (late phase). Moreover, there is room to consider ED as a marker of early sub-clinical CAD. It is therefore crucial to identify asymptomatic patients with ED who may be at risk of occult CAD. Initial screening may adopt risk assessment office-based approaches to score patient into low, intermediate or high risk of future cardiovascular events. Attention should be drawn to patients at intermediate risk. Targets for the assessment of sub-clinical CAD in this subset of patients should include both obstructive and non-obstructive CAD. Although less investigated, non-obstructive CAD is a more important target to assess since acute myocardial infarction is the result of an acute occlusion of a previously non critical coronary vessel. Several non-invasive tests may add important diagnostic and prognostic information in patients at intermediate coronary risk. Some of these directly assess coronary atherosclerosis burden – such as coronary calcium score by electron beam computed tomography – whereas others, such as carotid intima-media thickness by ultrasound are surrogates of coronary involvement.

Journal of diabetes & metabolism, Jun 11, 2018

Ek'sperimentuli da klinikuri medic'ina, Sep 6, 2022

In clinical practice, patients with metabolic syndrome and thyroid disease are often referred. It... more In clinical practice, patients with metabolic syndrome and thyroid disease are often referred. It is noteworthy that based on the results of various population studies, there has been an increase in both thyroid disease and the incidence of signs of metabolic syndrome in adults. Therefore, there has been a dramatic increase in interest in the study of possible associations between these two pathological conditions. Based on the results of various papers, the close relationship between these two pathological conditions is due on the one hand to the influence of thyroid hormones on carbohydrate, lipid metabolism and on the other hand the zobogenic effect of insulin on thyroid tissue. However, despite many scientific papers and population studies, the relationship between thyroid disease and components of the metabolic syndrome is still a matter of research, but in clinical practice, the results of these studies help to diagnose thyroid disease.

Global pediatric health, 2022

EXPERIMENTAL & CLINICAL MEDICINE GEORGIA

Vitamin B12 is distinguished by its unique beneficial properties that play a major role in the pr... more Vitamin B12 is distinguished by its unique beneficial properties that play a major role in the proper functioning of the body. Interest in vitamin B12 began 2 centuries ago and it is still relevant to study its role. Vitamin B12 plays a special role in the proper functioning of the immune system. With increasing statistics in the autoimmune disease registry around the world (including the most common thyroid autoimmune disease), the interest in medicine is to determine the correlation between vitamin B12 and autoimmune diseases. Various studies have shown a correlation between them, although there is a little evidence for a link between vitamin B12 and autoimmune diseases of the thyroid gland.

Endocrine, Metabolic & Immune Disorders - Drug Targets

Background: Autoimmune thyroid diseases (AITD) are the most prevalent organ-specific autoimmune d... more Background: Autoimmune thyroid diseases (AITD) are the most prevalent organ-specific autoimmune disorders. Vitamin B12 plays an important role in the proper functioning of the immune system. The aim of this study was therefore to investigate the correlation between vitamin B12 deficiency and AITD. Methods and Materials: A total of 306 patients (aged 18-65 years, mean – 37.6 ± 11.3 years and comprising 87 males and 219 females) were studied retrospectively (observational study). Patients were divided into groups: with and without vitamin B12 deficiency, and with and without AITD. Differences between groups were evaluated by Fisher’s exact test for qualitative variables and by Student’s t-test for quantitative variables. Correlations for quantitative factors were determined by the Pearson correlation coefficient and for qualitative factors by Spearman correlation analysis. The sensitivity and specificity of vitamin B12 deficiency for AITD were calculated by ROC analysis. Results: The ...

Journal of thyroid disorders & therapy, 2016

Clinical Case: This is the case study of one of the ordinary Georgian patient.Mr. B is 64 years o... more Clinical Case: This is the case study of one of the ordinary Georgian patient.Mr. B is 64 years old man, who was diagnosed type 2 diabetes 15 years ago. He has medical history of myocardial infarction (MI) at the age 58 and arterial hypertension II degree from the age 51. His last visit to endocrinologist was 3 years ago. Since then he is taking metformin 2000 mg/day, glimepiride 2 mg/day and prescription from cardiologist: atorvastatin, ACE inhibitors and cardioaspirin.He came to the clinic with several complaints, such as: fatigue and excessive sweeting during nighttime. As the patient has low income we could not perform all necessary blood tests, but choose the ones with greater informational value. The lab answers revealed that patient’s HbA1c was 7.3%; he had elevated transaminase levels (≈1.5 fold from ULN) and microalbumin and glucose in the urinalysis. According to HbA1c levels glycaemia goal was achieved for this patient, but we wondered why he had excessive sweeting and gl...