Shruti Bhatia - Academia.edu (original) (raw)

Papers by Shruti Bhatia

vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4... more vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4 days vs 26.9 ± 4.6 days in the 2nd group. The recurrence rate in the 1st group was 9.53% vs 24.6% in the 2nd group, which is probably due to wider excision of the perineal tissue using reconstructive plastic surgery. Five-year survival was 76.5% in the 1st vs 56% in the 2nd group. Conclusion The use of reconstructive plastic surgery for closing of wound defects after radical vulvectomy reduces the incidence of postoperative complications and improves oncological treatment results. Disclosures None.

Springer eBooks, 2019

High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progr... more High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progress to frank malignancy, and therefore some form of treatment is always indicated for these lesions. Traditionally, surgery including hysterectomy, conization, or wide local excision was considered the standard of care. However, with advances in our understanding of the natural history of human papillomavirus infection and widespread use of colposcopy, conservative management of these lesions is now possible. Treatment options have now evolved to local ablative procedures for intraepithelial lesions of the cervix, vulva, and vagina. Cryotherapy is the most widely used ablative method for treating cervical intraepithelial lesions confined to the ectocervix. Laser ablation, though expensive and not commonly available, is very effective for cervical lesions extending to vaginal fornices and also for vaginal and vulvar intraepithelial neoplasias. Thermal coagulation is another tool which is gaining popularity now owing to its portability and ease of use. In this chapter, we describe the different ablative treatment options for intraepithelial lesions and their applications in clinical practice.

Indian Journal of Gynecologic Oncology, Sep 28, 2018

Indian Journal of Gynecologic Oncology, Sep 21, 2017

Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment ... more Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment modality have not been established. Most Brenner tumors are benign, with only 1-2% being malignant. We present a case of 57-year-old women with a rare malignant Brenner tumor. She presented with complaint of abdominal pain and postmenopausal bleeding. Imaging revealed large complex solid cystic pelvic mass. She underwent staging ovarian laparotomy, and the specimen was sent for histopathological study. Histopathology revealed malignant Brenner tumor. On immunohistochemistry, tumor cells were immunoreactive for uroplakin, CK7, WT1, GATA-3 and Ki67 60% and nonimmunoreactive for CK20, favouring urothelial differentiation.

Indian Journal of Gynecologic Oncology, Mar 15, 2018

Objective To review the need for fertility preservation in young patients with breast cancer. Mat... more Objective To review the need for fertility preservation in young patients with breast cancer. Materials and Methods This retrospective study includes patients B 40 years with breast carcinoma treated at Action Cancer Hospital, New Delhi, from June 2010 to 31 July 2014. Patient age, marital status, parity, contraception use, and the need for fertility preservation were evaluated. Result Fifty-three patients were included in study with mean age 35.4 (SD: 4.1) years. Fifty (94.3%) patients were married, and four (7.5%) were nulliparous. All had regular menstrual cycles before treatment except one who had premature menopause. Thirty (56.6%) patients had used some form of contraception. Forty-eight patients underwent modified radical mastectomy, and five patients had breast conservative surgery. Most common histopathology was infiltrating duct carcinoma in fifty (94.3%) patients. Tumor was hormone responsive in twenty-four (45.3%) cases and triple negative in twenty one (39.6%) cases. Neo-adjuvant chemotherapy was given in four (7.5%) patients, adjuvant chemotherapy was given in fifty-one (96.2%) patients, thirty-three (62.3%) patients received adjuvant radiotherapy, and adjuvant hormone therapy was received by thirty-one (58.5%) patients. None of these patients were counseled regarding their fertility concerns, none was referred to oncofertility specialist before starting the treatment, and none was investigated for their future fertility prospects. No one was aware of fertility preservation methods. Fertility was desired by only nine (17%) patient at the time of diagnosis out of which four were nulliparous and five patients had single live issue. Conclusion In India, most women get married at early age and complete their family early. However, few patients are unable to complete their family at the time of diagnosis of breast cancer and need fertility preservation. Oncofertility counseling is of great importance to many young women diagnosed with cancer and should be managed in a multidisciplinary background. All options of fertility preservation should be discussed with them before starting treatment.

Indian Journal of Gynecologic Oncology, Jan 31, 2017

Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults.... more Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults. ES also occurs as a primary soft tissue neoplasm without involvement of bone. Usual sites of involvement are the deep soft tissues of the lower extremity and paravertebral region. Clinical or imaging findings are non-specific, and diagnosis is based on histology. We reported a rare case of an Extraosseous Ewing Sarcoma (EES) developed in the soft tissues of the anterior abdominal wall in midline position in a 63-year-old woman who presented with a painful abdominal mass. The case was suspected to be carcinoma ovary with pelvic deposits, however on laparotomy it was found to be a malignant anterior abdominal wall mass. The final diagnosis on immunohistochemical staining was EES.

The incidence and mortality rates from endometrial cancer are rising worldwide. Although there ar... more The incidence and mortality rates from endometrial cancer are rising worldwide. Although there are many chemotherapeutic and targeted therapy agents for ovarian and primary peritoneal cancers, very few therapies are available to treat advanced, recurrent, or metastatic endometrial cancer. Traditionally, therapy for endometrial cancer was based on histopathology alone. However, recent genomic studies have identified distinct molecular subtypes of endometrial cancer. These subtypes provide significant prognostic and therapeutic information. In the coming years, there is going to be an increasing reliance on the molecular and genomic features of endometrial cancers to guide treatment. Megestrol acetate has been used for several years for palliative treatment of advanced endometrial cancer. Recently, pembrolizumab has also been approved for microsatellite instability high endometrial cancers.

Infections and Pregnancy, 2022

for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early sta... more for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

Preventive Oncology for the Gynecologist, 2019

High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progr... more High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progress to frank malignancy, and therefore some form of treatment is always indicated for these lesions. Traditionally, surgery including hysterectomy, conization, or wide local excision was considered the standard of care. However, with advances in our understanding of the natural history of human papillomavirus infection and widespread use of colposcopy, conservative management of these lesions is now possible. Treatment options have now evolved to local ablative procedures for intraepithelial lesions of the cervix, vulva, and vagina. Cryotherapy is the most widely used ablative method for treating cervical intraepithelial lesions confined to the ectocervix. Laser ablation, though expensive and not commonly available, is very effective for cervical lesions extending to vaginal fornices and also for vaginal and vulvar intraepithelial neoplasias. Thermal coagulation is another tool which is gaining popularity now owing to its portability and ease of use. In this chapter, we describe the different ablative treatment options for intraepithelial lesions and their applications in clinical practice.

The incidence and mortality rates from endometrial cancer are rising worldwide. Although there ar... more The incidence and mortality rates from endometrial cancer are rising worldwide. Although there are many chemotherapeutic and targeted therapy agents for ovarian and primary peritoneal cancers, very few therapies are available to treat advanced, recurrent, or metastatic endometrial cancer. Traditionally, therapy for endometrial cancer was based on histopathology alone. However, recent genomic studies have identified distinct molecular subtypes of endometrial cancer. These subtypes provide significant prognostic and therapeutic information. In the coming years, there is going to be an increasing reliance on the molecular and genomic features of endometrial cancers to guide treatment. Megestrol acetate has been used for several years for palliative treatment of advanced endometrial cancer. Recently, pembrolizumab has also been approved for microsatellite instability high endometrial cancers.

vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4... more vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4 days vs 26.9 ± 4.6 days in the 2nd group. The recurrence rate in the 1st group was 9.53% vs 24.6% in the 2nd group, which is probably due to wider excision of the perineal tissue using reconstructive plastic surgery. Five-year survival was 76.5% in the 1st vs 56% in the 2nd group. Conclusion The use of reconstructive plastic surgery for closing of wound defects after radical vulvectomy reduces the incidence of postoperative complications and improves oncological treatment results. Disclosures None.

Indian Journal of Gynecologic Oncology, 2018

Objective To review the need for fertility preservation in young patients with breast cancer. Mat... more Objective To review the need for fertility preservation in young patients with breast cancer. Materials and Methods This retrospective study includes patients B 40 years with breast carcinoma treated at Action Cancer Hospital, New Delhi, from June 2010 to 31 July 2014. Patient age, marital status, parity, contraception use, and the need for fertility preservation were evaluated. Result Fifty-three patients were included in study with mean age 35.4 (SD: 4.1) years. Fifty (94.3%) patients were married, and four (7.5%) were nulliparous. All had regular menstrual cycles before treatment except one who had premature menopause. Thirty (56.6%) patients had used some form of contraception. Forty-eight patients underwent modified radical mastectomy, and five patients had breast conservative surgery. Most common histopathology was infiltrating duct carcinoma in fifty (94.3%) patients. Tumor was hormone responsive in twenty-four (45.3%) cases and triple negative in twenty one (39.6%) cases. Neo-adjuvant chemotherapy was given in four (7.5%) patients, adjuvant chemotherapy was given in fifty-one (96.2%) patients, thirty-three (62.3%) patients received adjuvant radiotherapy, and adjuvant hormone therapy was received by thirty-one (58.5%) patients. None of these patients were counseled regarding their fertility concerns, none was referred to oncofertility specialist before starting the treatment, and none was investigated for their future fertility prospects. No one was aware of fertility preservation methods. Fertility was desired by only nine (17%) patient at the time of diagnosis out of which four were nulliparous and five patients had single live issue. Conclusion In India, most women get married at early age and complete their family early. However, few patients are unable to complete their family at the time of diagnosis of breast cancer and need fertility preservation. Oncofertility counseling is of great importance to many young women diagnosed with cancer and should be managed in a multidisciplinary background. All options of fertility preservation should be discussed with them before starting treatment.

Indian Journal of Gynecologic Oncology, 2018

Indian Journal of Gynecologic Oncology, 2017

Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults.... more Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults. ES also occurs as a primary soft tissue neoplasm without involvement of bone. Usual sites of involvement are the deep soft tissues of the lower extremity and paravertebral region. Clinical or imaging findings are non-specific, and diagnosis is based on histology. We reported a rare case of an Extraosseous Ewing Sarcoma (EES) developed in the soft tissues of the anterior abdominal wall in midline position in a 63-year-old woman who presented with a painful abdominal mass. The case was suspected to be carcinoma ovary with pelvic deposits, however on laparotomy it was found to be a malignant anterior abdominal wall mass. The final diagnosis on immunohistochemical staining was EES.

Indian Journal of Gynecologic Oncology, 2017

Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment ... more Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment modality have not been established. Most Brenner tumors are benign, with only 1-2% being malignant. We present a case of 57-year-old women with a rare malignant Brenner tumor. She presented with complaint of abdominal pain and postmenopausal bleeding. Imaging revealed large complex solid cystic pelvic mass. She underwent staging ovarian laparotomy, and the specimen was sent for histopathological study. Histopathology revealed malignant Brenner tumor. On immunohistochemistry, tumor cells were immunoreactive for uroplakin, CK7, WT1, GATA-3 and Ki67 60% and nonimmunoreactive for CK20, favouring urothelial differentiation.

vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4... more vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4 days vs 26.9 ± 4.6 days in the 2nd group. The recurrence rate in the 1st group was 9.53% vs 24.6% in the 2nd group, which is probably due to wider excision of the perineal tissue using reconstructive plastic surgery. Five-year survival was 76.5% in the 1st vs 56% in the 2nd group. Conclusion The use of reconstructive plastic surgery for closing of wound defects after radical vulvectomy reduces the incidence of postoperative complications and improves oncological treatment results. Disclosures None.

Springer eBooks, 2019

High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progr... more High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progress to frank malignancy, and therefore some form of treatment is always indicated for these lesions. Traditionally, surgery including hysterectomy, conization, or wide local excision was considered the standard of care. However, with advances in our understanding of the natural history of human papillomavirus infection and widespread use of colposcopy, conservative management of these lesions is now possible. Treatment options have now evolved to local ablative procedures for intraepithelial lesions of the cervix, vulva, and vagina. Cryotherapy is the most widely used ablative method for treating cervical intraepithelial lesions confined to the ectocervix. Laser ablation, though expensive and not commonly available, is very effective for cervical lesions extending to vaginal fornices and also for vaginal and vulvar intraepithelial neoplasias. Thermal coagulation is another tool which is gaining popularity now owing to its portability and ease of use. In this chapter, we describe the different ablative treatment options for intraepithelial lesions and their applications in clinical practice.

Indian Journal of Gynecologic Oncology, Sep 28, 2018

Indian Journal of Gynecologic Oncology, Sep 21, 2017

Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment ... more Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment modality have not been established. Most Brenner tumors are benign, with only 1-2% being malignant. We present a case of 57-year-old women with a rare malignant Brenner tumor. She presented with complaint of abdominal pain and postmenopausal bleeding. Imaging revealed large complex solid cystic pelvic mass. She underwent staging ovarian laparotomy, and the specimen was sent for histopathological study. Histopathology revealed malignant Brenner tumor. On immunohistochemistry, tumor cells were immunoreactive for uroplakin, CK7, WT1, GATA-3 and Ki67 60% and nonimmunoreactive for CK20, favouring urothelial differentiation.

Indian Journal of Gynecologic Oncology, Mar 15, 2018

Objective To review the need for fertility preservation in young patients with breast cancer. Mat... more Objective To review the need for fertility preservation in young patients with breast cancer. Materials and Methods This retrospective study includes patients B 40 years with breast carcinoma treated at Action Cancer Hospital, New Delhi, from June 2010 to 31 July 2014. Patient age, marital status, parity, contraception use, and the need for fertility preservation were evaluated. Result Fifty-three patients were included in study with mean age 35.4 (SD: 4.1) years. Fifty (94.3%) patients were married, and four (7.5%) were nulliparous. All had regular menstrual cycles before treatment except one who had premature menopause. Thirty (56.6%) patients had used some form of contraception. Forty-eight patients underwent modified radical mastectomy, and five patients had breast conservative surgery. Most common histopathology was infiltrating duct carcinoma in fifty (94.3%) patients. Tumor was hormone responsive in twenty-four (45.3%) cases and triple negative in twenty one (39.6%) cases. Neo-adjuvant chemotherapy was given in four (7.5%) patients, adjuvant chemotherapy was given in fifty-one (96.2%) patients, thirty-three (62.3%) patients received adjuvant radiotherapy, and adjuvant hormone therapy was received by thirty-one (58.5%) patients. None of these patients were counseled regarding their fertility concerns, none was referred to oncofertility specialist before starting the treatment, and none was investigated for their future fertility prospects. No one was aware of fertility preservation methods. Fertility was desired by only nine (17%) patient at the time of diagnosis out of which four were nulliparous and five patients had single live issue. Conclusion In India, most women get married at early age and complete their family early. However, few patients are unable to complete their family at the time of diagnosis of breast cancer and need fertility preservation. Oncofertility counseling is of great importance to many young women diagnosed with cancer and should be managed in a multidisciplinary background. All options of fertility preservation should be discussed with them before starting treatment.

Indian Journal of Gynecologic Oncology, Jan 31, 2017

Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults.... more Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults. ES also occurs as a primary soft tissue neoplasm without involvement of bone. Usual sites of involvement are the deep soft tissues of the lower extremity and paravertebral region. Clinical or imaging findings are non-specific, and diagnosis is based on histology. We reported a rare case of an Extraosseous Ewing Sarcoma (EES) developed in the soft tissues of the anterior abdominal wall in midline position in a 63-year-old woman who presented with a painful abdominal mass. The case was suspected to be carcinoma ovary with pelvic deposits, however on laparotomy it was found to be a malignant anterior abdominal wall mass. The final diagnosis on immunohistochemical staining was EES.

The incidence and mortality rates from endometrial cancer are rising worldwide. Although there ar... more The incidence and mortality rates from endometrial cancer are rising worldwide. Although there are many chemotherapeutic and targeted therapy agents for ovarian and primary peritoneal cancers, very few therapies are available to treat advanced, recurrent, or metastatic endometrial cancer. Traditionally, therapy for endometrial cancer was based on histopathology alone. However, recent genomic studies have identified distinct molecular subtypes of endometrial cancer. These subtypes provide significant prognostic and therapeutic information. In the coming years, there is going to be an increasing reliance on the molecular and genomic features of endometrial cancers to guide treatment. Megestrol acetate has been used for several years for palliative treatment of advanced endometrial cancer. Recently, pembrolizumab has also been approved for microsatellite instability high endometrial cancers.

Infections and Pregnancy, 2022

for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early sta... more for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

Preventive Oncology for the Gynecologist, 2019

High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progr... more High-grade intraepithelial lesions are premalignant conditions. If left untreated, they can progress to frank malignancy, and therefore some form of treatment is always indicated for these lesions. Traditionally, surgery including hysterectomy, conization, or wide local excision was considered the standard of care. However, with advances in our understanding of the natural history of human papillomavirus infection and widespread use of colposcopy, conservative management of these lesions is now possible. Treatment options have now evolved to local ablative procedures for intraepithelial lesions of the cervix, vulva, and vagina. Cryotherapy is the most widely used ablative method for treating cervical intraepithelial lesions confined to the ectocervix. Laser ablation, though expensive and not commonly available, is very effective for cervical lesions extending to vaginal fornices and also for vaginal and vulvar intraepithelial neoplasias. Thermal coagulation is another tool which is gaining popularity now owing to its portability and ease of use. In this chapter, we describe the different ablative treatment options for intraepithelial lesions and their applications in clinical practice.

The incidence and mortality rates from endometrial cancer are rising worldwide. Although there ar... more The incidence and mortality rates from endometrial cancer are rising worldwide. Although there are many chemotherapeutic and targeted therapy agents for ovarian and primary peritoneal cancers, very few therapies are available to treat advanced, recurrent, or metastatic endometrial cancer. Traditionally, therapy for endometrial cancer was based on histopathology alone. However, recent genomic studies have identified distinct molecular subtypes of endometrial cancer. These subtypes provide significant prognostic and therapeutic information. In the coming years, there is going to be an increasing reliance on the molecular and genomic features of endometrial cancers to guide treatment. Megestrol acetate has been used for several years for palliative treatment of advanced endometrial cancer. Recently, pembrolizumab has also been approved for microsatellite instability high endometrial cancers.

vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4... more vs 44.6% in the 2nd group. The hospital stay was significantly less: in the 1st group: 18.8 ± 1.4 days vs 26.9 ± 4.6 days in the 2nd group. The recurrence rate in the 1st group was 9.53% vs 24.6% in the 2nd group, which is probably due to wider excision of the perineal tissue using reconstructive plastic surgery. Five-year survival was 76.5% in the 1st vs 56% in the 2nd group. Conclusion The use of reconstructive plastic surgery for closing of wound defects after radical vulvectomy reduces the incidence of postoperative complications and improves oncological treatment results. Disclosures None.

Indian Journal of Gynecologic Oncology, 2018

Objective To review the need for fertility preservation in young patients with breast cancer. Mat... more Objective To review the need for fertility preservation in young patients with breast cancer. Materials and Methods This retrospective study includes patients B 40 years with breast carcinoma treated at Action Cancer Hospital, New Delhi, from June 2010 to 31 July 2014. Patient age, marital status, parity, contraception use, and the need for fertility preservation were evaluated. Result Fifty-three patients were included in study with mean age 35.4 (SD: 4.1) years. Fifty (94.3%) patients were married, and four (7.5%) were nulliparous. All had regular menstrual cycles before treatment except one who had premature menopause. Thirty (56.6%) patients had used some form of contraception. Forty-eight patients underwent modified radical mastectomy, and five patients had breast conservative surgery. Most common histopathology was infiltrating duct carcinoma in fifty (94.3%) patients. Tumor was hormone responsive in twenty-four (45.3%) cases and triple negative in twenty one (39.6%) cases. Neo-adjuvant chemotherapy was given in four (7.5%) patients, adjuvant chemotherapy was given in fifty-one (96.2%) patients, thirty-three (62.3%) patients received adjuvant radiotherapy, and adjuvant hormone therapy was received by thirty-one (58.5%) patients. None of these patients were counseled regarding their fertility concerns, none was referred to oncofertility specialist before starting the treatment, and none was investigated for their future fertility prospects. No one was aware of fertility preservation methods. Fertility was desired by only nine (17%) patient at the time of diagnosis out of which four were nulliparous and five patients had single live issue. Conclusion In India, most women get married at early age and complete their family early. However, few patients are unable to complete their family at the time of diagnosis of breast cancer and need fertility preservation. Oncofertility counseling is of great importance to many young women diagnosed with cancer and should be managed in a multidisciplinary background. All options of fertility preservation should be discussed with them before starting treatment.

Indian Journal of Gynecologic Oncology, 2018

Indian Journal of Gynecologic Oncology, 2017

Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults.... more Ewing's sarcoma (ES) is the second most common malignant bone tumor in children and young adults. ES also occurs as a primary soft tissue neoplasm without involvement of bone. Usual sites of involvement are the deep soft tissues of the lower extremity and paravertebral region. Clinical or imaging findings are non-specific, and diagnosis is based on histology. We reported a rare case of an Extraosseous Ewing Sarcoma (EES) developed in the soft tissues of the anterior abdominal wall in midline position in a 63-year-old woman who presented with a painful abdominal mass. The case was suspected to be carcinoma ovary with pelvic deposits, however on laparotomy it was found to be a malignant anterior abdominal wall mass. The final diagnosis on immunohistochemical staining was EES.

Indian Journal of Gynecologic Oncology, 2017

Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment ... more Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment modality have not been established. Most Brenner tumors are benign, with only 1-2% being malignant. We present a case of 57-year-old women with a rare malignant Brenner tumor. She presented with complaint of abdominal pain and postmenopausal bleeding. Imaging revealed large complex solid cystic pelvic mass. She underwent staging ovarian laparotomy, and the specimen was sent for histopathological study. Histopathology revealed malignant Brenner tumor. On immunohistochemistry, tumor cells were immunoreactive for uroplakin, CK7, WT1, GATA-3 and Ki67 60% and nonimmunoreactive for CK20, favouring urothelial differentiation.