Shubha Jayaram - Academia.edu (original) (raw)

Papers by Shubha Jayaram

Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism where, underu... more Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism where, underutilization of glucose is associated with changes in lipid profile. Lipoprotein (a)

International Journal of Clinical Biochemistry and Research, 2014

Psoriasis is a chronic, inflammatory skin disease characterized by epidermal hyper proliferation,... more Psoriasis is a chronic, inflammatory skin disease characterized by epidermal hyper proliferation, differentiation and lymphocytic infiltration predominantly of T lymphocytes. Evidence have shown that psoriasis is an independent risk factor for cardiovascular diseases. hs-CRP is an acute phase reactant and best biomarker of inflammation that has been associated with cardiovascular disease(CVD) risk .Hence this study was undertaken to evaluate hs-CRP, lipid profile and Novel Lipid Indices in psoriatic patients. Materials and Methods: The study group consisted of 47 psoriasis cases and 47 healthy controls. PASI (Psoriasis Area and Severity Index) Score was done to assess severity of Psoriasis. Lipid profile (Total Cholesterol, Triglycerides, LDL and HDL) was measured in fully automated analyser. hs-CRP was measured by immuno turbidimetric method. Statistical analysis was done by using SPSS-16 version. Results: Statistically significant (p

Background: Human obesity is strongly associated with cardio metabolic disease. Cystatin C is a n... more Background: Human obesity is strongly associated with cardio metabolic disease. Cystatin C is a naturally occurring protease inhibitor and marker of cardiovascular disease. The main objective of present study was to estimate the serum levels of Cystatin C in individuals with normal BMI, and obese, aged between 18-39 Yrs and to compare the levels of serum Cystatin C among these individuals and to correlate the levels of serum Cystatin C with cardio metabolic risk factors. Material & Methods: The study population was taken from healthy volunteers of Mysore city, aged between 1839 years of either sex. The study population was divided into 2 groups based on BMI. Each group contains sample size of 45. Fasting serum sample was analyzed for Blood glucose, Total cholesterol, Total Triglycerides, Direct HDL cholesterol, Direct LDL Cholesterol by enzymatic method and serum Cystatin-C by immunoturbidimetric method using auto analyser. Results: The serum Cystatin C levels was significantly incr...

The Journal of medical research, 2015

Objectives: To Evaluate and compare lipoprotein(a) [Lp(a)], lipid profile and novel lipid indices... more Objectives: To Evaluate and compare lipoprotein(a) [Lp(a)], lipid profile and novel lipid indices in chronic kidney disease(CKD) patients undergoing hemodialysis with healthy controls. To find the correlation between Lp(a) with novel lipid indices. Methodology: The study group included 30 patients with CKD andage and sex matched 30 healthy controls were selected for the study. Lp(a) was estimated by immunoturbidimetric method. Lipid profile by enzymatic method. Lipid indices were calculated using appropriate formula. Results: There was significant increase in Lp (a)(p<0.000), triglyceride(p<0.05) and LDL-Cholesterol levels in cases compared to controls. Atherogenic index of plasma (AIP), Lipid tetrad index (LTI), Castellis risk index–2(CRI2) and Atherogenic co-efficient were also significantly increased in cases compared to controls but there was no significant increase in Castellis risk index – 1(CRI1). AIP showed significant positive correlation with Lp(a). Conclusion: The p...

Prevention of diabetes and its associated burden has become a major health issue worldwide. The p... more Prevention of diabetes and its associated burden has become a major health issue worldwide. The present study was undertaken to assess the changes in insulin sensitivity and endothelial dysfunction well before the onset of diabetes in population with positive family history for diabetes. The objectives of the study is to estimate the levels of serum Adiponectin, Visfatin, Insulin, HOMA IR and platelet derived microparticles P-selectin levels in offspring of type 2 Diabetes mellitus. The healthy volunteers who are aged between 1822 years of either sex, were selected based on their family history of diabetes. The study showed a significant decrease in serum Adiponectin and increase in serum Visfatin, Insulin, HOMA IR & P-selectin levels in the offspring of type 2diabetes. The Adiponectin showed a negative correlation with Visfatin, P selectin, Insulin & HOMA IR. Genetic predisposition for diabetes may influence adipocytokine levels which might play a key role in developing diabetes in...

Journal of Evidence Based Medicine and Healthcare, 2015

INTRODUCTION: Thyroid hormone is a central regulator of body haemodynamic, thermoregulation and m... more INTRODUCTION: Thyroid hormone is a central regulator of body haemodynamic, thermoregulation and metabolism. The effect of thyroid hormones on lipid metabolism is well known, whereas the effect on electrolytes and minerals has not been well established and also the underlying mechanisms not well understood. Thyroid hormones regulate the activity of sodium potassium pumps in most of the tissues. The higher prevalence of thyroid disease in women suggests that estrogen might be involved in the pathophysiology of thyroid dysfunction. With this background the present study was undertaken to assess the alterations in the levels of serum electrolytes in hyperthyroid, hypothyroid & euthyroid female patients. MATERIAL AND METHODS: The present study was conducted in female patients who attended medicine outpatient Department of S. N. Medical College & HSK Hospital, Bagalkot. Thyroid hormones were estimated by chemiluminiscence method. Electrolyte levels (Na, k & Cl) were measured by ion select...

The Lancet Oncology, 2021

Background In estimating the global burden of cancer, adolescents and young adults with cancer ar... more Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability we...

Background: Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism. ... more Background: Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism. Also it is proposed thatunderutilization of glucose is associated with changes in lipid profile. Lipoprotein (a) [Lp (a)] is regarded as an independent indicator of risk development of vascular disease which is also a diabetic complication. Changes in lipid profile are also well related with severity of DM as adjudged by glycated Hb (HbA1c). Objectives: The study intends to find the association between Lipid profile, Lp (a) and HbA1c levels in type 2 diabetic patients. Methods: A case-control study was conducted in Adichunchanagiri Institute of Medical Sciences, B.G.Nagara, Karnataka from 1 Jan to 15 June 2012. Study involved 80 participants of which 40 were patients admitted with diagnosis of DM and other 40 were healthy controls. Blood samples were collected in fasting state and analyzed for FBS, PPBS, HbA1c, TAG, VLDL, HDL, LDL and Lp(a) and values were tabulated for statistical evalu...

Background & Objectives: Gestational Diabetes Mellitus (GDM) is one of the most common medical co... more Background & Objectives: Gestational Diabetes Mellitus (GDM) is one of the most common medical complications of pregnancy. Complement 3(C3) is the central component of the complement system which induce inflammatory, immunomodulatory and metabolic responses. This passive immunity acquired by the fetus is crucial for the adaptation of the newborn to the extra uterine environment, providing protection against infections. The Objectives of the present study was to estimate the serum levels of complement3 (C3) & Immunoglobin (Ig) G in Gestational Diabetic and their newborns, and to compare the above parameters with normal pregnant females and their newborns. Material & Methods: Total 90 pregnant females aged between 20-40yrs with regular antenatal care at Cheluvamba Hospital & Mission Hospital, Mysore, were included in the study. Out of 90, 45 were diagnosed with gestational diabetes. About 4ml of blood sample was collected from the mother during the time of labour and 4ml of cord blood...

Background: According to foetal origin hypothesis, atherosclerosis originates during foetal perio... more Background: According to foetal origin hypothesis, atherosclerosis originates during foetal period. Studies have shown an enhanced rate of coronary heart disease among men and women whose birth weights were at a lower end of normal range. Objectives: 1) to compare lipid profile of umbilical cord blood of preterm and term neonates. 2) To compare lipid profile between male and female preterm neonates. 3) To determine Atherogenic Index of Plasma (AIP) and compare the obtained values between preterm and term neonates. Methodology: A case-control study was conducted in OBG Department, Cheluvamba Hospital, from June 2014 to July 2014. All the preterm deliveries reported during this period were included in the study. Gender matched term babies were selected as controls. The proforma included sociodemographic profile, obstetric history and cord blood lipid profile among preterm and term neonates. Results: The mean gestational age in term and preterm neonates was 39.16 ± 1.01 weeks and 33.13...

Background: Coronary Artery Disease is the leading cause of death worldwide and LDL has been reco... more Background: Coronary Artery Disease is the leading cause of death worldwide and LDL has been recommended as the primary lipid subset for prediction of risk of CAD NCEP guidelines. Many assays have been developed for measurement of LDL levels and have shown reasonable accuracy as compared to reference method but still not cost effective and cannot be affordable by majority of laboratories. Laboratories use the cost effective Friedewald’s formula for calculating the LDL instead of direct assay which give near to accurate value but has its own limitations. In recent days many newer formulae have come up with lesser limitations and here an attempt is made to evaluate these formulae and to correlate with direct measurement of LDL. Methodology: It’s a cross sectional study. Sampling technique is Census method and involves sample size of 1020 cases. The entire lipid Parameters (LDL, HDL, TC, and TG) were estimated using Kits purchased by Roche /Cobas and then LDL also calculated using vari...

Background: There is much evidence suggesting that nutrition and nutritional factors, especially ... more Background: There is much evidence suggesting that nutrition and nutritional factors, especially the trace elements zinc and copper may play a role in the formation of human cataract, a disease that is on the increase due to the growing percentage of elderly persons in the world population. Objectives: The present study was done to estimate levels of antioxidant trace elements zinc and copper in the serum samples of senile mature cataract patients. Methods: This is a case control study carried out in the Department of Biochemistry, PES Institute of Medical Sciences & Research, Kuppam, Chittoor district, Andhra Pradesh. 30 senile mature cataract patients and 30 normal age and sex matched controls were selected for the study. Serum zinc and copper levels were measured in above groups. Results: Serum Zinc levels in senile mature cataract patients was 126.63+78.40 µg/dl and in controls 131.01 + 90.2 µg/dl. serum copper levels in senile mature cataract patients was 85.82 ± 48.1 µg/dl and...

Introduction: Pregnancy Induced Hypertension (PIH) is a leading cause of fetal growth retardation... more Introduction: Pregnancy Induced Hypertension (PIH) is a leading cause of fetal growth retardation, infant morbidity, mortality and maternal death. Despite extensive research, there is a limited knowledge of pathophysiology and etiology of PIH. Recent studies have suggested the role of oxidative stress and altered endothelial function in PIH. However, there are very limited studies concerning the antioxidant status throughout normal gestation and in PIH. Aim: To determine the levels of antioxidants Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) in normal pregnancy and in pregnancy induced hypertension. Also, to compare the levels of these antioxidants with controls. Materials and Methods: 30 non pregnant healthy controls, 30 normal pregnant females and 30 pregnant females with PIH of age group 18-35 years were evaluated for antioxidant levels in blood. Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) levels were estimated in erythrocytes and compared with cont...

International Journal of Clinical Biochemistry and Research, 2014

The Journal of medical research, 2015

Journal of Evidence Based Medicine and Healthcare, 2015

The Lancet Oncology, 2021