Shuchi Mehta - Academia.edu (original) (raw)

Papers by Shuchi Mehta

Flavonoid Metabolism - Recent Advances and Applications in Crop Breeding [Working Title]

Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical... more Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical, and medicinal applications. They play a crucial role in life span shortening complications, including diabetes, CVS disorder, and cancer. They are the secondary metabolites essential natural products due to their anti-inflammatory, antioxidant, anticancer, anti-cholinesterase, disease combating, antimicrobial, hepatoprotective, neuroprotective, cardioprotective, antiallergic, and many more pharmacological activities causing substantial economic and social burdens. They have the ability to scavenge superoxide, hydroxyl, and lipid radicals. They are a group of polyphenolic compounds having 15 carbon skeleton consisting of two benzene rings with heterocyclic pyran ring, which are classified as anthocyanins, flavonols, isoflavonols, and flavanones, and present in vegetables, fruits, flowers, seeds, stems, and leaves.

Advance Pharmaceutical Journal

Flavonoid Metabolism - Recent Advances and Applications in Crop Breeding [Working Title]

Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical... more Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical, and medicinal applications. They play a crucial role in life span shortening complications, including diabetes, CVS disorder, and cancer. They are the secondary metabolites essential natural products due to their anti-inflammatory, antioxidant, anticancer, anti-cholinesterase, disease combating, antimicrobial, hepatoprotective, neuroprotective, cardioprotective, antiallergic, and many more pharmacological activities causing substantial economic and social burdens. They have the ability to scavenge superoxide, hydroxyl, and lipid radicals. They are a group of polyphenolic compounds having 15 carbon skeleton consisting of two benzene rings with heterocyclic pyran ring, which are classified as anthocyanins, flavonols, isoflavonols, and flavanones, and present in vegetables, fruits, flowers, seeds, stems, and leaves.

Management and Labour Studies, 2004

Impact of organizational culture (strong and weak) and use of influence tactics (soft and hard) o... more Impact of organizational culture (strong and weak) and use of influence tactics (soft and hard) on transformational leadership was studied using a 2 × 2 experimental design and a sample of 120 executives in a large manufacturing firm in eastern India. Results of analyses of variance show that leaders are seen as more transformational if the organizational culture is strong rather than weak, and if leaders use soft influence tactics rather than hard tactics. Transformational leadership is the highest when soft tactics are used in a strong culture, and the lowest when hard tactics are used in a weak culture.

Artificial cells, nanomedicine, and biotechnology, Jan 16, 2015

The present study aimed to develop lipid-polymer hybrid nanoparticles (LPNs) for the combined pul... more The present study aimed to develop lipid-polymer hybrid nanoparticles (LPNs) for the combined pulmonary delivery of isoniazid (INH) and ciprofloxacin hydrochloride (CIP HCl). Drug-loaded LPNs were prepared by the double-emulsification solvent evaporation method using the three-factor three-level Box-Behnken design. The optimized formulation had a size of 111.81 ± 1.2 nm, PDI of 0.189 ± 1.4, and PDE of 63.64 ± 2.12% for INH-loaded LPN, and a size of 172.23 ± 2.31 nm, PDI of 0.169 ± 1.23, and PDE of 68.49 ± 2.54% for CIP HCl-loaded LPN. Drug release was found to be sustained and controlled at lower pH and followed the Peppas model. The in vitro uptake study in alveolar macrophage (AM) showed that uptake of the drugs was increased significantly if administered in the form of LPN. The stability study proved the applications of adding PLGA in LPN as the polymeric core, which leads to a much more stable product as compared to other novel drug delivery systems. Spray drying was done to pro...

Journal of Molecular Catalysis, 1990

Abstract Mononuclear ruthenium (III) complexes [Ru (H-dmg) 2 XY] n (n=− 1, when X= Y= Cl− or ClO ... more Abstract Mononuclear ruthenium (III) complexes [Ru (H-dmg) 2 XY] n (n=− 1, when X= Y= Cl− or ClO 4− n= 0 when X= Cl− and Y= imidazole or 2-methylimidazole) were used as catalysts in water oxidation to molecular oxygen by electrolytic and chemical methods. ...

Artificial Cells, Nanomedicine, and Biotechnology, 2013

Objectives: Development of controlled and sustained drug delivery system (DDS) remains a great th... more Objectives: Development of controlled and sustained drug delivery system (DDS) remains a great thrust of human beings for the successful delivery of drugs due to various drawbacks of existing systems. In order to overcome these drawbacks, various stimuli-sensitive DDSs were developed in the recent years. Key findings: Stimuli are a state of responsiveness to sensory stimulation or excitability. Stimuli sensitive systems are those systems which deal with the changes in the physiology of body with respective to the environment changes. These systems may be very beneficial for the controlled and sustained delivery of drug in the body if proper work would be carried out on these types of systems. Controlled drug delivery became the standard criteria in modern pharmaceutical product design and an intensive research is still going on in achieving much better drug product with features like effectiveness, reliability, and safety. Many changes like photo and light, temperature, pH, ion, glucose, and redox affect the release of drug from the delivery system. These stimuli-sensitive systems are used for various purposes in various forms like in parenteral, ocular, peroral, rectal, vaginal, nasal, dermal and transdermal drug delivery. Summary: Various literature surveys revealed that stimuli-sensitive DDSs can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional techniques.

Journal of Plant Biochemistry and Biotechnology, 1994

The strain BYK1, capable of utilizing DAP or OX-DAPRO as a sole source of nitrogen and carbon was... more The strain BYK1, capable of utilizing DAP or OX-DAPRO as a sole source of nitrogen and carbon was identified as Pseudomonas stutzeri by various microbial and biochemical tests. Transformation experiments showed that the OX-DAPRO utilization property is encoded by the plasmid. ...

Drug Delivery, 2014

Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natu... more Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels.

The term “herbal drugs” word means by sources plant or part of plants that are used for the treat... more The term “herbal drugs” word means by sources plant or part of plants that are used for the treatment of various diseases, in terms of phyto-pharmaceuticals. Firstly it collectcoll or harvesting, drying, storage and then isolated and used (EMEA et al., 1998). The use of herbal drugs as medicine in the earliest form of healthcare known to delicacy and it is used in all cultures throughout history. Ancient humans well known their dependence on nature for a good healthy life and since that time humankind depended on the variety of plant resources for food, shelter, clothing and medicine to cure immensurable of diseases. The first written records explaining the use of plant in the healing of Mesopotamian clay tablet writing and Egyptian papyrus. Led by nature, taste and experience, primeval men and women cured illness by using plant parts, animal parts and minerals that were not a part of usual diet. Primeval persons learned by trial and error basis to identified beneficial plants with ...

Ginseng in Medicine [Working Title], 2021

Ginseng, the root of Panax species is a well-known conventional and perennial herb belonging to A... more Ginseng, the root of Panax species is a well-known conventional and perennial herb belonging to Araliaceae of various countries China, Korea, and Japan that is also known as the king of all herbs and famous for many years worldwide. It is a short underground rhizome that is associated with the fleshy root. Pharmacognostic details of cultivation and collection with different morphological characters are discussed. Phytocontent present is saponins glycosides, carbohydrates, polyacetylenes, phytosterols, nitrogenous substances, amino acids, peptides, vitamins, volatile oil, minerals, and enzymes details are discussed. The main focusing of the bioactive constituent of ginseng is ginsenosides are triterpenoid saponin glycosides having multifunctional pharmacological activities including anticancer, anti-inflammatory, antimicrobial, antioxidant and many more will be discussed. Ginseng is helpful in the treatment of microbial infection, inflammation, oxidative stress, diabetes, and obesity...

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of the present study is to evaluate in vitro anticancer property and ph... more Objective: The objective of the present study is to evaluate in vitro anticancer property and phytochemical analysis using liquid chromatography and mass spectroscopy (LCMS) method of hydroalcoholic extract of seeds of Annona squamosa (AS) Linn. Seeds of AS Linn. are traditional medicine treating various diseases and have shown anticancer activity. Due to lack of survival benefit, cancer is a deadly global disease.Method: The anticancer activity was evaluated using the sulforhodamine B assay method on five cancer cell lines: Breast cancer cell line, cervix cancer cell line (SiHa), colon cancer cell line (HT)-29, liver cancer cell line, and ovary cancer cell line (Ovcar). The phytochemical analysis was performed using LCMS method.Result: The phytochemical characterization was done using LCMS method which showed 15 different molecular weight compounds. The extract showed an average in vitro anticancer activity at a concentration of 100 μg/ml against all cancer cell lines. The best ac...

International Journal of Pharmacognosy and Phytochemical Research

Ethnopharmacological Relevance: Traditionally, Annona Sqamosa Linn. has been used for treatment o... more Ethnopharmacological Relevance: Traditionally, Annona Sqamosa Linn. has been used for treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice and other liver related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Sqamosa (AS) seeds. Aim of the study: The main objective of study is to evaluate hepatoprotective activity of the hydroalcoholic extract of seeds of Annona Squamosa Linn. using the carbon tetrachloride induced liver toxicity in rats. Material and methods: The activity was evaluated against carbon tetrachloride induced hepatotoxicity by measuring the levels of serum enzymes such as SGOT, ALP, SGPT and total bilirubin for liver function tests. Six groups of rats were used (n=6) and administered orally once daily with normal saline (normal control), carbon tetrachloride (toxic control), or ASE (100, 200, and 400 mg/kg) for 7 days, followed by the hepatotoxicity induction. Results: The extract showed significant hepatop...

Advance Pharmaceutical Journal

Artificial Cells, Nanomedicine, and Biotechnology, 2014

The present study aimed to develop a kinetically stable nanoemulsion of artemether with improved ... more The present study aimed to develop a kinetically stable nanoemulsion of artemether with improved solubility, stability and oral bioavailability. Nanoemulsion was prepared by ultrasonication technique using internal oil phase (consisted of the drug dissolved in coconut oil and span 80) and external phase (comprising tween 80 and ethanol dissolved in water). The formulations were optimized using various parameters like percentage transmittance, refractive index, drug content, viscosity, zeta potential and release rate. Stability studies were conducted for a period of 90 days using stability chambers. In vivo studies of the developed formulations were conducted on Wistar rats and data were analyzed statistically. The nanoemulsion as observed under transmission electron microscope were found to be spherical in shape with an average size of 79.0 nm and a zeta potential of -15 mV which indicated of good electrokinetic stability of nanoemulsion . Nanoemulsion was found to be clear and transparent in appearance with a percentage transmittance of 98.2. Refractive index of 1.32 of the nanoemulsion indicated the isotropic nature of the drug. Release rate of the drug from the nanoemulsion formulation was found to be quite significant (P < 0.001) as compared to the plain drug. In vivo oral bioavailability of the nanoemulsion formulation was found to be 2.6-fold higher than the plain drug (˜ 40%) as observed from pharmacokinetic studies. Thus it was observed that nanoemulsion proved itself as a promising alternate for improving the bioavailability of artemether.

Flavonoid Metabolism - Recent Advances and Applications in Crop Breeding [Working Title]

Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical... more Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical, and medicinal applications. They play a crucial role in life span shortening complications, including diabetes, CVS disorder, and cancer. They are the secondary metabolites essential natural products due to their anti-inflammatory, antioxidant, anticancer, anti-cholinesterase, disease combating, antimicrobial, hepatoprotective, neuroprotective, cardioprotective, antiallergic, and many more pharmacological activities causing substantial economic and social burdens. They have the ability to scavenge superoxide, hydroxyl, and lipid radicals. They are a group of polyphenolic compounds having 15 carbon skeleton consisting of two benzene rings with heterocyclic pyran ring, which are classified as anthocyanins, flavonols, isoflavonols, and flavanones, and present in vegetables, fruits, flowers, seeds, stems, and leaves.

Advance Pharmaceutical Journal

Flavonoid Metabolism - Recent Advances and Applications in Crop Breeding [Working Title]

Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical... more Flavonoids are broad-spectrum secondary metabolites with cosmetics, pharmaceutical, nutraceutical, and medicinal applications. They play a crucial role in life span shortening complications, including diabetes, CVS disorder, and cancer. They are the secondary metabolites essential natural products due to their anti-inflammatory, antioxidant, anticancer, anti-cholinesterase, disease combating, antimicrobial, hepatoprotective, neuroprotective, cardioprotective, antiallergic, and many more pharmacological activities causing substantial economic and social burdens. They have the ability to scavenge superoxide, hydroxyl, and lipid radicals. They are a group of polyphenolic compounds having 15 carbon skeleton consisting of two benzene rings with heterocyclic pyran ring, which are classified as anthocyanins, flavonols, isoflavonols, and flavanones, and present in vegetables, fruits, flowers, seeds, stems, and leaves.

Management and Labour Studies, 2004

Impact of organizational culture (strong and weak) and use of influence tactics (soft and hard) o... more Impact of organizational culture (strong and weak) and use of influence tactics (soft and hard) on transformational leadership was studied using a 2 × 2 experimental design and a sample of 120 executives in a large manufacturing firm in eastern India. Results of analyses of variance show that leaders are seen as more transformational if the organizational culture is strong rather than weak, and if leaders use soft influence tactics rather than hard tactics. Transformational leadership is the highest when soft tactics are used in a strong culture, and the lowest when hard tactics are used in a weak culture.

Artificial cells, nanomedicine, and biotechnology, Jan 16, 2015

The present study aimed to develop lipid-polymer hybrid nanoparticles (LPNs) for the combined pul... more The present study aimed to develop lipid-polymer hybrid nanoparticles (LPNs) for the combined pulmonary delivery of isoniazid (INH) and ciprofloxacin hydrochloride (CIP HCl). Drug-loaded LPNs were prepared by the double-emulsification solvent evaporation method using the three-factor three-level Box-Behnken design. The optimized formulation had a size of 111.81 ± 1.2 nm, PDI of 0.189 ± 1.4, and PDE of 63.64 ± 2.12% for INH-loaded LPN, and a size of 172.23 ± 2.31 nm, PDI of 0.169 ± 1.23, and PDE of 68.49 ± 2.54% for CIP HCl-loaded LPN. Drug release was found to be sustained and controlled at lower pH and followed the Peppas model. The in vitro uptake study in alveolar macrophage (AM) showed that uptake of the drugs was increased significantly if administered in the form of LPN. The stability study proved the applications of adding PLGA in LPN as the polymeric core, which leads to a much more stable product as compared to other novel drug delivery systems. Spray drying was done to pro...

Journal of Molecular Catalysis, 1990

Abstract Mononuclear ruthenium (III) complexes [Ru (H-dmg) 2 XY] n (n=− 1, when X= Y= Cl− or ClO ... more Abstract Mononuclear ruthenium (III) complexes [Ru (H-dmg) 2 XY] n (n=− 1, when X= Y= Cl− or ClO 4− n= 0 when X= Cl− and Y= imidazole or 2-methylimidazole) were used as catalysts in water oxidation to molecular oxygen by electrolytic and chemical methods. ...

Artificial Cells, Nanomedicine, and Biotechnology, 2013

Objectives: Development of controlled and sustained drug delivery system (DDS) remains a great th... more Objectives: Development of controlled and sustained drug delivery system (DDS) remains a great thrust of human beings for the successful delivery of drugs due to various drawbacks of existing systems. In order to overcome these drawbacks, various stimuli-sensitive DDSs were developed in the recent years. Key findings: Stimuli are a state of responsiveness to sensory stimulation or excitability. Stimuli sensitive systems are those systems which deal with the changes in the physiology of body with respective to the environment changes. These systems may be very beneficial for the controlled and sustained delivery of drug in the body if proper work would be carried out on these types of systems. Controlled drug delivery became the standard criteria in modern pharmaceutical product design and an intensive research is still going on in achieving much better drug product with features like effectiveness, reliability, and safety. Many changes like photo and light, temperature, pH, ion, glucose, and redox affect the release of drug from the delivery system. These stimuli-sensitive systems are used for various purposes in various forms like in parenteral, ocular, peroral, rectal, vaginal, nasal, dermal and transdermal drug delivery. Summary: Various literature surveys revealed that stimuli-sensitive DDSs can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional techniques.

Journal of Plant Biochemistry and Biotechnology, 1994

The strain BYK1, capable of utilizing DAP or OX-DAPRO as a sole source of nitrogen and carbon was... more The strain BYK1, capable of utilizing DAP or OX-DAPRO as a sole source of nitrogen and carbon was identified as Pseudomonas stutzeri by various microbial and biochemical tests. Transformation experiments showed that the OX-DAPRO utilization property is encoded by the plasmid. ...

Drug Delivery, 2014

Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natu... more Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels.

The term “herbal drugs” word means by sources plant or part of plants that are used for the treat... more The term “herbal drugs” word means by sources plant or part of plants that are used for the treatment of various diseases, in terms of phyto-pharmaceuticals. Firstly it collectcoll or harvesting, drying, storage and then isolated and used (EMEA et al., 1998). The use of herbal drugs as medicine in the earliest form of healthcare known to delicacy and it is used in all cultures throughout history. Ancient humans well known their dependence on nature for a good healthy life and since that time humankind depended on the variety of plant resources for food, shelter, clothing and medicine to cure immensurable of diseases. The first written records explaining the use of plant in the healing of Mesopotamian clay tablet writing and Egyptian papyrus. Led by nature, taste and experience, primeval men and women cured illness by using plant parts, animal parts and minerals that were not a part of usual diet. Primeval persons learned by trial and error basis to identified beneficial plants with ...

Ginseng in Medicine [Working Title], 2021

Ginseng, the root of Panax species is a well-known conventional and perennial herb belonging to A... more Ginseng, the root of Panax species is a well-known conventional and perennial herb belonging to Araliaceae of various countries China, Korea, and Japan that is also known as the king of all herbs and famous for many years worldwide. It is a short underground rhizome that is associated with the fleshy root. Pharmacognostic details of cultivation and collection with different morphological characters are discussed. Phytocontent present is saponins glycosides, carbohydrates, polyacetylenes, phytosterols, nitrogenous substances, amino acids, peptides, vitamins, volatile oil, minerals, and enzymes details are discussed. The main focusing of the bioactive constituent of ginseng is ginsenosides are triterpenoid saponin glycosides having multifunctional pharmacological activities including anticancer, anti-inflammatory, antimicrobial, antioxidant and many more will be discussed. Ginseng is helpful in the treatment of microbial infection, inflammation, oxidative stress, diabetes, and obesity...

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of the present study is to evaluate in vitro anticancer property and ph... more Objective: The objective of the present study is to evaluate in vitro anticancer property and phytochemical analysis using liquid chromatography and mass spectroscopy (LCMS) method of hydroalcoholic extract of seeds of Annona squamosa (AS) Linn. Seeds of AS Linn. are traditional medicine treating various diseases and have shown anticancer activity. Due to lack of survival benefit, cancer is a deadly global disease.Method: The anticancer activity was evaluated using the sulforhodamine B assay method on five cancer cell lines: Breast cancer cell line, cervix cancer cell line (SiHa), colon cancer cell line (HT)-29, liver cancer cell line, and ovary cancer cell line (Ovcar). The phytochemical analysis was performed using LCMS method.Result: The phytochemical characterization was done using LCMS method which showed 15 different molecular weight compounds. The extract showed an average in vitro anticancer activity at a concentration of 100 μg/ml against all cancer cell lines. The best ac...

International Journal of Pharmacognosy and Phytochemical Research

Ethnopharmacological Relevance: Traditionally, Annona Sqamosa Linn. has been used for treatment o... more Ethnopharmacological Relevance: Traditionally, Annona Sqamosa Linn. has been used for treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice and other liver related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Sqamosa (AS) seeds. Aim of the study: The main objective of study is to evaluate hepatoprotective activity of the hydroalcoholic extract of seeds of Annona Squamosa Linn. using the carbon tetrachloride induced liver toxicity in rats. Material and methods: The activity was evaluated against carbon tetrachloride induced hepatotoxicity by measuring the levels of serum enzymes such as SGOT, ALP, SGPT and total bilirubin for liver function tests. Six groups of rats were used (n=6) and administered orally once daily with normal saline (normal control), carbon tetrachloride (toxic control), or ASE (100, 200, and 400 mg/kg) for 7 days, followed by the hepatotoxicity induction. Results: The extract showed significant hepatop...

Advance Pharmaceutical Journal

Artificial Cells, Nanomedicine, and Biotechnology, 2014

The present study aimed to develop a kinetically stable nanoemulsion of artemether with improved ... more The present study aimed to develop a kinetically stable nanoemulsion of artemether with improved solubility, stability and oral bioavailability. Nanoemulsion was prepared by ultrasonication technique using internal oil phase (consisted of the drug dissolved in coconut oil and span 80) and external phase (comprising tween 80 and ethanol dissolved in water). The formulations were optimized using various parameters like percentage transmittance, refractive index, drug content, viscosity, zeta potential and release rate. Stability studies were conducted for a period of 90 days using stability chambers. In vivo studies of the developed formulations were conducted on Wistar rats and data were analyzed statistically. The nanoemulsion as observed under transmission electron microscope were found to be spherical in shape with an average size of 79.0 nm and a zeta potential of -15 mV which indicated of good electrokinetic stability of nanoemulsion . Nanoemulsion was found to be clear and transparent in appearance with a percentage transmittance of 98.2. Refractive index of 1.32 of the nanoemulsion indicated the isotropic nature of the drug. Release rate of the drug from the nanoemulsion formulation was found to be quite significant (P < 0.001) as compared to the plain drug. In vivo oral bioavailability of the nanoemulsion formulation was found to be 2.6-fold higher than the plain drug (˜ 40%) as observed from pharmacokinetic studies. Thus it was observed that nanoemulsion proved itself as a promising alternate for improving the bioavailability of artemether.