Shugo Suwazono - Academia.edu (original) (raw)

Papers by Shugo Suwazono

Intractable & Rare Diseases Research, 2018

Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is a motor an... more Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is a motor and sensory neuronopathy with autosomal dominant inheritance, adult onset, slowly progressive course, and is associated with TRK-fused gene (TFG) mutation. At advanced stages, respiratory failure and dysphagia becomes life-threatoning, and patients typically die by their 70s. Although there is currently no evidence for effective treatment, a therapy may be found by elucidation of the function of TFG. Recently its pathomechanism has been proposed to be associated with abnormalities in protein transfer from the endoplasmic reticulum. Such pathomechanisms might involve a similar process in amyotrophic lateral sclerosis; thus, its pathomechanisms and treatment strategy might make it a good model for neurodegenerative disorders. It is of great value to clarify the natural history of HMSN-P, in oder to judge the treatment effect. By evaluating 97 patients (79 out of 97 were examined and all confirmed with p.Pro 285 Leu mutation) in this study, it was confirmed that this disease follows a uniform course in the earlier stages, and there are individual differences in the onset between 20 and 30 years. Such uniformity might be due to the proposed single gene abnormality. At advanced stages, there are larger individual differences in the progression, but the reasons for these are unknown. Longer survival might be achieved with a better care for respiratory failure and dysphagia if such cares were undertaken at appropriate times.

The Japanese Journal of Rehabilitation Medicine

Supplemental material, sj-docx-1-qjp-10.1177_1747021820984623 for Selective adaptation in sentenc... more Supplemental material, sj-docx-1-qjp-10.1177_1747021820984623 for Selective adaptation in sentence comprehension: Evidence from event-related brain potentials by Masataka Yano, Shugo Suwazono, Hiroshi Arao, Daichi Yasunaga and Hiroaki Oishi in Quarterly Journal of Experimental Psychology

Japanese Journal of Medical Electronics and Biological Engineering, 1997

Journal of Neurology, 2021

Many neuropsychological disorders, especially attentional abnormality, are present in patients wi... more Many neuropsychological disorders, especially attentional abnormality, are present in patients with myotonic dystrophy type 1 (DM1), but the underlying mechanisms remain unclear. This study aimed to evaluate attention function by auditory event-related potential (ERP) P3a (novelty paradigm) in DM1 patients. A total of 10 young DM1 patients (mean age 30.4 years) and 14 age-matched normal controls participated in this study. ERPs were recorded using an auditory novel paradigm, consisting of three types of stimuli, i.e., standard sound (70%), target sound (20%), and various novel sounds (10%), and participants pressed buttons to the target sounds. ERP components P3b after the target stimuli and P3a following the novel stimuli were analyzed. Correlations of neuropsychological evaluations with the amplitudes and latencies of P3b and P3a were analyzed in DM1 patients. We found that P3a latency was significantly delayed in patients with DM1 compared with normal controls, although the latency and amplitude of P3b in DM1 patients were comparable with those in normal controls. The achievement rates of both the Symbol Digit Modality Test and the Paced Auditory Serial Addition Test were significantly correlated with P3a amplitude, as well as P3b amplitude. These results suggest that ERPs, including P3a and P3b, provide important insights into the physiological basis of neuropsychological abnormalities in patients with DM1, especially from the viewpoint of the frontal lobe and attention function.

Neuromuscular Disorders, 2021

To clarify the influence of coronavirus disease-19 (COVID-19) on the care of muscular dystrophy p... more To clarify the influence of coronavirus disease-19 (COVID-19) on the care of muscular dystrophy patients, we performed a questionnaire survey that was posted on the internet on May 11, 2020. By the end of July 2020, 542 responses had been collected. Approximately 30% of patients postponed regular consultations, and one-quarter of patients who received consultation more than once a month used telephone consultations. Two of 84 patients with Duchenne muscular dystrophy had reduced their steroid doses. A shortage of ventilator accessories and infection protection equipment occurred following the onset of COVID-19, and this shortage had a serious impact on medical care and infection prevention measures. Reductions in rehabilitation and other services, and avoidance of outings, led to a decrease in exercise and an increase in caregiver burden. Inpatients were restricted from going out and visiting family members. More than 20% of patients reported physical or mental complaints; however, few required treatment. COVID-19 has seriously affected the activities and quality of life of patients with muscular dystrophy. We will continue this survey and analyze the longitudinal changes.

Muscle & Nerve, 2020

We present the result of 6 yr monitoring of SgrA*, radio source associated with the supermassive ... more We present the result of 6 yr monitoring of SgrA*, radio source associated with the supermassive black hole at the centre of the Milky Way. Single dish observations were performed with the Itapetinga radio telescope at 7 mm, and the contribution of the SgrA Complex that surrounds SgrA* was subtracted and used as instantaneous calibrator. The observations were alternated every 10 min with those of the H II region SrgB2, which was also used as a calibrator. The reliability of the detections was tested comparing them with simultaneous observations using interferometric techniques. During the observing period we detected a continuous increase in the SgrA* flux density starting in 2008, as well as variability in timescales of days and strong intraday fluctuations. We investigated if the continuous increase in flux density is compatible with free-free emission from the tail of the disrupted compact cloud that is falling towards SgrA* and concluded that the increase is most probably intrinsic to SgrA*. Statistical analysis of the light curve using Stellingwerf and structure function methods revealed the existence of two minima, 156 ± 10 and 220 ± 10 d. The same statistical tests applied to a simulated light curve constructed from two quadratic sinusoidal functions superimposed to random variability reproduced very well the results obtained with the real light curve, if the periods were 57 and 156 d. Moreover, when a daily sampling was used in the simulated light curve, it was possible to reproduce the 2.3 GHz structure function obtained by Falcke in 1999, which revealed the 57 d period, while the 106 periodicity found by Zhao et al. in 2001 could be a resonance of this period.

Proceedings of the ISCIE International Symposium on Stochastic Systems Theory and its Applications, 1996

Muscle & nerve, Jan 28, 2017

This study sought to clarify whether specific cognitive abilities are impaired in patients with m... more This study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. Sixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL. QoL was assessed by 2 domains of the Muscular Dystrophy Quality of Life Scale (Psychosocial Relationships and Physical Functioning and Health). More than half of the patients exhibited cognitive impairment in attention/working memory, executive function, processing speed, and visuoconstructive ability. The Psychosocial Relationships factor was associated with processing speed, attention/working memory, and apathy, whereas depression and fatigue were associated with 2 QoL domains. Our study ident...

Clinical Neurophysiology, 2017

Electroencephalography and Clinical Neurophysiology, 1993

Movement Disorders, 2009

Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may b... more Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis.

Japanese Journal of Medical Electronics and Biological Engineering, 1994

Clinical Neurophysiology, 2000

Objective: We examined how behavioral context in¯uences novelty processing by varying the degree ... more Objective: We examined how behavioral context in¯uences novelty processing by varying the degree that a novel event predicted the occurrence of a subsequent target stimulus. Methods: Visual event-related potentials (ERPs) and reaction times (RTs) were recorded in 3 detection experiments (23 subjects). The predictive value of a novel stimulus on the occurrence of a subsequent target was varied as was novel-target pairing intervals (200±900 ms). In Experiment 1, novel stimuli always preceded a target, in Experiment 2, 40% of novel stimuli were followed by a target, and in Experiment 3, novel stimuli occurred randomly. Results: In Experiment 1, RTs following 100% predictive novels were shortened for targets at all spatial locations and novel-target pairing intervals. Novel stimuli predicting a target generated a central negativity peaking at 300 ms and reduced P3a and P3b ERPs. In Experiments 2 and 3, target RTs were prolonged only when novel and target stimuli were presented in the same spatial location at short ISIs (200 ms). The central novel N2 was smaller in amplitude in comparison to Experiment 1, and novelty P3a and target extrastriate N2 and posterior scalp P3b ERPs were enhanced. Conclusions: The enhanced N2 for100% predictive novel stimuli appears to index an alerting system facilitating behavioral detection. The same novel stimuli with no predictive value distract attention and generate a different ERP pattern characterized by increased novelty P3a and target P3b responses. The results indicate that behavioral context determines how novel stimuli are processed and in¯uence behavior.

Journal of the American Heart Association

Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction di... more Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction disease can cause fatal arrhythmias or sudden death in patients with myotonic dystrophy type 1. Methods and Results This study enrolled 506 patients with myotonic dystrophy type 1 (aged ≥15 years; >50 cytosine‐thymine‐guanine repeats) and was treated in 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow‐up. The cause of death or the occurrence of composite cardiac events (ie, ventricular arrhythmias, advanced atrioventricular blocks, and device implantations) were evaluated as significant outcomes. During a median follow‐up period of 87 months (Q1–Q3, 37–138 months), 71 patients expired. In the univariate analysis, pacemaker implantations (hazard ratio [HR], 4.35; 95% CI, 1.22–15....