Shuhui Wang - Academia.edu (original) (raw)

Papers by Shuhui Wang

Chinese journal of microbiology and immunology, 2013

Objective To study the biological properties of the recombinant vaccinia virus Tiantan strain wit... more Objective To study the biological properties of the recombinant vaccinia virus Tiantan strain with C8L-K3L region deletion and its immunogenicity.Methods The expression vector of recombinant vaccinia virus TianTan strain (VTT△C8-K3-gag) was constructed by replacing C8L-K3L genes with HIV gag gene and GFP gene.Viral replication capacities in chicken CEF,hamster BHK-21,monkey Vero and human HeLa cell lines were detected respectively.Virulence evaluation was carried out in mice and rabbit models,and immune effects of VTT△C8-K3-gag was evaluated in BALA/c mice model.Results The replication capacity of VTT△C8-K3-gag was impaired in chicken CEF,hamster BHK-21 and human HeLa cell lines,and was completely restricted in monkey Vero cell line as compared with the parental VTT.VTT△C8-K3-gag was less virulent than VTT in mice and rabbit models.The cellular and humoral responses to HIV elicited by VTT△C8-K3-gag alone or in combination with DNA vaccine were similar to that induced by VTKgpe,while...

Aerospace Science and Technology, 2015

Unwanted combustion instability occurs in many propulsion systems, such as rocket motors, and aer... more Unwanted combustion instability occurs in many propulsion systems, such as rocket motors, and aero-engines. It is typically caused by a coupling between acoustic waves and unsteady heat release from unsteady combustion. Combustion instability can be eliminated by using acoustic dampers, such as Helmholtz resonators (HRs), which introduce extra acoustic damping into the propulsion system. However, such acoustic dampers are generally only effective over a narrow frequency range. In this work, the damping effect of a Helmholtz resonator is optimized by tuning its neck area in real-time to stabilize an unstable combustion system over a broad frequency range. This is based on the fact that the resonator damping performance is maximized at resonance and varying its geometry can lead to its resonant frequency changes. Numerical investigation of a combustion system with a tunable Helmholtz resonator attached is conducted first. To validate the numerical results, experimental measurements are then performed on a Rijke tube with a neck-area tunable Helmholtz resonator. It is found that the unstable Rijke system is successfully stabilized by reducing the sound pressure level by more than 50 dB. Finally, off-design assessment of the tunable resonator damping performance is conducted by varying the dominant oscillation frequency by 24%. It is shown that the tunable resonator is capable to stabilize the combustion system again. This confirms that tunable Helmholtz resonators have great potential to be applied in practical combustion systems.

Proceedings of the 18th ACM international conference on Multimedia, 2010

For large scale image data mining, a challenging problem is to design a method that could work ef... more For large scale image data mining, a challenging problem is to design a method that could work efficiently under the situation of little ground-truth annotation and a mass of unlabeled or noisy data. As one of the major solutions, semi-supervised learning (SSL) has been deeply investigated and widely used in image classification, ranking and retrieval. However, most SSL approaches are not able to incorporate multiple information sources. Furthermore, no sample selection is done on unlabeled data, leading to the unpredictable risk brought by uncontrolled unlabeled data and heavy computational burden that is not suitable for learning on real world dataset. In this paper, we propose a scalable semi-supervised multiple kernel learning method (S 3 MKL) to deal with the first problem. Our method imposes group LASSO regularization on the kernel coefficients to avoid over-fitting and conditional expectation consensus for regularizing the behaviors of different kernel on the unlabeled data. To reduce the risk of using unlabeled data, we also design a hashing system where multiple kernel locality sensitive hashing (MKLSH) are constructed with respect to different kernels to identify a set of "informative" and "compact" unlabeled training subset from a large unlabeled data corpus. Combining S 3 MKL with MKLSH, the method is suitable for real world image classification and personalized web image re-ranking with very little user interaction. Comprehensive experiments are conducted to test the performance of our method, and the results show that our method provides promising powers for large scale real world image classification and retrieval.

2014 IEEE International Conference on Multimedia and Expo (ICME), 2014

Descriptive visual word vocabulary serves as the foundation of large scale image retrieval system... more Descriptive visual word vocabulary serves as the foundation of large scale image retrieval systems. However, the visual word descriptive power is limited by the construction mechanisms based on either cluster center or partitioned feature space, since such mechanisms may merge the sparsely distributed features and split the densely distributed features. Besides, there are a large number of outlier features that are not similar with any visual word. Quantizing such features into visual words inevitably decreases the visual word descriptive power. In this paper, we propose a novel Graph-Density-based visual word Vocabulary (GDV), which constructs the visual word by dense feature subgraph and directly measures the intra-word similarity by the corresponding graph density. Our method remarkably enhances the visual word descriptive power from the following three aspects: 1) GDV guarantees the high intra-word similarity by constructing visual words under the criterion of large graph density; 2) GDV improves the inter-word dissimilarity by alleviating the unexpected effect of subgraph splitting; 3) GDV suppresses the influence of outlier features by selectively quantizing only the features that are similar enough with the visual words. Extensive experiments demonstrate GDV's advanced descriptive power over traditional visual word vocabularies in enhancing both the retrieval accuracy and efficiency, which provides a higher level starting point for most image retrieval systems.

2015 IEEE International Conference on Multimedia and Expo (ICME), 2015

Different features describe different views of visual appearance, multi-view based methods can in... more Different features describe different views of visual appearance, multi-view based methods can integrate the information contained in each view and improve the image clustering performance. Most of the existing methods assume that the importance of one type of feature is the same to all the data. However, the visual appearance of images are different, so the description abilities of different features vary with different images. To solve this problem, we propose a groupaware multi-view fusion approach. Images are partitioned into groups which consist of several images sharing similar visual appearance. We assign different weights to evaluate the pairwise similarity between different groups. Then the clustering results and the fusion weights are learned by an iterative optimization procedure. Experimental results indicate that our approach achieves promising clustering performance compared with the existing methods.

Observations from both satellite instrument (Microwave Limb Sounder on Aura) and ground-based (FT... more Observations from both satellite instrument (Microwave Limb Sounder on Aura) and ground-based (FTUVS at Jet Propulsion Laboratory's Table Mountain Facility) instruments have shown that the variation in solar UV irradiance during the 11-year cycle is responsible for the long-term variability in atmospheric OH, which is a key species for middle atmospheric ozone destruction. Modeling these variations is expected to help improve understanding of the mechanisms through which the change in solar forcing governs the natural variability in middle atmospheric chemical composition. The Whole Atmospheric Community Climate Model (WACCM), a time-dependent global 3-D model, is used to simulate the observed long-term OH variability and its spatial distribution. The observed long-term OH column variability associated with the solar cycle is about 10% from peak to valley. Although the modeled OH variability shows a similar trend, the magnitudes of the modeled and observed variabilities are diff...

Nursing & Health Sciences, 2012

The present study investigated the relationship between sharps injuries and job burnout in nurses... more The present study investigated the relationship between sharps injuries and job burnout in nurses. Sharps injury questionnaires and the Maslach Burnout Inventory (MBI) questionnaires were used to investigate and analyze job burnout among 468 nurses, of which 458 effective questionnaires were collected, for a response rate of 97.86%. A total of 292 nurses had at least one sharps injury (63.76% of the 458 nurses). The dimension scores were higher for injured nurses compared with non-injured nurses. The difference between the dimensions of emotional exhaustion and depersonalization for nurses with sharps injuries was statistically significant (P < 0.05).A rank correlation analysis showed that these two dimensions had a positive correlation with sharps injuries (r = 0.69-0.78). The prevalence of sharps injuries in nursing is associated with depersonalization, as measured by the MBI. Nursing administrators should pay more attention to clinically burned-out nurses, and provide more opportunity to nurses for training and education to reduce the prevalence of sharps injuries.

Zygote, 2008

SummaryThe purpose of the present study was to evaluate the effects of serum-starvation, contact-... more SummaryThe purpose of the present study was to evaluate the effects of serum-starvation, contact-inhibition and roscovitine treatments on cell-cycle synchronization at the G0/G1stage of ear skin fibroblasts isolated from transgenic cloned cattle. The developmental competence of re-cloned embryos was also examined. Our results showed that the proportion of G0/G1cells from the serum-starved group at 3, 4 or 5 days was significantly higher compared with 1 or 2 days only (91.5, 91.7 and 93.5% versus 90.1 and 88.8%, respectively,p< 0.05); whilst there was no statistical difference among cells at 3, 4 or 5 days. For roscovitine-treated cells, the proportion of G0/G1cells at 2, 3, 4 or 5 days was significantly higher than those treated for 1 day only (91.1, 90.1, 89.4 and 91.3% versus 86.51%, respectively,p< 0.05). The proportion of contact-inhibited G0/G1cells rose significantly with treatment time, but was similar at 3, 4 and 5 days (89.4, 90.4, 91.4, 91.6 and 92.1%, respectively,p...

Proceedings of the National Academy of Sciences, 2013

The hydroxyl radical (OH) plays an important role in middle atmospheric photochemistry, particula... more The hydroxyl radical (OH) plays an important role in middle atmospheric photochemistry, particularly in ozone (O 3 ) chemistry. Because it is mainly produced through photolysis and has a short chemical lifetime, OH is expected to show rapid responses to solar forcing [e.g., the 11-y solar cycle (SC)], resulting in variabilities in related middle atmospheric O 3 chemistry. Here, we present an effort to investigate such OH variability using long-term observations (from space and the surface) and model simulations. Ground-based measurements and data from the Microwave Limb Sounder on the National Aeronautics and Space Administration’s Aura satellite suggest an ∼7–10% decrease in OH column abundance from solar maximum to solar minimum that is highly correlated with changes in total solar irradiance, solar Mg-II index, and Lyman-α index during SC 23. However, model simulations using a commonly accepted solar UV variability parameterization give much smaller OH variability (∼3%). Although...

During the Phoenix Sunrise Experiment in June-July, 2001, the vertical distributions of NO2, HONO... more During the Phoenix Sunrise Experiment in June-July, 2001, the vertical distributions of NO2, HONO, NO3 and several other trace gases were measured with a long-path differential optical absorption spectroscopy system in the downtown area. Strong vertical gradients of all observed species were observed during the night, clearly showing that nocturnal chemistry in this urban environment is height dependent. The disappearance of the gradients in the morning shows the onset of vertical mixing during the transition of a stable boundary layer to a well-mixed layer. During very stable nights, when NO and VOCs emissions were trapped near the ground, mixing ratios of NO3 up to 200 ppt were found at 110-140m above the ground. Using this information together with the measurements of NO2, vertical profiles of N2O5 can be derived. In addition, the vertical distribution of HONO and NO2 allows the investigation of heterogeneous HONO formation process on surfaces and the impact of relative humidity ...

Journal of Visual Communication and Image Representation, 2013

Recently, sparse coding has become popular for image classification. However, images are often ca... more Recently, sparse coding has become popular for image classification. However, images are often captured under different conditions such as varied poses, scales and different camera parameters. This means local features may not be discriminative enough to cope with these variations. To solve this problem, affine transformation along with sparse coding is proposed. Although proven effective, the affine sparse coding has no constraints on the tilt and orientations as well as the encoding parameter consistency of the transformed local features. To solve these problems, we propose a Laplacian affine sparse coding algorithm which combines the tilt and orientations of affine local features as well as the dependency among local features. We add tilt and orientation smooth constraints into the objective function of sparse coding. Besides, a Laplacian regularization term is also used to characterize the encoding parameter similarity. Experimental results on several public datasets demonstrate the effectiveness of the proposed method.

Journal of Controlled Release, 2013

Chromatographia, 2006

A simple and specific high performance liquid chromatographic (HPLC) method with UV detection usi... more A simple and specific high performance liquid chromatographic (HPLC) method with UV detection using picroside II as the internal standard was developed and validated to determine the concentration of paeoniflorin in rat plasma and study its pharmacokinetics after an single intravenous administration of 40 mg kg)1 paeoniflorin to Wistar rats. The analytes of interest were extracted from rat plasma samples by ethyl acetate after acidification with 0.05 mol L)1 NaH 2 PO 4 solution (pH 5.0). Chromatographic separation was achieved on an Agilent XDB C 18 column (250 • 4.6 mm I.D., 5 lm) with a Shim-pack GVP-ODS C 18 guard column (10 • 4.6 mm I.D., 5 lm) using a mobile phase consisting of acetonitrile-water-acetic acid (18:82:0.4, v/v/v) at a flow rate of 1.0 mL min)1. The UV detection was performed at a wavelength of 230 nm. The linear calibration curves were obtained in the concentration range of 0.05-200.0 lg mL)1 in rat plasma with the lower limit of quantification (LLOQ) of 0.05 lg mL)1. The intra-and inter-day precisions in terms of % relative standard deviation (RSD) were lower than 5.7 and 8.2% in rat plasma, respectively. The accuracy in terms of % relative error (RE) ranged from)1.9 to 2.6% in rat plasma. The extraction recoveries of paeoniflorin and picroside II were calculated to be 69.7 and 56.9%, respectively. This validated method was successfully applied to the pharmacokinetic study of a new paeoniflorin frozen dry power formulation. After single intravenous administration, the main pharmacokinetic parameters t 1/2 , AUC 0-¥ , CL TOT , V Z , MRT 0-¥ and V ss were 0.739 ± 0.232 h, 43.75 ± 6.90 lg h mL)1 , 15.50 ± 2.46 L kg)1 h)1 , 1.003 ± 0.401 L kg)1 , 0.480 ± 0.055 h and 0.444 ± 0.060 L kg)1 , respectively.

Chemical Engineering Journal, 2008

The natural rectorite (REC) was modified with the surfactant of dodecyl benzyl dimethyl ammonium ... more The natural rectorite (REC) was modified with the surfactant of dodecyl benzyl dimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide, respectively. Three kinds of organic-modified rectorite (OREC), termed OREC1, OREC2 and OREC3, respectively, were prepared. Three kinds of OREC were used as adsorbents for Cr(VI) removal in aqueous solution. Through FTIR and X-ray diffraction (XRD) analyses, it was confirmed that they indeed carried out cation exchange reaction between REC and surfactant. Through the research of Cr(VI) adsorption, the removal percentage (%) of Cr(VI) increased with increasing adsorbents dose. The adsorption efficiency of OREC adsorbent was greatly affected by the initial solution pH value. According to thermodynamics study, it can be concluded that the adsorption of Cr(VI) with three adsorbents was carried out spontaneously. The research of adsorption isotherm demonstrated that, adsorption reactions of three prepared OREC adsorbents belonged to Langmuir model. The kinetic data of Cr(VI) with OREC adsorbents were well fitted to the Lagergren rate equation, which indicated that the three adsorption processes belonged to first-order adsorption reaction. Values of coefficients of intra-particle diffusion and mass transfer have been determined for three different OREC adsorbents. Intra-particle diffusion analysis demonstrated that Cr(VI) ions diffused quickly at the beginning of the adsorption process, and then intra-particle diffusion slowed down and stabilized. Mass transfer analysis showed the process of transfer of Cr(VI) removal onto the adsorbents surface was rapid enough.

Biochemical and Biophysical Research Communications, 2008

Atmospheric Chemistry and Physics, 2014

Using Microwave Limb Sounder (MLS/Aura) and Medium Energy Proton and Electron Detector (MEPED/POE... more Using Microwave Limb Sounder (MLS/Aura) and Medium Energy Proton and Electron Detector (MEPED/POES) observations between 2005-2009, we study the longitudinal response of nighttime mesospheric OH to radiation belt electron precipitation. Our analysis concentrates on geomagnetic latitudes from 55-72 • N/S and altitudes between 70 and 78 km. The aim of this study is to better assess the spatial distribution of electron forcing, which is important for more accurate modelling of its atmospheric and climate effects. In the Southern Hemisphere, OH data show a hotspot, i.e. area of higher values, at longitudes between 150 • W-30 • E, i.e. poleward of the Southern Atlantic Magnetic Anomaly (SAMA) region. In the Northern Hemisphere, energetic electron precipitation-induced OH variations are more equally distributed with longitude. This longitudinal behaviour of OH can also be identified using Empirical Orthogonal Function analysis, and is found to be similar to that of MEPED-measured electron fluxes. The main difference is in the SAMA region, where MEPED appears to measure very large electron fluxes while MLS observations show no enhancement of OH. This indicates that in the SAMA region the MEPED observations are not related to precipitating electrons, at least not at energies >100 keV, but rather to instrument contamination. Analysis of selected OH data sets for periods of different geomagnetic activity levels shows that the longitudinal OH hotspot south of the SAMA (the Antarctic Peninsula region) is partly caused by strong, regional electron forcing, although atmospheric conditions also seem to play a role. Also, a weak signature of this OH hotspot is seen during periods of generally low geomagnetic activity, which suggests that there is a steady drizzle of high-energy electrons affecting the atmosphere, due to the Earth's magnetic field being weaker in this region.

Applied Optics, 2008

The Fourier Transform Ultraviolet Spectrometer (FTUVS) instrument has recorded a long-term data r... more The Fourier Transform Ultraviolet Spectrometer (FTUVS) instrument has recorded a long-term data record of the atmospheric column abundance of the hydroxyl radical (OH) using the technique of high resolution solar absorption spectroscopy. We report new efforts in improving the precision of the OH measurements in order to better model the diurnal, seasonal, and interannual variability of odd hydrogen (HO x) chemistry in the stratosphere, which, in turn, will improve our understanding of ozone chemistry and its long-term changes. Until the present, the retrieval method has used a single strong OH absorption line P 1 ð1Þ in the near-ultraviolet at 32; 341 cm −1. We describe a new method that uses an average based on spectral fits to multiple lines weighted by line strength and fitting precision. We have also made a number of improvements in the ability to fit a model to the spectral feature, which substantially reduces the scatter in the measurements of OH abundances.

OH measurements by Microwave Limb Sounder (MLS) onboard Aura during 2004 - 2007 are compared with... more OH measurements by Microwave Limb Sounder (MLS) onboard Aura during 2004 - 2007 are compared with ground-based OH column measurements by Fourier Transform Ultraviolet Spectrometer (FTUVS) over Jet Propulsion Laboratory (JPL)'s Table Mountain Facility (TMF). This is the first comparison of OH measurements from space- and ground-based instruments over seasonal and interannual time scales. The FTUVS measures the OH column