Si-Hyong Jang - Academia.edu (original) (raw)

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All India Institute of Medical Sciences Bhopal

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Papers by Si-Hyong Jang

Basic and Applied Pathology, 2010

Background and aim: Cyclooxygenase-2 (COX-2) plays an important role in colorectal cancer develop... more Background and aim: Cyclooxygenase-2 (COX-2) plays an important role in colorectal cancer development and is frequently up-regulated in colorectal cancer. The purpose of this study was to investigate COX-2 overexpression in colorectal adenocarcinoma and to evaluate the correlation with the clinicopathological parameters and p53 expression, as well as its effect on patient survival. Methods: We evaluated the expression of COX-2 and p53 on the tissue microarray of 414 colorectal adenocarcinomas by immunohistochemistry. Data was analyzed by Fisher's exact test, v 2-test, one-way ANOVA, Cox regression hazards model and log-rank test with Kaplan-Meier curves. Results: The cytoplasmic COX-2 overexpression was detected in 56.3% of colorectal adenocarcinoma samples. COX-2 overexpression was correlated with favorable clinicopathologic factors in lymph node metastasis (P = 0.002), American Joint Committee on Cancer and Dukes' stage (P = 0.008 and P = 0.017, respectively), and lymphatic invasion (P = 0.001). Other characteristics associated with COX-2 overexpression were colonic site of tumor (P = 0.008) and poor differentiation (P = 0.017). There was no correlation between COX-2 overexpression and p53 expression (P = 0.485). In univariate survival analysis, patients with COX-2 overexpression revealed better overall survival and diseasefree survival (P = 0.021 and P = 0.017, respectively, log-rank test). In multivariate survival analysis with the Cox proportional hazards model, COX-2 overexpression was an independent prognostic factor of overall survival and disease-free survival (P = 0.029 and P = 0.039, respectively). Conclusions: COX-2 overexpression was significantly associated with favorable clinicopathologic phenotype and an indicator of better survival in our cohort of colorectal cancer patients.

Oncotarget, Jan 16, 2015

Inhibitor of differentiation/DNA binding (Id)1 is a crucial regulator of mammary development and ... more Inhibitor of differentiation/DNA binding (Id)1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) activities in transgenic mice. MaSC-enriched basal cell expansion and increased self-renewal and in vivo regenerative capacity of MaSCs are observed in the mammary glands of MMTV-Id1 transgenic mice. Furthermore, MMTV-Id1 mice develop ductal hyperplasia and mammary tumors with highly expressed basal markers. Id1 also increases breast cancer stem cell (CSC) population and activity in human breast cancer lines. Moreover, the effects of Id1 on normal and malignant stem cell activities are mediated by the Wnt/c-Myc pathway. Collectively, these findings provide in vivo genetic evidence of Id1 functions as an oncogene in breast cancer and indicate that...

World journal of …, 2009