SiewLian Chong - Academia.edu (original) (raw)

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Papers by SiewLian Chong

Research paper thumbnail of A Real-World Study to End Tyrosine Kinase Inhibitor in Chronic Myeloid Leukaemia (EnTIC) in Malaysia: One Year Follow-up of Multicenter Study in Malaysia

Research paper thumbnail of Chronic Myeloid Leukemia Failed Second Generation Tyrosine Kinase Inhibitor Patients' Molecular Interrogation Using Next Generation Sequencing

Research paper thumbnail of How we treat T-cell acute lymphoblastic leukemia in adults

Blood, Jan 12, 2015

Acute lymphoblastic leukemia (ALL) of the T-cell immunophenotype (T-ALL) is an uncommon aggressiv... more Acute lymphoblastic leukemia (ALL) of the T-cell immunophenotype (T-ALL) is an uncommon aggressive leukemia that can present with leukemic and/or lymphomatous manifestations. An early T-cell precursor ALL has been identified as a poor prognostic subtype. Molecular studies are enhancing our understanding of the pathogenesis, and the discovery of activating mutations of NOTCH1 and FBXW7 in a majority of patients with T-ALL has been a seminal observation. Use of pediatric intensive combination chemotherapy regimens in adolescents and young adults has significantly improved the outcome of patients with T-cell ALL. The use of nelarabine for relapsed and refractory T-ALL results in responses in a substantial minority of patients. Allogeneic hematopoietic cell transplantation (HCT) still plays a key role in patients with high-risk or relapsed/refractory disease. Gamma-secretase inhibitors hold promise for treatment of patients with NOTCH1 and FBXW7 mutations, and the results of clinical tr...

Research paper thumbnail of Treatment Outcome and a Practical 10-Point Prognostic Index in Adult Patients with Non-M3 Acute Myeloid Leukemia: A Retrospective, Multicenter Study in Malaysia

Blood, 2019

Background: Literature on Acute Myeloid Leukemia (AML) survival and prognostic factors were often... more Background: Literature on Acute Myeloid Leukemia (AML) survival and prognostic factors were often derived from strict trial studies from developed country. A simple yet practical prognosis index has not been developed and tested in resource limited setting such as Malaysia. We described the treatment outcome and designed a 10 point prognostic index to predict survival of adult AML (non-M3) in real clinical practice in Malaysia. Methods: Data were retrospectively collected and analyzed from all adults with AML diagnosed and treated from 2007 to 2017 in three main hematology centers in Malaysia, Ampang Hospital, Sarawak General Hospital and Miri General Hospital. Treatment pattern and survival outcome were described. Multivariable analysis using Cox regression statistics were performed to identify significant prognostic variables affecting overall survival. Each variable were assigned points based on hazard ratios. A sum of the points led to a maximum score of 10. Patients were then c...

Research paper thumbnail of A Real-World Study to End Tyrosine Kinase Inhibitor in Chronic Myeloid Leukaemia (EnTIC) in Malaysia: One Year Follow-up of Multicenter Study in Malaysia

Research paper thumbnail of Chronic Myeloid Leukemia Failed Second Generation Tyrosine Kinase Inhibitor Patients' Molecular Interrogation Using Next Generation Sequencing

Research paper thumbnail of How we treat T-cell acute lymphoblastic leukemia in adults

Blood, Jan 12, 2015

Acute lymphoblastic leukemia (ALL) of the T-cell immunophenotype (T-ALL) is an uncommon aggressiv... more Acute lymphoblastic leukemia (ALL) of the T-cell immunophenotype (T-ALL) is an uncommon aggressive leukemia that can present with leukemic and/or lymphomatous manifestations. An early T-cell precursor ALL has been identified as a poor prognostic subtype. Molecular studies are enhancing our understanding of the pathogenesis, and the discovery of activating mutations of NOTCH1 and FBXW7 in a majority of patients with T-ALL has been a seminal observation. Use of pediatric intensive combination chemotherapy regimens in adolescents and young adults has significantly improved the outcome of patients with T-cell ALL. The use of nelarabine for relapsed and refractory T-ALL results in responses in a substantial minority of patients. Allogeneic hematopoietic cell transplantation (HCT) still plays a key role in patients with high-risk or relapsed/refractory disease. Gamma-secretase inhibitors hold promise for treatment of patients with NOTCH1 and FBXW7 mutations, and the results of clinical tr...

Research paper thumbnail of Treatment Outcome and a Practical 10-Point Prognostic Index in Adult Patients with Non-M3 Acute Myeloid Leukemia: A Retrospective, Multicenter Study in Malaysia

Blood, 2019

Background: Literature on Acute Myeloid Leukemia (AML) survival and prognostic factors were often... more Background: Literature on Acute Myeloid Leukemia (AML) survival and prognostic factors were often derived from strict trial studies from developed country. A simple yet practical prognosis index has not been developed and tested in resource limited setting such as Malaysia. We described the treatment outcome and designed a 10 point prognostic index to predict survival of adult AML (non-M3) in real clinical practice in Malaysia. Methods: Data were retrospectively collected and analyzed from all adults with AML diagnosed and treated from 2007 to 2017 in three main hematology centers in Malaysia, Ampang Hospital, Sarawak General Hospital and Miri General Hospital. Treatment pattern and survival outcome were described. Multivariable analysis using Cox regression statistics were performed to identify significant prognostic variables affecting overall survival. Each variable were assigned points based on hazard ratios. A sum of the points led to a maximum score of 10. Patients were then c...

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