Silvan Araujo - Academia.edu (original) (raw)

Papers by Silvan Araujo

$Research paper thumbnail of Antioxidants and cardioprotective effects of ethyl acetate fraction of Canavalia rosea leaves in myocardial ischemia-reperfusion injury$

Anais da Academia Brasileira de Ciências

Different degrees in the biological activities of Canavalia rosea had been previously reported. I... more Different degrees in the biological activities of Canavalia rosea had been previously reported. In this study, our group assessed the cardioprotective effects of the ethyl acetate fraction (EAcF) of the Canavalia rosea leaves. Firstly, it was confirmed, by in vitro approach, that the EAcF has high antioxidant properties due to the presence of important secondary metabolites, as flavonoids. In order to explore their potential protector against cardiovascular disorders, hearts were previously perfused with EAcF (300 μg.mL-1) and submitted to the global ischemia followed by reperfusion in Langendorff system. The present findings have demonstrated that EAcF restored the left ventricular developed pressure and decreased the arrhythmias severity index. Furthermore, EAcF significantly increased the glutathiones peroxidase activity with decreased malondialdehyde and creatine kinase levels. EAcF was effective upon neither the superoxide dismutase, glutationes reductase nor the catalase activities. In addition, the Western blot analysis revealed that ischemia-reperfusion injury significantly upregulates caspase 3 protein expression, while EAcF abolishes this effect. These results provide evidence that the EAcF reestablishes the cardiac contractility and prevents arrhythmias; it is suggested that EAcF could be used to reduce injury caused by cardiac reperfusion. However more clinical studies should be performed, before applying it in the clinic.

Motricidade, 2020

Physical exercise is a known factor that can promote oxidative stress and may result in cellular ... more Physical exercise is a known factor that can promote oxidative stress and may result in cellular damage if not neutralized by antioxidant mechanisms. The aim of this study was to determine if the level of hepatic oxidative stress resulting from high-intensity interval training (HIIT) is affected by the frequency pattern (consecutive vs. non-consecutive) of the training sessions. Thirty-two Wistar rats were divided equally into four groups: two control groups, (CS1) and (CS2), remained sedentary throughout the experiment, and two test groups, (CT1) and (CT2), and were submitted to HIIT for 12 consecutive and nonconsecutive (12 sessions, 3 times/wk over four weeks) days, respectively. There were no significant differences in markers of oxidative damage measured in hepatic tissue (TBARS) and markers of antioxidant activity (Sulfhydryl, FRAP), as well as markers of hepatic damage (AST and ALT) and antioxidant defense (Uric Acid) measured in plasma of both HIIT groups after training comp...

Journal of exercise physiology, 2017

Santos JL, Araujo SS, Estevam CS, Lima CA, Carvalho CRO, Lima FB, Marcal AC. Molecular Mechanisms... more Santos JL, Araujo SS, Estevam CS, Lima CA, Carvalho CRO, Lima FB, Marcal AC. Molecular Mechanisms of Muscle Glucose Uptake in Response to Resistance Exercise: A Review. JEPonline 2017;20(4):200-211. Evidence shows that physical exercise carried out systematically promotes numerous health benefits, including improvements in glucose homeostasis. Of all types of physical activity, resistance training is effective in promoting increased strength, speed, power, hypertrophy, and metabolic effects such as increased insulin sensitivity and control in glycogen metabolism. Since there are still gaps requiring attention in regards to the molecular mechanisms leading to effective insulin signaling, this paper attempts to review the effects and implications of resistance exercise on the major intracellular protein activities. In this regard, we set out to understand the role of resistance training on IRS1, IRS2, PI3K, Akt/PKB, and GLUT4 activity, which can lead to the development of possible fut...

BMJ, 2013

Objective To evaluate the association between body mass index and mortality from overall cardiova... more Objective To evaluate the association between body mass index and mortality from overall cardiovascular disease and specific subtypes of cardiovascular disease in east and south Asians. Design Pooled analyses of 20 prospective cohorts in Asia, including data from 835 082 east Asians and 289 815 south Asians. Cohorts were identified through a systematic search of the literature in early 2008, followed by a survey that was sent to each cohort to assess data availability. Setting General populations in east Asia (China, Taiwan, Singapore, Japan, and Korea) and south Asia (India and Bangladesh). Participants 1 124 897 men and women (mean age 53.4 years at baseline). Main outcome measures Risk of death from overall cardiovascular disease, coronary heart disease, stroke, and (in east Asians only) stroke subtypes. Results 49 184 cardiovascular deaths (40 791 in east Asians and 8393 in south Asians) were identified during a mean follow-up of 9.7 years. East Asians with a body mass index of 25 or above had a raised risk of death from overall cardiovascular disease, compared with the reference range of body mass index (values 22.5-24.9; hazard ratio 1.09 (95% confidence interval 1.

Motriz: Revista de Educação Física

To investigate the hypothesis that the resistance exercise (RE) may be safer if the blood pressur... more To investigate the hypothesis that the resistance exercise (RE) may be safer if the blood pressure (BP) is properly controlled through antihypertensive pharmacological treatment in hypertensive middle-aged women. Methods: The final sample was comprised of 19 hypertensive women, with an average age of 58±5 years and a body mass index of 29±5 Kg/m 2. They were divided into three groups: controlled (n=6), uncompensated (n=8), and untreated (n=5). The subjects from all groups were submitted to a test of maximal strength on extensor chair and held a session of RE (knee extension, 3x12 to 60% 1RM) and the cardiovascular response (BP and heart rate) was monitored continuously by photoplethysmography during exercise and until five minutes after exercise (recovery). Results: Systolic BP (SBP) and diastolic BP (DBP) responses were lower in the controlled group compared to the other groups (p<0.05). The heart rate was not different between groups, while the double product was lower in the controlled group compared to the untreated group (p<0.05). The SBP and DBP peaks were lower in the controlled group compared to the other groups (p<0.05). Conclusion: The BP increases significantly during RE when the hypertension is not controlled. Pharmacological control was shown to be effective in preventing the increase of BP during the performance of the RE.

Medicina

Background and objectives: The practice of physical exercise, especially resistance exercise, is ... more Background and objectives: The practice of physical exercise, especially resistance exercise, is important for the treatment and/or prevention of cardiovascular risk factors in adult individuals. However, there are few studies on its effects on adolescent individuals. Therefore, the aim of the present study was to evaluate the effects of applying a 12-week resistance training program on cardiovascular risk factors in adolescents. Materials and Methods: Thus, 122 adolescents aged 13–16 years of both genders participated in the study from school in the city of Lagarto, Sergipe (SE), Brazil, divided into two groups: Control Group (CG) and Group undergoing resistance training (RTG). Blood collection and anthropometric measurements were performed before and after the 12-week resistance training program (RTP). Results: After 12 weeks of the RTP in the adolescents, there was a reduction in the triglyceride variables (9.55%, p = 0.0286), Low-Density Lipoproteins (LDL) (5.42%, p = 0.0244), n...

Biológicas & Saúde

Estudos têm investigado a relação dos métodos Pilates® e musculação no desenvolvimento da resistê... more Estudos têm investigado a relação dos métodos Pilates® e musculação no desenvolvimento da resistência abdominal, alívio das dores lombares e manutenção da boa postura. O Método Pilates® surge como forma de condicionamento físico interessado em proporcionar bem-estar geral ao indivíduo, e capaz de proporcionar força, flexibilidade e boa postura. A musculação segue a mesma linha, além de proporcionar hipertrofia, fortalecimento de ossos, maior gasto calórico. A flexibilidade e a resistência abdominal são qualidades físicas componentes da aptidão física relacionada à saúde (AFRS), as quais devem ser devidamente treinadas. Os objetivos do presente estudo foram avaliar a influência do método Pilates® (PIL) e da musculação (MUS) sobre a resistência abdominal, flexibilidade e comparar aspectos antropométricos e da composição corporal em mulheres. A amostra foi composta por 20 mulheres, divididas em 2 grupos de 10 para cada método especificado. Foram obtidos os seguintes resultados para a r...

Pharmaceutical Biology, 2016

Context: Chrysobalanus icaco L. (Chrysobalanaceae) has been used for the treatment of abdominal p... more Context: Chrysobalanus icaco L. (Chrysobalanaceae) has been used for the treatment of abdominal pain and cramps. Objective: Assess the chemical and pharmacological profile of the lyophilized aqueous extract from C. icaco leaves (AEC). Materials and methods: Chromatographic methods were used to assess compounds from AEC. Mice were treated with vehicle (control group) or AEC (100, 200 or 400 mg/kg, p.o.) (group with 7-8 mice) and the analgesic profile was assessed employing the acetic acid-induced writhing, formalin, hot plate tests and hyperalgesia induced by carrageenan (CG) or tumour necrosis factor-alpha. The animal motor performance was assessed using rota-rod and grip strength tests. Results: The chromatographic profile of AEC demonstrated the presence of terpenoid compounds. The acute pretreatment with AEC, at all doses, produced a significant (p < 0.01) inhibition of painful bahaviour (11.4 ± 3.6; 10.3 ± 2.8; 11.3 ± 2.2) when compared to the control group (24.7 ± 4.7) in acetic acid-induced writhing test. In the formalin test, AEC were effective in the second phase (p < 0.01) (57.2 ± 10.3; 56.3 ± 9.2; 54.7 ± 8.9) when compared to control group (121.9 ± 18.5). No response was observed in the hot plate test. The higher dose of AEC produced a significant (p < 0.01 or p < 0.05) inhibitory effect on the mechanical hyperalgesia test. AEC did not affect the motor performance of the mice. Discussion: The terpenoids from AEC are known for its analgesic and anti-inflammatory properties. So, these results corroborate the experiments using the AEC in inflammatory pain protocols. Conclusion: Our results suggest that AEC act against inflammatory pain.

Fiep Bulletin on Line, 2009

ABSTRACT This study aimed to describe the health-related physical fitness of adolescents from pub... more ABSTRACT This study aimed to describe the health-related physical fitness of adolescents from public schools in the city of Aracaju, SE, Brazil, and the effects of growth and maturation on physical variables. The sample was composed of 288 elementary school students, 146 of whom were male and 142 female, aged between 10 and 14 years. The following variables were measured: body mass, height, flexibility, muscle strength/endurance and aerobic capacity. Descriptive statistics and Student’s t test for independent samples were used for data analysis, adopting a 5% significance level (p <0.05). When the results from the two sexes were compared, significant low variations were observed, always in favor of the males, in all variables with the exception of abdominal strength at 11, 12 and 13 years of age, strength/resistance of arms at 12 years and aerobic capacity (VO2max) at 10, 12 and 14 years, for all of which differences were not significant. Sexual maturity only had na effect on flexibility in males and VO2 max in both sexes. Rsumo O presente estudo teve como objetivo descrever a aptidão física relacionada à saúde e os efeitos do crescimento e maturação sobre as variáveis analisadas, em crianças e adolescentes de escolas públicas municipais na cidade de Aracaju (SE). A amostra foi composta por 288 estudantes do ensino fundamental, dos quais 146 eram do sexo masculino e 142 do sexo feminino, com idades entre 10 e 14 anos. Foram observadas as variáveis: massa corporal, estatura, flexibilidade, força/resistência muscular localizada e capacidade aeróbia. Como procedimentos de análise de dados, utilizaram-se a estatística descritiva e teste t de Student para grupos independentes, utilizando-se nível de significância de 5% (p < 0,05). Os resultados evidenciaram baixas variações significativas quando comparados ambos os sexos, exceto aos 11, 12 e 13 anos de idade, com relação à resistência abdominal, aos 12 anos, com relação à força/resistência de braços e a capacidade aeróbia (VO2max) aos 10, 12 e 14 anos, todos em favor do sexo masculino. Com relação à interferência da maturação sexual, encontraram-se diferenças significativas somente na flexibilidade do sexo masculino e no VO2 max em ambos os sexos.

$Research paper thumbnail of Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions$

Revista Brasileira de Farmacognosia, 2014

Dengue fever and schistosomiasis are major public health issues for which vector control using la... more Dengue fever and schistosomiasis are major public health issues for which vector control using larvicide and molluscicide substances present in plants provides a promising strategy. This study evaluated the potential toxicity of the extract of hydroethanol Schinopsis brasiliensis Engl., Anacardiaceae, stem bark and its chloroform, hexane, ethyl acetate, and hydromethanol fractions against Artemia salina and Aedes Aegypti larvae and snails Biomphalaria glabrata. All of the assays were performed in triplicate and the mean mortality rates were used to determine the LC 50 and LC 90 values using the probit method. The hydroethanol hydromethanol extract and fraction were free of toxicity towards A. salina (LC 50 > 1000 μg/ml), while chloroform fraction was moderately toxic (LC 50 313 μg/ml); ethyl acetate and hexane fractions displayed low toxicity, with LC 50 557 and 582 μg/ml, respectively. Chloroform, hexane, and ethyl acetate fractions showed larvicidal potential towards A. aegypti (LC 50 values of 345, 527 and 583 μg/ml, respectively), while chloroform and ethyl acetate fractions were highly toxic to B. glabrata (LC 90 values of 68 and 73 μg/ml, respectively). Based on these findings, ethyl acetate, chloroform, and hexane fractions should be further investigated for their potential use against the vectors of dengue and schistosomiasis.

Rbpfex Revista Brasileira De Prescricao E Fisiologia Do Exercicio, Mar 3, 2012

Effect of the method Samiball® in heart rate and performance of patients with sickle cell disease... more Effect of the method Samiball® in heart rate and performance of patients with sickle cell disease: case report

ABSTRACT RESUMO O lactato é um metabólito resultante da glicólise, que ocorre no sarcoplasma, pro... more ABSTRACT RESUMO O lactato é um metabólito resultante da glicólise, que ocorre no sarcoplasma, produzido proporcionalmente à atividade muscular. A síntese de amônia muscular durante exercícios prolongados está relacionada com as concentrações de AMP e ao catabolismo dos aminoácidos, sendo equivalente ao aumento da concentração de lactato. O objetivo do presente estudo foi avaliar o impacto da suplementação com glutamina sobre indicadores de fadiga muscular em ratos. Utilizaram-se 24 ratos Wistar, machos, adultos de 6 a 8 meses de idade, divididos em quatro grupos, Sedentário (SED), Sedentário Suplementado com Glutamina (GSED), Treinado (TRE) e Treinado Suplementado com Glutamina (GTRE). Com pesos atados à sua cauda (2% a 5% da massa corporal), os grupos TRE e GTRE foram submetidos a duas semanas de treinamento em natação. No último dia todos os grupos foram submetidos a exercício agudo, em seguida foram anestesiados e tiveram o sangue coletado. A dosagem dos metabólitos foi realizada por espectrofotometria. As concentrações de lactato e amônia não apresentaram diferenças significantes quando comparados os quatro grupos, embora os grupos TRE e GTRE mostraram-se mais protegidos contra a hiperamonemia e ao incremento do lactato. Portanto, foi possível concluir que a suplementação com glutamina associada ao treinamento crônico inibiu elevações importantes de lactato e de amônia, quando comparados com os grupos sedentários, suplementados ou não. Palavras-chave: Exercício aeróbico, Processo metabólico, Suplemento alimentar.

As respostas do lactato sanguíneo e da glicemia permitem a identificação do limiar anaeróbio. O p... more As respostas do lactato sanguíneo e da glicemia permitem a identificação do limiar anaeróbio. O presente estudo teve como objetivo central identificar a velocidade de corrida no limiar glicêmico. A amostra foi composta por 6 (seis) atletas masculinos de provas de fundo. Utilizou-se o protocolo de corrida progressiva composto por 6 séries de 800m e dosagens glicêmicas realizadas no intervalo de repouso entre cada série. O limiar anaeróbio foi identificado como a velocidade de corrida correspondente à menor glicemia durante o teste, denominado de limiar glicêmico. As alíquotas de sangue de aproximadamente 25 µL foram analisadas em glicosímetro clínico que apresenta o resultado glicêmico em cerca de 5 segundos. Os resultados mostraram diferenças significativas entre a velocidade do limiar glicêmico e a velocidade média de 3km, como também entre o consumo máximo de oxigênio e o consumo máximo de oxigênio da glicose mínima. Foi possível determinar as cargas de trabalho, velocidade de corrida no limiar glicêmico e o VO 2máx do limiar glicêmico, embora os níveis de glicose sanguínea entre as diferentes intensidades não tenham sido significantes. Concluiu-se que as cargas de trabalho de menor valor glicêmico, identificadas através de glicose sanguínea possibilitaram estimar a resposta lactacidêmica, que se aproxima do limiar anaeróbio.

Revista Brasileira De Prescricao E Fisiologia Do Exercicio, 2010

RESUMO A avaliação sistemática e quantitativa do condicionamento físico de jogadores de futebol é... more RESUMO A avaliação sistemática e quantitativa do condicionamento físico de jogadores de futebol é de suma importância para o acompanhamento periódico e o planejamento dos programas de treinamento. É importante salientar que os testes devem se aproximar ao máximo da prática esportiva, portanto, deve-se respeitar o princípio da especificidade. O presente estudo teve como objetivo avaliar as relações entre a potência anaeróbia em jo-gadores de futebol e os indicadores antropométricos da composição corporal: seis joga-dores de futebol, 23,0 anos (+5,06), adultos do sexo masculino, estatura 1,72 m (+0,01), IMC 23,5 kg/m2 (+3,1), RCQ 0,79 (+0,01). Utilizou-se o RAST, o qual consiste na execução de 6 corridas de 35 m na máxima velocidade, com intervalos de 10 segundos entre cada uma. O desempenho dos atletas em cada corrida foi cronometrado manualmente. Verificou-se forte correlação de Pearson e significante (p<0,05) entre o IMC e a potência média (r=0,82) e o índice de fadiga (r=0,88),...

Journal of Exercise Physiology Online

The purpose of this study was to evaluate the functional, anthropometric, and metabolic profiles ... more The purpose of this study was to evaluate the functional, anthropometric, and metabolic profiles of 24 soccer players in pre-season Northeast Brazil 2nd division. The metabolic profile was determined from blood samples collected during fasting. Although the anthropometric data are consistent with that of the national players, aerobic power (VO2 max 51.2 mL·kg-1·min-1 ±6.8) was lower. Anaerobic power (9.5 W·kg-1 ± 2.8) was close to the national mean, but anaerobic endurance was not. Urea, creatinine, albumin, and total protein were adequate when compared to similar athletes. The values for tissue injury enzymes, AST and ALT, were relatively high. The lipid profile values were consistent with the population references, but the athletes with an elevated lipid profile showed normal percent body fat (BF%). We concluded that the BF% is not a strong predictor of health alone.

Essential oils are complex systems resulting from secondary metabolism. Essential oil from Croton... more Essential oils are complex systems resulting from secondary metabolism. Essential oil from Croton argyrophyllus (EOCA) is commonly extracted from its leaves. In previous studies, were reported to the essential oil of the genus croton anti-inflammatory, antioxidant and antiproliferative activities. Thus becomes relevant to find the main compounds and citotoxicity concentration of EOCA. As this plant is greatly used among the communities of the semiarid region of Brazil, the present study aimed to identify the chemical composition and analyze the citotoxicity of EOCA.

This study aimed to describe the health-related physical fitness of adolescents from public schoo... more This study aimed to describe the health-related physical fitness of adolescents from public schools in the city of Aracaju, SE, Brazil, and the effects of growth and maturation on physical variables. The sample was composed of 288 elementary school students, 146 of whom were male and 142 female, aged between 10 and 14 years. The following variables were measured: body mass, height, flexibility, muscle strength/endurance and aerobic capacity. Descriptive statistics and Student’s t test for independent samples were used for data analysis, adopting a 5% significance level (p <0.05). When the results from the two sexes were compared, significant low variations were observed, always in favor of the males, in all variables with the exception of abdominal strength at 11, 12 and 13 years of age, strength/resistance of arms at 12 years and aerobic capacity (VO2max) at 10, 12 and 14 years, for all of which differences were not significant. Sexual maturity only had na effect on flexibility ...

P e r i ó di co d o I ns t i t uto Br a si l e ir o d e P e s q ui s a e Ens i no e m F i s io lo... more P e r i ó di co d o I ns t i t uto Br a si l e ir o d e P e s q ui s a e Ens i no e m F i s io lo g i a do Ex e rc íc i o w w w. i b p e f e x. c o m. b r / w w w. r b p f e x. c o m. b r RESUMO O objetivo da pesquisa foi identificar as características de formação acadêmica e metodologia de intervenção dos PT atuantes na cidade de Cacoal-RO. A amostra foi constituída por 44 PT (29 homens, 15 mulheres, 28,7±3,7 anos) atuantes em academias, clubes, residências e parques da cidade de Cacoal-RO. Como instrumento para coleta de dados foram utilizados dois questionários distintos com perguntas fechadas do tipo múltipla escolha, elaborados por Leal e colaboradores (2011) buscando identificar características da formação acadêmica, atuação profissional, elaboração e acompanhamento do treinamento com os clientes. Para análise, os dados foram tabuados e apresentados em distribuição percentual. A maioria dos profissionais eram homens jovens, semelhante a dados prévios da literatura. Com relação...