Ramit Singla - Academia.edu (original) (raw)

Papers by Ramit Singla

Research paper thumbnail of Incidence of Pediatric Stroke During the COVID-19 Pandemic in a Tertiary Care Center

Clinical Pediatrics, 2021

Children affected by the novel human coronavirus, severe acute respiratory syndrome-coronavirus d... more Children affected by the novel human coronavirus, severe acute respiratory syndrome-coronavirus disease-2019 (SARS-CoV-2, causing the COVID-19 [coronavirus disease-2019] pandemic) have been reported to have concurrent or postinfectious disorders of both the central and peripheral nervous systems1. Examples of central nervous system disorders associated with COVID-19 in children include headache, seizure, cerebral edema, demyelination, and ischemic or hemorrhagic stroke1-3. While certain case series have noted the increased incidence of stroke in adults (21% increased risk of any thromboembolic events, with a 2.5% increased risk of ischemic stroke) affected by COVID-19, there are limited data in children4-6. To some extent this may be due to baseline variation in the prevalence of stroke in children compared with adults.

Research paper thumbnail of WSO904915 Supplemental material - Supplemental material for Risk factors and outcomes of intravenous tissue plasminogen activator and endovascular thrombectomy utilization amongst pediatrics acute ischemic stroke

Supplemental material, WSO904915 Supplemental material for Risk factors and outcomes of intraveno... more Supplemental material, WSO904915 Supplemental material for Risk factors and outcomes of intravenous tissue plasminogen activator and endovascular thrombectomy utilization amongst pediatrics acute ischemic stroke by Preeti Malik, Urvish K Patel, Surabhi Kaul, Ramit Singla, Tapan Kavi, Kogulavadanan Arumaithurai and Vishal B Jani in International Journal of Stroke

Research paper thumbnail of Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis

Cureus, 2021

Introduction Intraventricular hemorrhage (IVH) is a common cause of morbidity and mortality in pr... more Introduction Intraventricular hemorrhage (IVH) is a common cause of morbidity and mortality in preterm neonates. IVH leads to complications such as posthemorrhagic hydrocephalus (PHH), which commonly occurs in neonates with a more severe degree of IVH. Hence, we aimed to evaluate the characteristics and outcomes of PHH in neonates with IVH. Methods We performed a systematic review of cases reported from January 1978 to December 2020 through the PubMed database, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the keywords 'intraventricular hemorrhage,' 'cerebral intraventricular hemorrhage,' and 'newborn.' A total of 79 articles were considered for analysis, and data on neonatal and maternal characteristics and outcomes were collected. The analysis was performed by using the χ2 test, Wilcoxon rank-sum test, and multivariate logistic regression model. Results We analyzed a total of 101 IVH cases, 54.5% were male and 62.4% preterm. Thirteen point nine percent (13.9%) presented with grade I, 35.6% grade II, and grade III respectively, and 8% grade IV IVH. Among the 59 (58.4%) neonates with PHH, 33.6% had resolved PHH and 24.8% had unresolved. In adjusted regression analysis, we found that neonates with resolved PHH have lower odds of having neurodevelopmental delay (OR:0.15, 95%CI:0.03-0.74; p=0.02) and death (OR:0.9;95%CI:0.01-0.99; p=0.049) as compared to unresolved PHH. Conclusion Our study showed that neonates with resolved PHH have a statistically significant lower risk of neurodevelopmental delay (NDD) and mortality. Future studies should be planned to evaluate the role of treatment and its effect on outcomes in IVH neonates with PHH as a complication.

Research paper thumbnail of Risk factors and outcomes of intravenous tissue plasminogen activator and endovascular thrombectomy utilization amongst pediatrics acute ischemic stroke

International Journal of Stroke, 2020

Background Pediatric stroke is a debilitating disease. There are several risk factors predisposin... more Background Pediatric stroke is a debilitating disease. There are several risk factors predisposing children to this life-threatening disease. Although, published literature estimates a relatively high incidence of pediatric stroke, treatment guidelines on intravenous tissue plasminogen activator and endovascular thrombectomy utilization remain a dilemma. There is a lack of large population-based studies and clinical trials evaluating the efficacy and safety outcomes associated with these treatments in this unique population. Aim We sought to determine the prevalence of risk factors, concurrent utilization of intravenous tissue plasminogen activator and endovascular thrombectomy, and associated outcomes in pediatric stroke hospitalizations. Methods We performed a retrospective analysis of the Nationwide Inpatient Sample data (2003–2014) in pediatric (1–21 years of age) acute ischemic stroke hospitalizations using ICD-9-CM codes. The multivariable survey logistic regression model was ...

Research paper thumbnail of Incidence of Pediatric Stroke During the COVID-19 Pandemic in a Tertiary Care Center

Clinical Pediatrics, 2021

Children affected by the novel human coronavirus, severe acute respiratory syndrome-coronavirus d... more Children affected by the novel human coronavirus, severe acute respiratory syndrome-coronavirus disease-2019 (SARS-CoV-2, causing the COVID-19 [coronavirus disease-2019] pandemic) have been reported to have concurrent or postinfectious disorders of both the central and peripheral nervous systems1. Examples of central nervous system disorders associated with COVID-19 in children include headache, seizure, cerebral edema, demyelination, and ischemic or hemorrhagic stroke1-3. While certain case series have noted the increased incidence of stroke in adults (21% increased risk of any thromboembolic events, with a 2.5% increased risk of ischemic stroke) affected by COVID-19, there are limited data in children4-6. To some extent this may be due to baseline variation in the prevalence of stroke in children compared with adults.

Research paper thumbnail of WSO904915 Supplemental material - Supplemental material for Risk factors and outcomes of intravenous tissue plasminogen activator and endovascular thrombectomy utilization amongst pediatrics acute ischemic stroke

Supplemental material, WSO904915 Supplemental material for Risk factors and outcomes of intraveno... more Supplemental material, WSO904915 Supplemental material for Risk factors and outcomes of intravenous tissue plasminogen activator and endovascular thrombectomy utilization amongst pediatrics acute ischemic stroke by Preeti Malik, Urvish K Patel, Surabhi Kaul, Ramit Singla, Tapan Kavi, Kogulavadanan Arumaithurai and Vishal B Jani in International Journal of Stroke

Research paper thumbnail of Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis

Cureus, 2021

Introduction Intraventricular hemorrhage (IVH) is a common cause of morbidity and mortality in pr... more Introduction Intraventricular hemorrhage (IVH) is a common cause of morbidity and mortality in preterm neonates. IVH leads to complications such as posthemorrhagic hydrocephalus (PHH), which commonly occurs in neonates with a more severe degree of IVH. Hence, we aimed to evaluate the characteristics and outcomes of PHH in neonates with IVH. Methods We performed a systematic review of cases reported from January 1978 to December 2020 through the PubMed database, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the keywords 'intraventricular hemorrhage,' 'cerebral intraventricular hemorrhage,' and 'newborn.' A total of 79 articles were considered for analysis, and data on neonatal and maternal characteristics and outcomes were collected. The analysis was performed by using the χ2 test, Wilcoxon rank-sum test, and multivariate logistic regression model. Results We analyzed a total of 101 IVH cases, 54.5% were male and 62.4% preterm. Thirteen point nine percent (13.9%) presented with grade I, 35.6% grade II, and grade III respectively, and 8% grade IV IVH. Among the 59 (58.4%) neonates with PHH, 33.6% had resolved PHH and 24.8% had unresolved. In adjusted regression analysis, we found that neonates with resolved PHH have lower odds of having neurodevelopmental delay (OR:0.15, 95%CI:0.03-0.74; p=0.02) and death (OR:0.9;95%CI:0.01-0.99; p=0.049) as compared to unresolved PHH. Conclusion Our study showed that neonates with resolved PHH have a statistically significant lower risk of neurodevelopmental delay (NDD) and mortality. Future studies should be planned to evaluate the role of treatment and its effect on outcomes in IVH neonates with PHH as a complication.

Research paper thumbnail of Risk factors and outcomes of intravenous tissue plasminogen activator and endovascular thrombectomy utilization amongst pediatrics acute ischemic stroke

International Journal of Stroke, 2020

Background Pediatric stroke is a debilitating disease. There are several risk factors predisposin... more Background Pediatric stroke is a debilitating disease. There are several risk factors predisposing children to this life-threatening disease. Although, published literature estimates a relatively high incidence of pediatric stroke, treatment guidelines on intravenous tissue plasminogen activator and endovascular thrombectomy utilization remain a dilemma. There is a lack of large population-based studies and clinical trials evaluating the efficacy and safety outcomes associated with these treatments in this unique population. Aim We sought to determine the prevalence of risk factors, concurrent utilization of intravenous tissue plasminogen activator and endovascular thrombectomy, and associated outcomes in pediatric stroke hospitalizations. Methods We performed a retrospective analysis of the Nationwide Inpatient Sample data (2003–2014) in pediatric (1–21 years of age) acute ischemic stroke hospitalizations using ICD-9-CM codes. The multivariable survey logistic regression model was ...