Siting Yang - Academia.edu (original) (raw)
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CSIC (Consejo Superior de Investigaciones Científicas-Spanish National Research Council)
Istituto Italiano di Tecnologia / Italian Institute of Technology
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Papers by Siting Yang
Biomedical Engineering Letters
Small, 2019
Flexible electronics that can form tight interfaces with neural tissues hold great promise for im... more Flexible electronics that can form tight interfaces with neural tissues hold great promise for improving the diagnosis and treatment of neurological disorders and advancing brain/machine interfaces. Here, the facile fabrication of a novel flexible micropillar electrode array (µPEA) is decribed based on a biotemplate method. The flexible and compliant µPEA can readily integrate with the soft surface of rat cerebral cortex. Moreover, the recording sites of the µPEA consist of protruding micropillars with nanoscale surface roughness that ensure tight interfacing and efficient electrical coupling with the nervous system. As a result, the flexible µPEA allows for in vivo multichannel recordings of epileptiform activity with high signal-to-noise ratio (SNR) of 252 ± 35. The ease of preparation, high flexibility, and biocompatibility make the µPEA an attractive tool for in vivo spatiotemporal mapping of neural activity.
Biomedical Engineering Letters
Small, 2019
Flexible electronics that can form tight interfaces with neural tissues hold great promise for im... more Flexible electronics that can form tight interfaces with neural tissues hold great promise for improving the diagnosis and treatment of neurological disorders and advancing brain/machine interfaces. Here, the facile fabrication of a novel flexible micropillar electrode array (µPEA) is decribed based on a biotemplate method. The flexible and compliant µPEA can readily integrate with the soft surface of rat cerebral cortex. Moreover, the recording sites of the µPEA consist of protruding micropillars with nanoscale surface roughness that ensure tight interfacing and efficient electrical coupling with the nervous system. As a result, the flexible µPEA allows for in vivo multichannel recordings of epileptiform activity with high signal-to-noise ratio (SNR) of 252 ± 35. The ease of preparation, high flexibility, and biocompatibility make the µPEA an attractive tool for in vivo spatiotemporal mapping of neural activity.