Sofia Blanco - Academia.edu (original) (raw)

Papers by Sofia Blanco

Research paper thumbnail of Discovery of Novel Non-Cyclam Polynitrogenated CXCR4 Coreceptor Inhibitors

Chemmedchem, 2008

HIV cell fusion and entry have been validated as targets for therapeutic intervention against inf... more HIV cell fusion and entry have been validated as targets for therapeutic intervention against infection. Bicyclams were the first low-molecular-weight compounds to show specific interaction with CXCR4. The most potent bicyclam was AMD3100, in which the two cyclam moieties are tethered by a 1,4-phenylenebis(methylene) bridge. It was withdrawn from clinical trials owing to its lack of oral bioavailability and cardiotoxicity. We have designed a combinatorial library of non-cyclam polynitrogenated compounds by preserving the main features of AMD3100. At least two nitrogen atoms on each side of the p-phenylene moiety, one in the benzylic position and the other(s) in the heterocyclic system were maintained, and the distances between them were similar to the nitrogen atom distances in cyclam. A selection of diverse compounds from this library were prepared, and their in vitro activity was tested in cell cultures against HIV strains. This led to the identification of novel potent CXCR4 coreceptor inhibitors without cytotoxicity at the tested concentrations.

Research paper thumbnail of Regulation of capsular polysialic acid biosynthesis by temperature in Pasteurella haemolytica A2

Febs Letters, 1999

The capsular polysaccharide of Pasteurella haemolytica A2 consists of a linear polymer of N-acety... more The capsular polysaccharide of Pasteurella haemolytica A2 consists of a linear polymer of N-acetylneuraminic acid (Neu5Ac) with K K(2^8) linkages. The production of this polymer is strictly regulated by the growth temperature and above 40³C no production is detected. Analysis of the enzymatic activities directly involved in its biosynthesis reveals that Neu5Ac lyase, CMP-Neu5Ac synthetase and polysialyltransferase are involved in this regulation. Very low activities were found in P. haemolytica grown at 43³C (at least 25 times lower than those observed when the growth temperature was 37³C). The synthesis of these enzymes increased rapidly when bacteria grown at 43³C were transferred to 37³C and decreased dramatically when cells grown at 37³C were transferred to 43³C. These findings indicate that the cellular growth temperature regulates the synthesis of these enzymes and hence the concentration of the intermediates necessary for capsular polysaccharide genesis in P. haemolytica A2.

Research paper thumbnail of Small intestinal malignancy and celiac disease

Research paper thumbnail of Violencia y embarazo en usuarias del sector salud en estados de alta marginación en México

Salud Publica De Mexico, 2006

Research paper thumbnail of Dissimilar Al to Mg Alloy Friction Stir Welds

Advanced Engineering Materials, 2006

In most alloy systems conventional welding processes can promote liquation of low melting point c... more In most alloy systems conventional welding processes can promote liquation of low melting point constituents. It has even been demonstrated that liquation in the sub-solidus heat affected zone can occur at temperatures well below that of the solidus of the bulk material.[1–3] Friction ...

Research paper thumbnail of Dew Points of Ternary Methane (or Ethane) + Carbon Dioxide + Water Mixtures: Measurement and Correlation

Energy & Fuels, 2004

Experimental measurements of dew points for seven methane + carbon dioxide + water mixtures in th... more Experimental measurements of dew points for seven methane + carbon dioxide + water mixtures in the pressure range of 1.1 × 10 5 -60.5 × 10 5 Pa in the temperature range of 243.1-288.1 K, and four ethane + carbon dioxide + water mixtures at pressures of 1.1 × 10 5 -20.3 × 10 5 Pa and temperatures of 252.2-288.4 K, were determined. The experimental results obtained on the ternary systems were analyzed in terms of a predictive excess function-equation of state (EF-EOS) method, which reproduced experimental dew-point temperature data within an absolute average deviation (AAD) of 0.1-2.1 K. The experimental results obtained for the studied mixtures at pressures of >5 × 10 5 Pa were also compared to a predictive equation of state (EOS) model. It reproduced experimental dew-point temperature data within AAD values of 0.9-2.1 K.

Research paper thumbnail of Densities and Isothermal Compressibilities at Pressures up to 20 MPa of the Systems 1Methyl2-pyrrolidone + 1Chloroalkane or + α,ω-Dichloroalkane

Journal of Chemical and Engineering Data, 2008

Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichloro... more Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichlorobutane, and 1,6-dichlorohexane were measured at (288.15, 298.15, 308.15, and 318.15) K at pressures up to 20 MPa, and from them, isothermal compressibilities were obtained. Densities

Research paper thumbnail of Dew Points of Ternary Ethane + Water + Methanol: Measurement and Correlation

Energy & Fuels, 2000

Experimental measurements of dew points for ternary propane+ water+ methanol were carried out bet... more Experimental measurements of dew points for ternary propane+ water+ methanol were carried out between 0.99× 10 5 Pa and 5.43× 10 5 Pa and the temperature range from 254.2 K to 282.7 K. An EOS-CR method (equation of state-chemical reticular) reproduces the ...

Research paper thumbnail of Dew points of binary carbon dioxide + water and ternary carbon dioxide + water + methanol mixtures

Fluid Phase Equilibria, 2004

Dew points for four carbon dioxide + water mixtures between 1.2 × 10 5 and 41.1 × 10 5 Pa in the ... more Dew points for four carbon dioxide + water mixtures between 1.2 × 10 5 and 41.1 × 10 5 Pa in the temperature range from 251.9 to 288.2 K, and eight carbon dioxide + water + methanol mixtures between 1.2 × 10 5 and 43.5 × 10 5 Pa and temperatures from 246.0 to 289.0 K were experimentally determined. The experimental results obtained on the binary and ternary systems were analysed in terms of a predictive excess function-equation of state (EF-EOS) method, which reproduced the experimental dew point temperature data with absolute average deviation (AAD) between 0.8 and 1.8 K for the systems with water, and from 0.0 to 2.7 K for the systems with water and methanol. The experimental results obtained for carbon dioxide + water mixtures, with molar fraction of water lower than 0.00174, at pressure values higher than 5 × 10 5 Pa were also compared to a predictive equation of state model. It reproduced experimental dew point temperature data with AAD between 0.2 and 0.6 K.

Research paper thumbnail of Dew points of ternary methane + water + methanol. Measurement and correlation

Canadian Journal of Chemistry-revue Canadienne De Chimie, 2000

Page 1. Dew points of ternary methane + water + methanol. Measurement and correlation Sofía T. Bl... more Page 1. Dew points of ternary methane + water + methanol. Measurement and correlation Sofía T. Blanco, Inmaculada Velasco, Evelyne Rauzy, and Santos Otín Abstract: A water and methanol dew point generation device has been built up and tested. ...

Research paper thumbnail of Dew Points of Binary Nitrogen + Water Mixtures

Physics and Chemistry of Liquids, 2002

... Titre du document / Document title. Dew points of binary nitrogen+water mixtures Auteur(s) / ... more ... Titre du document / Document title. Dew points of binary nitrogen+water mixtures Auteur(s) / Author(s). BLANCO Sofia T. (1) ; VELASCO Inmaculada (1) ; OTIN Santos (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). ...

Research paper thumbnail of Volumetric Behavior of the {CO 2 (1) + C 2 H 6 (2)} System in the Subcritical ( T = 293.15 K), Critical, and Supercritical ( T = 308.15 K) Regions

Journal of Physical Chemistry B, 2010

The volumetric behavior for the {CO2 (1) + C2H6 (2)} system has been studied. Density measurement... more The volumetric behavior for the {CO2 (1) + C2H6 (2)} system has been studied. Density measurements of {CO2 (1) + C2H6 (2)} binary mixtures at 293.15 and 308.15 K, at several pressures and compositions, and density measurements for infinitely dilute solutions at 304.21 and 308.15 K were carried out using an Anton Paar DMA 512-P vibrating-tube densimeter calibrated with the forced path mechanical calibration model. The mean relative standard deviation of density, s(rho)(r), was estimated to be better than 0.1%, and the uncertainties in temperature and pressure were estimated as +/-0.01 K and +/-0.001 MPa, respectively. In the experimental setup, an uncertainty in the mole fraction of u(x(j)) = +/-0.0015 has been achieved. Other properties related to P-rho-T-x data such as the compressibility factor, Z, excess molar volumes, V(m)(E), and partial molar volumes, V(i) and V(i)(infinity) have been calculated. The volumetric behavior has been compared with literature data and with that obtained from the PC-SAFT EoS rescaled parameters; these parameters have been obtained from our previous experimental values for the critical temperature and pressure of pure compounds. The value for the Krichevskii parameter, A(Kr), was obtained from the experimental density data for infinitely dilute solutions measured in this work, and it has been compared with that obtained from critical properties. Structural properties such as direct and total correlation function integrals and cluster size were calculated using the Krichevskii function concept.

Research paper thumbnail of Excess molar enthalpies of binary mixtures containing mono- and polybromoalkanes at 298.15 K

Journal of Chemical and Engineering Data, 1995

Hf of dimethylcarbonate, diethylcarbonate or propylene carbonate + trans-1,2-dichloroethylene, + ... more Hf of dimethylcarbonate, diethylcarbonate or propylene carbonate + trans-1,2-dichloroethylene, + trichloroethylene, and + tetrachloroethylene, respectively have been determined at 298.15 K using an LKB flow-microcalorimeter. Experimental data have been correlated by means of the Redlich-Kister equation and adjustable parameters have been evaluated by least-squares analysis. The HE values range from a minimum value of -1000 J molt I for diethylcarbonate + trans-1,2-dichloroethylene up to a maximum of 920 J molt ' for dimethylcarbonate + tetrachloroethylene.

Research paper thumbnail of Densities and Isothermal Compressibilities at Pressures up to 20 MPa of the Systems N , N -Dimethylformamide or N , N Dimethylacetamide + 1Chloroalkane

Journal of Chemical and Engineering Data, 2007

Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichloro... more Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichlorobutane, and 1,6-dichlorohexane were measured at (288.15, 298.15, 308.15, and 318.15) K at pressures up to 20 MPa, and from them, isothermal compressibilities were obtained. Densities

Research paper thumbnail of Excess enthalpies of dibromoalkane + benzene binary mixtures at 298.15 K

Journal of Chemical and Engineering Data, 1993

An isobaric and quasi-isothermic calorimeter hae been used to determine excess molar enthalpies, ... more An isobaric and quasi-isothermic calorimeter hae been used to determine excess molar enthalpies, HE, at 298.15 K and atmospheric pressure for seven binary mixtures containing a dibromoalkane (dibromomethane, l, a-dibromoethane, l, &dibromopropane, 1, 4-...

Research paper thumbnail of Excess molar volumes of nitrile + ketone mixtures at 298.15 K

Thermochimica Acta, 1994

Excess molar volumes of twelve binary nitrile + ketone mixtures (acetonitrile, butyronitrile or p... more Excess molar volumes of twelve binary nitrile + ketone mixtures (acetonitrile, butyronitrile or pentanenitrile + propanone, + butanone, + 2-pentanone or + 3-pentanone) have been determined from density measurements at 298.15 K using a vibrating-tube densitometer. Excess molar volumes for these mixtures are negative except for butyronitrile or pentanenitrile + propanone.

Research paper thumbnail of Critical Properties and High-Pressure Volumetric Behavior of the Carbon Dioxide + Propane System at T = 308.15 K. Krichevskii Function and Related Thermodynamic Properties

Journal of Physical Chemistry B, 2009

Critical properties and volumetric behavior for the {CO2(1)+C3H8(2)} system have been studied. Th... more Critical properties and volumetric behavior for the {CO2(1)+C3H8(2)} system have been studied. The critical locus was measured with a flow apparatus and detected by critical opalescence. For the mixtures, repeatabilities in critical temperature and pressure are rTc<or=0.15 K and rPc<or=0.013 MPa, respectively, and the confidence intervals calculated are c.i.(Tc)<0.32 K and c.i.(Pc)<0.034 MPa. The value for the Krichevskii parameter, AKr=-4.12 MPa, was obtained from the experimental critical data in this work. Additionally, the density measurements of 15 {CO2(1)+C3H8(2)} binary mixtures at 308.15 K and pressures up to 20 MPa were carried out using an Anton Paar DMA 512-P vibrating-tube densimeter calibrated with the forced path mechanical calibration model. The mean relative standard deviation of density, srhor, was estimated to be better than 0.1%, and the uncertainties in temperature and pressure are +/-0.01 K and +/-0.001 MPa, respectively. In the experimental setup, an uncertainty in the mole fraction, u(xj)=+/-0.0015, has been achieved. Other properties related to P-rho-T-x data such as saturated densities, rhoL and rhoV, compressibility factor, Z, excess molar volumes,VmE, and partial molar volumes, Vi, have been calculated. Structural properties such as direct and total correlation function integrals and cluster size were calculated using the Krichevskii function concept. Both the critical and volumetric behavior have been compared with literature data and with those obtained from the PC-SAFT and Patel-Teja equations of state.

Research paper thumbnail of Dew Points of Quaternary Methane + Carbon Dioxide + Water + Methanol Mixtures. Measurement and Correlation

Industrial & Engineering Chemistry Research, 2004

ABSTRACT Experimental measurements of dew points for 14 methane + carbon dioxide + water + methan... more ABSTRACT Experimental measurements of dew points for 14 methane + carbon dioxide + water + methanol mixtures at pressures between 1.0 × 105 and 59.1 × 105 Pa in the temperature range from 241.6 to 288.8 K were made. The experimental results obtained on the quaternary systems were analyzed in terms of a predictive EF−EOS (excess function−equation of state) method, which reproduced experimental dew-point temperature data within an AAD (absolute average deviation) of between 0.0 and 1.9 K.

Research paper thumbnail of Dew Points of Binary Propane or n -butane + Carbon Dioxide, Ternary Propane or n -butane + Carbon Dioxide + Water, and Quaternary Propane or n -butane + Carbon Dioxide + Water + Methanol Mixtures: Measurement and Modeling

Industrial & Engineering Chemistry Research, 2006

Dew points have been measured for binary propane or n-butane + carbon dioxide mixtures at pressur... more Dew points have been measured for binary propane or n-butane + carbon dioxide mixtures at pressures from 1.2 × 10 5 to 34.9 × 10 5 Pa and temperatures from 192.6 to 274.8 K, four ternary propane or n-butane + carbon dioxide + water mixtures from 1.1 × 10 5 to 20.7 × 10 5 Pa and temperatures from 247.5 to 289.0 K, and eight quaternary propane or n-butane + carbon dioxide + water + methanol mixtures from 1.1 × 10 5 to 21.8 × 10 5 Pa and temperatures from 249.8 to 289.9 K. The results are analyzed in terms of a predictive EF-EOS excess-function equation of state method based on the zeroth-approximation of Guggenheim's reticular model. This method has been chosen because it can be used to adequately predict the dew points of all the mixtures of our interest in the dew temperature and pressure ranges. In fact, the model reproduces the experimental dew-point temperature data within an AAD (absolute average deviation) of 1.6 and 1.3 K for the binary systems, between 0.1 and 2.5 K for the ternary systems, and between 0.0 and 5.1 K for the quaternary systems. The experimental results obtained for ternary propane or n-butane + carbon dioxide + water mixtures at pressure values higher than 5 × 10 5 Pa were also compared to a predictive EOS (equation of state) model. It reproduced experimental dew-point temperature data within AAD between 0.0 and 5.5 K.

Research paper thumbnail of Thermodynamic Properties of Synthetic Natural Gases. 2. Dew Point Curves of Synthetic Natural Gases and Their Mixtures with Water and Methanol. Measurement and Correlation

Energy & Fuels, 2002

Dew points for two synthetic natural gas (SNG) mixtures between 1.2 × 10 5 and 81.8 × 10 5 Pa in ... more Dew points for two synthetic natural gas (SNG) mixtures between 1.2 × 10 5 and 81.8 × 10 5 Pa in the temperature range from 213.6 to 261.4 K, four SNG + water mixtures between 1.1 × 10 5 and 41.0 × 10 5 Pa and temperatures from 244.7 to 288.1 K, and four SNG + water + methanol mixtures between 1.1 × 10 5 and 20.7 × 10 5 Pa and temperatures from 247.6 to 288.6 K were experimentally determined. The experimental results obtained on the multicomponent systems were analyzed in terms of a predictive excess function-equation of state (EF-EOS) method, which reproduced experimental dew point temperature data with absolute average deviation (AAD) between 0.9 and 3.1 K for the dry systems, from 0.0 to 1.6 K for the systems with water, and from 0.0 to 3.0 K for the systems with water and methanol. The experimental results obtained for synthetic natural gas (SNG) + water mixtures at pressure values higher than 5 × 10 5 Pa were also compared to a predictive equation of state (EOS) model. It reproduced experimental dew point temperature data within AAD between 1.8 and 5.3 K.

Research paper thumbnail of Discovery of Novel Non-Cyclam Polynitrogenated CXCR4 Coreceptor Inhibitors

Chemmedchem, 2008

HIV cell fusion and entry have been validated as targets for therapeutic intervention against inf... more HIV cell fusion and entry have been validated as targets for therapeutic intervention against infection. Bicyclams were the first low-molecular-weight compounds to show specific interaction with CXCR4. The most potent bicyclam was AMD3100, in which the two cyclam moieties are tethered by a 1,4-phenylenebis(methylene) bridge. It was withdrawn from clinical trials owing to its lack of oral bioavailability and cardiotoxicity. We have designed a combinatorial library of non-cyclam polynitrogenated compounds by preserving the main features of AMD3100. At least two nitrogen atoms on each side of the p-phenylene moiety, one in the benzylic position and the other(s) in the heterocyclic system were maintained, and the distances between them were similar to the nitrogen atom distances in cyclam. A selection of diverse compounds from this library were prepared, and their in vitro activity was tested in cell cultures against HIV strains. This led to the identification of novel potent CXCR4 coreceptor inhibitors without cytotoxicity at the tested concentrations.

Research paper thumbnail of Regulation of capsular polysialic acid biosynthesis by temperature in Pasteurella haemolytica A2

Febs Letters, 1999

The capsular polysaccharide of Pasteurella haemolytica A2 consists of a linear polymer of N-acety... more The capsular polysaccharide of Pasteurella haemolytica A2 consists of a linear polymer of N-acetylneuraminic acid (Neu5Ac) with K K(2^8) linkages. The production of this polymer is strictly regulated by the growth temperature and above 40³C no production is detected. Analysis of the enzymatic activities directly involved in its biosynthesis reveals that Neu5Ac lyase, CMP-Neu5Ac synthetase and polysialyltransferase are involved in this regulation. Very low activities were found in P. haemolytica grown at 43³C (at least 25 times lower than those observed when the growth temperature was 37³C). The synthesis of these enzymes increased rapidly when bacteria grown at 43³C were transferred to 37³C and decreased dramatically when cells grown at 37³C were transferred to 43³C. These findings indicate that the cellular growth temperature regulates the synthesis of these enzymes and hence the concentration of the intermediates necessary for capsular polysaccharide genesis in P. haemolytica A2.

Research paper thumbnail of Small intestinal malignancy and celiac disease

Research paper thumbnail of Violencia y embarazo en usuarias del sector salud en estados de alta marginación en México

Salud Publica De Mexico, 2006

Research paper thumbnail of Dissimilar Al to Mg Alloy Friction Stir Welds

Advanced Engineering Materials, 2006

In most alloy systems conventional welding processes can promote liquation of low melting point c... more In most alloy systems conventional welding processes can promote liquation of low melting point constituents. It has even been demonstrated that liquation in the sub-solidus heat affected zone can occur at temperatures well below that of the solidus of the bulk material.[1–3] Friction ...

Research paper thumbnail of Dew Points of Ternary Methane (or Ethane) + Carbon Dioxide + Water Mixtures: Measurement and Correlation

Energy & Fuels, 2004

Experimental measurements of dew points for seven methane + carbon dioxide + water mixtures in th... more Experimental measurements of dew points for seven methane + carbon dioxide + water mixtures in the pressure range of 1.1 × 10 5 -60.5 × 10 5 Pa in the temperature range of 243.1-288.1 K, and four ethane + carbon dioxide + water mixtures at pressures of 1.1 × 10 5 -20.3 × 10 5 Pa and temperatures of 252.2-288.4 K, were determined. The experimental results obtained on the ternary systems were analyzed in terms of a predictive excess function-equation of state (EF-EOS) method, which reproduced experimental dew-point temperature data within an absolute average deviation (AAD) of 0.1-2.1 K. The experimental results obtained for the studied mixtures at pressures of >5 × 10 5 Pa were also compared to a predictive equation of state (EOS) model. It reproduced experimental dew-point temperature data within AAD values of 0.9-2.1 K.

Research paper thumbnail of Densities and Isothermal Compressibilities at Pressures up to 20 MPa of the Systems 1Methyl2-pyrrolidone + 1Chloroalkane or + α,ω-Dichloroalkane

Journal of Chemical and Engineering Data, 2008

Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichloro... more Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichlorobutane, and 1,6-dichlorohexane were measured at (288.15, 298.15, 308.15, and 318.15) K at pressures up to 20 MPa, and from them, isothermal compressibilities were obtained. Densities

Research paper thumbnail of Dew Points of Ternary Ethane + Water + Methanol: Measurement and Correlation

Energy & Fuels, 2000

Experimental measurements of dew points for ternary propane+ water+ methanol were carried out bet... more Experimental measurements of dew points for ternary propane+ water+ methanol were carried out between 0.99× 10 5 Pa and 5.43× 10 5 Pa and the temperature range from 254.2 K to 282.7 K. An EOS-CR method (equation of state-chemical reticular) reproduces the ...

Research paper thumbnail of Dew points of binary carbon dioxide + water and ternary carbon dioxide + water + methanol mixtures

Fluid Phase Equilibria, 2004

Dew points for four carbon dioxide + water mixtures between 1.2 × 10 5 and 41.1 × 10 5 Pa in the ... more Dew points for four carbon dioxide + water mixtures between 1.2 × 10 5 and 41.1 × 10 5 Pa in the temperature range from 251.9 to 288.2 K, and eight carbon dioxide + water + methanol mixtures between 1.2 × 10 5 and 43.5 × 10 5 Pa and temperatures from 246.0 to 289.0 K were experimentally determined. The experimental results obtained on the binary and ternary systems were analysed in terms of a predictive excess function-equation of state (EF-EOS) method, which reproduced the experimental dew point temperature data with absolute average deviation (AAD) between 0.8 and 1.8 K for the systems with water, and from 0.0 to 2.7 K for the systems with water and methanol. The experimental results obtained for carbon dioxide + water mixtures, with molar fraction of water lower than 0.00174, at pressure values higher than 5 × 10 5 Pa were also compared to a predictive equation of state model. It reproduced experimental dew point temperature data with AAD between 0.2 and 0.6 K.

Research paper thumbnail of Dew points of ternary methane + water + methanol. Measurement and correlation

Canadian Journal of Chemistry-revue Canadienne De Chimie, 2000

Page 1. Dew points of ternary methane + water + methanol. Measurement and correlation Sofía T. Bl... more Page 1. Dew points of ternary methane + water + methanol. Measurement and correlation Sofía T. Blanco, Inmaculada Velasco, Evelyne Rauzy, and Santos Otín Abstract: A water and methanol dew point generation device has been built up and tested. ...

Research paper thumbnail of Dew Points of Binary Nitrogen + Water Mixtures

Physics and Chemistry of Liquids, 2002

... Titre du document / Document title. Dew points of binary nitrogen+water mixtures Auteur(s) / ... more ... Titre du document / Document title. Dew points of binary nitrogen+water mixtures Auteur(s) / Author(s). BLANCO Sofia T. (1) ; VELASCO Inmaculada (1) ; OTIN Santos (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). ...

Research paper thumbnail of Volumetric Behavior of the {CO 2 (1) + C 2 H 6 (2)} System in the Subcritical ( T = 293.15 K), Critical, and Supercritical ( T = 308.15 K) Regions

Journal of Physical Chemistry B, 2010

The volumetric behavior for the {CO2 (1) + C2H6 (2)} system has been studied. Density measurement... more The volumetric behavior for the {CO2 (1) + C2H6 (2)} system has been studied. Density measurements of {CO2 (1) + C2H6 (2)} binary mixtures at 293.15 and 308.15 K, at several pressures and compositions, and density measurements for infinitely dilute solutions at 304.21 and 308.15 K were carried out using an Anton Paar DMA 512-P vibrating-tube densimeter calibrated with the forced path mechanical calibration model. The mean relative standard deviation of density, s(rho)(r), was estimated to be better than 0.1%, and the uncertainties in temperature and pressure were estimated as +/-0.01 K and +/-0.001 MPa, respectively. In the experimental setup, an uncertainty in the mole fraction of u(x(j)) = +/-0.0015 has been achieved. Other properties related to P-rho-T-x data such as the compressibility factor, Z, excess molar volumes, V(m)(E), and partial molar volumes, V(i) and V(i)(infinity) have been calculated. The volumetric behavior has been compared with literature data and with that obtained from the PC-SAFT EoS rescaled parameters; these parameters have been obtained from our previous experimental values for the critical temperature and pressure of pure compounds. The value for the Krichevskii parameter, A(Kr), was obtained from the experimental density data for infinitely dilute solutions measured in this work, and it has been compared with that obtained from critical properties. Structural properties such as direct and total correlation function integrals and cluster size were calculated using the Krichevskii function concept.

Research paper thumbnail of Excess molar enthalpies of binary mixtures containing mono- and polybromoalkanes at 298.15 K

Journal of Chemical and Engineering Data, 1995

Hf of dimethylcarbonate, diethylcarbonate or propylene carbonate + trans-1,2-dichloroethylene, + ... more Hf of dimethylcarbonate, diethylcarbonate or propylene carbonate + trans-1,2-dichloroethylene, + trichloroethylene, and + tetrachloroethylene, respectively have been determined at 298.15 K using an LKB flow-microcalorimeter. Experimental data have been correlated by means of the Redlich-Kister equation and adjustable parameters have been evaluated by least-squares analysis. The HE values range from a minimum value of -1000 J molt I for diethylcarbonate + trans-1,2-dichloroethylene up to a maximum of 920 J molt ' for dimethylcarbonate + tetrachloroethylene.

Research paper thumbnail of Densities and Isothermal Compressibilities at Pressures up to 20 MPa of the Systems N , N -Dimethylformamide or N , N Dimethylacetamide + 1Chloroalkane

Journal of Chemical and Engineering Data, 2007

Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichloro... more Densities of pure N, N-dimethylformamide, N,N-dimethylacetamide, 1,2-dichloroethane, 1,4-dichlorobutane, and 1,6-dichlorohexane were measured at (288.15, 298.15, 308.15, and 318.15) K at pressures up to 20 MPa, and from them, isothermal compressibilities were obtained. Densities

Research paper thumbnail of Excess enthalpies of dibromoalkane + benzene binary mixtures at 298.15 K

Journal of Chemical and Engineering Data, 1993

An isobaric and quasi-isothermic calorimeter hae been used to determine excess molar enthalpies, ... more An isobaric and quasi-isothermic calorimeter hae been used to determine excess molar enthalpies, HE, at 298.15 K and atmospheric pressure for seven binary mixtures containing a dibromoalkane (dibromomethane, l, a-dibromoethane, l, &dibromopropane, 1, 4-...

Research paper thumbnail of Excess molar volumes of nitrile + ketone mixtures at 298.15 K

Thermochimica Acta, 1994

Excess molar volumes of twelve binary nitrile + ketone mixtures (acetonitrile, butyronitrile or p... more Excess molar volumes of twelve binary nitrile + ketone mixtures (acetonitrile, butyronitrile or pentanenitrile + propanone, + butanone, + 2-pentanone or + 3-pentanone) have been determined from density measurements at 298.15 K using a vibrating-tube densitometer. Excess molar volumes for these mixtures are negative except for butyronitrile or pentanenitrile + propanone.

Research paper thumbnail of Critical Properties and High-Pressure Volumetric Behavior of the Carbon Dioxide + Propane System at T = 308.15 K. Krichevskii Function and Related Thermodynamic Properties

Journal of Physical Chemistry B, 2009

Critical properties and volumetric behavior for the {CO2(1)+C3H8(2)} system have been studied. Th... more Critical properties and volumetric behavior for the {CO2(1)+C3H8(2)} system have been studied. The critical locus was measured with a flow apparatus and detected by critical opalescence. For the mixtures, repeatabilities in critical temperature and pressure are rTc<or=0.15 K and rPc<or=0.013 MPa, respectively, and the confidence intervals calculated are c.i.(Tc)<0.32 K and c.i.(Pc)<0.034 MPa. The value for the Krichevskii parameter, AKr=-4.12 MPa, was obtained from the experimental critical data in this work. Additionally, the density measurements of 15 {CO2(1)+C3H8(2)} binary mixtures at 308.15 K and pressures up to 20 MPa were carried out using an Anton Paar DMA 512-P vibrating-tube densimeter calibrated with the forced path mechanical calibration model. The mean relative standard deviation of density, srhor, was estimated to be better than 0.1%, and the uncertainties in temperature and pressure are +/-0.01 K and +/-0.001 MPa, respectively. In the experimental setup, an uncertainty in the mole fraction, u(xj)=+/-0.0015, has been achieved. Other properties related to P-rho-T-x data such as saturated densities, rhoL and rhoV, compressibility factor, Z, excess molar volumes,VmE, and partial molar volumes, Vi, have been calculated. Structural properties such as direct and total correlation function integrals and cluster size were calculated using the Krichevskii function concept. Both the critical and volumetric behavior have been compared with literature data and with those obtained from the PC-SAFT and Patel-Teja equations of state.

Research paper thumbnail of Dew Points of Quaternary Methane + Carbon Dioxide + Water + Methanol Mixtures. Measurement and Correlation

Industrial & Engineering Chemistry Research, 2004

ABSTRACT Experimental measurements of dew points for 14 methane + carbon dioxide + water + methan... more ABSTRACT Experimental measurements of dew points for 14 methane + carbon dioxide + water + methanol mixtures at pressures between 1.0 × 105 and 59.1 × 105 Pa in the temperature range from 241.6 to 288.8 K were made. The experimental results obtained on the quaternary systems were analyzed in terms of a predictive EF−EOS (excess function−equation of state) method, which reproduced experimental dew-point temperature data within an AAD (absolute average deviation) of between 0.0 and 1.9 K.

Research paper thumbnail of Dew Points of Binary Propane or n -butane + Carbon Dioxide, Ternary Propane or n -butane + Carbon Dioxide + Water, and Quaternary Propane or n -butane + Carbon Dioxide + Water + Methanol Mixtures: Measurement and Modeling

Industrial & Engineering Chemistry Research, 2006

Dew points have been measured for binary propane or n-butane + carbon dioxide mixtures at pressur... more Dew points have been measured for binary propane or n-butane + carbon dioxide mixtures at pressures from 1.2 × 10 5 to 34.9 × 10 5 Pa and temperatures from 192.6 to 274.8 K, four ternary propane or n-butane + carbon dioxide + water mixtures from 1.1 × 10 5 to 20.7 × 10 5 Pa and temperatures from 247.5 to 289.0 K, and eight quaternary propane or n-butane + carbon dioxide + water + methanol mixtures from 1.1 × 10 5 to 21.8 × 10 5 Pa and temperatures from 249.8 to 289.9 K. The results are analyzed in terms of a predictive EF-EOS excess-function equation of state method based on the zeroth-approximation of Guggenheim's reticular model. This method has been chosen because it can be used to adequately predict the dew points of all the mixtures of our interest in the dew temperature and pressure ranges. In fact, the model reproduces the experimental dew-point temperature data within an AAD (absolute average deviation) of 1.6 and 1.3 K for the binary systems, between 0.1 and 2.5 K for the ternary systems, and between 0.0 and 5.1 K for the quaternary systems. The experimental results obtained for ternary propane or n-butane + carbon dioxide + water mixtures at pressure values higher than 5 × 10 5 Pa were also compared to a predictive EOS (equation of state) model. It reproduced experimental dew-point temperature data within AAD between 0.0 and 5.5 K.

Research paper thumbnail of Thermodynamic Properties of Synthetic Natural Gases. 2. Dew Point Curves of Synthetic Natural Gases and Their Mixtures with Water and Methanol. Measurement and Correlation

Energy & Fuels, 2002

Dew points for two synthetic natural gas (SNG) mixtures between 1.2 × 10 5 and 81.8 × 10 5 Pa in ... more Dew points for two synthetic natural gas (SNG) mixtures between 1.2 × 10 5 and 81.8 × 10 5 Pa in the temperature range from 213.6 to 261.4 K, four SNG + water mixtures between 1.1 × 10 5 and 41.0 × 10 5 Pa and temperatures from 244.7 to 288.1 K, and four SNG + water + methanol mixtures between 1.1 × 10 5 and 20.7 × 10 5 Pa and temperatures from 247.6 to 288.6 K were experimentally determined. The experimental results obtained on the multicomponent systems were analyzed in terms of a predictive excess function-equation of state (EF-EOS) method, which reproduced experimental dew point temperature data with absolute average deviation (AAD) between 0.9 and 3.1 K for the dry systems, from 0.0 to 1.6 K for the systems with water, and from 0.0 to 3.0 K for the systems with water and methanol. The experimental results obtained for synthetic natural gas (SNG) + water mixtures at pressure values higher than 5 × 10 5 Pa were also compared to a predictive equation of state (EOS) model. It reproduced experimental dew point temperature data within AAD between 1.8 and 5.3 K.