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Papers by Sofija Davidovic

Praktikum Iz Oftalmologije

Ophthalmology, 2007

To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece... more To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of the foldable hydrophobic acrylic AcrySof intraocular lens (IOL) over a 5-year period. Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison. Fifty-two patients with bilateral age-related cataract (104 eyes). Each study patient had cataract surgery in both eyes and received a 1-piece AcrySof IOL in 1 eye and a 3-piece AcrySof IOL in the other eye. Follow-up examinations were performed at 1 week, 1 month, 6 months, and 1, 2, and 5 years. Digital retroillumination images were obtained of each eye. The amount of posterior capsule opacification (score range, 0-10) was assessed subjectively at the slit lamp and objectively using automated image analysis software 1, 2, and 5 years after surgery. Posterior capsule opacification score (scale, 0-10). There was no significant difference between the 1-piece and 3-piece AcrySof IOL in ...

Vision related quality of life: A cataract study

Medicinski pregled, 2007

654 Latinovic S, i sai: Studi ja Katarakte Sknéenice VQOL - Vision related Quality of Life ECCE -... more 654 Latinovic S, i sai: Studi ja Katarakte Sknéenice VQOL - Vision related Quality of Life ECCE - ekstrakapsularna ekscizija katarakte FAKO - fakoemulzifikaoija sociva IOS - intraokularno socivo sanje kvaliteta hirurskog rada, razvoj dobre oftal-moloske prakse u zastiti vida i ...

Changes of serum VEGF concentration after intravitreal injection of Avastin in treatment of diabetic retinopathy

European Journal of Ophthalmology, 2012

Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopat... more Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopathy. The aim of our study was to analyze effect of 1.25 mg of intravitreal Avastin on serum concentration of vascular endothelial growth factor (VEGF) in diabetic patients. Participants were 10 diabetic patients on insulin therapy, without any other eye or systemic disease, and no kidney disfunction. Both eyes of diabetic patients were injected simultaneously with 1.25 mg of intravitreal Avastin, as a first step in treatment of nonproliferative diabetic retinopathy with clinically significant macular edema (4 patients), and of proliferative diabetic retinopathy (6 patients). Fluorescein angiography was performed prior to and laser therapy followed 1 month after Avastin treatment. VEGF concentration in patients serum was measured by ELISA technique: on the day of the Avastin administration, and 1, 7, and 28 days after intravitreal injection. In all analyzed participants, 24 hours after Avastin treatment, serum levels of VEGF were lower then basal (preinjection value). Maximal reduction of serum VEGF was noted on the 7th postoperative day. Twenty-eight days after, VEGF level in serum was raised, without completely reaching basal preoperative concentrations in most patients. Intravitreal injections of anti-VEGF drugs have an effect on decreasing systemic VEGF values. Rhythm of changes in serum VEGF concentrations and lowest detected concentration on the seventh postinjection day are according to pharmacokinetics of Avastin in serum and vitreous, reported by similar studies. The small number of patients involved in this pilot study implicates the need for further studies.

Journal of Medical Biochemistry, 2000

List of abbreviations: AIP -atherogenic index of plasma, BMIbo dy mass index, BSA -body surface a... more List of abbreviations: AIP -atherogenic index of plasma, BMIbo dy mass index, BSA -body surface area, CAD -coronary arterial disease, C -cholesterol, CCr -creatinine clearance, DM -diabetes mellitus, DN -diabetic nephropathy, HHcy -hyperhomo cystei ne mia, IM -infarctus myocardii, LPI -lipid pentad index, LTI -lipid tetrad index, NHcy -normohomocysteinemia, oxLDL -oxidised low density cholesterol, PAD -peripheral artery disease, sdLDL -small dense low density cholesterol, TAS -systolic blood pressure, TAD -diastolic blood pressure, tHcy -total homocysteine, UAE -urinary albumin excretion.

Praktikum Iz Oftalmologije

Ophthalmology, 2007

To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece... more To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of the foldable hydrophobic acrylic AcrySof intraocular lens (IOL) over a 5-year period. Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison. Fifty-two patients with bilateral age-related cataract (104 eyes). Each study patient had cataract surgery in both eyes and received a 1-piece AcrySof IOL in 1 eye and a 3-piece AcrySof IOL in the other eye. Follow-up examinations were performed at 1 week, 1 month, 6 months, and 1, 2, and 5 years. Digital retroillumination images were obtained of each eye. The amount of posterior capsule opacification (score range, 0-10) was assessed subjectively at the slit lamp and objectively using automated image analysis software 1, 2, and 5 years after surgery. Posterior capsule opacification score (scale, 0-10). There was no significant difference between the 1-piece and 3-piece AcrySof IOL in ...

Vision related quality of life: A cataract study

Medicinski pregled, 2007

654 Latinovic S, i sai: Studi ja Katarakte Sknéenice VQOL - Vision related Quality of Life ECCE -... more 654 Latinovic S, i sai: Studi ja Katarakte Sknéenice VQOL - Vision related Quality of Life ECCE - ekstrakapsularna ekscizija katarakte FAKO - fakoemulzifikaoija sociva IOS - intraokularno socivo sanje kvaliteta hirurskog rada, razvoj dobre oftal-moloske prakse u zastiti vida i ...

Changes of serum VEGF concentration after intravitreal injection of Avastin in treatment of diabetic retinopathy

European Journal of Ophthalmology, 2012

Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopat... more Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopathy. The aim of our study was to analyze effect of 1.25 mg of intravitreal Avastin on serum concentration of vascular endothelial growth factor (VEGF) in diabetic patients. Participants were 10 diabetic patients on insulin therapy, without any other eye or systemic disease, and no kidney disfunction. Both eyes of diabetic patients were injected simultaneously with 1.25 mg of intravitreal Avastin, as a first step in treatment of nonproliferative diabetic retinopathy with clinically significant macular edema (4 patients), and of proliferative diabetic retinopathy (6 patients). Fluorescein angiography was performed prior to and laser therapy followed 1 month after Avastin treatment. VEGF concentration in patients serum was measured by ELISA technique: on the day of the Avastin administration, and 1, 7, and 28 days after intravitreal injection. In all analyzed participants, 24 hours after Avastin treatment, serum levels of VEGF were lower then basal (preinjection value). Maximal reduction of serum VEGF was noted on the 7th postoperative day. Twenty-eight days after, VEGF level in serum was raised, without completely reaching basal preoperative concentrations in most patients. Intravitreal injections of anti-VEGF drugs have an effect on decreasing systemic VEGF values. Rhythm of changes in serum VEGF concentrations and lowest detected concentration on the seventh postinjection day are according to pharmacokinetics of Avastin in serum and vitreous, reported by similar studies. The small number of patients involved in this pilot study implicates the need for further studies.

Journal of Medical Biochemistry, 2000

List of abbreviations: AIP -atherogenic index of plasma, BMIbo dy mass index, BSA -body surface a... more List of abbreviations: AIP -atherogenic index of plasma, BMIbo dy mass index, BSA -body surface area, CAD -coronary arterial disease, C -cholesterol, CCr -creatinine clearance, DM -diabetes mellitus, DN -diabetic nephropathy, HHcy -hyperhomo cystei ne mia, IM -infarctus myocardii, LPI -lipid pentad index, LTI -lipid tetrad index, NHcy -normohomocysteinemia, oxLDL -oxidised low density cholesterol, PAD -peripheral artery disease, sdLDL -small dense low density cholesterol, TAS -systolic blood pressure, TAD -diastolic blood pressure, tHcy -total homocysteine, UAE -urinary albumin excretion.