Sohaib Aziz - Academia.edu (original) (raw)

Papers by Sohaib Aziz

Research paper thumbnail of Effectiveness and Reliability of Scalp Cooling in Preventing Hair Loss Caused by Chemotherapy

Kocaeli Medical Journal, 2021

Saç dökülmesi, sitotoksik kemoterapilerin en korkulan yan etkilerinden biri olup çok sayıda hasta... more Saç dökülmesi, sitotoksik kemoterapilerin en korkulan yan etkilerinden biri olup çok sayıda hastanın psikososyal durumunu olumsuz yönde etkilemektedir. Çalışmamızda kemoterapi sırasında saçlı deri soğutma yönteminin kemoterapşye bağlı saç dökülmesini önlemedeki etkinliğini, kısa ve uzun dönemdeki istenmeyen etkilerini ve hastanın psikososyal durumunda yarattığı değişiklikleri incelemeyi amaçladık YÖNTEM ve GEREÇLER: Eylül 2018 ve Ocak 2020 tarihleri arasında saçlı deri soğutma yöntemini kullanan 76 ve kullanmayan 75 olmak üzere toplam 151 hasta çalışmaya dahil edildi. Saç dökülme derecesini belirlemek için National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) treatment related alopecia grading system kullanıldı BULGULAR: Saçlı deri soğutma sistemini kullanan hastalarda grade 1 saç dökülmesi oranı %77,6 iken kullanmayan hastalarda bu oran %1,3 idi. Yöntemi kullanan ve kullanmayan hastalar arasında izlem süresi boyunca yan etki profili acısından anlamlı bir fark bulunmadı. TARTIŞMA ve SONUÇ: Saçlı deri soğutma sisteminin kemoterapi ilişkili saç dökülmesini engelleme konusundaki bilgiler gün geçtikçe artıyor olmasına rağmen konu ile ilgili randomize,kontrollü,prospektif çalışma sayısı çok azdır. Bu nedenle çalışmamızın bu yöntemin erkili ve güvenilir olduğuna dair sunduğu verilerin literatür için değerli olduğunu düşünüyoruz Anahtar Kelimeler: saçlı deri soğutma, soğuk kepler, saç dökülmesinin engellenmesi, kemoterapiye bağlı saç dökülmesinin önlenmesi ABSTRACT INTRODUCTION: Hair loss is one of the most feared side effects of cytotoxic chemotherapy and affects the psychosocial status of the patient the most. In our study, we aimed to examine to what extent cooling the scalp with a scalp cooling system can prevent hair loss during chemotherapy, the short-and long-term toxicity of this system, and its effect on the psychosocial status of the patien METHODS: A total of 151 patients were enrolled; of them, 76 and 75 were sequentially using scalp cooling and the control group. We used National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) treatment related alopecia grading system for grading hair loss RESULTS: The proportion of grade 1 (less than 50% off hair loss) alopecia was 77,6% in the scalp cooling group and %1,3 in the control group. In the patients who used the system, no short-and long-term side effects that could be considered significant compared to the control group were not detected. DISCUSSION AND CONCLUSION: Although data on the effectiveness and reliability of scalp cooling used to prevent alopecia caused by chemotherapy is increasing day by day, the number of randomized, controlled, prospective studies on this subject is too few. Our study reveals that scalp cooling reliably and significantly reduces chemotherapy-induced hair loss is well tolerated and improves patients mental health and social condition significantly. However, there is still a need for studies with larger groups.

Research paper thumbnail of Systemic Aspergillosis: Radiological Findings in a Case With Diffuse Large B Cell Lymphoma Treated by Ibrutinib

Cureus, 2021

Herein, we present a case of systemic aspergillosis with a fatal outcome in a case with diffuse l... more Herein, we present a case of systemic aspergillosis with a fatal outcome in a case with diffuse large B cell lymphoma (DLBCL) treated by ibrutinib. Aspergillosis was suspected clinically and proven microbiologically. Radiological findings were compatible with aspergillosis. We aim to review radiological findings in a case with DLBCL treated with ibrutinib, which is an important tyrosine kinase inhibitor used in lymphoid neoplasias.

Research paper thumbnail of Frailty significantly impairs the short term prognosis in elderly patients with heart failure

Journal of Geriatric Cardiology : JGC, 2018

Background Frailty is a condition of elderly characterized by increased vulnerability to stressfu... more Background Frailty is a condition of elderly characterized by increased vulnerability to stressful events with high risk of adverse outcomes. The purpose of this study was to evaluate the association between frailty and adverse outcomes including death and hospitalization due to heart failure in elderly patients. Methods We included patients aged ≥ 65 years with the diagnosis of heart failure. The clinical and laboratory data, echocardiography and ECGs were recorded. Additionally, the frailty scores of the patients were evaluated according to Canadian Study of Health and Aging. All the patients were divided as frail or non-frail. The groups were compared for their characteristics and the occurrence of clinical outcomes. Results We included 86 eligible patients. The median follow-up time was four months. The mean age was 75 ± 6.5 years. Of these 86 patients, 17 (19.7%) patients encountered an event (death and/or hospitalization). Nine patients (10.4%) died during follow-up. Thirty pa...

Research paper thumbnail of Kolon Karsinomunun Preoperatif Lenf Nodu Evrelemesinde Pet-Bt’nin Etkinliği

Giris: Erken evre Kolon kanserinde en onemli prognostik belirtec bolgesel Lenf Nodu (LN) metastaz... more Giris: Erken evre Kolon kanserinde en onemli prognostik belirtec bolgesel Lenf Nodu (LN) metastazi durumudur. Ayrica uygun tedavi planinin yapilabilmesinin en onemli sarti da tam evrelemenin yapilmis olmasidir. Amac: Calismamizda erken evre Kolon kanserinde preoperatif Pozitron Emisyon Tomografisi (PET/BT)’nin bolgesel LN’lari ile ilskisini incelemeyi amacladik. Yontemler: Klinigimizde Mart 2014 ve Temmuz 2019 tarihleri arasinda tedavi ettigimiz 83 erken evre Kolon kanseri hastasinin verilerini retrospektif olarak analiz ettik. Preoperatif PET/BT bulgulari ile Patolojik evrelemedeki bulgulari karsilastirdik Bulgular: Erken evre Kolon kanserinde PET/BT’nin LN metastazini gostermede sensitivite, spesifite ve dogruluk oranini sirasiyla %66,7, %64 ve %65,1 olarak belirledik. Tartisma: Calismamiza gore erken evre kolon kanserinde PET/BT’nin LN metastazini gostermedeki sensitivite ve spesifitesi tatmin edici olmaktan uzaktir. Sonuc: Konu ile ilgili yayinlanmis calismalarda genel olarak ko...

Research paper thumbnail of Effectiveness and Reliability of Scalp Cooling in Preventing Hair Loss Caused by Chemotherapy

Kocaeli Medical Journal, 2021

Saç dökülmesi, sitotoksik kemoterapilerin en korkulan yan etkilerinden biri olup çok sayıda hasta... more Saç dökülmesi, sitotoksik kemoterapilerin en korkulan yan etkilerinden biri olup çok sayıda hastanın psikososyal durumunu olumsuz yönde etkilemektedir. Çalışmamızda kemoterapi sırasında saçlı deri soğutma yönteminin kemoterapşye bağlı saç dökülmesini önlemedeki etkinliğini, kısa ve uzun dönemdeki istenmeyen etkilerini ve hastanın psikososyal durumunda yarattığı değişiklikleri incelemeyi amaçladık YÖNTEM ve GEREÇLER: Eylül 2018 ve Ocak 2020 tarihleri arasında saçlı deri soğutma yöntemini kullanan 76 ve kullanmayan 75 olmak üzere toplam 151 hasta çalışmaya dahil edildi. Saç dökülme derecesini belirlemek için National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) treatment related alopecia grading system kullanıldı BULGULAR: Saçlı deri soğutma sistemini kullanan hastalarda grade 1 saç dökülmesi oranı %77,6 iken kullanmayan hastalarda bu oran %1,3 idi. Yöntemi kullanan ve kullanmayan hastalar arasında izlem süresi boyunca yan etki profili acısından anlamlı bir fark bulunmadı. TARTIŞMA ve SONUÇ: Saçlı deri soğutma sisteminin kemoterapi ilişkili saç dökülmesini engelleme konusundaki bilgiler gün geçtikçe artıyor olmasına rağmen konu ile ilgili randomize,kontrollü,prospektif çalışma sayısı çok azdır. Bu nedenle çalışmamızın bu yöntemin erkili ve güvenilir olduğuna dair sunduğu verilerin literatür için değerli olduğunu düşünüyoruz Anahtar Kelimeler: saçlı deri soğutma, soğuk kepler, saç dökülmesinin engellenmesi, kemoterapiye bağlı saç dökülmesinin önlenmesi ABSTRACT INTRODUCTION: Hair loss is one of the most feared side effects of cytotoxic chemotherapy and affects the psychosocial status of the patient the most. In our study, we aimed to examine to what extent cooling the scalp with a scalp cooling system can prevent hair loss during chemotherapy, the short-and long-term toxicity of this system, and its effect on the psychosocial status of the patien METHODS: A total of 151 patients were enrolled; of them, 76 and 75 were sequentially using scalp cooling and the control group. We used National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) treatment related alopecia grading system for grading hair loss RESULTS: The proportion of grade 1 (less than 50% off hair loss) alopecia was 77,6% in the scalp cooling group and %1,3 in the control group. In the patients who used the system, no short-and long-term side effects that could be considered significant compared to the control group were not detected. DISCUSSION AND CONCLUSION: Although data on the effectiveness and reliability of scalp cooling used to prevent alopecia caused by chemotherapy is increasing day by day, the number of randomized, controlled, prospective studies on this subject is too few. Our study reveals that scalp cooling reliably and significantly reduces chemotherapy-induced hair loss is well tolerated and improves patients mental health and social condition significantly. However, there is still a need for studies with larger groups.

Research paper thumbnail of Systemic Aspergillosis: Radiological Findings in a Case With Diffuse Large B Cell Lymphoma Treated by Ibrutinib

Cureus, 2021

Herein, we present a case of systemic aspergillosis with a fatal outcome in a case with diffuse l... more Herein, we present a case of systemic aspergillosis with a fatal outcome in a case with diffuse large B cell lymphoma (DLBCL) treated by ibrutinib. Aspergillosis was suspected clinically and proven microbiologically. Radiological findings were compatible with aspergillosis. We aim to review radiological findings in a case with DLBCL treated with ibrutinib, which is an important tyrosine kinase inhibitor used in lymphoid neoplasias.

Research paper thumbnail of Frailty significantly impairs the short term prognosis in elderly patients with heart failure

Journal of Geriatric Cardiology : JGC, 2018

Background Frailty is a condition of elderly characterized by increased vulnerability to stressfu... more Background Frailty is a condition of elderly characterized by increased vulnerability to stressful events with high risk of adverse outcomes. The purpose of this study was to evaluate the association between frailty and adverse outcomes including death and hospitalization due to heart failure in elderly patients. Methods We included patients aged ≥ 65 years with the diagnosis of heart failure. The clinical and laboratory data, echocardiography and ECGs were recorded. Additionally, the frailty scores of the patients were evaluated according to Canadian Study of Health and Aging. All the patients were divided as frail or non-frail. The groups were compared for their characteristics and the occurrence of clinical outcomes. Results We included 86 eligible patients. The median follow-up time was four months. The mean age was 75 ± 6.5 years. Of these 86 patients, 17 (19.7%) patients encountered an event (death and/or hospitalization). Nine patients (10.4%) died during follow-up. Thirty pa...

Research paper thumbnail of Kolon Karsinomunun Preoperatif Lenf Nodu Evrelemesinde Pet-Bt’nin Etkinliği

Giris: Erken evre Kolon kanserinde en onemli prognostik belirtec bolgesel Lenf Nodu (LN) metastaz... more Giris: Erken evre Kolon kanserinde en onemli prognostik belirtec bolgesel Lenf Nodu (LN) metastazi durumudur. Ayrica uygun tedavi planinin yapilabilmesinin en onemli sarti da tam evrelemenin yapilmis olmasidir. Amac: Calismamizda erken evre Kolon kanserinde preoperatif Pozitron Emisyon Tomografisi (PET/BT)’nin bolgesel LN’lari ile ilskisini incelemeyi amacladik. Yontemler: Klinigimizde Mart 2014 ve Temmuz 2019 tarihleri arasinda tedavi ettigimiz 83 erken evre Kolon kanseri hastasinin verilerini retrospektif olarak analiz ettik. Preoperatif PET/BT bulgulari ile Patolojik evrelemedeki bulgulari karsilastirdik Bulgular: Erken evre Kolon kanserinde PET/BT’nin LN metastazini gostermede sensitivite, spesifite ve dogruluk oranini sirasiyla %66,7, %64 ve %65,1 olarak belirledik. Tartisma: Calismamiza gore erken evre kolon kanserinde PET/BT’nin LN metastazini gostermedeki sensitivite ve spesifitesi tatmin edici olmaktan uzaktir. Sonuc: Konu ile ilgili yayinlanmis calismalarda genel olarak ko...