Soheila Borji - Academia.edu (original) (raw)
Papers by Soheila Borji
Asian Pacific Journal of Cancer Prevention
Objective: Irisin, mostly known as an exercise-induced fat browning myokine, has been recently de... more Objective: Irisin, mostly known as an exercise-induced fat browning myokine, has been recently detected in several cancer cells, and its potential for being utilized as a biomarker for early diagnosis of some cancers, such as Gastric cancer (GC), is the subject of speculation. The present study aims to compare serum irisin levels in GC patients and healthy controls and assess the interrelation between irisin and oxidative stress markers. Methods: In this case-control study, 22 newly diagnosed GC patients and 29 healthy controls were recruited based on the inclusion criteria. Serum levels of irisin were quantified in duplicates by ELISA. Oxidative stress indices, including total antioxidant power in sera, thiol group, malondialdehyde, and superoxide dismutase concentrations, were also measured in both groups. An independent-sample t-test was used to compare the means between the two studied groups. Results: Serum levels of irisin were significantly higher in the GC group compared with those of their healthy counterparts (p =0.032). No significant differences were observed between the two groups in terms of the serum total antioxidant power or the oxidative stress marker, including MDA, thiol groups, and SOD concentration in sera. Furthermore, there was no significant association between irisin, FRAP, the Thiol group, and the SOD activity. Conclusion: According to the finding, the increased serum levels of irisin in GC patients can play a potential role in the early diagnosis of the GC patients; hence, this peptide can be employed as a new diagnostic indicator of GC.
Background: Sodium valporate and carbamazepine are among frequent medications utilized for seizur... more Background: Sodium valporate and carbamazepine are among frequent medications utilized for seizure control in children. Several adverse effects such as fatty liver disease, lipid profi le changes and increased Intima-Media Thickness (IMT) were reported among cases who were treated with these medications. Methods: Here we assessed 38 children (under 18) who were treated by sodium valporate and carbamazepine for at least six months for developing adverse effects including fatty liver disease, lipid profi le changes and increased IMT. Cases who were treated with two or more antiepileptic-drugs or treated less than six months with each of drugs were excluded. Fasting venous blood sample drawn andradiologic evaluation of liver and both carotid arteries by two independent individuals performed. Results: We found fatty liver disease in fi ve patients who were treated with sodium valporate and lower White Blood Cell (WBC) count in carbamazepine group. Lipid profi les and IMT of both carotid...
Asian Pacific Journal of Cancer Prevention
Objective: Irisin, mostly known as an exercise-induced fat browning myokine, has been recently de... more Objective: Irisin, mostly known as an exercise-induced fat browning myokine, has been recently detected in several cancer cells, and its potential for being utilized as a biomarker for early diagnosis of some cancers, such as Gastric cancer (GC), is the subject of speculation. The present study aims to compare serum irisin levels in GC patients and healthy controls and assess the interrelation between irisin and oxidative stress markers. Methods: In this case-control study, 22 newly diagnosed GC patients and 29 healthy controls were recruited based on the inclusion criteria. Serum levels of irisin were quantified in duplicates by ELISA. Oxidative stress indices, including total antioxidant power in sera, thiol group, malondialdehyde, and superoxide dismutase concentrations, were also measured in both groups. An independent-sample t-test was used to compare the means between the two studied groups. Results: Serum levels of irisin were significantly higher in the GC group compared with those of their healthy counterparts (p =0.032). No significant differences were observed between the two groups in terms of the serum total antioxidant power or the oxidative stress marker, including MDA, thiol groups, and SOD concentration in sera. Furthermore, there was no significant association between irisin, FRAP, the Thiol group, and the SOD activity. Conclusion: According to the finding, the increased serum levels of irisin in GC patients can play a potential role in the early diagnosis of the GC patients; hence, this peptide can be employed as a new diagnostic indicator of GC.
Background: Sodium valporate and carbamazepine are among frequent medications utilized for seizur... more Background: Sodium valporate and carbamazepine are among frequent medications utilized for seizure control in children. Several adverse effects such as fatty liver disease, lipid profi le changes and increased Intima-Media Thickness (IMT) were reported among cases who were treated with these medications. Methods: Here we assessed 38 children (under 18) who were treated by sodium valporate and carbamazepine for at least six months for developing adverse effects including fatty liver disease, lipid profi le changes and increased IMT. Cases who were treated with two or more antiepileptic-drugs or treated less than six months with each of drugs were excluded. Fasting venous blood sample drawn andradiologic evaluation of liver and both carotid arteries by two independent individuals performed. Results: We found fatty liver disease in fi ve patients who were treated with sodium valporate and lower White Blood Cell (WBC) count in carbamazepine group. Lipid profi les and IMT of both carotid...