Solon Schur - Academia.edu (original) (raw)

Papers by Solon Schur

Research paper thumbnail of Failure to reproduce reversal of hippocampal LTP by the PKCinhibitor, ZIP

Research paper thumbnail of Comorbidities and medical complications in hospitalized subarachnoid hemorrhage patients

Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating condition with a case fatality of ... more Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating condition with a case fatality of 36% at 30 days. Risk factors for mortality in SAH patients include patient demographics and the severity of the neurological injury. Pre-existing conditions and non-neurological medical complications occurring during the index hospitalization are also risk factors for mortality in SAH. The magnitude of the effect on mortality of pre-existing conditions and medical complications, however, is less well understood. In this study, we aim to determine the effect of pre-existing conditions and medical complications on SAH mortality. For a 25% random sample of the Greater Montreal Region, we used discharge abstracts, physician billings, and death certificate records, to identify adult patients with a new diagnosis of non-traumatic SAH who underwent cerebral angiography or surgical clipping of an aneurysm between 1997 and 2014. The one-year mortality rate was 14.76% (94/637). Having ≥3 pre-exist...

Research paper thumbnail of New interinstitutional, multimodal presurgical evaluation protocol associated with improved seizure freedom for poorly defined cases of focal epilepsy in children

Journal of Neurosurgery: Pediatrics

OBJECTIVE In an attempt to improve postsurgical seizure outcomes for poorly defined cases (PDCs) ... more OBJECTIVE In an attempt to improve postsurgical seizure outcomes for poorly defined cases (PDCs) of pediatric focal epilepsy (i.e., those that are not visible or well defined on 3T MRI), the authors modified their presurgical evaluation strategy. Instead of relying on concordance between video-electroencephalography and 3T MRI and using functional imaging and intracranial recording in select cases, the authors systematically used a multimodal, 3-tiered investigation protocol that also involved new collaborations between their hospital, the Montreal Children’s Hospital, and the Montreal Neurological Institute. In this study, the authors examined how their new strategy has impacted postsurgical outcomes. They hypothesized that it would improve postsurgical seizure outcomes, with the added benefit of identifying a subset of tests contributing the most. METHODS Chart review was performed for children with PDCs who underwent resection following the new strategy (i.e., new protocol [NP]),...

Research paper thumbnail of Optimal Bone Flap Size for Decompressive Craniectomy for Refractory Increased Intracranial Pressure in Traumatic Brain Injury: Taking the Patient's Head Size into Account

Research paper thumbnail of Clinical Characterization of Traumatic Acute Interhemispheric Subdural Hematoma

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

ABSTRACT: Object: Interhemispheric subdural hematomas (IHSDHs) are thought to be rare. Surgical m... more ABSTRACT: Object: Interhemispheric subdural hematomas (IHSDHs) are thought to be rare. Surgical management of these lesions presents a challenge as they are in close proximity to the sagittal sinus and bridging veins. IHSDHs are poorly characterized clinically and their exact incidence is unknown. There are also no clear guidelines for the management of IHSDH. Methods: This is a retrospective review of all admitted patients with a diagnosis of traumatic brain injury over a 4-year period at a Level I trauma centre. Clinical characteristics of all patients with subdural hematoma (SDH) and IHSDH were collected. Results: Of 2165 admissions, 1182 patients had acute traumatic SDHs, 420 patients had IHSDHs (1.9% of admissions and 35.5% of SDH), 35 (8.3% of IHSDH) were ≥8 mm in width. IHSDH was isolated in 16 (3.8%) of the cases. Average age was 61.7 ± 21.5 years for all IHSDHs and 77.1 ± 10.4 for large IHSDH (p < 0.001). For large IHSDH, a transient loss of consciousness (LOC) occurred ...

Research paper thumbnail of Assessing the association of tumor consistency and gland manipulation on hormonal outcomes and delayed hyponatremia in pituitary macroadenoma surgery

Interdisciplinary Neurosurgery

Research paper thumbnail of Prophylactic and Therapeutic Hypothermia in Severe Traumatic Brain Injury

Research paper thumbnail of Significance of FDG-PET Hypermetabolism in Children with Intractable Focal Epilepsy

Pediatric neurosurgery, 2018

Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routin... more Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routinely used in the presurgical workup of children with medically intractable epilepsy (MIE). FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well established. We performed a retrospective study of patients who underwent FDG-PET during the presurgical workup of MIE over a 4-year period, between 1 January 2010 and 31 December 2013, at the Children's Hospital Colorado, CO, USA. Focal FDG-PET hypermetabolism was identified in 7 (2.2%) of 317 patients. The median age was 124 months, all cases with catastrophic epilepsy. Surface electroencephalography (EEG) performed concomitantly with FDG injections revealed ictal EEG discharges in 2 patients, frequent interictal epileptiform discharges (IEDs) in 3, occasional IEDs in 1, and no IEDs in 1. All 7 patients underwent functional hemispherectomies. Histopathology revealed type 1 ...

Research paper thumbnail of Preoperative Embolization and Complete Tumoral Resection of a Cervical Aggressive Epithelioid Osteoblastoma

World neurosurgery, 2017

Epithelioid "aggressive" osteoblastoma (EOB) is a rare and more aggressive subtype of o... more Epithelioid "aggressive" osteoblastoma (EOB) is a rare and more aggressive subtype of osteoblastoma (OB) with a higher recurrence rate, greater risk of malignant transformation, larger size, and greater intraoperative blood loss. The present case report illustrates that preoperative angioembolization of an EOB can be safely performed with low intraoperative blood loss. A 21-year-old male patient presented to our institution with a 4-month history of neck discomfort, radicular pain in the proximal right arm, and mild weakness of the right biceps and triceps muscles. Imaging was suggestive of EOB, and computed tomography-guided biopsy confirmed the diagnosis. The patient underwent same-day preoperative angioembolization of the major feeding vessels and subsequent complete tumor resection. During the procedure, he experienced minimal blood loss and did not require blood transfusion. EOB is a highly vascular primary bony lesion. To minimize intraoperative blood loss, preoperat...

Research paper thumbnail of Patterns of Pituitary Injury during Endoscopic Transsphenoidal Pituitary Surgery: Correlation of Intra-Operative Videos with Endocrinological Outcomes in 76 Patients

Journal of Neurological Surgery Part B: Skull Base

Research paper thumbnail of In Reply to the Letter to the Editor Regarding “Optimal Bone Flap Size for Decompressive Craniectomy for Refractory Increased Intracranial Pressure in Traumatic Brain Injury: Taking the Patient's Head Size into Account”

Research paper thumbnail of Quantified Volumetric Analysis and Clinical Outcomes of Endoscopic Endonasal Transsphenoidal Pituitary Macroadenoma Resection

Journal of Neurological Surgery Part B: Skull Base, 2015

Research paper thumbnail of Failure to reproduce reversal of hippocampal LTP by the PKCinhibitor, ZIP

Research paper thumbnail of Comorbidities and medical complications in hospitalized subarachnoid hemorrhage patients

Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating condition with a case fatality of ... more Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating condition with a case fatality of 36% at 30 days. Risk factors for mortality in SAH patients include patient demographics and the severity of the neurological injury. Pre-existing conditions and non-neurological medical complications occurring during the index hospitalization are also risk factors for mortality in SAH. The magnitude of the effect on mortality of pre-existing conditions and medical complications, however, is less well understood. In this study, we aim to determine the effect of pre-existing conditions and medical complications on SAH mortality. For a 25% random sample of the Greater Montreal Region, we used discharge abstracts, physician billings, and death certificate records, to identify adult patients with a new diagnosis of non-traumatic SAH who underwent cerebral angiography or surgical clipping of an aneurysm between 1997 and 2014. The one-year mortality rate was 14.76% (94/637). Having ≥3 pre-exist...

Research paper thumbnail of New interinstitutional, multimodal presurgical evaluation protocol associated with improved seizure freedom for poorly defined cases of focal epilepsy in children

Journal of Neurosurgery: Pediatrics

OBJECTIVE In an attempt to improve postsurgical seizure outcomes for poorly defined cases (PDCs) ... more OBJECTIVE In an attempt to improve postsurgical seizure outcomes for poorly defined cases (PDCs) of pediatric focal epilepsy (i.e., those that are not visible or well defined on 3T MRI), the authors modified their presurgical evaluation strategy. Instead of relying on concordance between video-electroencephalography and 3T MRI and using functional imaging and intracranial recording in select cases, the authors systematically used a multimodal, 3-tiered investigation protocol that also involved new collaborations between their hospital, the Montreal Children’s Hospital, and the Montreal Neurological Institute. In this study, the authors examined how their new strategy has impacted postsurgical outcomes. They hypothesized that it would improve postsurgical seizure outcomes, with the added benefit of identifying a subset of tests contributing the most. METHODS Chart review was performed for children with PDCs who underwent resection following the new strategy (i.e., new protocol [NP]),...

Research paper thumbnail of Optimal Bone Flap Size for Decompressive Craniectomy for Refractory Increased Intracranial Pressure in Traumatic Brain Injury: Taking the Patient's Head Size into Account

Research paper thumbnail of Clinical Characterization of Traumatic Acute Interhemispheric Subdural Hematoma

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

ABSTRACT: Object: Interhemispheric subdural hematomas (IHSDHs) are thought to be rare. Surgical m... more ABSTRACT: Object: Interhemispheric subdural hematomas (IHSDHs) are thought to be rare. Surgical management of these lesions presents a challenge as they are in close proximity to the sagittal sinus and bridging veins. IHSDHs are poorly characterized clinically and their exact incidence is unknown. There are also no clear guidelines for the management of IHSDH. Methods: This is a retrospective review of all admitted patients with a diagnosis of traumatic brain injury over a 4-year period at a Level I trauma centre. Clinical characteristics of all patients with subdural hematoma (SDH) and IHSDH were collected. Results: Of 2165 admissions, 1182 patients had acute traumatic SDHs, 420 patients had IHSDHs (1.9% of admissions and 35.5% of SDH), 35 (8.3% of IHSDH) were ≥8 mm in width. IHSDH was isolated in 16 (3.8%) of the cases. Average age was 61.7 ± 21.5 years for all IHSDHs and 77.1 ± 10.4 for large IHSDH (p < 0.001). For large IHSDH, a transient loss of consciousness (LOC) occurred ...

Research paper thumbnail of Assessing the association of tumor consistency and gland manipulation on hormonal outcomes and delayed hyponatremia in pituitary macroadenoma surgery

Interdisciplinary Neurosurgery

Research paper thumbnail of Prophylactic and Therapeutic Hypothermia in Severe Traumatic Brain Injury

Research paper thumbnail of Significance of FDG-PET Hypermetabolism in Children with Intractable Focal Epilepsy

Pediatric neurosurgery, 2018

Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routin... more Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routinely used in the presurgical workup of children with medically intractable epilepsy (MIE). FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well established. We performed a retrospective study of patients who underwent FDG-PET during the presurgical workup of MIE over a 4-year period, between 1 January 2010 and 31 December 2013, at the Children's Hospital Colorado, CO, USA. Focal FDG-PET hypermetabolism was identified in 7 (2.2%) of 317 patients. The median age was 124 months, all cases with catastrophic epilepsy. Surface electroencephalography (EEG) performed concomitantly with FDG injections revealed ictal EEG discharges in 2 patients, frequent interictal epileptiform discharges (IEDs) in 3, occasional IEDs in 1, and no IEDs in 1. All 7 patients underwent functional hemispherectomies. Histopathology revealed type 1 ...

Research paper thumbnail of Preoperative Embolization and Complete Tumoral Resection of a Cervical Aggressive Epithelioid Osteoblastoma

World neurosurgery, 2017

Epithelioid "aggressive" osteoblastoma (EOB) is a rare and more aggressive subtype of o... more Epithelioid "aggressive" osteoblastoma (EOB) is a rare and more aggressive subtype of osteoblastoma (OB) with a higher recurrence rate, greater risk of malignant transformation, larger size, and greater intraoperative blood loss. The present case report illustrates that preoperative angioembolization of an EOB can be safely performed with low intraoperative blood loss. A 21-year-old male patient presented to our institution with a 4-month history of neck discomfort, radicular pain in the proximal right arm, and mild weakness of the right biceps and triceps muscles. Imaging was suggestive of EOB, and computed tomography-guided biopsy confirmed the diagnosis. The patient underwent same-day preoperative angioembolization of the major feeding vessels and subsequent complete tumor resection. During the procedure, he experienced minimal blood loss and did not require blood transfusion. EOB is a highly vascular primary bony lesion. To minimize intraoperative blood loss, preoperat...

Research paper thumbnail of Patterns of Pituitary Injury during Endoscopic Transsphenoidal Pituitary Surgery: Correlation of Intra-Operative Videos with Endocrinological Outcomes in 76 Patients

Journal of Neurological Surgery Part B: Skull Base

Research paper thumbnail of In Reply to the Letter to the Editor Regarding “Optimal Bone Flap Size for Decompressive Craniectomy for Refractory Increased Intracranial Pressure in Traumatic Brain Injury: Taking the Patient's Head Size into Account”

Research paper thumbnail of Quantified Volumetric Analysis and Clinical Outcomes of Endoscopic Endonasal Transsphenoidal Pituitary Macroadenoma Resection

Journal of Neurological Surgery Part B: Skull Base, 2015