Somanath Padhi - Academia.edu (original) (raw)
Papers by Somanath Padhi
Turkish Journal of Haematology, 2014
The Turkish Journal of Gastroenterology, 2015
Iranian Journal of Medical Sciences, Jun 1, 2013
Mediterranean journal of hematology and infectious diseases, 2016
Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) whi... more Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) which has been sporadically reported in the literature. We describe the bone marrow (BM) changes and clinicolaboratory characteristics of 25 of 198 adult cases (>16 years) with cutaneous hyperpigmentation who underwent BM evaluation for cytopenia (s). Twenty-one of 25 cases (84%) had MA, while MA without hyperpigmentation occurred only in 12 of remainder 173 cases (P<0.001). Knuckle pad hyperpigmentation (KP) was noted in 16 (64%) cases; whereas 9 (36%) had diffuse brownish black discoloration (DP) of the palms and/or soles. Eighteen of 25 (72%) cases had pancytopenia (13 with KP) and 7 of 25 (28%) had bicytopenia (3 with KP). In addition, five cases (20%) presented with pyrexia. Of the 17 cases where data available, eleven were B12 deficient [<190 pg/ml; eight had severe deficiency (<100 pg/ml); ref.; 190-800pg/ml], while 4 had pure folate deficiency (< 4.0 ng/ml; ref.; 4-20...
Journal of Cancer Research and Therapeutics, 2015
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. It usually develops in e... more Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. It usually develops in euthyroid patients with history of long standing Hashimoto's thyroiditis. Here, we describe the development of PTC in a seronegative patient with subclinical thyrotoxicosis. We suggest that any cold nodule having high-risk features on ultrasonography in hyperthyroid patients should be thoroughly evaluated for the possibility of a thyroid malignancy and the possible role of nonthyroid stimulating hormone regulatory molecules, in thyroid carcinogenesis needs to be further explored.
Ovarian Sertoli Leydig Cell Tumor a Rare Tumor With Atypical Presentation, Jan 21, 2013
Saudi Journal of Gastroenterology, 2015
Background /Aim: Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic tech... more Background /Aim: Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic technique, which utilizes spectral narrow band filter for the visualization of mucosal patterns and microvasculature. Nonerosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) and it is characterized by reflux symptoms without mucosal breaks on white light endoscopy (WLE). Biopsies from distal esophagus of GERD patients show group of histologic features such as basal cell hyperplasia, elongation of lamina propria papillae, and inflammatory cells. The present study was undertaken to evaluate diagnostic utility of NBI endoscopy and biopsy study in NERD patients and also to correlate NBI endoscopy findings with histologic features of GERD. A total of 71 cases of NERD having symptom score more than 10 and those not having erosion on WLE were recruited prospectively and underwent NBI endoscopic examination. Two mucosal biopsies were taken at 3 cm above the squamocolumnar junction. Histologic features of GERD were seen in 50 (70.4%) out of 71 cases. No significant correlation between NBI endoscopic findings with histologic features of GERD was found. The present study showed that histopathologic evaluation of distal esophageal mucosa has promising diagnostic value over NBI endoscopy in NERD patients. Use of newly introduced NBI technique requires tremendous familiarity for the detection of the cases of NERD, which show histologic features of GERD.
Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multi... more Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multiple myeloma (MM). This may be detected in uptoup to 30% cases by immunohistochemistry (IHC), and up to 40-50% cases by molecular studies. However, studies on the clinical significance of cyclin D1 dysregulation in MM have been inconclusive. We aimed to study the pattern of cyclin D1 expression in MM by IHC, and correlate with selected clinicopathologic features. Materials and Methods: Formalin fixed, decalcified, bone marrow trephine sections from 14 symptomatic patients of MM (13 newly diagnosed and one1 relapsed) were subjected to cyclin D1 IHC by using a rabbit monoclonal antibody to cyclin D1 (clone EPR2241). Results: Cyclin D1 expression (in ≥ 10% tumor cell nuclei) was observed in 8 of 14 cases (57%). Cyclin D1 positive (+) group had significantly lower haemoglobin level (P = 0.03) than cyclin D1 negative (−-) group (n = 6); though both groups showed no statistical significance (P ...
The Kuwait medical journal: KMJ: the official journal of the Kuwait Medical Association
Objective: To study the cytogenetic profileofnewlydiagnosed patients with pediatric acute lymphob... more Objective: To study the cytogenetic profileofnewlydiagnosed patients with pediatric acute lymphoblastic leukemia (ALL) Design: Prospective case control study Setting: Tertiary care hospital in India Subjects: Newly diagnosed patients with pediatric ALL Interventions: Karyotype analysis of bone marrow aspirate samples by routine G-Banding technique and analysis as per International System for Cytogenetic Nomenclature (ISCN), 2005 criteria. Results: The study included 23 male and eight female patients (M:F = 2.8:1). ALL-L2 was the most common morphological phenotype (18 / 31, 58%). Sixteen out of thirty one (51.6%) patients were hypodiploid (2n < 46), 10 / 31(32.0%) hyperdiploid (2n > 46) and 5 / 31(16.0%) aneuploid. Among hypodiploid groups, nine (29.0%) had modal chromosome number as 40-45, five(16.0%)as 31-39 and two (6.5%) as 25-30. Among hyperdiploid group, 7 (22.5%) had modal chromosome number as 51-60 followed by 2n = 47-50 (three patients, 6.5%). The chromosomes (Chr) 2,...
Iranian journal of medical sciences, 2013
Deficiency of vitamin B12 and/or folic acid as a cause of pyrexia, though known, is rarely report... more Deficiency of vitamin B12 and/or folic acid as a cause of pyrexia, though known, is rarely reported in literature. We aimed to report a case in a 51 year old woman, who presented with fever and pancytopenia and was diagnosed to have megaloblastic anemia secondary to vitamin B12 and folate deficiency. The pyrexia subsided following the intramuscular injection of vitamin B12 and oral folic acid administration. All the other infective, inflammatory/autoimmune, endocrine causes of pyrexia were excluded by appropriate investigations. Therefore, we suggest that all physicians be aware of megaloblastic anemia as a treatable cause of pyrexia in order to avoid unnecessary costly investigations and antibiotic usage.
The Malaysian journal of pathology, 2014
Non-erosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) defined as ... more Non-erosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) defined as symptomatic GERD without mucosal breaks on endoscopy. There is no gold standard for diagnosis of NERD till date. Biopsy from the distal esophagus in patients of GERD is said to reveal characteristic, although non-specific injury patterns such as squamous cell hyperplasia and intraepithelial inflammatory cell infiltration, collectively known as microscopic esophagitis. Recently, dilated intercellular spaces (DIS) are also shown to be associated with NERD. The present study was undertaken to evaluate the role of biopsy in NERD cases. Two mucosal biopsies were taken at 3 cm above the squamocolumnar junction (SCJ) from 71 cases of NERD having symptom scores of more than 10. Biopsies were evaluated for features of microscopic esophagitis and DIS, and the results were analyzed. Fifty out of 71 (70.4%) patients with symptomatic NERD had features of microscopic esophagitis. DIS was noted in 46/7...
International Journal of Diabetes in Developing Countries, 2012
ABSTRACT Inflammation, endothelial dysfunction, and oxidative stress are postulated to be the pri... more ABSTRACT Inflammation, endothelial dysfunction, and oxidative stress are postulated to be the principal events in the pathogenesis of type 2 diabetes mellitus and its vascular complications. Serum Nitric Oxide metabolites (NOX) and high sensitivity C-reactive protein (hs-CRP) were measured in eighty non-obese, type 2 diabetic males (40 to 65 years) without (group B, N040) and with vascular disease [16 retinopathy (group C), 24 hypertension (group D)]; and compared with forty healthy, age and sex matched control subjects (group A). The mean age of diabetic patients and healthy controls was 49.5±5.80 vs. 51.0±7.15 years, respectively (P00.212). Diabetic group had higher Fasting Plasma Glucose (FPG), hs-CRP, and NOX levels than control group (135.3±28.69 vs. 96.7±10.46; 5.1±2.59 vs. 1.7± 0.54; 61.1±15.67 vs. 37.1±3.69, respectively, P00.001). When compared with diabetics without complication (53.7±10.37), levels of NOX were significantly higher (P0 0.001) both in retinopathy (74.5±19.39) and hypertension (64.4±13.60) group, whereas that of hs-CRP (4.4±2.85 vs.6.5±2.93, P00.015) differed only in retinopathy group. There was no difference between retinopathy and hypertension group. There was significant (P<0.05) positive correlation between age, duration of diabetes, hs-CRP, and NOX; hs-CRP and NOX among group B and C. A negative correlation was noted between hs-CRP and NOX (r0−0.068, P0 0.752) among hypertensives. By multivariate regression analysis, FPG, hs-CRP and NOX were found to be independent indicators of complications after adjustment for age and duration of diabetes. This study reveals that NOX and hs- CRP are important biomarkers in type 2 diabetes mellitus and its associated vascular complications.
Caryologia, 2011
Page 1. CARYOLOGIA *Corresponding author: phone 08940108170; fax 91-413-2656273; e-mail: somanath... more Page 1. CARYOLOGIA *Corresponding author: phone 08940108170; fax 91-413-2656273; e-mail: somanath.padhi@gmail.com Vol. 64, no. 1: 33-41, 2011 Cytogenetic profile of pediatric acute lymphoblastic leukemia (ALL): analysis of 31 cases with review of literature ...
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2014
Sertoli Leydig Cell Tumours (SLCTs) are rare, unilateral, sex cord stromal tumours of ovary, whic... more Sertoli Leydig Cell Tumours (SLCTs) are rare, unilateral, sex cord stromal tumours of ovary, which constitute less than 1% of all the ovarian neoplasms. These tumours can be functionally diverse and they may have heterologous elements. We aim to report a case of a 25-year- old woman who presented with suprapubic pain of 5 days duration, a unilateral adnexal mass, hypertestosteronism without virilization. Intraoperative frozen section of the unilateral salpingo-oophorectomy specimen was suggestive of granulosa cell tumour. Histopathological examination, supplemented with alpha-inhibin immunohistochemistry, was diagnostic of Meyer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s type II SLCT. Clinical presentation, pathology and the diagnostic pitfalls in the present case have been presented with a brief review of literature.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013
Factitious biochemical reports result in the misguiding of clinicians, unnecessary retesting, wro... more Factitious biochemical reports result in the misguiding of clinicians, unnecessary retesting, wrong diagnoses and incorrect treatments. A vigilant biochemist identifies these factitious biochemical reports and alerts the clinician regarding the proper interpretation of the biochemical reports, thus preventing a misdiagnosis and an incorrect treatment. We are presenting a case report of a multiple myeloma patient who presented with factitious biochemical reports which were caused due to paraproteinaemia. In the present case, the patient presented with an underestimation of urea and creatinine, an underestimation of sodium, low albumin levels and high phosphate levels. On repeating the same tests after dilutions and deproteinizing, the effects of the paraproteins on the above mentioned tests were reduced. Thus, from the observations of our study, we suggest that the interference by paraproteinaemia can be reduced by analyzing the biochemical parameters after dilution and deproteinization.
![Research paper thumbnail of Isolated deletion of the long arm of chromosome 20 [del(20q12)] in myelodysplastic syndrome: a case report and literature review](https://attachments.academia-assets.com/53590407/thumbnails/1.jpg)
](Singapore Medical Journal, 2013
Isolated deletion of the long arm of chromosome 20 [del(20q12)] is a rare abnormality in patients... more Isolated deletion of the long arm of chromosome 20 [del(20q12)] is a rare abnormality in patients with de novo myelodysplastic syndrome. It is characterised by refractory thrombocytopenia, minimal haematological dysplasia and a lower risk for progression to acute myeloid leukaemia. Its distinction from chronic autoimmune thrombocytopenia, although clinically and morphologically difficult, is critical. We report a case of refractory cytopenia and unilineage dysplasia in an elderly woman with isolated del(20q12), identified via fluorescence in situ hybridisation analysis of her bone marrow. In order to avoid a misdiagnosis, we suggest that cytogenetic analysis be performed on all patients suspected to have myelodysplastic syndrome with predominant thrombocytopenic presentation.
Australasian Medical Journal, 2013
Carcinoma of the stomach rarely disseminates to bone. We report a case of compressive myeloradicu... more Carcinoma of the stomach rarely disseminates to bone. We report a case of compressive myeloradiculopathy from extensive metastases to the spine, which on evaluation originated from adenocarcinoma of the stomach. Magnetic resonance imaging of the spine showed osteolytic and osteosclerotic metastases. Gastrointestinal endoscopy revealed ulcerative growth in the stomach that on biopsy showed poorly differentiated adenocarcinoma. This case is unique in that the initial presentation of gastric cancer itself was bony metastases without any gastrointestinal symptoms or liver involvement. Moreover, metastases were osteosclerotic as well, which is against the general belief that gastric cancer produces only osteolytic secondaries.
Frontiers of Medicine in China, 2013
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, potentially life threatening, hyper infl... more Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, potentially life threatening, hyper inflammatory syndrome of diverse etiologies. Cardinal signs include prolonged fever, organomegaly, and persistent unexplained cytopenias. In spite of the well known diagnostic criteria put forth by HLH society, this continues to pose great diagnostic challenge in both pediatric and adult intensive care settings. We describe 4 adult (2 males, 2 females, aged 19, 29, 40, and 17 years) and 3 pediatric (2 males, 1 female, aged 1 month, 6 months, and 12 years) patients with secondary HLH who satisfied the HLH-2004 diagnostic criteria. Definite evidence of hemophagocytosis was noted in 4 patients on initial bone marrow examination. The underlying etiologies were as follows: Rickettsia tsutsugamushi (case 1), autoimmune disorder (case 2), systemic onset juvenile idiopathic arthritis (sJIA) (case 3), unknown bite (possibly a venomous snake) (case 4), Plasmodium vivax (case 5), Cytomegalo virus (case 6), and Mycobacterium tuberculosis (case 7). In one patient, hemophagocytosis was presumed to have been exacerbated by administration of granulocyte monocyte colony stimulating factor (GMCSF) for severe neutropenia. Two patients died with disseminated intravascular coagulation (DIC) and multi organ failure within few days of HLH diagnosis. Immunosuppressive therapy was started in 3 patients, and etoposide was started in one patient only. Due to lack of specificity of diagnostic criteria, diagnosing and differentiating HLH from its closest mimickers like sepsis/septic shock may be quite challenging in critically ill patients. Therefore, increasing awareness among physicians is essential for early diagnosis and effective therapy to reduce the mortality.
Turkish Journal of Haematology, 2014
The Turkish Journal of Gastroenterology, 2015
Iranian Journal of Medical Sciences, Jun 1, 2013
Mediterranean journal of hematology and infectious diseases, 2016
Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) whi... more Cutaneous hyperpigmentation is an often overlooked clinical sign in megaloblastic anemia (MA) which has been sporadically reported in the literature. We describe the bone marrow (BM) changes and clinicolaboratory characteristics of 25 of 198 adult cases (>16 years) with cutaneous hyperpigmentation who underwent BM evaluation for cytopenia (s). Twenty-one of 25 cases (84%) had MA, while MA without hyperpigmentation occurred only in 12 of remainder 173 cases (P<0.001). Knuckle pad hyperpigmentation (KP) was noted in 16 (64%) cases; whereas 9 (36%) had diffuse brownish black discoloration (DP) of the palms and/or soles. Eighteen of 25 (72%) cases had pancytopenia (13 with KP) and 7 of 25 (28%) had bicytopenia (3 with KP). In addition, five cases (20%) presented with pyrexia. Of the 17 cases where data available, eleven were B12 deficient [<190 pg/ml; eight had severe deficiency (<100 pg/ml); ref.; 190-800pg/ml], while 4 had pure folate deficiency (< 4.0 ng/ml; ref.; 4-20...
Journal of Cancer Research and Therapeutics, 2015
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. It usually develops in e... more Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. It usually develops in euthyroid patients with history of long standing Hashimoto's thyroiditis. Here, we describe the development of PTC in a seronegative patient with subclinical thyrotoxicosis. We suggest that any cold nodule having high-risk features on ultrasonography in hyperthyroid patients should be thoroughly evaluated for the possibility of a thyroid malignancy and the possible role of nonthyroid stimulating hormone regulatory molecules, in thyroid carcinogenesis needs to be further explored.
Ovarian Sertoli Leydig Cell Tumor a Rare Tumor With Atypical Presentation, Jan 21, 2013
Saudi Journal of Gastroenterology, 2015
Background /Aim: Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic tech... more Background /Aim: Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic technique, which utilizes spectral narrow band filter for the visualization of mucosal patterns and microvasculature. Nonerosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) and it is characterized by reflux symptoms without mucosal breaks on white light endoscopy (WLE). Biopsies from distal esophagus of GERD patients show group of histologic features such as basal cell hyperplasia, elongation of lamina propria papillae, and inflammatory cells. The present study was undertaken to evaluate diagnostic utility of NBI endoscopy and biopsy study in NERD patients and also to correlate NBI endoscopy findings with histologic features of GERD. A total of 71 cases of NERD having symptom score more than 10 and those not having erosion on WLE were recruited prospectively and underwent NBI endoscopic examination. Two mucosal biopsies were taken at 3 cm above the squamocolumnar junction. Histologic features of GERD were seen in 50 (70.4%) out of 71 cases. No significant correlation between NBI endoscopic findings with histologic features of GERD was found. The present study showed that histopathologic evaluation of distal esophageal mucosa has promising diagnostic value over NBI endoscopy in NERD patients. Use of newly introduced NBI technique requires tremendous familiarity for the detection of the cases of NERD, which show histologic features of GERD.
Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multi... more Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multiple myeloma (MM). This may be detected in uptoup to 30% cases by immunohistochemistry (IHC), and up to 40-50% cases by molecular studies. However, studies on the clinical significance of cyclin D1 dysregulation in MM have been inconclusive. We aimed to study the pattern of cyclin D1 expression in MM by IHC, and correlate with selected clinicopathologic features. Materials and Methods: Formalin fixed, decalcified, bone marrow trephine sections from 14 symptomatic patients of MM (13 newly diagnosed and one1 relapsed) were subjected to cyclin D1 IHC by using a rabbit monoclonal antibody to cyclin D1 (clone EPR2241). Results: Cyclin D1 expression (in ≥ 10% tumor cell nuclei) was observed in 8 of 14 cases (57%). Cyclin D1 positive (+) group had significantly lower haemoglobin level (P = 0.03) than cyclin D1 negative (−-) group (n = 6); though both groups showed no statistical significance (P ...
The Kuwait medical journal: KMJ: the official journal of the Kuwait Medical Association
Objective: To study the cytogenetic profileofnewlydiagnosed patients with pediatric acute lymphob... more Objective: To study the cytogenetic profileofnewlydiagnosed patients with pediatric acute lymphoblastic leukemia (ALL) Design: Prospective case control study Setting: Tertiary care hospital in India Subjects: Newly diagnosed patients with pediatric ALL Interventions: Karyotype analysis of bone marrow aspirate samples by routine G-Banding technique and analysis as per International System for Cytogenetic Nomenclature (ISCN), 2005 criteria. Results: The study included 23 male and eight female patients (M:F = 2.8:1). ALL-L2 was the most common morphological phenotype (18 / 31, 58%). Sixteen out of thirty one (51.6%) patients were hypodiploid (2n < 46), 10 / 31(32.0%) hyperdiploid (2n > 46) and 5 / 31(16.0%) aneuploid. Among hypodiploid groups, nine (29.0%) had modal chromosome number as 40-45, five(16.0%)as 31-39 and two (6.5%) as 25-30. Among hyperdiploid group, 7 (22.5%) had modal chromosome number as 51-60 followed by 2n = 47-50 (three patients, 6.5%). The chromosomes (Chr) 2,...
Iranian journal of medical sciences, 2013
Deficiency of vitamin B12 and/or folic acid as a cause of pyrexia, though known, is rarely report... more Deficiency of vitamin B12 and/or folic acid as a cause of pyrexia, though known, is rarely reported in literature. We aimed to report a case in a 51 year old woman, who presented with fever and pancytopenia and was diagnosed to have megaloblastic anemia secondary to vitamin B12 and folate deficiency. The pyrexia subsided following the intramuscular injection of vitamin B12 and oral folic acid administration. All the other infective, inflammatory/autoimmune, endocrine causes of pyrexia were excluded by appropriate investigations. Therefore, we suggest that all physicians be aware of megaloblastic anemia as a treatable cause of pyrexia in order to avoid unnecessary costly investigations and antibiotic usage.
The Malaysian journal of pathology, 2014
Non-erosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) defined as ... more Non-erosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) defined as symptomatic GERD without mucosal breaks on endoscopy. There is no gold standard for diagnosis of NERD till date. Biopsy from the distal esophagus in patients of GERD is said to reveal characteristic, although non-specific injury patterns such as squamous cell hyperplasia and intraepithelial inflammatory cell infiltration, collectively known as microscopic esophagitis. Recently, dilated intercellular spaces (DIS) are also shown to be associated with NERD. The present study was undertaken to evaluate the role of biopsy in NERD cases. Two mucosal biopsies were taken at 3 cm above the squamocolumnar junction (SCJ) from 71 cases of NERD having symptom scores of more than 10. Biopsies were evaluated for features of microscopic esophagitis and DIS, and the results were analyzed. Fifty out of 71 (70.4%) patients with symptomatic NERD had features of microscopic esophagitis. DIS was noted in 46/7...
International Journal of Diabetes in Developing Countries, 2012
ABSTRACT Inflammation, endothelial dysfunction, and oxidative stress are postulated to be the pri... more ABSTRACT Inflammation, endothelial dysfunction, and oxidative stress are postulated to be the principal events in the pathogenesis of type 2 diabetes mellitus and its vascular complications. Serum Nitric Oxide metabolites (NOX) and high sensitivity C-reactive protein (hs-CRP) were measured in eighty non-obese, type 2 diabetic males (40 to 65 years) without (group B, N040) and with vascular disease [16 retinopathy (group C), 24 hypertension (group D)]; and compared with forty healthy, age and sex matched control subjects (group A). The mean age of diabetic patients and healthy controls was 49.5±5.80 vs. 51.0±7.15 years, respectively (P00.212). Diabetic group had higher Fasting Plasma Glucose (FPG), hs-CRP, and NOX levels than control group (135.3±28.69 vs. 96.7±10.46; 5.1±2.59 vs. 1.7± 0.54; 61.1±15.67 vs. 37.1±3.69, respectively, P00.001). When compared with diabetics without complication (53.7±10.37), levels of NOX were significantly higher (P0 0.001) both in retinopathy (74.5±19.39) and hypertension (64.4±13.60) group, whereas that of hs-CRP (4.4±2.85 vs.6.5±2.93, P00.015) differed only in retinopathy group. There was no difference between retinopathy and hypertension group. There was significant (P<0.05) positive correlation between age, duration of diabetes, hs-CRP, and NOX; hs-CRP and NOX among group B and C. A negative correlation was noted between hs-CRP and NOX (r0−0.068, P0 0.752) among hypertensives. By multivariate regression analysis, FPG, hs-CRP and NOX were found to be independent indicators of complications after adjustment for age and duration of diabetes. This study reveals that NOX and hs- CRP are important biomarkers in type 2 diabetes mellitus and its associated vascular complications.
Caryologia, 2011
Page 1. CARYOLOGIA *Corresponding author: phone 08940108170; fax 91-413-2656273; e-mail: somanath... more Page 1. CARYOLOGIA *Corresponding author: phone 08940108170; fax 91-413-2656273; e-mail: somanath.padhi@gmail.com Vol. 64, no. 1: 33-41, 2011 Cytogenetic profile of pediatric acute lymphoblastic leukemia (ALL): analysis of 31 cases with review of literature ...
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2014
Sertoli Leydig Cell Tumours (SLCTs) are rare, unilateral, sex cord stromal tumours of ovary, whic... more Sertoli Leydig Cell Tumours (SLCTs) are rare, unilateral, sex cord stromal tumours of ovary, which constitute less than 1% of all the ovarian neoplasms. These tumours can be functionally diverse and they may have heterologous elements. We aim to report a case of a 25-year- old woman who presented with suprapubic pain of 5 days duration, a unilateral adnexal mass, hypertestosteronism without virilization. Intraoperative frozen section of the unilateral salpingo-oophorectomy specimen was suggestive of granulosa cell tumour. Histopathological examination, supplemented with alpha-inhibin immunohistochemistry, was diagnostic of Meyer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s type II SLCT. Clinical presentation, pathology and the diagnostic pitfalls in the present case have been presented with a brief review of literature.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013
Factitious biochemical reports result in the misguiding of clinicians, unnecessary retesting, wro... more Factitious biochemical reports result in the misguiding of clinicians, unnecessary retesting, wrong diagnoses and incorrect treatments. A vigilant biochemist identifies these factitious biochemical reports and alerts the clinician regarding the proper interpretation of the biochemical reports, thus preventing a misdiagnosis and an incorrect treatment. We are presenting a case report of a multiple myeloma patient who presented with factitious biochemical reports which were caused due to paraproteinaemia. In the present case, the patient presented with an underestimation of urea and creatinine, an underestimation of sodium, low albumin levels and high phosphate levels. On repeating the same tests after dilutions and deproteinizing, the effects of the paraproteins on the above mentioned tests were reduced. Thus, from the observations of our study, we suggest that the interference by paraproteinaemia can be reduced by analyzing the biochemical parameters after dilution and deproteinization.
Singapore Medical Journal, 2013
Isolated deletion of the long arm of chromosome 20 [del(20q12)] is a rare abnormality in patients... more Isolated deletion of the long arm of chromosome 20 [del(20q12)] is a rare abnormality in patients with de novo myelodysplastic syndrome. It is characterised by refractory thrombocytopenia, minimal haematological dysplasia and a lower risk for progression to acute myeloid leukaemia. Its distinction from chronic autoimmune thrombocytopenia, although clinically and morphologically difficult, is critical. We report a case of refractory cytopenia and unilineage dysplasia in an elderly woman with isolated del(20q12), identified via fluorescence in situ hybridisation analysis of her bone marrow. In order to avoid a misdiagnosis, we suggest that cytogenetic analysis be performed on all patients suspected to have myelodysplastic syndrome with predominant thrombocytopenic presentation.
Australasian Medical Journal, 2013
Carcinoma of the stomach rarely disseminates to bone. We report a case of compressive myeloradicu... more Carcinoma of the stomach rarely disseminates to bone. We report a case of compressive myeloradiculopathy from extensive metastases to the spine, which on evaluation originated from adenocarcinoma of the stomach. Magnetic resonance imaging of the spine showed osteolytic and osteosclerotic metastases. Gastrointestinal endoscopy revealed ulcerative growth in the stomach that on biopsy showed poorly differentiated adenocarcinoma. This case is unique in that the initial presentation of gastric cancer itself was bony metastases without any gastrointestinal symptoms or liver involvement. Moreover, metastases were osteosclerotic as well, which is against the general belief that gastric cancer produces only osteolytic secondaries.
Frontiers of Medicine in China, 2013
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, potentially life threatening, hyper infl... more Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, potentially life threatening, hyper inflammatory syndrome of diverse etiologies. Cardinal signs include prolonged fever, organomegaly, and persistent unexplained cytopenias. In spite of the well known diagnostic criteria put forth by HLH society, this continues to pose great diagnostic challenge in both pediatric and adult intensive care settings. We describe 4 adult (2 males, 2 females, aged 19, 29, 40, and 17 years) and 3 pediatric (2 males, 1 female, aged 1 month, 6 months, and 12 years) patients with secondary HLH who satisfied the HLH-2004 diagnostic criteria. Definite evidence of hemophagocytosis was noted in 4 patients on initial bone marrow examination. The underlying etiologies were as follows: Rickettsia tsutsugamushi (case 1), autoimmune disorder (case 2), systemic onset juvenile idiopathic arthritis (sJIA) (case 3), unknown bite (possibly a venomous snake) (case 4), Plasmodium vivax (case 5), Cytomegalo virus (case 6), and Mycobacterium tuberculosis (case 7). In one patient, hemophagocytosis was presumed to have been exacerbated by administration of granulocyte monocyte colony stimulating factor (GMCSF) for severe neutropenia. Two patients died with disseminated intravascular coagulation (DIC) and multi organ failure within few days of HLH diagnosis. Immunosuppressive therapy was started in 3 patients, and etoposide was started in one patient only. Due to lack of specificity of diagnostic criteria, diagnosing and differentiating HLH from its closest mimickers like sepsis/septic shock may be quite challenging in critically ill patients. Therefore, increasing awareness among physicians is essential for early diagnosis and effective therapy to reduce the mortality.