Somayeh Nasiripour - Academia.edu (original) (raw)

Papers by Somayeh Nasiripour

Coronaviruses, Nov 13, 2023

Journal of pharmaceutical care, 2016

Background: Antibiotic-resistant pathogens are problem in many geographic areas. The selection of... more Background: Antibiotic-resistant pathogens are problem in many geographic areas. The selection of appropriate antibiotics to treat Gram-negative bacteremia may be life-saving. The aim of this study was to evaluate the incidence of decreased antibiotic susceptibility among aerobic gram-negative bacilli isolated from hospitalized patients of Bandar Abbas general hospital. Methods: Consecutive specimens collected on clinical indications from hospitalized patients were cultured. The minimum inhibitory concentrations (MICs) of antimicrobial agents were determined by the agar dilution method according to the National Committee for Clinical Laboratory Standards (NCCLS) guidelines. Results: In this study 494 positive samples during one year were evaluated. The most common site of isolation was urinary system. The most frequently isolated organisms were E.coli (%47.3), Kelebsiella pneumonia (%19.9) and Pseudomonas aeruginosa (%16.2). Resistance to ceftriaxone, ceftazidime and cefepime was more than %50. MIC results revealed that E.coli was sensitive to amikacin, ciprofloxacin and meropenem more than %75; whereas sensitivity to ceftriaxone, ceftazidime and cefepime was less than %30. Klebsiella showed sensitivity to amikacin %77.1; however sensitivity to ceftriaxone, ceftazidime and cefepime less than %25. In addition, sensitivity of Pseudomonas aeruginosa to amikacin, ciprofloxacin and imipenem was more than %65; while sensitivity to ceftriaxone, ceftazidime and cefepime was %25 or less. Conclusions: The high incidence of reduced antibiotic susceptibility among gramnegative bacteria in this hospital suggests that more effective strategies are needed to control the selection and spread of resistant organisms.

International Journal of Fertility & Sterility, 2019

Background This study assessed the effects of a lactobacillus-based medication on pain intensity ... more Background This study assessed the effects of a lactobacillus-based medication on pain intensity scores in women with endometriosis. Materials and Methods The present randomized pilot placebo-controlled trial was done on eligible women who were surgically and pathologically diagnosed with endometriosis. Thirty-seven participants who had not received hormonal treatment in the last three months, were enrolled and randomized into LactoFem®and placebo groups. Lactobacillus capsules or placebo were administrated orally once a day for 8 weeks. Patients were assessed for pain severity using Visual Analogue Scale (VAS) scores for dysmenorrhea, dyspareunia and chronic pelvic pain at baseline and after 8 and 12 weeks post-intervention. Results Mean age of participants and mean body mass index (BMI) for the LactoFem®and control groups were compara- ble. All patients had stage 3 and 4 of the disease based on revised American fertility society (AFS) classification of endome- triosis. Mean initia...

Clinical Radiology, 2019

Clinical Radiology j o ur n a l ho m e p a g e : w w w. c l i ni c a l ra d i o l og y o nl i n e... more Clinical Radiology j o ur n a l ho m e p a g e : w w w. c l i ni c a l ra d i o l og y o nl i n e. n e t

Anaesthesiology Intensive Therapy

LetterS to the editor dear editor, Sedation and analgesia in critically ill patients are among th... more LetterS to the editor dear editor, Sedation and analgesia in critically ill patients are among the most important aspects of care delivery in the intensive care unit (iCU) [1]. it can be challenging when dealing with critically ill patients who have a history of substance abuse. Cannabis has analgesic, anxiolytic, antiemetic, and antispastic properties and has been in widespread use and abuse for thousands of years globally. Although some published case reports have shown that cannabis users demanded elevated doses of intravenous and inhaled anaesthetics during anaesthesia induction and/or maintenance [2, 3], data regarding cannabis and its interactions with commonly used sedative and analgesic agents in the iCU setting are scarce. Flisberg et al. [4] in a prospective, randomized, single-blinded human study assessed the induction doses of propofol in patients using cannabis. this study included 30 male cannabis users and 30 control individuals. induction doses of propofol to achieve the target bispectral index values were not significantly different in the 2 groups. however, in the cannabis user group significantly higher doses of propofol were required to achieve adequate sedation for successful laryngeal mask insertion. the authors concluded that to achieve satisfactory clinical response, higher doses of propofol are required in cannabis users. in addition, imasogi et al. [5] implemented a case-control study on the correlation between cannabis use and propofol anaesthesia during endoscopy. in total 318 members participated (cases, n = 151; controls, n = 167) in this study. their results

Background: Recently, immunomodulatory effect of vitamin D was documented. It was proposed that s... more Background: Recently, immunomodulatory effect of vitamin D was documented. It was proposed that serum level of vitamin D in some populations including patients with asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), tuberculosis and respiratory infections is lower than normal. We have evaluated serum vitamin D concentration in H1N1 infected patients. Methods: Fifty-two patients with documented H1N1 influenza were enrolled the study during pandemic 2009 flu. Patients' demographic data was recorded and one venous blood sample (3 ml) was collected from each patient at same time a day (at morning). Serum 25 (OH) D concentrations was measured by Chemiluminescence method. Results: Median (interquartiles 25-75) serum 25 (OH) D concentrations in the studied population was 26.62 (13.85-45.86) nmol/l. In men and women enrolled in the study, medians (interquartiles 25-75) of serum 25(OH) D were 28.95 (21.10-44.55) and 16.72 (10.48-98.34), respectively. Serum vitamin D concentration was higher in women than men, but it was not statistically significant. Conclusion: Based on vitamin D deficiency definition [serum 25(OH) D levels less than 35 nmol/l], 60.8% of the Iranian H1N1 infected patients had vitamin D deficiency.

The Journal of Clinical Pharmacology

CVD Prevention and Control, 2009

Physiology and Pharmacology, 2017

Achilles tendinitis is a rare adverse effect of the fluoroquinolone antibiotics. Fluoroquinolone ... more Achilles tendinitis is a rare adverse effect of the fluoroquinolone antibiotics. Fluoroquinolone antibiotics have widespread usage for treatment of Gram-negativerelated infections particularly urinary tract and respiratory infections. Due to the prevalent usage of this family of antibiotics, it is necessary to be careful about their side effects including Achilles tendinitis, which can ensue tendon rupture. This case report introduces an 84-year-old man diagnosed with Achilles tendinitis due to consumption of ciprofloxacin for treatment of urethritis. The patient experienced pain on posterior region of the left ankle after three days of antibiotic therapy onset and the pain was alleviated within a week following ciprofloxacin cessation along with treatment with nonsteroidal anti-inflammatory drugs. The Naranjo score was determined seven for this patient; accordingly, ciprofloxacin was the probable cause of this reaction. Early diagnosis of fluoroquinolones-associated Achilles tendin...

Tehran University Medical Journal TUMS Publications, 2016

Iranian journal of allergy, asthma, and immunology, 2013

One of the most important goals in treating chronic diseases, especially asthma, is the promotion... more One of the most important goals in treating chronic diseases, especially asthma, is the promotion of quality of life (QOL). The present study aimed at identifying the effect of educating method on the QOL of children, who suffered from asthma.In this clinical trial study, 80 children aged 6-12 years with asthma were divided into two groups: control (face-to-face method) and experimental (visual concept mapping method). The QOL of both groups was measured before and after educating by the Juniper's Quality of Life Questionnaire with a one-month interval.The rate of change in the QOL score of the experimental group was 0.3 (±0.7) both before and after intervention and 0.1 (±0.3) in the control group, which was statistically significant (p<0.05).Educating by the visual concept mapping method with regard to the manner of using sprays is taken into account as an efficient and effective method in improving the QOL of children with asthma.

Background: Melasma is an acquired facial hyperpigmentation that is chronic and resistant to trea... more Background: Melasma is an acquired facial hyperpigmentation that is chronic and resistant to treatment. This study aimed at comparing the therapeutic response and safety of 5% methimazole cream versus 2% hydroquinone cream in Iranian females with melasma. Methods: This was a randomized, controlled, double-blind clinical trial. Fifty-eight patients aged 18 to 50, and who had been clinically diagnosed with melasma were enrolled. They were randomly divided to 2 groups: those treated with 5% methimazole cream and those treated with 2% hydroquinone once nightly for 8 weeks. Their responses to treatment were evaluated using the Melasma area and severity index (MASI), the ∆E score obtained using VisioFace digital photography, and the patients' own satisfaction. Safety was assessed by measuring thyroid-stimulating hormone (TSH) levels. For statistical analysis, the SPSS version 16.0 for Windows (SPSS Inc., Chicago, IL) was used. Results: The subjective assessments of methimazole and hydroquinone (patient satisfaction) were as follows: excellent and good, 67.7% for methimazole vs. 70.3% for hydroquinone, and moderate and mild, 32.2% for methimazole versus 29.6% for hydroquinone. The assessments showed no statistical differences between the 2 groups (P = 0.942). At the end of treatment, MASI scores were significantly lower in the methimazole group than in the hydroquinone group (P = 0.042). The VisioFace∆E scores were also significantly lower in the methimazole group than in the hydroquinone group (P = 0.049). Serum thyroid stimulating hormone (TSH) levels showed no statistical differences between the 2 groups (P = 0.613). Conclusions: Compared with 2% hydroquinone, topical methimazole was more effective for improving melasma and had no effect on serum TSH levels. Therefore, methimazole could be considered as a first-line or combination therapy for melasma.

The Journal of Clinical Pharmacology, 2020

A pneumonia of unknown source was first reported to the World Health Organization Country Office ... more A pneumonia of unknown source was first reported to the World Health Organization Country Office from Wuhan, China, on December 31, 2019. Analysis of the samples obtained from the lower respiratory tract confirmed a novel coronavirus, which is now known as coronavirus disease 2019 (COVID-19). On March 11, 2020, the World Health Organization stated that COVID-19 was a pandemic disease with a mortality rate of about 3.7%.1,2 Recently, several studies have reported that a subgroup of patients with intense COVID-19 could have suffered from a cytokine release syndrome (CRS).2 CRS is a potentially life-threatening toxicity with an initial increase of tumor necrosis factor-α (TNF-α), followed by an increase in interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, and interferonγ (IFN-γ ).3 A cytokine profile was detected in COVID-19, including increased IL-2, IL-7, IFN-γ , granulocyte colony-stimulating factor, monocyte chemoattractant protein 1, macrophage inflammatory protein 1-α, and TNF-α.4 In addition, increased ferritin and IL-6 were introduced as predictors of fatality in COVID-19.5 All reported data could be considered as proof, confirming the activation of inflammation processes and the occurrence of CRS in critical patients with COVID-19. Colchicine is as an old drug, an alkaloid derived from autumn crocus, which has been used to treat several inflammatory diseases for many years. Several mechanisms of action for the anti-inflammatory effects of colchicine have been reported in the literature.6,7 The ability of colchicine to bind to free tubulin dimers, which may result in the blockage of the following microtubule polymerization,8 is believed to be one of the most famous mechanisms. This mechanism seems to lead to the interruption of inflammatory cell activities and cytokine release.9 Moreover, colchicine may control the white blood cell (WBC)-mediated inflammatory activities, counting the inhibiting WBC production of superoxides and release of numerous cytokines and pyrogens.10 Therefore, it may generally target WBCs, resulting in microtubule depolymerization, which in turn inhibits motility, phagocytosis, and degranulation of the WBCs. Furthermore, colchicine may suppress IL-1β and IL-18 release by interacting with Nod-like receptor protein 3 inflammasome protein complex.11 Colchicine is approved for the treatment of patients with acute gout and familial Mediterranean fever as well as other inflammatory conditions, including pericarditis and acute coronary syndrome (ACS), urarthritis, and other disorders.12-14 Martínez et al13 studied the effect of colchicine on local cardiac production of inflammatory cytokines in patients with ACS. They concluded that the local cardiac production of inflammatory cytokines containing IL-1β, IL-18, and IL-6 were elevated in patients with ACS. It was also inferred that the treatment with short-term colchicine could quickly and predominantly decrease the levels of IL-1β, IL-18, and IL-6 cytokines. Recently, Mehta et al2 recommended that immunosuppression could be useful in patients with severe COVID-19 by hyperinflammation. According to a recent hypothesis, production of the inflammatory cytokines such as IL-1β and IL-6 is a key downstream inflammatory mechanism in patients with severe COVID-19. Therefore, colchicine, as a simple and cheap drug with adequate safety profile, can be

Cell Cycle, 2020

To date, proposed therapies and antiviral drugs have been failed to cure coronavirus disease 2019... more To date, proposed therapies and antiviral drugs have been failed to cure coronavirus disease 2019 (COVID-19) patients. However, at least two drug companies have applied for emergency use authorization with the United States Food and Drug Administration for their coronavirus vaccine candidates and several other vaccines are in various stages of development to determine safety and efficacy. Recently, some studies have shown the role of different human and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) microRNAs (miRNAs) in the pathophysiology of COVID-19. miRNAs are non-coding single-stranded RNAs, which are involved in several physiological and pathological conditions, such as cell proliferation, differentiation, and metabolism. They act as negative regulators of protein synthesis through binding to the 3′ untranslated region (3′ UTR) of the complementary target mRNA, leading to mRNA degradation or inhibition. The databases of Google Scholar, Scopus, PubMed, and Web of Science were searched for literature regarding the importance of miRNAs in the SARS-CoV-2 life cycle, pathogenesis, and genomic mutations. Furthermore, promising miRNAs as a biomarker or antiviral agent in COVID-19 therapy are reviewed.