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Papers by Sonal Bhadane
The Journal of the Acoustical Society of America, 2012
Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused... more Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused ultrasound). In this work, the effects of treatment parameters on HIFU thermal lesion volume and temperature are investigated. Ex vivo tissues were treated with a 2 MHz HIFU beam in absence and presence of the Artenga® microbubbles at varying HIFU focal intensities (600-2400 W/cm 2), microbubble concentrations, and exposure durations (3-10 s). The temperature was measured at 1 mm from the focus using a K-type calibrated thermocouple. Thermal lesion volume was measured based on an ellipsoid model. Microbubbles increased the lesion volume and peak temperature achieved with HIFU. At the intensity of 2316 W/cm 2 , the lesion volume increased by two folds, and the peak temperature increased by 16 ºC with microbubbles. This effect depended on microbubble concentration, ultrasound intensity and exposure duration. Lower intensities and shorter exposure time durations were required at higher microbubble concentrations to ablate the tissue. It was concluded that the efficacy of the HIFU therapy in combination with microbubbles can be controlled through ultrasound and microbubble exposure parameters
Microbubble agents have been shown to increase therapeutic effect of HIFU (High intensity focused... more Microbubble agents have been shown to increase therapeutic effect of HIFU (High intensity focused ultrasound). Here, the effects of treatment parameters on lesion volume and temperature are investigated.
The Journal of the Acoustical Society of America, 2012
High-resolution coregistered intravascular imaging with integrated ultrasound and optical coheren... more High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe Appl. Phys. Lett. 97, 133702 (2010) Mechanism of voltage production and frequency dependence of the ultrasonic vibration potential J. Appl. Phys. 105, 102003 (2009) Ultrasonic enrichment of microspheres for ultrasensitive biomedical analysis in confocal laser-scanning fluorescence detection J. Appl. Phys. 96, 1242 (2004) Ultrasound-modulated optical computed tomography of biological tissues Appl. Phys. Lett. 84, 1597Lett. 84, (2004 Ultrasonic manipulation of locomotive microorganisms and evaluation of their activity Abstract -Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused ultrasound). In this work, the effects of treatment parameters on HIFU thermal lesion volume and temperature are investigated. Ex vivo tissues were treated with a 2 MHz HIFU beam in absence and presence of the Artenga® microbubbles at varying HIFU focal intensities (600-2400 W/cm 2 ), microbubble concentrations, and exposure durations (3-10 s). The temperature was measured at 1 mm from the focus using a K-type calibrated thermocouple. Thermal lesion volume was measured based on an ellipsoid model. Microbubbles increased the lesion volume and peak temperature achieved with HIFU. At the intensity of 2316 W/cm 2 , the lesion volume increased by two folds, and the peak temperature increased by 16 ºC with microbubbles. This effect depended on microbubble concentration, ultrasound intensity and exposure duration. Lower intensities and shorter exposure time durations were required at higher microbubble concentrations to ablate the tissue. It was concluded that the efficacy of the HIFU therapy in combination with microbubbles can be controlled through ultrasound and microbubble exposure parameters Keywords: High intensity focused ultrasound (HIFU), microbubble, thermal lesion.
The Journal of the Acoustical Society of America, 2012
Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused... more Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused ultrasound). In this work, the effects of treatment parameters on HIFU thermal lesion volume and temperature are investigated. Ex vivo tissues were treated with a 2 MHz HIFU beam in absence and presence of the Artenga® microbubbles at varying HIFU focal intensities (600-2400 W/cm 2), microbubble concentrations, and exposure durations (3-10 s). The temperature was measured at 1 mm from the focus using a K-type calibrated thermocouple. Thermal lesion volume was measured based on an ellipsoid model. Microbubbles increased the lesion volume and peak temperature achieved with HIFU. At the intensity of 2316 W/cm 2 , the lesion volume increased by two folds, and the peak temperature increased by 16 ºC with microbubbles. This effect depended on microbubble concentration, ultrasound intensity and exposure duration. Lower intensities and shorter exposure time durations were required at higher microbubble concentrations to ablate the tissue. It was concluded that the efficacy of the HIFU therapy in combination with microbubbles can be controlled through ultrasound and microbubble exposure parameters
Microbubble agents have been shown to increase therapeutic effect of HIFU (High intensity focused... more Microbubble agents have been shown to increase therapeutic effect of HIFU (High intensity focused ultrasound). Here, the effects of treatment parameters on lesion volume and temperature are investigated.
The Journal of the Acoustical Society of America, 2012
High-resolution coregistered intravascular imaging with integrated ultrasound and optical coheren... more High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe Appl. Phys. Lett. 97, 133702 (2010) Mechanism of voltage production and frequency dependence of the ultrasonic vibration potential J. Appl. Phys. 105, 102003 (2009) Ultrasonic enrichment of microspheres for ultrasensitive biomedical analysis in confocal laser-scanning fluorescence detection J. Appl. Phys. 96, 1242 (2004) Ultrasound-modulated optical computed tomography of biological tissues Appl. Phys. Lett. 84, 1597Lett. 84, (2004 Ultrasonic manipulation of locomotive microorganisms and evaluation of their activity Abstract -Microbubble agents have been shown to increase therapeutic effect of HIFU (high intensity focused ultrasound). In this work, the effects of treatment parameters on HIFU thermal lesion volume and temperature are investigated. Ex vivo tissues were treated with a 2 MHz HIFU beam in absence and presence of the Artenga® microbubbles at varying HIFU focal intensities (600-2400 W/cm 2 ), microbubble concentrations, and exposure durations (3-10 s). The temperature was measured at 1 mm from the focus using a K-type calibrated thermocouple. Thermal lesion volume was measured based on an ellipsoid model. Microbubbles increased the lesion volume and peak temperature achieved with HIFU. At the intensity of 2316 W/cm 2 , the lesion volume increased by two folds, and the peak temperature increased by 16 ºC with microbubbles. This effect depended on microbubble concentration, ultrasound intensity and exposure duration. Lower intensities and shorter exposure time durations were required at higher microbubble concentrations to ablate the tissue. It was concluded that the efficacy of the HIFU therapy in combination with microbubbles can be controlled through ultrasound and microbubble exposure parameters Keywords: High intensity focused ultrasound (HIFU), microbubble, thermal lesion.