Songül Özyurt - Academia.edu (original) (raw)

Papers by Songül Özyurt

Multidisciplinary Respiratory Medicine, 2014

Background: The protein neutrophil gelatinase-associated lipocalin (NGAL) is a mediator synthesiz... more Background: The protein neutrophil gelatinase-associated lipocalin (NGAL) is a mediator synthesized and released by neutrophils. Its physiological function is as yet unclear. Levels in blood increase in several inflammatory diseases. High serum values indicate poor prognosis for several diseases. Pleural effusion may appear as the result of various pathologies. The most common cause is heart failure (HF). Other common causes include parapneumonic (PPE) and malignant (MPE) pleural effusions, and pulmonary embolism. Tubercular effusion (TE) is commonly encountered in Turkey and similar developing countries. The purpose of this study was to investigate the effectiveness of NGAL, a current inflammation marker, in discriminating between different etiological diseases that cause pleural effusion. Methods: The study was performed at the Recep Tayyip Erdoğan University Faculty of Medicine Chest Diseases Clinic. One hundred patients were included in the study, 25 with parapneumonic effusion, 25 with heart failure-related effusion, 25 with tubercular effusion and 25 with cancer-related effusion. NGAL was measured in patients' serum and pleural fluids. Results: Serum NGAL levels in PPE (171 ± 56 ng/ml) were significantly higher (p < 0.001) than those in HF (86 ± 31 ng/ml), CA (103 ± 42 ng/ml) and TE (63 ± 19 ng/ml). Pleural NGAL levels were also significantly higher in PPE compared to HF, MPE and TE (p < 0.001). Serum NGAL levels exhibited a positive correlation with white blood cell (WBC), neutrophil, C-reactive protein (CRP), sedimentation, serum LDH, creatinine, pleural leukocyte and pleural neutrophil numbers. The most significant correlation was between NGAL level and WBC (p < 0.001, r = 0.579). Both serum and pleural NGAL levels are highly effective in differentiating patients with PPE from those without PPE (AUC: 0.910 and 0.790, respectively). Conclusions: NGAL can be used in the diagnosis of diseases with an acute inflammatory course. Serum and pleural NGAL levels can differentiate PPE from other diseases causing pleural fluid with high sensitivity and specificity.

European review for medical and pharmacological sciences, 2021

OBJECTIVE Inflammation and platelet activation play a role in the pathogenesis of obstructive sle... more OBJECTIVE Inflammation and platelet activation play a role in the pathogenesis of obstructive sleep apnea syndrome (OSAS). In this study, it was aimed to investigate the effectiveness of the systemic inflammation markers, the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and WMR (white blood cell count (WBC) to mean platelet volume (MPV) ratio), in determining the severity of OSAS. PATIENTS AND METHODS The study included 207 patients who visited the pulmonology polyclinic between 1 and 31 January 2020 with complaints of snoring, apnea periods during sleep and sleepiness and were assessed with polysomnography (PSG) with the indication of hospitalization. The patients were grouped based on their apnea-hypopnea index (AHI) scores as 54 patients with AHI<5 as the control group, 41 patients with AHI=5-15 as the mild, 54 patients with AHI=15-30 as the moderate and 58 patients with AHI>30 as the severe OSAS groups. From the complete blood counts of the patients, ...

Tüberküloz ve toraks, 2007

Anthracotic pigmentation in the bronchial mucosa has been regarded as a bronchoscopic finding of ... more Anthracotic pigmentation in the bronchial mucosa has been regarded as a bronchoscopic finding of pneumoconiosis or evidence of heavy atmospheric soot. Anthracotic pigmentation with bronchial narrowing or obliteration, surrounded by calcified or noncalcified lymph nodes is typical finding of anthracofibrosis. There is a potential relationship between bronchial anthracofibrosis and tuberculosis. Tuberculous lymphadenopathy of superior mediastinum presentation with hoarseness is very rare. The paper reports a case of tuberculous mediastinal lymphadenitis with anthracosis causing vocal cord paralysis. A 66-year-old woman was admitted to our clinic with the symptoms of dry cough, hoarseness, malaise, anorexia, night sweats and with the multiple mediastinal lymphadenopathy. Fiberoptic bronchoscopy revealed left vocal cord paralysis, bronchial mucosal inflammation and multiple anthracotic plaques. Bronchial lavage and mucosal biopsy were negative for malignancy and tuberculosis. The thorac...

Fighting the COVID-19 Pandemic, 2021

To evaluate the index cases leading to the transmission of healthcare workers (HCWs) in Rize/Turk... more To evaluate the index cases leading to the transmission of healthcare workers (HCWs) in Rize/Turkey Recep Tayyip Erdogan University Faculty of Medicine Education and Research Hospital with COVID-19 infection and the clinical features of infected HCWs. The first two COVID-19 test positive patients treated at Rize/Turkey between 10.03.2020 and 12.04.2020 and HCWs those who examined these two patients whose COVID-19 PCR test results were positive were included in this study. In Rize/Turkey, the first and second cases of positive COVID-19 which was recorded on 13.03.2020 on 25.03.2020, 27 HCWs (female, 63%, n = 17 and male, 37%, n = 10 and the mean age was 33.2 ± 6.9 years) who contacted during the treatment of these cases and became COVID-19 positive were examined. The median of symptom duration (days) of the HCWs was 5 days (range: 0–17 days). Fever, 55.6% (n = 15); malaise, 44.4% (n = 12); cough, 40.7% (n = 11); sore throat, 33.3% (n = 9); myalgia, 33.3% (n = 9); dyspnea, 14.8% (n = ...

Pulmonary actinomycosis is a severe clinical condition that may cause death if unrecognized. It m... more Pulmonary actinomycosis is a severe clinical condition that may cause death if unrecognized. It may occur in patients who were previously healthy or may develop in patients with chronic immunosuppressant conditions. Presently described is a rare case of massive pulmonary hemorrhage with a related angioinvasive Actinomyces infection. A 52-year-old formerly immunocompetent man was admitted to the hospital due to blood-streaked sputum. A computed tomography image of the thorax taken after the patient’s clinical status suddenly worsened revealed total collapse of the left lung. No tumoral lesion was observed, but extensive necrosis of the mucosa of both main bronchi with massive hemorrhage in the left main bronchus was noticed in an urgent bronchoscopy performed in the intensive care unit. A histopathological examination of the mucosal punch biopsy demonstrated aggregates of filamentous Grampositive organisms indicating Actinomyces infection. Selective embolization of a branch of the fe...

Journal of Gerontological Social Work

Respiratory Case Reports, 2015

On sekiz yaşında erkek hasta nefes darlığı, öksürük, kanlı balgam şikayetiyle hastanemize başvurd... more On sekiz yaşında erkek hasta nefes darlığı, öksürük, kanlı balgam şikayetiyle hastanemize başvurdu. Fizik bakıda vital bulguları normaldi. Alt dudakta herpes labialis ve akciğerler orta-alt bölgede inspiratuar raller mevcuttu. Laboratuvarında lökosit 21 .7OO/mm3, hemoglobin 6,80 g/dL, hematokrit %23,2, CRP 5,46mg/dl ve viral panelinde HSV-1 lgM pozitifti. Toraks BT'de her iki akciğerde diffüz buzlu cam opasitesi, interlobuler septal kalınlaşmalar görülmekteydi. Fiberoptik bronkoskopide trakeobron- şial sistemde diffüz eritem ve kanama saptandı. Bronkoalveoler lavajda hemosiderin yüklü makrofajlar görüldü. HSV-l'e bağlı pnömoni ve diffüz alveoler hemoraji (DAH) düşünülen hastaya acyclovir, kortikosteroid, eritrosit süspansiyonu, taze donmuş plazma ve tranexamik asit başlandı. Tedaviye dramatik cevap gelişti. Sonuç olarak, HSV-1 pnömonisinin sıklıkla immün suprese ve yoğun bakım hastalarında görüldüğü bilinmesine karşın olgumuzda immünitesi normal, genç bir hastada HSV-l'e bağlı pnömoni ve DAH kliniğinin geliştiğini görmekteyiz. Bu olgunun HSV-l'e bağlı gelişen, DAH patolojisiyle seyreden ve seyrek görülen bir olgu olduğu kanısındayız.An 18-year-old man was admitted to the hospital with the complaints of dyspnea, cough and hemopty- sis. The physical examination revealed, herpes labials on the lower lip and crackles in the middle and lower regions of both lungs. Laboratory tests revealed a leukocyt count of 21.700/mm3, hemoglobulin level of 6.80 g/dL, hematocrit of 23.2%, CRP of 5.46 mg/dl, and HSV-1 IgM was positive. The thorax CT revealed bilateral and diffuse ground glass appear- ance and interlobuler septal thickening on both pul- monary paranchymal areas. Active bleeding was observed in the entire tracheobronchial system by bronchoscopy. Microscopic images showed hemo- siderin-loaded macrophages. We diagnosed HSV-1 related pneumonia and diffuse alveolar hemorrhage (DAH). We treated the patient with acyclovir, cortico- steroid, erythrocyte suspension, cryoprecipitate, and tranexamic acid. The patient improved dramatically. Finally, while HSV-1 related pneumonia is usually seen in immunocompromised hosts and critically ill patients, in the present case, a healthy immunocom- petent man was infected with HSV-1. Following medi- cation, the patient was completely healed. We think that the current case is a rare disease of HSV-1 lead- ing to DA

Annals of Clinical and Analytical Medicine, 2021

Aim: In this study, we aimed to compare copeptin with N-terminal pro-brain natriuretic peptide (N... more Aim: In this study, we aimed to compare copeptin with N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I for predicting severity and 3-month mortality in acute PE in the emergency department (ED). Material and Methods: All ED patients older than 18 years who were confirmed to have acute PE within six hours of diagnostic work-up were enrolled and prospectively screened. Risk stratification was made according to the 2014 European Society of Cardiology guideline on PE. The study endpoints were defined as 3-month mortality, presence of non-low risk PE, and presence of right ventricular (RV) dysfunction. The Mann-Whitney U test was used for the comparison of medians. Receiver operating characteristic curves were generated and the area under the curve (AUC) was calculated to determine the best cutoff values of copeptin and NT-proBNP. A P value < 0.05 was considered statistically significant. Results: The study enrolled 82 patients. Twelve patients who died during 3 months had higher concentrations of NT-proBNP and copeptin, but not troponin I. The AUCs of NT-proBNP and copeptin to accurately predict the 3-month mortality were 0.73 ± 0.09 (95% CI, 0.62-0.82; p = 0.013) and 0.78 ± 0.09 (95% CI, 0.68-0.86; p = 0.003), respectively. Low-risk patients, according to Pulmonary Embolism Severity Index, had lower concentrations of copeptin and NT-proBNP compared to intermediate-high risk patients. All three markers discriminated the presence of RV dysfunction truly. Discussion: Copeptin correlates with NT-proBNP and appears beneficial for early risk stratification of acute pulmonary embolism in the ED.

Nigerian Journal of Clinical Practice, 2020

Objective: The blaOXA resistance genes and ISAba1 were examined in 70 samples from lower respirat... more Objective: The blaOXA resistance genes and ISAba1 were examined in 70 samples from lower respiratory tract of hospitalized patients. Materials and Methods: Of the 67 isolates obtained, almost half (46.3%) of them were from endotracheal aspirate, and most were collected from the intensive care units of the reanimation (37.3%) and internal medicine (32.8%) units. Results: Three samples from the internal medicine intensive care unit had positive cultures. Of the multidrug resistant (MDR) samples, 70 isolates (>50%) were moderately sensitive, while fewer (10%) were resistant to tigecycline. In contrast, 100% were sensitive to colistin. All strains were found to be positive for blaOXA-23-like and blaOXA-51-like genes, whereas no blaOXA-40-like and blaOXA-58-like genes were detected. The ISAba1 positivity rate was 90.0%. Pattern 5 was mainly identified among the 22 different patterns. Of note, 50% of Pattern 5 was found in the patients of the internal medicine intensive care unit, and a third was associated with ventilator-associated pneumonia. Importantly, the internal medicine unit's equipment was found to be culture positive. Conclusion: Findings obtained from this study suggest that isolates can easily spread through the hospital via isolate cross-contamination caused by health personnel. These contaminating isolates may be able to maintain their presence within the hospital for a long time.

The Clinical Respiratory Journal, 2020

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease showing acute exac... more Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease showing acute exacerbations during its course. Comorbidities often accompany. Non‐thyroidal illness syndrome (NTIS) occurs because of the functional impairment in the hypothalamic‐pituitary‐thyroid axis in severe critical cases. The objective of the current study is to determine the prevalence of NTIS among hospitalised patients due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and to reveal the factors affecting thyroid functions.

Turkish Thoracic Journal, 2019

Güncel Göğüs Hastalıkları Serisi, 2018

İnsanlarda beklenen ortalama yaşam süresinin artmasıyla birlikte kanser vakalarında da artışlar g... more İnsanlarda beklenen ortalama yaşam süresinin artmasıyla birlikte kanser vakalarında da artışlar görülmektedir. Özellikle akciğer kanserinin görülme sıklığı ve mortalitesi dünya çapında artmaya devam etmektedir. Bu hastalarda sıklıkla akut ciddi semptomlar ve yaşamı tehdit eden durumlar ortaya çıkmakta ve acil tıbbi bakım gerekmektedir. Akciğer kanserinde acil servise başvuru ve mortalite diğer solit tümörlerden daha fazla görülmektedir. Bu acil durumlar kanserle direkt veya dolaylı olarak ya da tümörün tedavisi ile ortaya çıkar ve potansiyel olarak yaşamı tehdit eder. Tümörün bölgesel yayılımı ilişkili olarak vena kava süperior sendromu, perikardiyal tamponat, masif hemoptizi, massif plevral efüzyon ve akut hava yolu obstrüksiyonu görülmektedir. Hiperkalsemi, hiponatremi, uygunsuz ADH salınımı sendromu ve tümör lizis sendromu ise akciğer kanserinde ortaya çıkan metabolik acil durumlardır. Beyin metastazları, kemik metastazları ve spinal kord basısı uzak metastazlara bağlı olarak ortaya çıkmaktadır. Ayrıca, bu hastalarda kemoterapiye bağlı olarak febril nötropeni, hipersensitivite reaksiyonları ve anaflaksi, radyoterapiye bağlı olarak akut radyasyon pnömonitisi ve özefajit ortaya çıkmaktadır. Onkolojik aciller hayatı tehtit eder ve mortalitesi yüksektir. Mortalite ve morbiditeyi azaltmak için erken tanı ve tedavi büyük önem taşır. Çünkü tanı ve tedavide gecikmeler çoğu zaman ölümle sonuçlanabilmektedir.

Journal of Experimental and Clinical Medicine, 2013

This study aimed to evaluate the diagnostic and therapeutic value of videothoracoscopy in patient... more This study aimed to evaluate the diagnostic and therapeutic value of videothoracoscopy in patients with pleural effusion. A total of 41 patients underwent video-assisted thoracic surgery (VATS) were analyzed, 25 male and 16 female. The mean age was 52.1 years (ranged between 18 and 92 years). Pleural effusion was left sided in 19 cases (46.4%), right sided in 14 cases (34.1%) and bilateral in eight cases (19.5%). Subjects with exudative and hemorrhagic pleural effusions in thoracentesis were included in the study. In all cases; complete blood count, electrocardiography (ECG), arterial blood gas, coagulation profile and respiratory function test (RFT) were performed. Two view chest X-ray and computed tomography scans were done to determine the localization of fluid and to decide the access point to thorax prior to procedure. One-lung ventilation was achieved in 20 patients under general anestesia, whereas double lung ventilation was preferred in 13 cases intolerant of one-lung ventilation. The procedure was carried out under local anesthesia in eight cases due to their high risk for general anesthesia. An approximately 50cc of pleural fluid and at least two pieces of pleural biopsy specimen for cytopathological examination were collected in all cases. Among the study population, 33 of cases were diagnosed with a benign disease and the remaining eight cases with a malign disease. Taking age ranges into account, non-specific pleuritis and tuberculosis pleuritis were most commonly diagnosed between 20 to 40 years of age whereas malign pathologies between 40-60 years of age. Diagnostic success of the procedure was found to be 97.6%. Patients with malign effusion underwent chemical pleurodesis with talc powder. No complication developed in our cases. VATS seems to be an effective method in the diagnosis and treatment of patients with pleural effusion.

American Journal of Kidney Diseases, 2013

Neutrophil Gelatinase-Associated Lipocalin (NGAL), neutrophils and chronic kidney disease: which ... more Neutrophil Gelatinase-Associated Lipocalin (NGAL), neutrophils and chronic kidney disease: which comes first

toraks.org.tr

Asker adayı 1505 kişide, mikrofilm taraması sırasında 'Bacillus Calmette-Guerin'(BCG) a... more Asker adayı 1505 kişide, mikrofilm taraması sırasında 'Bacillus Calmette-Guerin'(BCG) aşı durumunu değerlendirmek amacıyla BCG skar oranlarına bakıldı. Asker adaylarının 1418'inde (% 94) BCG skarı bulunmaktaydı. Gençlerin 14'ü (% 0.9) okuma ve yazma ...

The Turkish Journal of Geriatrics, 2018

This study aims to examine the clinical differences between the Pulmonary Thromboembolism patient... more This study aims to examine the clinical differences between the Pulmonary Thromboembolism patients aged 65 and above and younger patients attending the clinic of chest diseases. Materials and Method: The study sample included the patients diagnosed with Pulmonary Thromboembolism at the Chest Diseases Clinic of Recep Tayyip Erdoğan University Faculty of Medicine between June 2016 and December 2017. Patients' files were scanned retrospectively and the participants were divided into two groups: elderly patients aged 65 and over (elder) and patients under 65 years of age (younger). These two groups were compared in terms of clinical, laboratory and radiological characteristics of Pulmonary Thromboembolism. Results: A total of 149 patients consisting of 90 (60%) female and 59 (40%) male patients with an average age of 73±13 years (22-94) were included in the study. The most common symptom was dyspnea and the most frequently observed risk factor was immobility. The prevalence of chest pain was significantly higher in the patients younger group than elder group. Besides, no change in consciousness was observed in the patients in younger group, while altered state of consciousness was observed in 17 (15%) of 113 patients in elder group. Conclusion: Especially in patients elder, chest pain loses its significance, while unexpected symptoms such as altered state of consciousness can be observed. This should be taken into account; otherwise it may result in a delay in diagnosis.

Canadian Respiratory Journal, 2022

Purpose. Thiols are sulfhydryl-containing organic compounds that have an important role in preven... more Purpose. Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls. Materials and Methods. Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (−SH); TT: total thiol (−SH + SS); SS: disulfide (−SS); SS-SH: disulfide/native thiol index; SS-TT: disulphide/total thiol index; SH-TT: native thiol/total thiol index), and ischemia-modified albumin (IMA) levels were examined in the stable bronchiectasis group and the control group. Thiol-disulfide homeostasis was evaluated using a novel and automated assay. Findings and Result. Blood native thiol levels in patients with stable bronchiectasis were found to be significantly higher compare...