Jong-Suk Song - Academia.edu (original) (raw)

Papers by Jong-Suk Song

Research paper thumbnail of Population demographic history of a temperate shrub, Rhododendron weyrichii (Ericaceae), on continental islands of Japan and South Korea

Ecology and evolution, Dec 1, 2016

Continental islands provide opportunities for testing the effects of isolation and migration on g... more Continental islands provide opportunities for testing the effects of isolation and migration on genetic variation in plant populations. In characteristic of continental islands is that the geographic connections between these islands, which are currently distinguished by seaways, have experienced fluctuations caused by sea-level changes due to climate oscillations during the Quaternary. Plant populations on the islands have migrated between these islands via the exposed seafloors or been isolated. Here, we examined the demographic history of a temperate shrub, Rhododendron weyrichii, which is distributed in the southwestern parts of the Japanese archipelago and on an island of South Korea, using statistical phylogeographic approaches based on the DNA sequences of two chloroplast and eight nuclear loci in samples analyzed from 18 populations on eight continental islands, and palaeodistribution modeling. Time estimates for four island populations indicate that the durations of vicaria...

Research paper thumbnail of Korean Forest Database

Biodiversity & Ecology, 2012

Research paper thumbnail of Risk Factors of Iris Posterior Synechia Formation after Phacovitrectomy with Three-Piece Acrylic IOL or Single-Piece Acrylic IOL

Ophthalmologica, 2009

Aims: To identify the risk factors of posterior iris synechia formation after phacovitrectomy wit... more Aims: To identify the risk factors of posterior iris synechia formation after phacovitrectomy with posterior chamber single-piece acrylic intraocular lens (IOL; Acrysof® SA60AT) or 3-piece acrylic IOL (Acrysof® MA60BM) implantation. Methods: We selected 153 eyes of 153 patients treated by phacovitrectomy between March 2000 and August 2006 and retrospectively reviewed the relationship between iris posterior synechiae and various factors, such as IOL type, tamponade, preoperative iris posterior synechiae, major indications for surgery, axial length and preoperative anterior chamber (AC) depth. Results: IOL type (p = 0.0447), C3F8 gas tamponades (p = 0.0074), preoperative iris posterior synechiae (p = 0.0001) and postoperative AC fibrin deposition (p = 0.0303) were significantly associated with postoperative iris posterior synechiae by multiple logistic regression analysis. The odds ratio (OR) for single-piece IOL versus 3-piece IOL was 2.658 (95% confidence interval, CI: 1.010–6.993),...

Research paper thumbnail of Decrease in carbamylation of rubisco by high CO2 concentration is due to decrease of rubisco activase in kidney bean

Journal of Plant Biology, 1997

Decrease in rubisco activation at high CO2 concentration was caused by decrease in carbamylation ... more Decrease in rubisco activation at high CO2 concentration was caused by decrease in carbamylation of rubisco (Rohet al., 1996). However, it is unclear whether decrease in carbamylation rate at high CO2 concentration is due to decrease in activity itself or content of rubisco activase. To clarify this ambiguity, investigation was performed to determine effects of CO2 concentration on rubisco activase

Research paper thumbnail of Large‐scale phytogeographical patterns in East Asia in relation to latitudinal and climatic gradients

Journal of Biogeography, 2003

Aim This paper aims at determining how different floristic elements (e.g. cosmopolitan, tropical... more Aim This paper aims at determining how different floristic elements (e.g. cosmopolitan, tropical, and temperate) change with latitude and major climate factors, and how latitude affects the floristic relationships between East Asia and the other parts of the world.Location East Asia from the Arctic to tropical regions, an area crossing over 50° of latitudes and covering the eastern part of China, Korea, Japan and the eastern part of Russia.Methods East Asia is divided into forty‐five geographical regions. Based on the similarity of their world‐wide distributional patterns, a total of 2808 indigenous genera of seed plants found in East Asia were grouped into fourteen geographical elements, belonging to three major categories (cosmopolitan, tropical and temperate). The 50°‐long latitudinal gradient of East Asia was divided into five latitudinal zones, each of c. 10°. Phytogeographical relationships of East Asia to latitude and climatic variables were examined based on the forty‐fiv...

Research paper thumbnail of Induction of FGF-2 Synthesis by IL-1β in Aqueous Humor through P13-Kinase and p38 in Rabbit Corneal Endothelium

Investigative Opthalmology & Visual Science, 2010

Research paper thumbnail of Human Corneal Endothelial Cells Employ Phosphorylation of p27Kip1at Both Ser10 and Thr187 Sites for FGF-2-Mediated Cell Proliferation via PI 3-Kinase

Investigative Opthalmology & Visual Science, 2011

Research paper thumbnail of Tree growth and competition in a post‐logging Quercus mongolica forest on Mt. Sobaek, South Korea

Ecological Research, 2008

Secondary woodlands in South Korea cover most mountains from low to middle elevations. While gene... more Secondary woodlands in South Korea cover most mountains from low to middle elevations. While general patterns of forest succession are well understood, little is known about mechanisms of stand recovery after disturbance. We examined the spatio‐temporal variations in establishment, growth, size inequality, and mode of competition among trees in a 50‐year‐old post‐logging Quercus mongolica‐dominated stand. We further compared the growth and stem allometry of single trees, presumably of seed origin, with multi‐stemmed trees resprouting from stumps. Q. mongolica formed the upper canopy 16–22 m tall, 88.3% of total stand basal area, and 36.2% of total stem density, with most trees established during the first post‐logging decade (51.2% were resprouts). During the first three decades, the Q. mongolica recruits grew exponentially, and disproportionately more in diameter than few older reserved trees left after the last cutting. This substantially decreased size inequality. The reverse tre...

Research paper thumbnail of Invasion ofambrosia artemisiifolial. (compositae) in the Ukrainian Carpathians Mts. and the transcarpathian plain (central Europe)

Korean Journal of Biological Sciences, 1998

... Gravitation gradient m asl, 1*01) Active temperatures sum gradient, lech nog eric ecosystems ... more ... Gravitation gradient m asl, 1*01) Active temperatures sum gradient, lech nog eric ecosystems •IA ... Dr. W. Junk Publication, Hague, pp 1-370. Holub J and Jirasek V (1971) Terminologie. ... Preslia 43: 69-87. Jackowiak B (1993) Atlas of distribution of vascular plants in Poznan. ...

Research paper thumbnail of Transorbital−intracranial injury by a chopstick: three‐dimensional computed tomography

Acta Ophthalmologica Scandinavica, 2005

Research paper thumbnail of Clinical exhibition of increased accommodative loads for binocular fusion in patients with basic intermittent exotropia

BMC ophthalmology, Jan 7, 2016

To investigate the accommodative loads change needed to maintain binocular fusion in patients wit... more To investigate the accommodative loads change needed to maintain binocular fusion in patients with intermittent exotropia (IXT). Seventeen consecutive patients with basic IXT and 15 normal controls were recruited. The WAM-5500 autorefractor (GrandSeiko, Fukuyama, Japan) was used to measure refractive error (D) under binocular and monocular viewing conditions at 6 m, 50 cm, 33 cm and 20 cm. The difference between binocular and monocular refractive error (D) at each distance defined the change in the accommodative load. The changes in accommodative load were compared between IXT patients and normal controls. We also investigated the change in accommodative loads according to the fixing preference in patients with IXT. In IXT patients, the mean angles of deviation were 20.2 ± 7.19 and 21.0 ± 8.02 prism diopters at 6 m and 33 cm, respectively. Under binocular viewing, the changes in accommodative loads of each eye in IXT patients were significantly higher at 50, 33 and 20 cm than those ...

Research paper thumbnail of The Relationship Between Morphology and Function of the Meibomian Glands

Eye & contact lens, Jan 13, 2016

Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease (DED). Meibomian gland dy... more Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease (DED). Meibomian gland dysfunction is divided into two major categories based on meibomian gland secretion: low delivery and high delivery. The low-delivery states are further classified as either hyposecretory or obstructive subtype, and the high-delivery state is termed "hypersecretory MGD." Two parameters are commonly used to evaluate meibomian gland function: lipid layer thickness and meibum quality and expressibility. To evaluate the morphology of meibomian glands, meibography is used to detect meibomian gland dropout. Functional and morphological changes of meibomian glands are often thought to be well correlated; in reality, many cases do not because some patients have characteristics of both hypersecretory and obstructive subtypes. We suggest that the MGD classification system should be modified to include a mixed subtype to explain such patients.

Research paper thumbnail of Immediate Effect of 3% Diquafosol Ophthalmic Solution on Tear MUC5AC Concentration and Corneal Wetting Ability in Normal and Experimental Keratoconjunctivitis Sicca Rat Models

Current eye research, Jan 28, 2016

To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentratio... more To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. Rats were divided into normal and KCS groups. 3% of diquafosol solution was instilled into the right eye and normal saline into the left eye in both groups. To determine the peak time of tear MUC5AC concentration, tears were collected after 3% diquafosol instillation every 5 min up to 20 min. The tear film stability and the numbers of PAS-positive goblet cells were compared in both models. After diquafosol instillation, tear MUC5AC concentration increased steadily for 15 min, at which point the MUC5AC concentration reached its peak. In both normal and KCS groups, the MUC5AC concentration at 15 min was higher after instillation of 3% diquafosol solution (17.77 ± 2.09 ng/ml in the normal group, 9.65 ± 3.51 ng/ml in the KCS group) than that after saline ins...

Research paper thumbnail of Meibomian Gland Dysfunction in Patients With Chemotherapy-Induced Lacrimal Drainage Obstruction

Cornea, 2017

To investigate the relationship between chemotherapy-induced lacrimal drainage (LD) obstruction a... more To investigate the relationship between chemotherapy-induced lacrimal drainage (LD) obstruction and obstructive meibomian gland dysfunction. Twenty patients who had received chemotherapy were divided into 2 groups, according to the presence of LD obstruction: the LD obstruction group (n = 10) and control group (n = 10). Upper and lower meibomian gland loss was evaluated using noncontact meibography, and tear film lipid layer thickness was measured using an interferometer. The mean values of the right and left eyes of each patient were used to compare parameters between both groups. The LD obstruction group had higher levels of meibomian gland loss in both upper (42.9% ± 16.4%) and lower meibomian glands (80.1% ± 16.7%) than did the control group (17.3% ± 6.7% and 22.8% ± 13.0%, respectively) (P < 0.001 and P < 0.001, respectively). In the LD obstruction group, meibomian gland loss in the lower eyelid was significantly higher than that in the upper eyelid (P < 0.001). The li...

Research paper thumbnail of Effect of cataract surgery on intraocular pressure in supine and lateral decubitus body postures

Indian journal of ophthalmology, 2016

To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recum... more To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recumbent body postures including supine and lateral decubitus (LD) positions. This prospective, observational study included patients who had no glaucoma and who had planned to undergo phacoemulsification and intraocular lens implantation in one eye. Before and 1 month after cataract surgery, IOP was measured in both eyes using the Tono-Pen AVIA. We measured IOP in the sitting, supine, and LD (with the operated eye placed on the lower side) positions. IOP was measured 10 min after assuming each position in a randomized sequence. The Wilcoxon signed-rank test was used to compare the IOP changes before and 1 month after phacoemulsification in all postures. Twenty-nine patients participated in this study. Postoperative IOP was lower than the preoperative IOP when measured by Goldmann applanation tonometry in the sitting position (13.8 ± 1.9 mmHg vs. 12.6 ± 2.1 mmHg, P = 0.007). The postoperativ...

Research paper thumbnail of The Effects of Surgical Punctual Occlusion on Patients with Aqueous Deficient Dry Eye

Journal of the Korean Ophthalmological Society, 2016

Research paper thumbnail of Influence of benomyl on photosynthetic capacity in soybean leaves

Biotechnology and Bioprocess Engineering, 2001

... [13] Thringstrup, I. and S. Rosendahl (1994) Quantification of fungal activity in arbuscular ... more ... [13] Thringstrup, I. and S. Rosendahl (1994) Quantification of fungal activity in arbuscular mycorrhizal symbiosis by polyacrylamide gel eletrophoresis and densitometry of malate dehydrogenase. Soil Biol. ... 84: 930-936. [22] Roh, KS, JK Kim, SD Song, HS Chung, and JS Song ...

Research paper thumbnail of Modified Haigis Formula Effective Lens Position Equation for Ciliary Sulcus-Implanted Intraocular Lenses

American journal of ophthalmology, Jan 8, 2015

To investigate the effect of a modified Haigis formula effective lens position equation on improv... more To investigate the effect of a modified Haigis formula effective lens position equation on improving refractive outcomes in eyes with ciliary sulcus-implanted intraocular lenses (IOLs). Retrospective cross-sectional study. One hundred thirty-two eyes of 132 consecutive patients who underwent phacoemulsification with implantation of a ZA9003 (Abbott Medical Optics Inc.; 69 eyes) or AR40e (Abbott Medical Optics Inc.; 63 eyes) IOL in the ciliary sulcus were enrolled. The modified effective lens position (ELP) equation based on the corneal radius (CR) (ELP-β0-β1×CR, where β0 and β1 are parameters in the linear regression analysis) was obtained using linear regression analysis in each IOL group, and was applied to the other IOL group in order to evaluate its effect on refractive outcomes in an independent data set. The median absolute error (MedAE) was predicted using the modified effective lens position equation and was compared with that predicted using the adjusted IOL power. The modi...

Research paper thumbnail of Immediate Effects of 3% Diquafosol and 0.1% Hyaluronic Acid Ophthalmic Solution on Tear Break-Up Time in Normal Human Eyes

Journal of Ocular Pharmacology and Therapeutics, 2015

The purpose of this study was to evaluate the immediate effect of 3% diquafosol ophthalmic soluti... more The purpose of this study was to evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear break-up time (TBUT) in normal human eyes, and to compare it with that of saline and 0.1% hyaluronate ophthalmic solution. Cross sectional comparative study in the first study, 10 healthy volunteers underwent topical application of 2 different ophthalmic solutions in each eye. Saline was randomly applied to one eye and 3% diquafosol ophthalmic solution was added to the fellow eye. TBUT was measured and video recorded before application and at 5, 10, 15, and 20 min after. The TBUT in each eye was compared at each time point with regard to the 2 different ophthalmic solutions. In the second study, another 10 healthy volunteers were included. The same methods were used to compare the immediate effects of 0.1% hyaluronate and 3% diquafosol ophthalmic solution application on TBUT. In the first study, topical instillation of saline did not increase TBUT. However, 3% diquafosol significantly increased TBUT for up to 15 min after application. At every time point, the TBUT increased more significantly from baseline in the diquafosol group than it did in the saline group. In the second study, 0.1% hyaluronate increased TBUT for up to 5 min after application, while 3% diquafosol increased TBUT for up to 15 min. Although the TBUT changes after 5 min were not significantly different between the 2 groups, the TBUT changes at 10, 15, and 20 min were significantly greater in the 3% diquafosol group than they were in the 0.1% hyaluronic acid group (+1.58 ± 0.82 vs. +0.53 ± 1.36 at 10 min, +0.67 ± 0.91 vs. -0.04 ± 1.29 at 15 min, and -0.06 ± 0.96 vs. -0.59 ± 0.90, diquafosol group vs. hyaluronic acid group). One drop of 3% diquafosol increased TBUT for up to 15 min after application. The immediate effect of 3% diquafosol on TBUT was greater than that of saline and even that of 1% hyaluronate ophthalmic solution.

Research paper thumbnail of Phytogeography of Northeast Asia

Northeast Asia as defined in this study includes the Russian Far East, Northeast China, the north... more Northeast Asia as defined in this study includes the Russian Far East, Northeast China, the northern part of the Korean Peninsula, and Hokkaido Island (Japan). We determined the species richness of Northeast Asia at various spatial scales, analyzed the floristic relationships among geographic regions within Northeast Asia, and compared the flora of Northeast Asia with surrounding floras. The flora of Northeast Asia consists of 971 genera and 4953 species of native vascular plants. Based on their worldwide distributions, the 971 gen- era were grouped into fourteen phytogeographic elements. Over 900 species of vascular plants are endemic to Northeast Asia. Northeast Asia shares 39% of its species with eastern Siberia-Mongolia, 24% with Europe, 16.2% with western North America, and 12.4% with eastern North America. Species richness and floristic relationships among different regions within Northeast Asia were discussed. The northernmost (Arctic) region shares 64% of its genera and 9% o...

Research paper thumbnail of Population demographic history of a temperate shrub, Rhododendron weyrichii (Ericaceae), on continental islands of Japan and South Korea

Ecology and evolution, Dec 1, 2016

Continental islands provide opportunities for testing the effects of isolation and migration on g... more Continental islands provide opportunities for testing the effects of isolation and migration on genetic variation in plant populations. In characteristic of continental islands is that the geographic connections between these islands, which are currently distinguished by seaways, have experienced fluctuations caused by sea-level changes due to climate oscillations during the Quaternary. Plant populations on the islands have migrated between these islands via the exposed seafloors or been isolated. Here, we examined the demographic history of a temperate shrub, Rhododendron weyrichii, which is distributed in the southwestern parts of the Japanese archipelago and on an island of South Korea, using statistical phylogeographic approaches based on the DNA sequences of two chloroplast and eight nuclear loci in samples analyzed from 18 populations on eight continental islands, and palaeodistribution modeling. Time estimates for four island populations indicate that the durations of vicaria...

Research paper thumbnail of Korean Forest Database

Biodiversity & Ecology, 2012

Research paper thumbnail of Risk Factors of Iris Posterior Synechia Formation after Phacovitrectomy with Three-Piece Acrylic IOL or Single-Piece Acrylic IOL

Ophthalmologica, 2009

Aims: To identify the risk factors of posterior iris synechia formation after phacovitrectomy wit... more Aims: To identify the risk factors of posterior iris synechia formation after phacovitrectomy with posterior chamber single-piece acrylic intraocular lens (IOL; Acrysof® SA60AT) or 3-piece acrylic IOL (Acrysof® MA60BM) implantation. Methods: We selected 153 eyes of 153 patients treated by phacovitrectomy between March 2000 and August 2006 and retrospectively reviewed the relationship between iris posterior synechiae and various factors, such as IOL type, tamponade, preoperative iris posterior synechiae, major indications for surgery, axial length and preoperative anterior chamber (AC) depth. Results: IOL type (p = 0.0447), C3F8 gas tamponades (p = 0.0074), preoperative iris posterior synechiae (p = 0.0001) and postoperative AC fibrin deposition (p = 0.0303) were significantly associated with postoperative iris posterior synechiae by multiple logistic regression analysis. The odds ratio (OR) for single-piece IOL versus 3-piece IOL was 2.658 (95% confidence interval, CI: 1.010–6.993),...

Research paper thumbnail of Decrease in carbamylation of rubisco by high CO2 concentration is due to decrease of rubisco activase in kidney bean

Journal of Plant Biology, 1997

Decrease in rubisco activation at high CO2 concentration was caused by decrease in carbamylation ... more Decrease in rubisco activation at high CO2 concentration was caused by decrease in carbamylation of rubisco (Rohet al., 1996). However, it is unclear whether decrease in carbamylation rate at high CO2 concentration is due to decrease in activity itself or content of rubisco activase. To clarify this ambiguity, investigation was performed to determine effects of CO2 concentration on rubisco activase

Research paper thumbnail of Large‐scale phytogeographical patterns in East Asia in relation to latitudinal and climatic gradients

Journal of Biogeography, 2003

Aim This paper aims at determining how different floristic elements (e.g. cosmopolitan, tropical... more Aim This paper aims at determining how different floristic elements (e.g. cosmopolitan, tropical, and temperate) change with latitude and major climate factors, and how latitude affects the floristic relationships between East Asia and the other parts of the world.Location East Asia from the Arctic to tropical regions, an area crossing over 50° of latitudes and covering the eastern part of China, Korea, Japan and the eastern part of Russia.Methods East Asia is divided into forty‐five geographical regions. Based on the similarity of their world‐wide distributional patterns, a total of 2808 indigenous genera of seed plants found in East Asia were grouped into fourteen geographical elements, belonging to three major categories (cosmopolitan, tropical and temperate). The 50°‐long latitudinal gradient of East Asia was divided into five latitudinal zones, each of c. 10°. Phytogeographical relationships of East Asia to latitude and climatic variables were examined based on the forty‐fiv...

Research paper thumbnail of Induction of FGF-2 Synthesis by IL-1β in Aqueous Humor through P13-Kinase and p38 in Rabbit Corneal Endothelium

Investigative Opthalmology & Visual Science, 2010

Research paper thumbnail of Human Corneal Endothelial Cells Employ Phosphorylation of p27Kip1at Both Ser10 and Thr187 Sites for FGF-2-Mediated Cell Proliferation via PI 3-Kinase

Investigative Opthalmology & Visual Science, 2011

Research paper thumbnail of Tree growth and competition in a post‐logging Quercus mongolica forest on Mt. Sobaek, South Korea

Ecological Research, 2008

Secondary woodlands in South Korea cover most mountains from low to middle elevations. While gene... more Secondary woodlands in South Korea cover most mountains from low to middle elevations. While general patterns of forest succession are well understood, little is known about mechanisms of stand recovery after disturbance. We examined the spatio‐temporal variations in establishment, growth, size inequality, and mode of competition among trees in a 50‐year‐old post‐logging Quercus mongolica‐dominated stand. We further compared the growth and stem allometry of single trees, presumably of seed origin, with multi‐stemmed trees resprouting from stumps. Q. mongolica formed the upper canopy 16–22 m tall, 88.3% of total stand basal area, and 36.2% of total stem density, with most trees established during the first post‐logging decade (51.2% were resprouts). During the first three decades, the Q. mongolica recruits grew exponentially, and disproportionately more in diameter than few older reserved trees left after the last cutting. This substantially decreased size inequality. The reverse tre...

Research paper thumbnail of Invasion ofambrosia artemisiifolial. (compositae) in the Ukrainian Carpathians Mts. and the transcarpathian plain (central Europe)

Korean Journal of Biological Sciences, 1998

... Gravitation gradient m asl, 1*01) Active temperatures sum gradient, lech nog eric ecosystems ... more ... Gravitation gradient m asl, 1*01) Active temperatures sum gradient, lech nog eric ecosystems •IA ... Dr. W. Junk Publication, Hague, pp 1-370. Holub J and Jirasek V (1971) Terminologie. ... Preslia 43: 69-87. Jackowiak B (1993) Atlas of distribution of vascular plants in Poznan. ...

Research paper thumbnail of Transorbital−intracranial injury by a chopstick: three‐dimensional computed tomography

Acta Ophthalmologica Scandinavica, 2005

Research paper thumbnail of Clinical exhibition of increased accommodative loads for binocular fusion in patients with basic intermittent exotropia

BMC ophthalmology, Jan 7, 2016

To investigate the accommodative loads change needed to maintain binocular fusion in patients wit... more To investigate the accommodative loads change needed to maintain binocular fusion in patients with intermittent exotropia (IXT). Seventeen consecutive patients with basic IXT and 15 normal controls were recruited. The WAM-5500 autorefractor (GrandSeiko, Fukuyama, Japan) was used to measure refractive error (D) under binocular and monocular viewing conditions at 6 m, 50 cm, 33 cm and 20 cm. The difference between binocular and monocular refractive error (D) at each distance defined the change in the accommodative load. The changes in accommodative load were compared between IXT patients and normal controls. We also investigated the change in accommodative loads according to the fixing preference in patients with IXT. In IXT patients, the mean angles of deviation were 20.2 ± 7.19 and 21.0 ± 8.02 prism diopters at 6 m and 33 cm, respectively. Under binocular viewing, the changes in accommodative loads of each eye in IXT patients were significantly higher at 50, 33 and 20 cm than those ...

Research paper thumbnail of The Relationship Between Morphology and Function of the Meibomian Glands

Eye & contact lens, Jan 13, 2016

Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease (DED). Meibomian gland dy... more Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease (DED). Meibomian gland dysfunction is divided into two major categories based on meibomian gland secretion: low delivery and high delivery. The low-delivery states are further classified as either hyposecretory or obstructive subtype, and the high-delivery state is termed "hypersecretory MGD." Two parameters are commonly used to evaluate meibomian gland function: lipid layer thickness and meibum quality and expressibility. To evaluate the morphology of meibomian glands, meibography is used to detect meibomian gland dropout. Functional and morphological changes of meibomian glands are often thought to be well correlated; in reality, many cases do not because some patients have characteristics of both hypersecretory and obstructive subtypes. We suggest that the MGD classification system should be modified to include a mixed subtype to explain such patients.

Research paper thumbnail of Immediate Effect of 3% Diquafosol Ophthalmic Solution on Tear MUC5AC Concentration and Corneal Wetting Ability in Normal and Experimental Keratoconjunctivitis Sicca Rat Models

Current eye research, Jan 28, 2016

To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentratio... more To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. Rats were divided into normal and KCS groups. 3% of diquafosol solution was instilled into the right eye and normal saline into the left eye in both groups. To determine the peak time of tear MUC5AC concentration, tears were collected after 3% diquafosol instillation every 5 min up to 20 min. The tear film stability and the numbers of PAS-positive goblet cells were compared in both models. After diquafosol instillation, tear MUC5AC concentration increased steadily for 15 min, at which point the MUC5AC concentration reached its peak. In both normal and KCS groups, the MUC5AC concentration at 15 min was higher after instillation of 3% diquafosol solution (17.77 ± 2.09 ng/ml in the normal group, 9.65 ± 3.51 ng/ml in the KCS group) than that after saline ins...

Research paper thumbnail of Meibomian Gland Dysfunction in Patients With Chemotherapy-Induced Lacrimal Drainage Obstruction

Cornea, 2017

To investigate the relationship between chemotherapy-induced lacrimal drainage (LD) obstruction a... more To investigate the relationship between chemotherapy-induced lacrimal drainage (LD) obstruction and obstructive meibomian gland dysfunction. Twenty patients who had received chemotherapy were divided into 2 groups, according to the presence of LD obstruction: the LD obstruction group (n = 10) and control group (n = 10). Upper and lower meibomian gland loss was evaluated using noncontact meibography, and tear film lipid layer thickness was measured using an interferometer. The mean values of the right and left eyes of each patient were used to compare parameters between both groups. The LD obstruction group had higher levels of meibomian gland loss in both upper (42.9% ± 16.4%) and lower meibomian glands (80.1% ± 16.7%) than did the control group (17.3% ± 6.7% and 22.8% ± 13.0%, respectively) (P < 0.001 and P < 0.001, respectively). In the LD obstruction group, meibomian gland loss in the lower eyelid was significantly higher than that in the upper eyelid (P < 0.001). The li...

Research paper thumbnail of Effect of cataract surgery on intraocular pressure in supine and lateral decubitus body postures

Indian journal of ophthalmology, 2016

To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recum... more To investigate the effect of phacoemulsification on intraocular pressure (IOP) in different recumbent body postures including supine and lateral decubitus (LD) positions. This prospective, observational study included patients who had no glaucoma and who had planned to undergo phacoemulsification and intraocular lens implantation in one eye. Before and 1 month after cataract surgery, IOP was measured in both eyes using the Tono-Pen AVIA. We measured IOP in the sitting, supine, and LD (with the operated eye placed on the lower side) positions. IOP was measured 10 min after assuming each position in a randomized sequence. The Wilcoxon signed-rank test was used to compare the IOP changes before and 1 month after phacoemulsification in all postures. Twenty-nine patients participated in this study. Postoperative IOP was lower than the preoperative IOP when measured by Goldmann applanation tonometry in the sitting position (13.8 ± 1.9 mmHg vs. 12.6 ± 2.1 mmHg, P = 0.007). The postoperativ...

Research paper thumbnail of The Effects of Surgical Punctual Occlusion on Patients with Aqueous Deficient Dry Eye

Journal of the Korean Ophthalmological Society, 2016

Research paper thumbnail of Influence of benomyl on photosynthetic capacity in soybean leaves

Biotechnology and Bioprocess Engineering, 2001

... [13] Thringstrup, I. and S. Rosendahl (1994) Quantification of fungal activity in arbuscular ... more ... [13] Thringstrup, I. and S. Rosendahl (1994) Quantification of fungal activity in arbuscular mycorrhizal symbiosis by polyacrylamide gel eletrophoresis and densitometry of malate dehydrogenase. Soil Biol. ... 84: 930-936. [22] Roh, KS, JK Kim, SD Song, HS Chung, and JS Song ...

Research paper thumbnail of Modified Haigis Formula Effective Lens Position Equation for Ciliary Sulcus-Implanted Intraocular Lenses

American journal of ophthalmology, Jan 8, 2015

To investigate the effect of a modified Haigis formula effective lens position equation on improv... more To investigate the effect of a modified Haigis formula effective lens position equation on improving refractive outcomes in eyes with ciliary sulcus-implanted intraocular lenses (IOLs). Retrospective cross-sectional study. One hundred thirty-two eyes of 132 consecutive patients who underwent phacoemulsification with implantation of a ZA9003 (Abbott Medical Optics Inc.; 69 eyes) or AR40e (Abbott Medical Optics Inc.; 63 eyes) IOL in the ciliary sulcus were enrolled. The modified effective lens position (ELP) equation based on the corneal radius (CR) (ELP-β0-β1×CR, where β0 and β1 are parameters in the linear regression analysis) was obtained using linear regression analysis in each IOL group, and was applied to the other IOL group in order to evaluate its effect on refractive outcomes in an independent data set. The median absolute error (MedAE) was predicted using the modified effective lens position equation and was compared with that predicted using the adjusted IOL power. The modi...

Research paper thumbnail of Immediate Effects of 3% Diquafosol and 0.1% Hyaluronic Acid Ophthalmic Solution on Tear Break-Up Time in Normal Human Eyes

Journal of Ocular Pharmacology and Therapeutics, 2015

The purpose of this study was to evaluate the immediate effect of 3% diquafosol ophthalmic soluti... more The purpose of this study was to evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear break-up time (TBUT) in normal human eyes, and to compare it with that of saline and 0.1% hyaluronate ophthalmic solution. Cross sectional comparative study in the first study, 10 healthy volunteers underwent topical application of 2 different ophthalmic solutions in each eye. Saline was randomly applied to one eye and 3% diquafosol ophthalmic solution was added to the fellow eye. TBUT was measured and video recorded before application and at 5, 10, 15, and 20 min after. The TBUT in each eye was compared at each time point with regard to the 2 different ophthalmic solutions. In the second study, another 10 healthy volunteers were included. The same methods were used to compare the immediate effects of 0.1% hyaluronate and 3% diquafosol ophthalmic solution application on TBUT. In the first study, topical instillation of saline did not increase TBUT. However, 3% diquafosol significantly increased TBUT for up to 15 min after application. At every time point, the TBUT increased more significantly from baseline in the diquafosol group than it did in the saline group. In the second study, 0.1% hyaluronate increased TBUT for up to 5 min after application, while 3% diquafosol increased TBUT for up to 15 min. Although the TBUT changes after 5 min were not significantly different between the 2 groups, the TBUT changes at 10, 15, and 20 min were significantly greater in the 3% diquafosol group than they were in the 0.1% hyaluronic acid group (+1.58 ± 0.82 vs. +0.53 ± 1.36 at 10 min, +0.67 ± 0.91 vs. -0.04 ± 1.29 at 15 min, and -0.06 ± 0.96 vs. -0.59 ± 0.90, diquafosol group vs. hyaluronic acid group). One drop of 3% diquafosol increased TBUT for up to 15 min after application. The immediate effect of 3% diquafosol on TBUT was greater than that of saline and even that of 1% hyaluronate ophthalmic solution.

Research paper thumbnail of Phytogeography of Northeast Asia

Northeast Asia as defined in this study includes the Russian Far East, Northeast China, the north... more Northeast Asia as defined in this study includes the Russian Far East, Northeast China, the northern part of the Korean Peninsula, and Hokkaido Island (Japan). We determined the species richness of Northeast Asia at various spatial scales, analyzed the floristic relationships among geographic regions within Northeast Asia, and compared the flora of Northeast Asia with surrounding floras. The flora of Northeast Asia consists of 971 genera and 4953 species of native vascular plants. Based on their worldwide distributions, the 971 gen- era were grouped into fourteen phytogeographic elements. Over 900 species of vascular plants are endemic to Northeast Asia. Northeast Asia shares 39% of its species with eastern Siberia-Mongolia, 24% with Europe, 16.2% with western North America, and 12.4% with eastern North America. Species richness and floristic relationships among different regions within Northeast Asia were discussed. The northernmost (Arctic) region shares 64% of its genera and 9% o...