Sonia Melo - Academia.edu (original) (raw)

Papers by Sonia Melo

Research paper thumbnail of Mo1234: RAB27A EXPRESSION IS DECREASED IN PANCREATIC CANCER

Research paper thumbnail of Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to Fuel Tumor Progression - Source data file

Source data file linked to manuscript "Extracellular Vesicles from Pancreatic Cancer Stem Ce... more Source data file linked to manuscript "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to Fuel Tumor Progression" <br><br>Authors: Carolina F. Ruivo<sup>1,2,3*</sup>, Nuno Bastos<sup>1,2,3*</sup>, Bárbara Adem<sup>1,2,3</sup>,<sup> </sup>Inês A. Batista<sup>1,2,3</sup>, Cecília Duraes<sup>1,2</sup>,<sup> </sup>Carlos A. Melo<sup>4</sup>,<sup> </sup>Stéphanie A. Castaldo<sup>1,2,5</sup>, Francisco J Campos‐Laborie<sup>4</sup>,<sup> </sup>Pedro Moutinho-Ribeiro<sup>6,7</sup>, Barbara Mourão<sup>8</sup>, Ana R. Costa-Pinto<sup>1,2</sup>, Soraia da Silva<sup>1,2¥</sup>, Hugo Osorio<sup>1,2,7</sup>, Sergio Ciordia<sup>9</sup>, José L. Costa<sup>2,7</sup>, David W. Goodrich<sup>10...

Research paper thumbnail of Dentro da torre: identidade e “escrita feminina” em Adília Lopes

Moderna Sprak, Dec 15, 2012

Resumo Lida numa perspetiva de género, a obra da poetisa portuguesa contemporânea Adília Lopes le... more Resumo Lida numa perspetiva de género, a obra da poetisa portuguesa contemporânea Adília Lopes levanta questões identitárias e subjetivas presentes nas teorizações feministas. Destruindo a autoridade autoral, a escritora constrói-se como autora de poesia, isto é, como poetisa, pondo em causa a instituição literatura e por extensão as próprias normas sociais, culturais e genéricas instauradas. Portadora de uma voz ímpar no panorama literário português, Adília segue os passos de uma linhagem feminina (e feminista) presente, por exemplo, no uso da figura mítica de Mariana Alcoforado.

Research paper thumbnail of Additional file 12: Table S9. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

The multivariate Cox proportional hazards model of the fourth CRC patient cohort. (XLSX 19 kb)

Research paper thumbnail of Additional file 11: Table S8. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological features of the fourth CRC patient cohort. (XLSX 10 kb)

Research paper thumbnail of Additional file 9: Table S6b. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate analysis of the overall survival for the second CRC patient cohort. (... more Univariate and multivariate analysis of the overall survival for the second CRC patient cohort. (XLSX 10 kb)

Research paper thumbnail of Additional file 8: Table S6a. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate logistic regression of the second CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 7: Table S5. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological features of the second CRC patient cohort. (XLSX 10 kb)

Research paper thumbnail of Additional file 10: Table S7. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological characteristics of the metastatic colorectal carcinoma from the third CRC pa... more Clinico-pathological characteristics of the metastatic colorectal carcinoma from the third CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 6: Table S4b. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate analysis of the disease-specific survival for the first CRC patient c... more Univariate and multivariate analysis of the disease-specific survival for the first CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 5: Table S4a. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate logistic regression of the first CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 4: Table S3. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological characteristics of first CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 3: of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Supplementary Figures S1â 21. (DOC 61 mb)

Research paper thumbnail of Additional file 2: Table S2. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Primer sequences used for qRT-PCR, RACE, siRNAs, and vector construction in this study. (XLSX 11 kb)

Research paper thumbnail of Additional file 1: Table S1. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Genetic information about the pyknon-containing regions. (XLSX 12 kb)

Research paper thumbnail of Abstract 2010: Pancreatic cancer stem cell exosomes drive a hierarchical intratumor communication network that fuels disease progression through hippo pathway inhibition

Cancer Research, 2021

Intra-tumor heterogeneity represents a major challenge for cancer treatment. Resistance to therap... more Intra-tumor heterogeneity represents a major challenge for cancer treatment. Resistance to therapy and tumorigenic ability varies greatly between distinct subpopulations of cancer cells. Intercellular communication is critical to establish a cooperative environment that maintains tumor heterogeneity and potentiates disease progression. However, how subpopulations of cancer cells interact to support tumor progression is not fully understood. Exosomes have the potential to re-educate recipient cells through the delivery of their cargo, emerging as the main mediators of intercellular communication. Here we demonstrate that subpopulations of pancreatic cancer cells use exosomes to establish a hierarchical and dynamic communication network, the ExoNet. Exosomes from cancer stem cells (CSC) are preferentially taken up by non-CSC (NCSC). Targeted inhibition of CSC exosomes in PDAC orthotopic, genetically engineered and patient-derived xenograft mouse models is sufficient to impair tumor gr...

Research paper thumbnail of Utilisation d'exosomes pour le traitement de maladies

La presente invention concerne des nanoparticules a base de lipides (par exemple des liposomes ou... more La presente invention concerne des nanoparticules a base de lipides (par exemple des liposomes ou des exosomes) possedant CD47 a leur surface et comprenant un agent therapeutique (par exemple une proteine therapeutique, un anticorps, un ARN inhibiteur et/ou un medicament a petites molecules). En outre, la presente invention a trait a l'utilisation de ces nanoparticules a base de lipides a des fins therapeutiques.

Research paper thumbnail of Fr334 AGRIN PROTEIN AS A MOLECULAR PROGNOSTIC BIOMARKER IN PANCREATIC DUCTAL ADENOCARCINOMA

Research paper thumbnail of Exosomal Glypican-1 in Patients With Pancreatic Adenocarcinoma and Associated Risk Groups

American Journal of Gastroenterology, 2017

Research paper thumbnail of RECOLHA E ANÁLISE DE DADOS NUMA PERSPECTIVA FENOMENOLÓGICA: registros das redes sociais como corpus documental numa investigação em educação

Cadernos de Pesquisa, 2018

A pesquisa fenomenológica numa investigação qualitativa é peculiar por trazer ao campo epistemoló... more A pesquisa fenomenológica numa investigação qualitativa é peculiar por trazer ao campo epistemológico a lógica da compreensão do fenômeno em si por meio de num exercício exaustivo de redução, na busca da essência do fenômeno no momento em que ele acontece. O desafio neste estudo ainda vai mais além: realizar as reduções por meio das primeiras recolhas e análises de dados de postagens realizadas em dois grupos criados no Facebook, de duas Turmas de escolares participantes de um Projeto Educativo intitulado Projeto Aprender a Conhecer: Pesquisar de Corpo Inteiro (PAC), que ocorre numa Escola Pública Brasileira, objeto desta investigação. Diante disso, este artigo apresenta um pequeno extrato de um doutoramento em curso. Os resultados apontaram que uma análise fenomenológica de documentos virtuais requer um olhar bastante criterioso, bem como a necessidade da utilização de um enxerto-hermenêutico, que no nosso ponto de vista, permitiu emergir as primeiras tendências da análise. Enfim, ...

Research paper thumbnail of Mo1234: RAB27A EXPRESSION IS DECREASED IN PANCREATIC CANCER

Research paper thumbnail of Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to Fuel Tumor Progression - Source data file

Source data file linked to manuscript "Extracellular Vesicles from Pancreatic Cancer Stem Ce... more Source data file linked to manuscript "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to Fuel Tumor Progression" <br><br>Authors: Carolina F. Ruivo<sup>1,2,3*</sup>, Nuno Bastos<sup>1,2,3*</sup>, Bárbara Adem<sup>1,2,3</sup>,<sup> </sup>Inês A. Batista<sup>1,2,3</sup>, Cecília Duraes<sup>1,2</sup>,<sup> </sup>Carlos A. Melo<sup>4</sup>,<sup> </sup>Stéphanie A. Castaldo<sup>1,2,5</sup>, Francisco J Campos‐Laborie<sup>4</sup>,<sup> </sup>Pedro Moutinho-Ribeiro<sup>6,7</sup>, Barbara Mourão<sup>8</sup>, Ana R. Costa-Pinto<sup>1,2</sup>, Soraia da Silva<sup>1,2¥</sup>, Hugo Osorio<sup>1,2,7</sup>, Sergio Ciordia<sup>9</sup>, José L. Costa<sup>2,7</sup>, David W. Goodrich<sup>10...

Research paper thumbnail of Dentro da torre: identidade e “escrita feminina” em Adília Lopes

Moderna Sprak, Dec 15, 2012

Resumo Lida numa perspetiva de género, a obra da poetisa portuguesa contemporânea Adília Lopes le... more Resumo Lida numa perspetiva de género, a obra da poetisa portuguesa contemporânea Adília Lopes levanta questões identitárias e subjetivas presentes nas teorizações feministas. Destruindo a autoridade autoral, a escritora constrói-se como autora de poesia, isto é, como poetisa, pondo em causa a instituição literatura e por extensão as próprias normas sociais, culturais e genéricas instauradas. Portadora de uma voz ímpar no panorama literário português, Adília segue os passos de uma linhagem feminina (e feminista) presente, por exemplo, no uso da figura mítica de Mariana Alcoforado.

Research paper thumbnail of Additional file 12: Table S9. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

The multivariate Cox proportional hazards model of the fourth CRC patient cohort. (XLSX 19 kb)

Research paper thumbnail of Additional file 11: Table S8. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological features of the fourth CRC patient cohort. (XLSX 10 kb)

Research paper thumbnail of Additional file 9: Table S6b. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate analysis of the overall survival for the second CRC patient cohort. (... more Univariate and multivariate analysis of the overall survival for the second CRC patient cohort. (XLSX 10 kb)

Research paper thumbnail of Additional file 8: Table S6a. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate logistic regression of the second CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 7: Table S5. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological features of the second CRC patient cohort. (XLSX 10 kb)

Research paper thumbnail of Additional file 10: Table S7. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological characteristics of the metastatic colorectal carcinoma from the third CRC pa... more Clinico-pathological characteristics of the metastatic colorectal carcinoma from the third CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 6: Table S4b. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate analysis of the disease-specific survival for the first CRC patient c... more Univariate and multivariate analysis of the disease-specific survival for the first CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 5: Table S4a. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Univariate and multivariate logistic regression of the first CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 4: Table S3. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Clinico-pathological characteristics of first CRC patient cohort. (XLSX 9 kb)

Research paper thumbnail of Additional file 3: of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Supplementary Figures S1â 21. (DOC 61 mb)

Research paper thumbnail of Additional file 2: Table S2. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Primer sequences used for qRT-PCR, RACE, siRNAs, and vector construction in this study. (XLSX 11 kb)

Research paper thumbnail of Additional file 1: Table S1. of N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Genetic information about the pyknon-containing regions. (XLSX 12 kb)

Research paper thumbnail of Abstract 2010: Pancreatic cancer stem cell exosomes drive a hierarchical intratumor communication network that fuels disease progression through hippo pathway inhibition

Cancer Research, 2021

Intra-tumor heterogeneity represents a major challenge for cancer treatment. Resistance to therap... more Intra-tumor heterogeneity represents a major challenge for cancer treatment. Resistance to therapy and tumorigenic ability varies greatly between distinct subpopulations of cancer cells. Intercellular communication is critical to establish a cooperative environment that maintains tumor heterogeneity and potentiates disease progression. However, how subpopulations of cancer cells interact to support tumor progression is not fully understood. Exosomes have the potential to re-educate recipient cells through the delivery of their cargo, emerging as the main mediators of intercellular communication. Here we demonstrate that subpopulations of pancreatic cancer cells use exosomes to establish a hierarchical and dynamic communication network, the ExoNet. Exosomes from cancer stem cells (CSC) are preferentially taken up by non-CSC (NCSC). Targeted inhibition of CSC exosomes in PDAC orthotopic, genetically engineered and patient-derived xenograft mouse models is sufficient to impair tumor gr...

Research paper thumbnail of Utilisation d'exosomes pour le traitement de maladies

La presente invention concerne des nanoparticules a base de lipides (par exemple des liposomes ou... more La presente invention concerne des nanoparticules a base de lipides (par exemple des liposomes ou des exosomes) possedant CD47 a leur surface et comprenant un agent therapeutique (par exemple une proteine therapeutique, un anticorps, un ARN inhibiteur et/ou un medicament a petites molecules). En outre, la presente invention a trait a l'utilisation de ces nanoparticules a base de lipides a des fins therapeutiques.

Research paper thumbnail of Fr334 AGRIN PROTEIN AS A MOLECULAR PROGNOSTIC BIOMARKER IN PANCREATIC DUCTAL ADENOCARCINOMA

Research paper thumbnail of Exosomal Glypican-1 in Patients With Pancreatic Adenocarcinoma and Associated Risk Groups

American Journal of Gastroenterology, 2017

Research paper thumbnail of RECOLHA E ANÁLISE DE DADOS NUMA PERSPECTIVA FENOMENOLÓGICA: registros das redes sociais como corpus documental numa investigação em educação

Cadernos de Pesquisa, 2018

A pesquisa fenomenológica numa investigação qualitativa é peculiar por trazer ao campo epistemoló... more A pesquisa fenomenológica numa investigação qualitativa é peculiar por trazer ao campo epistemológico a lógica da compreensão do fenômeno em si por meio de num exercício exaustivo de redução, na busca da essência do fenômeno no momento em que ele acontece. O desafio neste estudo ainda vai mais além: realizar as reduções por meio das primeiras recolhas e análises de dados de postagens realizadas em dois grupos criados no Facebook, de duas Turmas de escolares participantes de um Projeto Educativo intitulado Projeto Aprender a Conhecer: Pesquisar de Corpo Inteiro (PAC), que ocorre numa Escola Pública Brasileira, objeto desta investigação. Diante disso, este artigo apresenta um pequeno extrato de um doutoramento em curso. Os resultados apontaram que uma análise fenomenológica de documentos virtuais requer um olhar bastante criterioso, bem como a necessidade da utilização de um enxerto-hermenêutico, que no nosso ponto de vista, permitiu emergir as primeiras tendências da análise. Enfim, ...