Paolo Sossai - Academia.edu (original) (raw)

Papers by Paolo Sossai

Revista médica de Chile, 2003

Journal of Applied Health Sciences and Medicine, 2024

Cleveland Clinic Journal of Medicine

European Review for Medical and Pharmacological Sciences, Nov 1, 2021

Understanding the evolutionary dynamics of the Coronavirus disease 2019 (COVID-19) pandemic in th... more Understanding the evolutionary dynamics of the Coronavirus disease 2019 (COVID-19) pandemic in the coming months is a matter of great importance and urgency for governments worldwide, making fundamental decisions based on what is known about the transmission mechanisms of the virus and its survival in the environment. The present study aimed to evaluate the impact of demographic variables, solar radiation and relative humidity on the spread of the COVID-19 pandemic of the various regions in Italy. The retrospective longitudinal study was conducted, and data used in this study was obtained from the Italian Health Ministry. Descriptive statistics included mean, frequency, and percentage, and results presented by graphs were calculated. The infection trend was investigated by comparing it with the demographic situation and the irradiation indices of solar ultraviolet light that are detected with the changing seasons. The present study reported that the geographic areas with higher population density and lower solar radiation during the autumn and winter months were most affected by SARS-CoV-2. The analysis carried out can provide a predictive model for the future phases of the COVID-19 pandemic in Italy, regardless of the adoption of lockdown measures and behavioral factors.

Inflammatory bowel diseases and the general practitioner’s role in a region

Minerva gastroenterologica e dietologica, 2007

The American journal of gastroenterology, 1995

Continuous intragastric pH monitoring was used in a large group of gastric ulcer patients to asse... more Continuous intragastric pH monitoring was used in a large group of gastric ulcer patients to assess whether the 24-h acidity pattern varies in relation to the ulcer location within the stomach and to assess whether there is a circadian rhythm of pH fluctuations in this disease. One hundred and thirty-three consecutive patients (79 male and 54 female, mean age 53 yr) with endoscopically and histologically proven benign gastric ulcer and 131 healthy subjects (70 male and 61 female, mean age 48 yr) were studied with a pH minielectrode positioned in the gastric corpus. Ulcer patients were divided into four subgroups in relation to the crater site: 1) above the angulus (n = 23); 2) angularis (n = 42); 3) antral (n = 26); and 4) prepyloric (n = 42). Subgroups 1 and 2 are characterized by significantly lower acidity (p < 0.0001) than healthy subjects for every time segment examined (24-h, day and night). Antral ulcers are less acidic than normal for both the total 24-h period (p < 0....

Clinical and Experimental Gastroenterology, 2010

Background: Inflammatory bowel diseases (IBD) are a serious burden for both patients and health c... more Background: Inflammatory bowel diseases (IBD) are a serious burden for both patients and health care providers because of the young age at which they occur and their chronic course. Aim: The purpose of this study was to assess how general practitioners (GPs) in the area of Camerino-Matelica, Marche (Central Italy) manage their patients with IBD. Materials and methods: Before providing an educational course about IBD to GPs, we administered a simple questionnaire containing 10 multiple-choice questions, allowing for only one possible answer, to GPs in the target area. After the educational course we administered a satisfaction questionnaire and evaluated the hospitalization rates for IBD in the catchment area in the year following the course. Results: In our GP sample, 71.8% indicated that they needed better instruction regarding IBD to enable them to diagnose the conditions given the difficulties posed by nonspecific symptoms and the need to use invasive diagnostic methods such as colonoscopy. Early results after the educational course for GPs indicate a reduced rate of hospitalization for IBD but these data must be confirmed by future research. Conclusions: If specialists and GPs managed IBD patients more carefully, their patients would probably suffer from fewer relapses and would have a better quality of life, which would be likely to mean considerable cost savings for the public health care system and society in general.

Schweizerische Medizinische Wochenschrift, Jun 6, 2012

In this brief review, we present some data from the literature on butyric acid and some of its mo... more In this brief review, we present some data from the literature on butyric acid and some of its more interesting potential uses, especially in the field of gastroenterology. Due to its principal characteristics, butyric acid is primarily used for pathologies of the colon (functional, inflammatory). Although only preliminary data are available, butyric acid may also have interesting extraintestinal applications, such as in the treatment of haematological, metabolic, and neurological pathologies.

Annals of Pharmacotherapy, Dec 1, 1998

1. MacKichan JJ. Carbamazepine. In: Taylor WJ, Caviness MHD, eds. A textbook for the clinical app... more 1. MacKichan JJ. Carbamazepine. In: Taylor WJ, Caviness MHD, eds. A textbook for the clinical application of therapeutic drug monitoring. Irving, TX: Abbott Laboratories, 1986:211-24. 2. Rowland M. Elimination. In: Rowland M, Tozer TN, eds. Clinical pharmacokinetics. Concepts and applications. 2nd ed. Philadelphia: Lea and Febiger. 1989:177-93. 3. Williams RL. Drug administration in hepatic disease. N Engl J Med 1983:309:1616-22. 4. Hooper WD, Dubetz DK, Bochner F, Cotter LM, Smith GA, Eadie MJ, et al. Plasma protein binding of carbamazepine. Clin Pharmacol Ther 1975;17:433-40. 5. Matsuo F, Bergen D, Faught E, Messenheimer JA, Dren AT, Rudd GD, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology 1993;43:2284-91. 6. Eriksson AS, Hoppu K, Nergardh A, Boreus L. Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. Epilepsia 1996;37:769-73. 7. Bond S. Clinical relevance of the effect of hepatic disease on drug disposition. Am J Hosp Pharm 1978;35:406-14. 8. Blaschke TF. Protein binding and kinetics of drugs in liver diseases. Clin Pharmacokinet 1977;2:32-44.

Journal of Chemotherapy, 2005

We investigated the in vitro influence of HAF on the antibacterial activity of moxifloxacin again... more We investigated the in vitro influence of HAF on the antibacterial activity of moxifloxacin against Escherichia coli ATCC 10798, Escherichia coli K-12, Proteus rettgeri (Sanelli), Staphylococcus aureus ATCC 25923, Staphylococcus aureus NCTC 1808 and Staphylococcus epidermidis ATCC 12228. Human ascitic fluid was obtained from 6 cirrhotic patients by paracentesis. The interaction effect was evaluated by the checkerboard technique. Our results indicate the ability of human ascitic fluid to reduce minimum inhibitory concentrations of moxifloxacin against Gram-negative bacteria, but not against Gram-positives.

Mount Sinai Journal of Medicine, Nov 1, 2001

Mesalamine-induced pulmonary adverse drug reactions (ADRs) in the course of therapy for inflammat... more Mesalamine-induced pulmonary adverse drug reactions (ADRs) in the course of therapy for inflammatory bowel diseases are rare events, having been reported in only 21 cases. This response, resembling hypersensitivity pneumonitis, is considered to be immunologically mediated and thus dose-independent. We report the case of a 70-year-old woman with ulcerative colitis (UC) who developed biopsy-proven interstitial pulmonary disease (lymphocytic alveolitis and mild interstitial pulmonary fibrosis) three months after starting mesalamine therapy. The usual treatment in cases of ADR is cessation of the drug and initiation of corticosteroids. In this case, we continued the mesalamine therapy but halved the dose, and did not add corticosteroids. This approach led to a remission of the pulmonary manifestations without a resurgence of UC symptoms. Based on a review of the literature and our own observation, we challenge the concept that mesalamine-induced pulmonary injury is always due to a hypersensitivity reaction. The evidence suggests that in some cases pulmonary ADR is dose-related; in such instances the most accepted therapy is not necessarily the most appropriate one.

International Maritime Health, 2020

We report the current situation regarding the COVID-19 pandemic with particular regard to seafare... more We report the current situation regarding the COVID-19 pandemic with particular regard to seafarers and with the indications drawn up by the Centro Internazionale Radio Medico (C.I.R.M.) in this regard.

International Journal of Clinical Practice, 2020

Revista médica de Chile, 2003

Journal of Applied Health Sciences and Medicine, 2024

Cleveland Clinic Journal of Medicine

European Review for Medical and Pharmacological Sciences, Nov 1, 2021

Understanding the evolutionary dynamics of the Coronavirus disease 2019 (COVID-19) pandemic in th... more Understanding the evolutionary dynamics of the Coronavirus disease 2019 (COVID-19) pandemic in the coming months is a matter of great importance and urgency for governments worldwide, making fundamental decisions based on what is known about the transmission mechanisms of the virus and its survival in the environment. The present study aimed to evaluate the impact of demographic variables, solar radiation and relative humidity on the spread of the COVID-19 pandemic of the various regions in Italy. The retrospective longitudinal study was conducted, and data used in this study was obtained from the Italian Health Ministry. Descriptive statistics included mean, frequency, and percentage, and results presented by graphs were calculated. The infection trend was investigated by comparing it with the demographic situation and the irradiation indices of solar ultraviolet light that are detected with the changing seasons. The present study reported that the geographic areas with higher population density and lower solar radiation during the autumn and winter months were most affected by SARS-CoV-2. The analysis carried out can provide a predictive model for the future phases of the COVID-19 pandemic in Italy, regardless of the adoption of lockdown measures and behavioral factors.

Inflammatory bowel diseases and the general practitioner’s role in a region

Minerva gastroenterologica e dietologica, 2007

The American journal of gastroenterology, 1995

Continuous intragastric pH monitoring was used in a large group of gastric ulcer patients to asse... more Continuous intragastric pH monitoring was used in a large group of gastric ulcer patients to assess whether the 24-h acidity pattern varies in relation to the ulcer location within the stomach and to assess whether there is a circadian rhythm of pH fluctuations in this disease. One hundred and thirty-three consecutive patients (79 male and 54 female, mean age 53 yr) with endoscopically and histologically proven benign gastric ulcer and 131 healthy subjects (70 male and 61 female, mean age 48 yr) were studied with a pH minielectrode positioned in the gastric corpus. Ulcer patients were divided into four subgroups in relation to the crater site: 1) above the angulus (n = 23); 2) angularis (n = 42); 3) antral (n = 26); and 4) prepyloric (n = 42). Subgroups 1 and 2 are characterized by significantly lower acidity (p < 0.0001) than healthy subjects for every time segment examined (24-h, day and night). Antral ulcers are less acidic than normal for both the total 24-h period (p < 0....

Clinical and Experimental Gastroenterology, 2010

Background: Inflammatory bowel diseases (IBD) are a serious burden for both patients and health c... more Background: Inflammatory bowel diseases (IBD) are a serious burden for both patients and health care providers because of the young age at which they occur and their chronic course. Aim: The purpose of this study was to assess how general practitioners (GPs) in the area of Camerino-Matelica, Marche (Central Italy) manage their patients with IBD. Materials and methods: Before providing an educational course about IBD to GPs, we administered a simple questionnaire containing 10 multiple-choice questions, allowing for only one possible answer, to GPs in the target area. After the educational course we administered a satisfaction questionnaire and evaluated the hospitalization rates for IBD in the catchment area in the year following the course. Results: In our GP sample, 71.8% indicated that they needed better instruction regarding IBD to enable them to diagnose the conditions given the difficulties posed by nonspecific symptoms and the need to use invasive diagnostic methods such as colonoscopy. Early results after the educational course for GPs indicate a reduced rate of hospitalization for IBD but these data must be confirmed by future research. Conclusions: If specialists and GPs managed IBD patients more carefully, their patients would probably suffer from fewer relapses and would have a better quality of life, which would be likely to mean considerable cost savings for the public health care system and society in general.

Schweizerische Medizinische Wochenschrift, Jun 6, 2012

In this brief review, we present some data from the literature on butyric acid and some of its mo... more In this brief review, we present some data from the literature on butyric acid and some of its more interesting potential uses, especially in the field of gastroenterology. Due to its principal characteristics, butyric acid is primarily used for pathologies of the colon (functional, inflammatory). Although only preliminary data are available, butyric acid may also have interesting extraintestinal applications, such as in the treatment of haematological, metabolic, and neurological pathologies.

Annals of Pharmacotherapy, Dec 1, 1998

1. MacKichan JJ. Carbamazepine. In: Taylor WJ, Caviness MHD, eds. A textbook for the clinical app... more 1. MacKichan JJ. Carbamazepine. In: Taylor WJ, Caviness MHD, eds. A textbook for the clinical application of therapeutic drug monitoring. Irving, TX: Abbott Laboratories, 1986:211-24. 2. Rowland M. Elimination. In: Rowland M, Tozer TN, eds. Clinical pharmacokinetics. Concepts and applications. 2nd ed. Philadelphia: Lea and Febiger. 1989:177-93. 3. Williams RL. Drug administration in hepatic disease. N Engl J Med 1983:309:1616-22. 4. Hooper WD, Dubetz DK, Bochner F, Cotter LM, Smith GA, Eadie MJ, et al. Plasma protein binding of carbamazepine. Clin Pharmacol Ther 1975;17:433-40. 5. Matsuo F, Bergen D, Faught E, Messenheimer JA, Dren AT, Rudd GD, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology 1993;43:2284-91. 6. Eriksson AS, Hoppu K, Nergardh A, Boreus L. Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. Epilepsia 1996;37:769-73. 7. Bond S. Clinical relevance of the effect of hepatic disease on drug disposition. Am J Hosp Pharm 1978;35:406-14. 8. Blaschke TF. Protein binding and kinetics of drugs in liver diseases. Clin Pharmacokinet 1977;2:32-44.

Journal of Chemotherapy, 2005

We investigated the in vitro influence of HAF on the antibacterial activity of moxifloxacin again... more We investigated the in vitro influence of HAF on the antibacterial activity of moxifloxacin against Escherichia coli ATCC 10798, Escherichia coli K-12, Proteus rettgeri (Sanelli), Staphylococcus aureus ATCC 25923, Staphylococcus aureus NCTC 1808 and Staphylococcus epidermidis ATCC 12228. Human ascitic fluid was obtained from 6 cirrhotic patients by paracentesis. The interaction effect was evaluated by the checkerboard technique. Our results indicate the ability of human ascitic fluid to reduce minimum inhibitory concentrations of moxifloxacin against Gram-negative bacteria, but not against Gram-positives.

Mount Sinai Journal of Medicine, Nov 1, 2001

Mesalamine-induced pulmonary adverse drug reactions (ADRs) in the course of therapy for inflammat... more Mesalamine-induced pulmonary adverse drug reactions (ADRs) in the course of therapy for inflammatory bowel diseases are rare events, having been reported in only 21 cases. This response, resembling hypersensitivity pneumonitis, is considered to be immunologically mediated and thus dose-independent. We report the case of a 70-year-old woman with ulcerative colitis (UC) who developed biopsy-proven interstitial pulmonary disease (lymphocytic alveolitis and mild interstitial pulmonary fibrosis) three months after starting mesalamine therapy. The usual treatment in cases of ADR is cessation of the drug and initiation of corticosteroids. In this case, we continued the mesalamine therapy but halved the dose, and did not add corticosteroids. This approach led to a remission of the pulmonary manifestations without a resurgence of UC symptoms. Based on a review of the literature and our own observation, we challenge the concept that mesalamine-induced pulmonary injury is always due to a hypersensitivity reaction. The evidence suggests that in some cases pulmonary ADR is dose-related; in such instances the most accepted therapy is not necessarily the most appropriate one.

International Maritime Health, 2020

We report the current situation regarding the COVID-19 pandemic with particular regard to seafare... more We report the current situation regarding the COVID-19 pandemic with particular regard to seafarers and with the indications drawn up by the Centro Internazionale Radio Medico (C.I.R.M.) in this regard.

International Journal of Clinical Practice, 2020