Charles Soule - Academia.edu (original) (raw)

Papers by Charles Soule

Research paper thumbnail of Poster: Measurement of Biomechanical Properties of Tissues Under Uniaxial Stress

Research paper thumbnail of Assessment of Ablative Therapies in Swine: Response of Respiratory Diaphragm to Varying Doses

Annals of Biomedical Engineering, 2018

Ablation is a common procedure for treating patients with cancer, cardiac arrhythmia, and other c... more Ablation is a common procedure for treating patients with cancer, cardiac arrhythmia, and other conditions, yet it can cause collateral injury to the respiratory diaphragm. Collateral injury can alter the diaphragm's properties and/or lead to respiratory dysfunction. Thus, it is important to understand the diaphragm's physiologic and biomechanical properties in response to ablation therapies, in order to better understand ablative modalities, minimize complications, and maximize the safety and efficacy of ablative procedures. In this study, we analyzed physiologic and biomechanical properties of swine respiratory diaphragm muscle bundles when exposed to 5 ablative modalities. To assess physiologic properties, we performed in vitro tissue bath studies and measured changes in peak force and baseline force. To assess biomechanical properties, we performed uniaxial stress tests, measuring force-displacement responses, stress-strain characteristics, and avulsion forces. After treating the muscle bundles with all 5 ablative modalities, we observed dose-dependent sustained reductions in peak force and transient increases in baseline force-but no consistent dose-dependent biomechanical responses. These data provide novel insights into the effects of various ablative modalities on the respiratory diaphragm, insights that could enable improvements in ablative techniques and therapies.

Research paper thumbnail of The Comparative assessment of clinical ablative therapies: effects on physiological and biomechanical properties of contractile tissues in response to therapeutic doses

University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Adviso... more University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Advisor: Arthur G. Erdman. 1 computer file (PDF); xi, 357 pages, appendices 1-7.

Research paper thumbnail of Effects of Ablation (Radio Frequency, Cryo, Microwave) on Physiologic Properties of the Human Vastus Lateralis

IEEE Transactions on Biomedical Engineering, 2018

Research paper thumbnail of Tissue Necrosis Associated With Chemical Ablations1

Journal of Medical Devices, 2016

Research paper thumbnail of Simultaneous In Vivo Assessment of Contractile Properties and Electromyographic (EMG) Activities in a Knock-Out Mouse Model of Myotonic Dystrophy

Journal of Medical Devices, 2011

Research paper thumbnail of Effect of Tissue Dehydration on Smooth Muscle Cell Contractility, Collagen Matrix Structure and Overall Artery Biomechanics

ASME 2008 Summer Bioengineering Conference, Parts A and B, 2008

ABSTRACT

Research paper thumbnail of Radiofrequency Ablation for Hepatocellular Carcinoma: Enhanced Ablative Responses Utilizing Adjuvant NaCl Pretreatments 1

Journal of Medical Devices, 2015

Research paper thumbnail of Interspecies Differences in Electromechanical and Histological Characteristics of Human and Swine Esophagus1

Journal of Medical Devices, 2015

Research paper thumbnail of Measurement of Biomechanical Properties of Tissues Under Uniaxial Stress1

Journal of Medical Devices, 2014

Research paper thumbnail of Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle

Muscle & Nerve, 2005

A link between the cardioprotective benefits of pharmacological preconditioning and natural mamma... more A link between the cardioprotective benefits of pharmacological preconditioning and natural mammalian hibernation is considered to involve the cellular activation of opioid receptors and subsequent opening of K(ATP) channels. In previous studies, we have demonstrated the protective effects of specific delta-opioid agonists against porcine cardiac ischemia/reperfusion injury. We hypothesize here that preincubation with hibernation induction trigger (HIT) should confer a similar protection in skeletal muscles. Therefore, muscle bundles from swine were pretreated with plasma from hibernating woodchucks (HWP) for 30 min, then exposed to hypoxia for 90 min and reoxygenation for 120 min. Stimulated twitch forces were assessed. The functional effects of pretreatment with nonhibernation (summer) woodchuck plasma, a K(ATP) blocker, or opioid antagonist were also studied. During the reoxygenation period, significantly greater force recoveries were observed only for bundles pretreated with HWP; this response was blocked by naloxone (P < 0.05). We conclude that HIT pretreatment could be used to confer protection against hypoxia/reperfusion injury of skeletal muscles of nonhibernators; it could potentially be utilized to prevent injury during surgical procedures requiring ischemia.

Research paper thumbnail of Isolated atrial segment pacing: A physiological alternative to AV junctional ablation with ventricular pacing

Research paper thumbnail of The effects of propofol on myotonic reaction in skeletal muscle

European Journal of Anaesthesiology, 2008

Research paper thumbnail of Isolated four-chamber working swine heart model

The Annals of Thoracic Surgery, 2000

Research paper thumbnail of In Vitro Studies of Human Hearts

The Annals of Thoracic Surgery, 2005

Research paper thumbnail of Freeze–Thaw Induced Biomechanical Changes in Arteries: Role of Collagen Matrix and Smooth Muscle Cells

Annals of Biomedical Engineering, 2010

Research paper thumbnail of In Vitro Effects of Propofol and Volatile Agents on Pharmacologically Induced Chloride Channel Myotonia

Anesthesiology, 2009

Background Anesthetic choice for patients with chloride channel myotonia remains under debate. Th... more Background Anesthetic choice for patients with chloride channel myotonia remains under debate. The authors have, therefore, investigated the in vitro effects of various anesthetic agents on pharmacologically induced chloride channel myotonia. Methods Functionally viable (> 10 mN force generation) rectus abdominis muscle preparations obtained from normal swine were investigated using in vitro muscle contracture test baths. During continuous 0.1-Hz supramaximal electrical stimulation, the chloride channel blocker 9-anthracenecarboxylic acid (64 microM) was added before the addition of propofol or one of three volatile anesthetics. The concentration of propofol in either Intralipid (n = 11) or dimethyl sulfoxide (n = 10) was doubled every 10 min (from 4-512 microM). The concentration of halothane (n = 8), isoflurane (n = 8), and sevoflurane (n = 8) was doubled from 0.25 vol% up to the maximum dose according to calibrated vaporizers. Control muscle bundles were either untreated (n = ...

Research paper thumbnail of Lactic acid restores skeletal muscle force in an in vitro fatigue model: are voltage-gated chloride channels involved?

AJP: Cell Physiology, 2012

High interstitial K+ concentration ([K+]) has been reported to impede normal propagation of elect... more High interstitial K+ concentration ([K+]) has been reported to impede normal propagation of electrical impulses along the muscle cell membrane (sarcolemma) and then also into the transverse tubule system; this is one considered underlying mechanism associated with the development of muscle fatigue. Interestingly, the extracellular buildup of lactic acid, once considered an additional cause for muscle fatigue, was recently shown to have force-restoring effects in such conditions. Specifically, it was proposed that elevated lactic acid (and intracellular acidosis) may lead to inhibition of voltage-gated chloride channels, thereby reestablishing better excitability of the muscle cell sarcolemma. In the present study, using an in vitro muscle contractile experimental setup to study functionally viable rectus abdominis muscle preparations obtained from normal swine, we examined the effects of 20 mM lactic acid and 512 μM 9-anthracenecarboxylic acid (9-AC; a voltage-gated chloride channel...

Research paper thumbnail of Physiological Tissue Response to Various Ablative Modalities1

Journal of Medical Devices, 2014

Research paper thumbnail of The Comparative assessment of clinical ablative therapies: effects on physiological and biomechanical properties of contractile tissues in response to therapeutic doses

University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Adviso... more University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Advisor: Arthur G. Erdman. 1 computer file (PDF); xi, 357 pages, appendices 1-7.

Research paper thumbnail of Poster: Measurement of Biomechanical Properties of Tissues Under Uniaxial Stress

Research paper thumbnail of Assessment of Ablative Therapies in Swine: Response of Respiratory Diaphragm to Varying Doses

Annals of Biomedical Engineering, 2018

Ablation is a common procedure for treating patients with cancer, cardiac arrhythmia, and other c... more Ablation is a common procedure for treating patients with cancer, cardiac arrhythmia, and other conditions, yet it can cause collateral injury to the respiratory diaphragm. Collateral injury can alter the diaphragm's properties and/or lead to respiratory dysfunction. Thus, it is important to understand the diaphragm's physiologic and biomechanical properties in response to ablation therapies, in order to better understand ablative modalities, minimize complications, and maximize the safety and efficacy of ablative procedures. In this study, we analyzed physiologic and biomechanical properties of swine respiratory diaphragm muscle bundles when exposed to 5 ablative modalities. To assess physiologic properties, we performed in vitro tissue bath studies and measured changes in peak force and baseline force. To assess biomechanical properties, we performed uniaxial stress tests, measuring force-displacement responses, stress-strain characteristics, and avulsion forces. After treating the muscle bundles with all 5 ablative modalities, we observed dose-dependent sustained reductions in peak force and transient increases in baseline force-but no consistent dose-dependent biomechanical responses. These data provide novel insights into the effects of various ablative modalities on the respiratory diaphragm, insights that could enable improvements in ablative techniques and therapies.

Research paper thumbnail of The Comparative assessment of clinical ablative therapies: effects on physiological and biomechanical properties of contractile tissues in response to therapeutic doses

University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Adviso... more University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Advisor: Arthur G. Erdman. 1 computer file (PDF); xi, 357 pages, appendices 1-7.

Research paper thumbnail of Effects of Ablation (Radio Frequency, Cryo, Microwave) on Physiologic Properties of the Human Vastus Lateralis

IEEE Transactions on Biomedical Engineering, 2018

Research paper thumbnail of Tissue Necrosis Associated With Chemical Ablations1

Journal of Medical Devices, 2016

Research paper thumbnail of Simultaneous In Vivo Assessment of Contractile Properties and Electromyographic (EMG) Activities in a Knock-Out Mouse Model of Myotonic Dystrophy

Journal of Medical Devices, 2011

Research paper thumbnail of Effect of Tissue Dehydration on Smooth Muscle Cell Contractility, Collagen Matrix Structure and Overall Artery Biomechanics

ASME 2008 Summer Bioengineering Conference, Parts A and B, 2008

ABSTRACT

Research paper thumbnail of Radiofrequency Ablation for Hepatocellular Carcinoma: Enhanced Ablative Responses Utilizing Adjuvant NaCl Pretreatments 1

Journal of Medical Devices, 2015

Research paper thumbnail of Interspecies Differences in Electromechanical and Histological Characteristics of Human and Swine Esophagus1

Journal of Medical Devices, 2015

Research paper thumbnail of Measurement of Biomechanical Properties of Tissues Under Uniaxial Stress1

Journal of Medical Devices, 2014

Research paper thumbnail of Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle

Muscle & Nerve, 2005

A link between the cardioprotective benefits of pharmacological preconditioning and natural mamma... more A link between the cardioprotective benefits of pharmacological preconditioning and natural mammalian hibernation is considered to involve the cellular activation of opioid receptors and subsequent opening of K(ATP) channels. In previous studies, we have demonstrated the protective effects of specific delta-opioid agonists against porcine cardiac ischemia/reperfusion injury. We hypothesize here that preincubation with hibernation induction trigger (HIT) should confer a similar protection in skeletal muscles. Therefore, muscle bundles from swine were pretreated with plasma from hibernating woodchucks (HWP) for 30 min, then exposed to hypoxia for 90 min and reoxygenation for 120 min. Stimulated twitch forces were assessed. The functional effects of pretreatment with nonhibernation (summer) woodchuck plasma, a K(ATP) blocker, or opioid antagonist were also studied. During the reoxygenation period, significantly greater force recoveries were observed only for bundles pretreated with HWP; this response was blocked by naloxone (P < 0.05). We conclude that HIT pretreatment could be used to confer protection against hypoxia/reperfusion injury of skeletal muscles of nonhibernators; it could potentially be utilized to prevent injury during surgical procedures requiring ischemia.

Research paper thumbnail of Isolated atrial segment pacing: A physiological alternative to AV junctional ablation with ventricular pacing

Research paper thumbnail of The effects of propofol on myotonic reaction in skeletal muscle

European Journal of Anaesthesiology, 2008

Research paper thumbnail of Isolated four-chamber working swine heart model

The Annals of Thoracic Surgery, 2000

Research paper thumbnail of In Vitro Studies of Human Hearts

The Annals of Thoracic Surgery, 2005

Research paper thumbnail of Freeze–Thaw Induced Biomechanical Changes in Arteries: Role of Collagen Matrix and Smooth Muscle Cells

Annals of Biomedical Engineering, 2010

Research paper thumbnail of In Vitro Effects of Propofol and Volatile Agents on Pharmacologically Induced Chloride Channel Myotonia

Anesthesiology, 2009

Background Anesthetic choice for patients with chloride channel myotonia remains under debate. Th... more Background Anesthetic choice for patients with chloride channel myotonia remains under debate. The authors have, therefore, investigated the in vitro effects of various anesthetic agents on pharmacologically induced chloride channel myotonia. Methods Functionally viable (> 10 mN force generation) rectus abdominis muscle preparations obtained from normal swine were investigated using in vitro muscle contracture test baths. During continuous 0.1-Hz supramaximal electrical stimulation, the chloride channel blocker 9-anthracenecarboxylic acid (64 microM) was added before the addition of propofol or one of three volatile anesthetics. The concentration of propofol in either Intralipid (n = 11) or dimethyl sulfoxide (n = 10) was doubled every 10 min (from 4-512 microM). The concentration of halothane (n = 8), isoflurane (n = 8), and sevoflurane (n = 8) was doubled from 0.25 vol% up to the maximum dose according to calibrated vaporizers. Control muscle bundles were either untreated (n = ...

Research paper thumbnail of Lactic acid restores skeletal muscle force in an in vitro fatigue model: are voltage-gated chloride channels involved?

AJP: Cell Physiology, 2012

High interstitial K+ concentration ([K+]) has been reported to impede normal propagation of elect... more High interstitial K+ concentration ([K+]) has been reported to impede normal propagation of electrical impulses along the muscle cell membrane (sarcolemma) and then also into the transverse tubule system; this is one considered underlying mechanism associated with the development of muscle fatigue. Interestingly, the extracellular buildup of lactic acid, once considered an additional cause for muscle fatigue, was recently shown to have force-restoring effects in such conditions. Specifically, it was proposed that elevated lactic acid (and intracellular acidosis) may lead to inhibition of voltage-gated chloride channels, thereby reestablishing better excitability of the muscle cell sarcolemma. In the present study, using an in vitro muscle contractile experimental setup to study functionally viable rectus abdominis muscle preparations obtained from normal swine, we examined the effects of 20 mM lactic acid and 512 μM 9-anthracenecarboxylic acid (9-AC; a voltage-gated chloride channel...

Research paper thumbnail of Physiological Tissue Response to Various Ablative Modalities1

Journal of Medical Devices, 2014

Research paper thumbnail of The Comparative assessment of clinical ablative therapies: effects on physiological and biomechanical properties of contractile tissues in response to therapeutic doses

University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Adviso... more University of Minnesota Ph.D. dissertation. September 2014. Major: Biomedical Engineering. Advisor: Arthur G. Erdman. 1 computer file (PDF); xi, 357 pages, appendices 1-7.