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Papers by Sreenu Jennepalli
![Research paper thumbnail of Synthesis of Mono and Bis[60]fullerene-Based Dicationic Peptoids](https://attachments.academia-assets.com/86168715/thumbnails/1.jpg)
](European Journal of Organic Chemistry, 2014
Increasing biological applications of fullerenyl amino acids and their derivatives encouraged us ... more Increasing biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono and bis [60]fullerenyldihydropyrrole carboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di and tetra cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
Journal of the American Chemical Society, 2014
Density-functional theory (DFT) calculations indicate that van der Waals fullerene dimers and lar... more Density-functional theory (DFT) calculations indicate that van der Waals fullerene dimers and larger oligomers can form interstitial electron traps in which the electrons are even more strongly bound than in isolated fullerene radical anions. The fullerenes behave like "super atoms" and the interstitial electron traps represent one-electron intermolecular σ-bonds. Spectroelectrochemical measurements on a bis-fullerene-substituted peptide provide experimental support. The proposed deep electron traps are relevant for all organic electronics applications in which noncovalently linked fullerenes in van der Waals contact with one another serve as n-type semiconductors. 1, 1 .-, 1 2-2, 2 .-, 2 2-3, 3 .-(-)
![Research paper thumbnail of ChemInform Abstract: [60]Fullerenyl Amino Acids and Peptides: A Review of their Synthesis and Applications](https://attachments.academia-assets.com/86168716/thumbnails/1.jpg)
](![Research paper thumbnail of [60]Fullerenyl amino acids and peptides: a review of their synthesis and applications](https://attachments.academia-assets.com/86168711/thumbnails/1.jpg)
](RSC Adv., 2014
This review reports on the latest progress in the synthesis of fullerenyl amino acids and related... more This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N- and C-capping amino acids, and those amino acids in which the [60]fullerene group is attached to the amino acid side chain.
European Journal of Medicinal Chemistry, 2003
Bioorganic & Medicinal Chemistry, 2010
Influenza virus infection constitutes a significant health problem in need of more effective ther... more Influenza virus infection constitutes a significant health problem in need of more effective therapies. We have recently identified ((2R,3S,4R,5R)-3-acetoxy-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3,4-dimethyl-tetrahydrofuran-2-yl) methyl benzoate (18c) as a potent influenza virus inhibitor. We now here report the synthesis and evaluation of a series of C-3 0 modified ribose nucleosides. These novel compounds were prepared, primarily by taking known ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5oxo-tetrahydrofuran-2-yl)methyl benzoate (1) and converting it in to C-3 keto sugar (7), reacting C-3 keto group with methyl magnesium bromide, followed by coupling these sugars with purine and pyrimidine bases. Anti influenza viral activity was determined by screening against both A and B viral strains.
The present invention provides new heterocyclic compounds, particularly substituted pyridines, me... more The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
![Research paper thumbnail of Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry and material science applications](https://attachments.academia-assets.com/80843607/thumbnails/1.jpg)
](Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry Synthesis of [60]fulle... more Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry and material science applications and material science applications
RSC Advances, 2021
Removing per- and polyfluoroalkyl substances (PFASs) from water by ceric ammonium nitrate (CAN).
Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producin... more Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and limited, and thus inexpensive drug treatments for C. difficile infection (CDI) with improved efficacy and specificity are urgently needed. To improve the solubility of our cationic amphiphilic 1,1′-binaphthylpeptidomimetics developed earlier that showed promise in an in vivo murine CDI model we have synthesized related compounds with an N-arytriazole or N-naphthyltriazole moiety instead of the 1,1′-biphenyl or 1,1′-binaphthyl moiety. This modification was made to increase the polarity and thus water solubility of the overall peptidomimetics, while maintaining the aromatic character. The dicationic N-naphthyltriazole derivative 40 was identified as a C. difficile-selective antibacterial with MIC values of 8 µg/mL against C. difficile strains ATC...
ACS Omega
Breakdown and utilization of cellulose are critical for the bioenergy sector; however, current ce... more Breakdown and utilization of cellulose are critical for the bioenergy sector; however, current cellulose-to-energy conversion schemes often consume large quantities of unrecoverable chemicals, or are expensive, due to the need for enzymes or high temperatures. In this paper, we demonstrate a new method for converting cellulose into soluble compounds using a mixture of Fe 2+ and Fe 3+ as catalytic centers for the breakdown, yielding Fe 3 O 4 nanoparticles during the hydrothermal process. Iron precursors transformed more than 61% of microcrystalline cellulose into solutes, with the composition of the solute changing with the initial Fe 3+ concentration. The primary products of the breakdown of cellulose were a range of aldaric acids with different molecular weights. The nanoparticles have concentration-dependent tuneable sizes between 6.7 and 15.8 nm in diameter. The production of value-added nanomaterials at low temperatures improves upon the economics of traditional cellulose-to-energy conversion schemes with the precursor value increasing rather than deteriorating over time.
![Research paper thumbnail of Synthesis of Mono and Bis[60]fullerene-Based Dicationic Peptoids](https://attachments.academia-assets.com/45498634/thumbnails/1.jpg)
](European Journal of Organic Chemistry, 2014
2015). Synthesis of mono and bis[60]fullerene-based dicationic peptoids.
European Journal of Organic Chemistry, 2014
Increasing biological applications of fullerenyl amino acids and their derivatives encouraged us ... more Increasing biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono and bis [60]fullerenyldihydropyrrole carboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di and tetra cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
Journal of the American Chemical Society, 2014
Density-functional theory (DFT) calculations indicate that van der Waals fullerene dimers and lar... more Density-functional theory (DFT) calculations indicate that van der Waals fullerene dimers and larger oligomers can form interstitial electron traps in which the electrons are even more strongly bound than in isolated fullerene radical anions. The fullerenes behave like "super atoms" and the interstitial electron traps represent one-electron intermolecular σ-bonds. Spectroelectrochemical measurements on a bis-fullerene-substituted peptide provide experimental support. The proposed deep electron traps are relevant for all organic electronics applications in which noncovalently linked fullerenes in van der Waals contact with one another serve as n-type semiconductors. 1, 1 .-, 1 2-2, 2 .-, 2 2-3, 3 .-(-)
RSC Adv., 2014
This review reports on the latest progress in the synthesis of fullerenyl amino acids and related... more This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N- and C-capping amino acids, and those amino acids in which the [60]fullerene group is attached to the amino acid side chain.
European Journal of Medicinal Chemistry, 2003
Bioorganic & Medicinal Chemistry, 2010
Influenza virus infection constitutes a significant health problem in need of more effective ther... more Influenza virus infection constitutes a significant health problem in need of more effective therapies. We have recently identified ((2R,3S,4R,5R)-3-acetoxy-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3,4-dimethyl-tetrahydrofuran-2-yl) methyl benzoate (18c) as a potent influenza virus inhibitor. We now here report the synthesis and evaluation of a series of C-3 0 modified ribose nucleosides. These novel compounds were prepared, primarily by taking known ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5oxo-tetrahydrofuran-2-yl)methyl benzoate (1) and converting it in to C-3 keto sugar (7), reacting C-3 keto group with methyl magnesium bromide, followed by coupling these sugars with purine and pyrimidine bases. Anti influenza viral activity was determined by screening against both A and B viral strains.
The present invention provides new heterocyclic compounds, particularly substituted pyridines, me... more The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry Synthesis of [60]fulle... more Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry Synthesis of [60]fullerenyl amino acid derivatives for medicinal chemistry and material science applications and material science applications
RSC Advances, 2021
Removing per- and polyfluoroalkyl substances (PFASs) from water by ceric ammonium nitrate (CAN).
Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producin... more Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and limited, and thus inexpensive drug treatments for C. difficile infection (CDI) with improved efficacy and specificity are urgently needed. To improve the solubility of our cationic amphiphilic 1,1′-binaphthylpeptidomimetics developed earlier that showed promise in an in vivo murine CDI model we have synthesized related compounds with an N-arytriazole or N-naphthyltriazole moiety instead of the 1,1′-biphenyl or 1,1′-binaphthyl moiety. This modification was made to increase the polarity and thus water solubility of the overall peptidomimetics, while maintaining the aromatic character. The dicationic N-naphthyltriazole derivative 40 was identified as a C. difficile-selective antibacterial with MIC values of 8 µg/mL against C. difficile strains ATC...
ACS Omega
Breakdown and utilization of cellulose are critical for the bioenergy sector; however, current ce... more Breakdown and utilization of cellulose are critical for the bioenergy sector; however, current cellulose-to-energy conversion schemes often consume large quantities of unrecoverable chemicals, or are expensive, due to the need for enzymes or high temperatures. In this paper, we demonstrate a new method for converting cellulose into soluble compounds using a mixture of Fe 2+ and Fe 3+ as catalytic centers for the breakdown, yielding Fe 3 O 4 nanoparticles during the hydrothermal process. Iron precursors transformed more than 61% of microcrystalline cellulose into solutes, with the composition of the solute changing with the initial Fe 3+ concentration. The primary products of the breakdown of cellulose were a range of aldaric acids with different molecular weights. The nanoparticles have concentration-dependent tuneable sizes between 6.7 and 15.8 nm in diameter. The production of value-added nanomaterials at low temperatures improves upon the economics of traditional cellulose-to-energy conversion schemes with the precursor value increasing rather than deteriorating over time.
European Journal of Organic Chemistry, 2014
2015). Synthesis of mono and bis[60]fullerene-based dicationic peptoids.